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Micro-flow structure at regime transition from bubbling to turbulent fluidization in a fluidized bed

Particuology 2024年第6期89卷 117-130页

作者： Chaoyu Yan Yue yuan Xiaoyang wei Jesse Zhu State Key Laboratory of Heavy Oil Processing Beijing Key Laboratory of Process Fluid Filtration and SeparationCollege of Mechanical and Transportation EngineeringChina University of PetroleumBeijing 102249China China Beacons Institute The University of NottinghamNingbo315100China Department of Chemical and Biochemical Engineering University of Western OntarioLondonOntarioN6A 5B9Canada

Gas-solid fluidized beds have found extensive utilization in frontline manufacturing,in particular as low-velocity *** fluidization status,the bubbling or turbulent flow regime and the transition in between,determine the system performance in practical *** the convoluted hydrodynamics are quantitively evaluated through numerous data-processing methodologies,none of them alone can reflect all the critical information to identify the transition from the bubbling to the turbulent ***,this study was to exploit a coupling data processing methodology,in the combination of standard deviation,power spectrum density,probability density function,wavelet transform,and wavelet multiresolution method,to jointly explain the micro-flow structure at the regime transition from bubbling to turbulent *** transient differential pressure fluctuation was measured for the evaluation in a fluidized bed(0.267 m i.d.×2.5 m height)with FCC catalysts(d_(p)=65μm,ρ_(p)=1780kg/m^(3))at different superficial gas velocities(0.02–1.4 m/s).The results show that the onset of turbulent fluidization starts earlier in the top section of the bed than in the bottom *** wavelet decomposition displays that the fluctuation of differential pressure mainly concentrates on the sub-signals with an intermediate frequency *** sub-signals could be synthesized into three types of scales(micro-scale,meso-scale,and macro-scale),representing the multi-scale hydrodynamics in the fluidized *** micro-scale signal has the characteristic information of bubbling fluidization,and the characteristic information of turbulent fluidization is mainly represented by the meso-scale *** work provides a systematic comprehension of fluidization status assessment and serves as an impetus for more coupling analysis in this sector.

关键词： Flow regime transition Bubbling fluidization Turbulent fluidization Micro-flow structure Differential pressure fluctuation

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Follicle stimulating hormone controls granulosa cell glutamine synthesis to regulate ovulation

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Protein & Cell 2024年第7期15卷 512-529页

作者： Kai-Hui Zhang Fei-Fei Zhang zhi-Ling Zhang Ke-Fei Fang Wen-Xing Sun Na Kong Min Wu Hai-Ou Liu Yan Liu zhi Li Qing-Qing Cai Yang Wang Quan-wei wei Peng-Cheng Lin Yan Lin wei Xu Cong-Jian Xu Yi-yuan yuan Shi-Min Zhao The Obstetrics&Gynecology Hospital of Fudan University State Key Laboratory of Genetic EngineeringFudan UniversityShanghai 200090China Shanghai Key Laboratory of Metabolic Remodeling and Children’s Hospital of Fudan UniversityShanghai 200032China School of Life Sciences and Institutes of Biomedical Sciences Fudan UniversityShanghai 200438China Department of Nutrition and Food Hygiene School of Public HealthNantong UniversityNantong 226019China Reproductive Medicine Center The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Shanghai Fifth People’s Hospital of Fudan University Fudan UniversityShanghai 200240China Department of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210014China Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province College of PharmacyQinghai University for NationalitiesXining 810007China Pediatric Research Institute Children’s Hospital Affiliated to Shandong University(Jinan Children’s Hospital)Jinan 250022China

Polycystic ovary syndrome(PCOS)is the leading cause of anovulatory *** understanding of the ovulation drivers hinders PCOS ***,we report that follicle stimulating hormone(FSH)controls follicular fluid(FF)glutamine levels to determine *** ovulation starts from FF-exposing granulosa cell(GC)*** glutamine,which decreases in pre-ovulation porcine FF,elevates in PCOS patients ***-glutamine chow to elevate FF glutamine inhibits mouse GC apoptosis and induces hormonal,metabolic,and morphologic PCOS ***,follicle-development-driving FSH promotes GC glutamine synthesis to elevate FF glutamine,which maintain follicle wall integrity by inhibiting GC apoptosis through inactivating ASK1-JNK apoptotic *** and glutamine inhibit the rapture of cultured murine *** removal or ASK1-JNK pathway activation with metformin or AT-101 reversed PCOS traits in PCOS models that are induced with either glutamine or *** suggest that glutamine,FSH,and ASK1-JNK pathway are targetable to alleviate PCOS.

关键词： ovulation glutamine granulosa cells PCOS FSH

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Classification of complete 3-dimensional self-shrinkers in the Euclidean space R^(4)

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Science China Mathematics 2024年第4期67卷 873-882页

作者： Qing-Ming Cheng zhi Li Guoxin wei Department of Applied Mathematics Faculty of ScienceFukuoka UniversityFukuoka 814-0180Japan College of Mathematics and Information Science Henan Normal UniversityXinxiang 453007China School of Mathematical Sciences South China Normal UniversityGuangzhou 510631China

In this paper,we completely classify 3-dimensional complete self-shrinkers with the constant norm S of the second fundamental form and the constant f3in the Euclidean space R^(4),where hij’s are components of the sec... 详细信息

关键词： mean curvature ow self-shrinker the generalized maximum principle

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Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng Li yuan Yang Hua Yue Shuang Wang Xiao Zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

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Characterization of Changes and Driver Microbes in Gut Microbiota During Healthy Aging Using A Captive Monkey Model

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Genomics, Proteomics & Bioinformatics 2022年第2期20卷 350-365页

作者： zhi-yuan wei Jun-Hua Rao Ming-Tian Tang Guo-An Zhao Qi-Chun Li Li-Ming Wu Shao-Qiang Liu Bi-Hai Li Bai-Quan Xiao Xing-Yin Liu Jian-Huan Chen Guangdong Key Laboratory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhou 510260China Laboratory of Genomic and Precision Medicine Wuxi School of MedicineJiangnan UniversityWuxi 214122China Joint Primate Research Center for Chronic Diseases Jiangnan University and Institute of ZoologyGuangdong Academy of SciencesWuxi School of MedicineJiangnan UniversityWuxi 214122China Department of Pathogen-Microbiology Division Nanjing Medical UniversityNanjing 211166China

Recent population studies have significantly advanced our understanding of how age shapes the gut ***,the actual role of age could be inevitably confounded due to the complex and variable environmental factors in human populations.A well-controlled environment is thus necessary to reduce undesirable confounding effects,and recapitulate age-dependent changes in the gut microbiota of healthy *** we performed 16S rRNA gene sequencing,characterized the age-associated gut microbial profiles from infant to elderly crab-eating macaques reared in captivity,and systemically revealed the lifelong dynamic changes of the primate gut *** the most significant age-associated taxa were mainly found as commensals such as Faecalibacterium,the abundance of a group of suspicious pathogens such as Helicobacter was exclusively increased in infants,underlining their potential role in host ***,topology analysis indicated that the network connectivity of gut microbiota was even more agedependent than taxonomic diversity,and its tremendous decline with age could probably be linked to healthy ***,we identified key driver microbes responsible for such age-dependent network changes,which were further linked to altered metabolic functions of lipids,carbohydrates,and amino acids,as well as phenotypes in the microbial *** current study thus demonstrates the lifelong age-dependent changes and their driver microbes in the primate gut microbiota,and provides new insights into their roles in the development and healthy aging of their hosts.

关键词： Age-dependent change Non-human primate Healthy gut microbiota Network connectivity Driver microbe

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High Speed Sintering:Assessing the Influence of Energy Input on Microstructure and Mechanical Properties of Polyether Block Amide(PEBA)Parts

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Chinese Journal of Polymer Science 2024年第5期42卷 675-682,I0004,I0010页

作者： Jiang-Tao Sun zhi-Yong Fan Yi-wei Mao wei Li wei Zhu Dao-Sheng Cai Qing-Song wei State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430074China National Engineering Research Centre for High Efficiency Grinding Hunan UniversityChangsha410082China Wuhan EasyMFG Technology CO. LTDWuhan430074China

High speed sintering,a new powder-bed fusion additive manufacturing technology,utilizes infrared lights(IR)to intensely heat and melt polymer *** presence of defects such as porosity,which is associated with particle coalescence,is highly dependdent on the level of energy *** study investigate the influcence of energy input on porosity and its subsequent effects on the mechanical properties and microstructures of PEBA *** parts were manufactured with a variety of lamp powers,resulting in a range of energy input levels spanning from low to ***,they underwent testing using Archimedes’method,followed by tensile *** porosity,mechanical characteristics,and energy input exhibit a strong correlation;inadequate energy input was the primary cause of pore *** the reduced IR light power resulted in the following outcomes:porosity,ultimate tensile strength,and elongation of 1.37%,7.6 MPa,and 194.2%,*** the energy input was further increased,the porosity was reduced to as low as 0.05%and the ultimate tensile strength and elongation were increased to their peak values of 233.8%and 9.1 MPa,respectively.

关键词： High speed sintering Additive manufacturing Energy input Powder bed fusion PEBA

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Progress in ceramic materials and structure design toward advanced thermal barrier coatings

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Journal of Advanced Ceramics 2022年第7期11卷 985-1068页

作者： zhi-yuan wei Guo-Hui MENG Lin CHEN Guang-Rong LI Mei-Jun LIU wei-Xu ZHANG Li-Na ZHAO Qiang ZHANG Xiao-Dong ZHANG Chun-Lei WAN zhi-Xue QU Lin CHEN Jing FENG Ling LIU Hui DONG Ze-Bin BAO Xiao-Feng ZHAO Xiao-Feng ZHANG Lei GUO Liang WANG Bo CHENG wei-wei ZHANG Peng-Yun XU Guan-Jun YANG Hong-Neng CAI Hong CUI You WANG Fu-Xing YE Zhuang MA wei PAN Min LIU Ke-Song ZHOU Chang-Jiu LI State Key Laboratory for Mechanical Behavior of Materials School of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China State Key Laboratory for Strength and Vibration of Mechanical Structures Department of Engineering MechanicsSchool of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Xi’an Aerospace Composite Research Institute Xi’an 710025China AECC Beijing Institute of Aeronautical Materials Beijing 100095China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State Key Laboratory of New Ceramics&Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional MaterialsEducation Ministry of ChinaFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Xi’an Key Laboratory of High Performance Oil and Gas Field Materials School of Materials Science and EngineeringXi’an Shiyou UniversityXi’an 710065China Shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Shanghai Key Laboratory of Advanced High-temperature Materials and Precision Forming Shanghai Jiao Tong UniversityShanghai 200240China National Engineering Laboratory for Modern Materials Surface Engineering Technology the Key Lab of Guangdong for Modern Surface Engineering TechnologyInstitute of New MaterialsGuangdong Academy of SciencesGuangzhou 510650China School of Materials Science and Engineering Tianjin UniversityTianjin 300072China Integrated Computational Materials Research Centre Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 201899China State Key Laboratory of Advanced Processing and Recycling of

Thermal barrier coatings(TBCs)can effectively protect the alloy substrate of hot components in aeroengines or land-based gas turbines by the thermal insulation and corrosion/erosion resistance of the ceramic top ***,the continuous pursuit of a higher operating temperature leads to degradation,delamination,and premature failure of the top *** new ceramic materials and new coating structures must be developed to meet the demand for future advanced TBC *** this paper,the latest progress of some new ceramic materials is first ***,a comprehensive spalling mechanism of the ceramic top coat is summarized to understand the dependence of lifetime on various factors such as oxidation scale growth,ceramic sintering,erosion,and calcium–magnesium–aluminium–silicate(CMAS)molten salt ***,new structural design methods for high-performance TBCs are discussed from the perspectives of lamellar,columnar,and nanostructure *** latest developments of ceramic top coat will be presented in terms of material selection,structural design,and failure mechanism,and the comprehensive guidance will be provided for the development of next-generation advanced TBCs with higher temperature resistance,better thermal insulation,and longer lifetime.

关键词： thermal barrier coatings(TBCs) ceramic material degradation and failure structure design long lifetime

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Perception field based imitation learning for unlabeled multi-agent pathfinding

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Science China(Information Sciences) 2024年第5期67卷 115-135页

作者： Wenjie CHU Ailun YU wei ZHANG Haiyan ZHAO zhi JIN School of Computer Science Peking University Key Laboratory of High-Confidence Software Technologies (Peking University) Ministry of Education

This paper proposes an imitation learning method to learn a universal agent policy for unlabeled multi-agent pathfinding(unlabeled MAPF) in grid environments. The method transforms the unlabeled MAPF problem into a series of temporal-independent homogeneous classification problems for each *** on this transformation, a neural network is designed to imitate a distance-optimal expert *** neural network consists of two successive modules: perception field learner and field integrating *** former refines and encodes the current system state into a perception field for each agent by combining a set of learnable field-generating functions. The latter takes an agent's perception field as input and decides the agent's next action based on a triplet cross-attention mechanism. We evaluate our method on a diverse set of unlabeled MAPF tasks. Compared with state-of-the-art counterparts, the experimental results manifest the superiority of the proposed method in both generalization ability and scalability.

关键词： unlabeled multi-agent pathfinding perception field triplet cross-attention multi-agent imitation learning learning-based planning

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High-Order Two-Scale Asymptotic Paradigm for the Elastodynamic Homogenization of Periodic Composites

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Acta Mechanica Solida Sinica 2024年第1期37卷 124-138页

作者： wei-zhi Luo Mu He Liang Xia Qi-Chang He State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China Laboratoire Modélisation et Simulation Multi-Echelle MSME UMR 8208 CNRSUniversite Gustave Eiffel77454 Marne-la-ValléeFrance

The classical two-scale asymptotic paradigm provides macroscopic and microscopic analyses for the elastodynamic homogenization of periodic composites based on the spatial or/and temporal variable,which offers an approximate framework for the asymptotic homogenization analysis of the motion ***,in this framework,the growing complexity of the homogenization formulation gradually becomes an obstacle as the asymptotic order *** such a context,a compact,fast,and accurate asymptotic paradigm is *** work reviews the high-order spatial two-scale asymptotic paradigm with the effective displacement field representation and optimizes the implementation by symmetrizing the tensor to be ***,the modified implementation gets rid of the excessive memory consumption required for computing the high-order tensor,which is demonstrated by representative one-and two-dimensional *** numerical results show that(1)the contrast of the material parameters between media in composites directly affects the convergence rate of the asymptotic results for the homogenization of periodic composites,(2)the convergence error of the asymptotic results mainly comes from the truncation error of the modified asymptotic homogenized motion equation,and(3)the excessive norm of the normalized wavenumber vector in the two-dimensional inclusion case may lead to a non-convergence of the asymptotic results.

关键词： Composites Homogenization Asymptotic analysis Dynamics Dispersion

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A Low Cost, Green Sustainable and Biodegradable Biomass-based Fluorine-free Water and Oil Repellent

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Chinese Journal of Polymer Science 2024年第4期42卷 480-491页

作者： zhi-wei Shen Shu-Feng Hu Chen Zeng wei-Qing Kong Mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers&Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China State Key Laboratory of Pulp and Paper Engineering School of Light Industry and EngineeringSouth China University of TechnologyGuangzhou510630China

With the global ban on plastics intensifying, the substitution of plastic with paper has garnered increasing attention. However, the inadequate water and oil repellency of pulp molding hinders its practical applications. Currently, the common method to enhance the oil and water repellency of pulp molding is by adding fluorinated water and oil repellents. Nevertheless, fluorinated compounds are environmentally and physiologically harmful. Therefore, the development of fluorine-free, water and oil repellent alternatives is crucial. In this study, chitosan and stearic acid were utilized as the first and second layers of the oil and water repellent coatings, respectively. The coated samples exhibited favorable water repellency, with a water contact angle of 116.4°, and excellent oil repellency, achieving a 12/12 rating on the kit scale. Importantly, the samples did not exhibit any leakage after being soaked in hot water and hot oil at 95±5℃ for 30 min, demonstrating remarkable performance as a barrier against hot water and oil. Moreover, the coated samples displayed outstanding mechanical properties, thermal stability, biodegradability, and recyclability. The approach presented in this study is simple, cost-effective, environmentally friendly, and represents a promising technique for producing fluoride-free, oil-and water-resistant pulp molding products.

关键词： Biomass Fluoride-free Oil-andwater-resistant Plasticfree

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