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Metabolic checkpoints in neurodegenerative T helper 17（TH17） and neuroregenerative regulatory T(Treg) cells as new therapeutic targets for multiple sclerosis

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Neural Regeneration Research 2020年第2期15卷 267-269页

作者： Hongx.ng Shen James A. Bonner Lewis zhichang Shi Department of Radiation Oncology The University of Alabama at BirminghamBirminghamALUSA O'Neal Comprehensive Cancer Center The University of Alabama at BirminghamBirminghamALUSA Department of Microbiology The University of Alabama at BirminghamBirminghamALUSAProgram in ImmunologyThe University of Alabama at BirminghamBirminghamALUSA

The central nervous system (CNS) is an immune-privileged site with tightly-regulated immune responses, a concept proposed by Nobel Laureate Sir Peter Medawar in 1960. Under physiological conditions, only a few T lymph... 详细信息

关键词： Metabolic checkpoints multiple sclerosis CNS

Improving Nitrogen Use Efficiency in Rice through Enhancing Root Nitrate Uptake Mediated by a Nitrate Transporter, NRT1.1B

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Journal of Genetics and Genomics 2015年第9期42卷 463-465页

作者： zhichang Chen JianFeng Ma Institute of Plant Science and Resources Okayama University

Nitrogen （N） is one of most important nutrients for crop production, which makes up 1%-5% of total plant dry matter （Marschner, 2012）. Due to the limited availability of N in soil, application of N fertilizers has been an important agronomic practice to increase crop yield. However, over-application of N fertilizers has caused pollution of N in soil, water and air. It was estimated that the nitrogen use efficiency （NUE, the total biomass or grain yield produced per unit of applied fertilizer N） in cereal crops is as low as 33% （Raun and Johnson, 1999）. Therefore, improving NUE together with reducing application of N fertilizers is an important issue for environment and sustainable production of crops. This is especially important for rice, which is a staple food for half population in the world.

关键词： NRT1.1B Improving Nitrogen Use Efficiency in Rice through Enhancing Root Nitrate Uptake Mediated by a Nitrate Transporter

Recent advances in the synthesis and applications of furocoumarin derivatives

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Chinese Chemical Letters 2023年第9期34卷 119-133页

作者： Chaoyue Chen Zheng-Bin Tang zhichang Liu School of Chemistry and Chemical Engineering Jiangsu University of TechnologyChangzhou 213001China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province Department of ChemistrySchool of Science and Research Center for Industries of the FutureWestlake Universityand Westlake Institute for Advanced StudyHangzhou 310030China

Furocoumarins are an important class of heterocyclic compounds with a fused tricyclic structure of coumarin and furan *** are commonly found in bioactive natural products and have a diverse range of biological and pharmaceutical properties,including cytotox.city,photosensitivity,insecticidal,antibacterial,and antifungal activity,among *** elegant linear/angular tricyclic skeleton and superior pharmacological properties,make them ideal for building and developing advanced biological scaffolds for biomedical *** a result,the family of furocoumarins has been the focus of intensive research,and lots of encouraging progress have been achieved in recent *** review summarizes the most recent methods reported for the synthesis of the furocoumarin derivative family,along with their applications in medicinal chemistry covering from 2018 to 2022.

关键词： Furocoumarin Coumarin Furan Synthesis Pharmaceutical activity Applications

Influence of Design Reference on Tracking Performance of Feedback Control

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Transactions of Tianjin University 2018年第1期24卷 66-72页

作者： Qiqi Zhao zhichang Qin Jianqiao Sun School of Mechanical Engineering Tianjin University School of Engineering University of California Merced

In this paper, we present an investigation on the tracking performances of feedback control as a function of reference signals. We use multi-objective optimal designs of feedback controls as a fair basis for comparing different control designs, and ex.mine step, ramp, and periodic signals at various frequencies. Through comparing the tracking performances of controls designed with different reference signals,we find that the controls designed with ramp signals perform better in tracking step and ramp references than those designed with step signals. To track periodic signals, we find that the controls designed with periodic signals at the same frequency generally provide the best performance, and those designed with step and ramp signals perform comparably.

关键词： Reference signal Tracking performance Feedback control Multi-objective optimization

Ex.erimental results for the vapor-liquid equilibria of 0(formaldehyde+1,3,5-triox.ne+methanol+salt+water)systems and comparison with predictions

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Chinese Journal of Chemical Engineering 2021年第4期34卷 291-300页

作者： x.anming Zhang Mengchen Li Yufeng Hu zhichang Liu Shuqin Mo State Key Laboratory of Heavy Oil Processing and High Pressure Fluid Phase Behavior&Property Research Laboratory China University of PetroleumBeijing 102249China School of Chemical Engineering Ordos Institute of TechnologyOrdos 017000China PetroChina Petrochemical Research Institute Science Base PetroChina Beijing 102206China

The salt effect on the vaporliquid phase equilibrium(VLE)of solvent mix.ures is of significant interest in the industrial production of 1,3,*** data for the VLE of quinary systems(formaldehyde+1,3,5triox.ne+methanol+salt+water)and their ternary subsystems(formaldehyde+salt+water),(1,3,5triox.ne+salt+water),and(methanol+salt+water)were systematic measured under atmospheric *** salts considered included KBr,NaNO_(3),and CaCl_(2).The ex.ended UNIFAC model was used to describe the VLE of the saltcontaining reactive *** model parameters were determined from the ex.erimental VLE data of ternary systems or obtained from the literature,and then were used to predict the VLE of systems(1,3,5triox.ne+KBr+water),(methanol+KBr+water),(formaldehyde+KBr+water),and(formaldehyde+1,3,5triox.ne+methanol+salt+water)with salt=KBr,NaNO_(3),and CaCl_(2).The predicted results showed good agreements with the measured ***,the model was used to uncover the salt effect on the VLE of these multisolvent reactive systems.

关键词： Vapor liquid equilibria Reactive distillation Activity coefficient 1,3,5-Triox.ne production UNIFAC Salt effect

Multi-Objective Optimal Feedback Controls for Under-Actuated Dynamical System

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Journal of Shanghai Jiaotong university(Science) 2020年第5期25卷 545-552页

作者： QIN zhichang x.N Ying SUN Jianqiao School of Transportation and Vehicle Engineering Shandong University of TechnologyZibo 255000ShandongChina School of Mechanical Engineering Tianjin University of TechnologyTianjin 300384China Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control Tianjin University of TechnologyTianjin 300384China School of Engineering University of California MercedCA 95343USA

This paper presents a study of optimal control design for a single-inverted pendulum(SIP)system with the multi-objective particle swarm optimization(MOPSO)*** proportional derivative(PD)control algorithm is utilized to control the *** the SIP system is nonlinear and the output(the pendulum angle)cannot be directly controlled(it is under-actuated),the PD control gains are not tuned with classical *** this work,the MOPSO method is used to obtain the best PD *** use of multi-objective optimization algorithm allows the control design of the system without the need of linearization,which is not provided by using classical *** multi-objective optimal control design of the nonlinear system involves four design parameters(PD gains)and six.objective functions(time-domain performance indices).The HausdorfF distances of consecutive Pareto sets,obtained in the MOPSO iterations,are computed to check the convergence of the MOPSO *** MOPSO algorithm finds the Pareto set and the Pareto front *** simulations and ex.eriments of the rotary inverted pendulum system are done to verify this design *** and ex.erimental results show that the multi-objective optimal controls offer a wide range of choices including the ones that have comparable performances to the linear quadratic regulator(LQR)control.

关键词： multi-objective optimal control under-actuated system particle swarm optimization(PSO) rotary inverted pendulum

Research and Modeling on the Characteristic Changes of EMI Filter Passive Components under the Influence of Aging

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Chinese Journal of Electrical Engineering 2022年第3期8卷 2-11页

作者： Wenzhe Su Hong Li zhichang Yang Baihua Zhang School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China State Key Laboratory of Advanced Power Transmission Technology State Grid Smart Grid Research Institute Co.Ltd.Beijing 100044China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100044Chin

At present,the power density of power electronic devices in data centers and electric vehicles is constantly increasing,and numerous electronic components are concentrated in a tight,high-temperature environment,which aggravates the performance degradation of electronic ***,x.and Y capacitors,common-mode inductors,and differential-mode inductors used for electromagnetic interference(EMI)suppression suffer from aging effects,and their performance continues to ***,the electromagnetic compatibility test is often conducted immediately after the power electronic equipment leaves the *** electromagnetic compatibility of power electronic equipment is affected by aging,which is not assessed in current industrial *** study conducts aging ex.eriments on passive electronic components in EMI filters and measures the impedance in the frequency range from 150 kHz to 30 ***,a multi-element aging model based on electromagnetic field analysis is *** proposed model is suitable for electromagnetic compatibility analysis considering ***,the aging performance of a commercial two-stage EMI filter is predicted to verify the model proposed in the *** proposed model ex.lains the degeneration of the EMI filter with aging in the frequency range of 150 kHz to 1 MHz,with a max.mum amplitude error of 0.58 dB and phase error of 1.0°.

关键词： EMI filter passive components impedance model multi-element aging model

Numerical simulation of two-phase flow and droplet breakage of glycerin-water mix.ure and kerosene in the cyclone reactor

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Chinese Journal of Chemical Engineering 2021年第6期34卷 150-159页

作者： Yanni Chi Rui Zhang x.anghai Meng Jian x. Wei Du Haiyan Liu zhichang Liu State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China

A liquid-liquid cyclone reactor(LLCR)was designed to achieve mix.ng-reaction-separation integration during isobutane alkylation catalyzed by ionic ***,studies of the droplets deformation and breakage in the kind of reactors are *** this work,the research studied the velocity distribution,pressure field,and turbulent field to investigate the flow pattern and the main energy loss location in the LLCR through the computational fluid dynamics(CFD)*** simulation results were verified by ex.eriemnts to prove the correctness of the *** the deformation and breakage process of droplets,and the influencing factors of droplets breakage were studied by remodeling which was based on the tangential velocity distribution result of the three dimensional *** three dimensional simulation results clearly showed that the pressure of the LLCR was mainly concentrated in the cone section and fluid turbulent motion was the most intense near the lateral *** reconstruct the results of the two dimensional model clearly showed that the deformation and breakage location of droplets were mainly occurred in the velocity boundary layer,while it was difficult to break in the mainstream *** addition,low surface tension and high Weber number had a positive effect on droplet breakage.

关键词： Liquid-liquid cyclone reactor Ionic liquid separation Droplet deformation Droplet breakage Computational fluid dynamics

A New Active Gate Driver for MOSFET to Suppress Turn-Off Spike and Oscillation

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Chinese Journal of Electrical Engineering 2018年第2期4卷 43-49页

作者： Yanfeng Jiang Chao Feng zhichang Yang x.ngran Zhao Hong Li School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China

MOSFETs are widely used in power electronics *** to the high di/dt and dv/dt of the MOSFET and parasitic parameters in the circuit,drain voltage spikes and oscillations will be generated during turn-off,which can affect the safety of the device and degrade the system's electromagnetic *** paper first studies the relationship between drain voltage spike and gate voltage during *** on the effect of gate voltage on drain voltage spike,a new active gate driver that optimizes gate voltage is *** proposed active gate driver detects the slope of the drain voltage and generates a positive pulse in the drain current fall phase to increase the gate voltage,thereby suppressing drain voltage spike and *** order to verify the effectiveness of the proposed active gate driver,a simulation circuit and an ex.erimental platform are constructed and compared with the conventional gate *** and ex.erimental results show that the new active gate driver can effectively suppress the drain voltage spike and oscillation of MOSFETs,and can effectively reduce high-frequency EMI.

关键词： Active gate driver electromagnetic interference voltage spike oscillation