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Neuroscience Bulletin 2024年第4期40卷 553-556页

作者： yuan dong Li Tang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Qingdao Institute of Measurement Technology Qingdao266000China

Neurodegenerative diseases,including Alzheimer's disease(AD)and Parkinson's disease(PD),are the most common causes of *** drugs for such diseases can only provide temporary help with the symptoms,leaving the discovery of new drugs urgently in *** cells are the local immune cells in the nervous system and have been recognized as the key player in neuroinflammation that contributes to the process of neurodegeneration[1],raising the discussion of aiming microglia as the therapeutic target for clinical treatment of neurodegenerative diseases.

关键词： inflammation degenerative drugs

Development and performance evaluation of high temperature resistant strong adsorption rigid blocking agent

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Petroleum Science 2024年第4期21卷 2650-2662页

作者： Zhe Xu Jin-Sheng Sun Jing-Ping Liu Kai-He Lv Xiao-dong dong Zong-Lun Wang Tai-Feng Zhang yuan-Wei Sun zhi-Wen Dai School of Petroleum Engineering China University of Petroleum (East China) CNPC Engineering Technology R&D Company Limited

As drilling wells continue to move into deep ultra-deep layers, the requirements for temperature resistance of drilling fluid treatments are getting higher and higher. Among them, blocking agent, as one of the key treatment agents, has also become a hot spot of research. In this study, a high temperature resistant strong adsorption rigid blocking agent(QW-1) was prepared using KH570 modified silica,acrylamide(AM) and allyltrimethylammonium chloride(TMAAC). QW-1 has good thermal stability,average particle size of 1.46 μm, water contact angle of 10.5., has a strong hydrophilicity, can be well dispersed in water. The experimental results showed that when 2 wt% QW-1 was added to recipe A(4 wt% bentonite slurry+0.5 wt% DSP-1(filtration loss depressant)), the API filtration loss decreased from 7.8to 6.4 m L. After aging at 240.C, the API loss of filtration was reduced from 21 to 14 m L, which has certain performance of high temperature loss of filtration. At the same time, it is effective in sealing 80-100mesh and 100-120 mesh sand beds as well as 3 and 5 μm ceramic sand discs. Under the same conditions,the blocking performance was superior to silica(5 μm) and calcium carbonate(2.6 μm). In addition, the mechanism of action of QW-1 was further investigated. The results show that QW-1 with amide and quaternary ammonium groups on the molecular chain can be adsorbed onto the surface of clay particles through hydrogen bonding and electrostatic interaction to form a dense blocking layer, thus preventing further intrusion of drilling fluid into the formation.

关键词： High adsorption Rigid microsphere High temperature resistance Blocking performance

New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves

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Chinese Journal of Natural Medicines 2024年第2期22卷 161-170页

作者： SUN Zeshi LIN Shan WU zhi-Li dong Hong-yuan XU Xi-Ke LI Hui-Liang WANG Jinxin School of Pharmacy Second Military Medical UniversityShanghai 200433China State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China

Our continued works on the chemical constituents of Ginkgo biloba(***)leaves has led to the isolation of two novel phenylbutenoids(1,2),along with five previously unidentified terpene glycosides(3−7).Among them,compounds 1 and 2 represent unique(Z)-phenylbutenoids,3−6 are megastigmane glycosides,and 7 is identified as a rare bilobanone glycoside(Fig.1).This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from *** chemical structures of these compounds were elucidated through extensive spectroscopic analysis,including HR-ESI-MS and various 1D and 2D NMR ***,the absolute configurations of these molecules were determined using Mosher’s method,ECD experiments,and Cu-KαX-ray crystallographic analyses.

关键词： Ginkgo biloba Phenylbutenoid Megastigmane glycoside Bilobanone glycoside

Research on Regional Differences and Influencing Factors of China's Carbon Emissions

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Journal of Systems Science and Information 2024年第2期12卷 161-190页

作者： Likang ZHANG Jichang dong zhi dong School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China Technology and Engineering Center for Space Utilization Chinese Academy of SciencesBeijing 100045China

This paper studies the regional differences,dynamic evolution and influencing factors of regional carbon emission intensity(CEI)in 262 cities and 5 regional urban agglomerations(UAs)in *** Dagum Gini coefficient is used to analyze the intra-regional and inter-regional differences in carbon emissions,and the temporal evolution of the absolute differences of CEI among regions is analyzed by means of kernel density estimation(KDE).The paper provides an in-depth study on the spatial difference and temporal evolution of CEI in Chinese cities and major strategic *** Moran index and LISA’s test,the spatial correlation of carbon emission in prefecture-level cities is tested,and its spatial agglomeration characteristics are *** is found that China’s CEI is decreasing year by year,presenting a spatial pattern of“low in the south but high in the north”.Based on the calculation of carbon emission intensity at the urban level,this paper conducts LDMI factor decomposition research on carbon emission intensity at the national and key regions,and analyzes the impact of the impact factors on carbon emission *** research results provide a path for China’s green development at the city level and urban agglomeration level,and a theoretical support for different regions and cities to introduce emission and carbon reduction policies.

关键词： carbon emission intensity regional differences industrial structure

Interleukins in Epilepsy:Friend or Foe

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Neuroscience Bulletin 2024年第5期40卷 635-657页

作者： yuan dong Xia Zhang Ying Wang Neuropsychiatry Research Institute The Affiliated Hospital of Qingdao UniversityQingdao UniversityQingdao266000China Program in Cellular and Molecular Medicine Boston Children’s HospitalBostonMA02115USA

Epilepsy is a chronic neurological disorder with recurrent unprovoked seizures,affecting~65 million *** in patients with epilepsy and animal models suggests a contribution of neuroinflammation to epileptogenesis and the development of ***(ILs),as one of the major contributors to neuroinflammation,are intensively studied for their association and modulatory effects on ictogenesis and *** are commonly divided into pro-and anti-inflammatory cytokines and therefore are expected to be pathogenic or neuroprotective in ***,both protective and destructive effects have been reported for many *** may be due to the complex nature of ILs,and also possibly due to the different disease courses that those ILs are involved *** this review,we summarize the contributions of different ILs in those processes and provide a current overview of recent research advances,as well as preclinical and clinical studies targeting ILs in the treatment of epilepsy.

关键词： Epilepsy Interleukins Neuroinflammation

Strong invariance principle for a counterbalanced random walk

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 370-380页

作者： TAN Hui-qun HU zhi-shui dong Liang International Institute of Finance School of ManagementUniversity of Science and Technology of ChinaHefei 230026China Center for Basic Teaching and Experiment Nanjing University of Science and TechnologyJiangyin 214443China

We study a counterbalanced random walkS_(n)=X_(1)+…+X_(n),which is a discrete time non-Markovian process andX_(n) are given recursively as *** n≥2,X_(n) is a new independent sample from some fixed law̸=0 with a fixed probability p,andX_(n)=−X_(v(n))with probability 1−p,where v(n)is a uniform random variable on{1;…;n−1}.We apply martingale method to obtain a strong invariance principle forS_(n).

关键词： random walk martingale invariance principle

Luminescent terphen[3]arene sulfate-activated FRET assemblies for cell imaging

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Chinese Chemical Letters 2024年第9期35卷 183-186页

作者： zhixue Liu Haiqi Chen Lijuan Guo Xinyao Sun zhi-yuan Zhang Junyi Chen Ming dong Chunju Li Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China

Multicharged supramolecular assemblies based on luminescent macrocycle play an important role in extending their optical properties and ***,we reported macrocyclic supramolecular assemblies based on luminescent terphen[3]arene sulfate(TP[3]AS)and tetraphenylethylene pyridinium(TPE-4Py)through electrostatic interactions,host-guest encapsulation andπ-πstacking interactions.F?rster resonance energy transfer(FRET)process from TP[3]AS to TPE-4Py was achieved with the energy transfer efficiency of 99.9%,accompanied by TPE-4Py fluorescence emission bathochromic shifted of 15 nm and enhanced by 1.68 times in PBS *** contrast,other non-luminescent sulfato-β-cyclodextrin and sulfobutylether-β-cyclodextrin only can enhance the fluorescence intensity of TPE-4Py without bathochromic *** to the strong fluorescence and good stability of TPE-4Py@TP[3]AS,it can be used for optical imaging in living cells,which provided an effective approach for the construction of assembling-confined luminescent biomaterials.

关键词： Luminescent macrocycle Terphenarene sulfate Multicharged assembly Multivalent interactions Forster resonance energy transfer Cell imaging

Efficient spectral single-pixel imaging via Morton frequency-domain scanning [Invited]

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Chinese Optics Letters 2024年第6期22卷 8-14页

作者： Zi-dong Zhao Zhao-Hua Yang zhi-Hao Zhao Ling-An Wu yuan-Jin Yu School of Instrumentation and Optoelectronic Engineering Beihang UniversityBeijing 100191China Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Automation MIIT Key Laboratory of Complex-field Intelligent SensingBeijing Institute of TechnologyBeijing 100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019China

Single-pixel imaging (SPI) captures two-dimensional images utilizing a sequence of modulation patterns and measurements recorded by a single-pixel detector. However, the sequential measurement of a scene is time-consuming, especially for high-spatial-resolution imaging. Furthermore, for spectral SPI, the enormous data storage and processing time requirements substantially diminish imaging efficiency. To reduce the required number of patterns, we propose a strategy by optimizing a Hadamard pattern sequence via Morton frequency domain scanning to enhance the quality of a reconstructed spectral cube at low sampling rates. Additionally, we expedite spectral cube reconstruction, eliminating the necessity for a large Hadamard matrix. We demonstrate the effectiveness of our approach through both simulation and experiment,achieving sub-Nyquist sampling of a three-dimensional spectral cube with a spatial resolution of 256×256 pixels and181 spectral bands and a reduction in reconstruction time by four orders of magnitude. Consequently, our method offers an efficient solution for compressed spectral imaging.

关键词： single-pixel imaging spectral imaging optimized Hadamard basis

Receptivity of Mack modes to localized unsteady blowing and suction in a chemical non-equilibrium hypersonic boundary layer

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Acta Mechanica Sinica 2024年第7期40卷 1-18页

作者： Qingjiang yuan Runjie Song Ming dong State Key laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China

This paper studies the local receptivity of the Mack-mode instability to localized unsteady blowing and suction(UBS)in a chem-ical non-equilibrium(CNE)hypersonic boundary *** five-species CNE model is employed,and the receptivity efficiency is formulated by use of the residual *** with the results for the calorically perfect gas(CPG)model,we find that the real-gas effect enhances the receptivity efficiency remarkably in the majority of the second-mode frequency band,and the enhancement is mainly attributed to the modification of the base flow due to the CNE effect,which is akin to the cold-wall effect in hypersonic boundary *** with the destabilizing role of the CNE effect on the Mack second mode,it is concluded that the CNE effect would lead to a greater linearly accumulated perturbation amplitude,implying premature of transition to turbulence in a high-enthalpy hypersonic boundary layer subject to localized perturbations.

关键词： Chemical non-equilibrium flow Boundary-layer instability Hypersonic Receptivity Transition to turbulence

Local search yields a PTAS for fixed-dimensional k-means problem with penalties

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Journal of the Operations Research Society of China 2024年第2期12卷 351-362页

作者： Fan yuan Da-Chuan Xu dong-Lei Du dong-Mei Zhang Beijing Institute for Scientific and Engineering Computing Beijing University of TechnologyBeijing 100124China Faculty of Management University of New BrunswickFrederictonNB E3B 9Y2Canada School of Computer Science and Technology Shandong Jianzhu UniversityJinan 250101ShandongChina

We study a problem called the k-means problem with penalties(k-MPWP),which is a natural generalization of the typical k-means *** this problem,we have a set D of client points in R^(d),a set F of possible centers in R^(d),and a penalty cost Pj>O for each point j∈*** are also given an integer k which is the size of the center point *** want to find a center point set S■F with size k,choose a penalized subset of clients P■D,and assign every client in D\P to its open *** goal is to minimize the sum of the squared distances between every point in D\P to its assigned centre point and the sum of the penalty costs for all clients in *** using the multi-swap local search technique and under the fixed-dimensional Euclidean space setting,we present a polynomial-time approximation scheme(PTAS)for the k-MPWP.

关键词： Approximation algorithm k-means Local search Penalty