New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves
作者机构：School of PharmacySecond Military Medical UniversityShanghai 200433China State Key Laboratory of New Drug and Pharmaceutical ProcessShanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China
出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)
年 卷 期：2024年第22卷第2期
页 面：161-170页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by the National Natural Science Foundation of China(Nos.82141203,82003624,82004003,82004215) the Science and Technology Commission of Shanghai Municipality(Nos.20YF1458700,20YF1459000) the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTDD-202004) Shanghai Frontiers Science Center of TCM Chemical Biology,Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.16DZ2280200)
主 题：Ginkgo biloba Phenylbutenoid Megastigmane glycoside Bilobanone glycoside
摘 要：Our continued works on the chemical constituents of Ginkgo biloba(***)leaves has led to the isolation of two novel phenylbutenoids(1,2),along with five previously unidentified terpene glycosides(3−7).Among them,compounds 1 and 2 represent unique(Z)-phenylbutenoids,3−6 are megastigmane glycosides,and 7 is identified as a rare bilobanone glycoside(Fig.1).This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from *** chemical structures of these compounds were elucidated through extensive spectroscopic analysis,including HR-ESI-MS and various 1D and 2D NMR ***,the absolute configurations of these molecules were determined using Mosher’s method,ECD experiments,and Cu-KαX-ray crystallographic analyses.
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