检索结果-南通市图书馆

Outcomes in patients with Fournier’s gangrene originating from the anorectal region with a particular focus on those without perineal involvement

引用

Gastroenterology Report 2019年第3期7卷 212-217,I0003页

作者： Hong-Cheng Lin Zu-Qing Chen Hua-Xian Chen Qiu-Lan He zhi-Min Liu zhi-yang zhou Rong Shi Dong-Lin Ren Department of Coloproctology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases GuangzhouGuangdong 510655China Guangdong Institute of Gastroenterology GuangzhouGuangdong 510655China Department of Colorectal Surgery People’s Hospital Affiliated to Fujian University of Traditional ChineseFuzhouFujian 350004China Department of Anaesthesiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080China Department of Radiology the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655China

Background and aim:Fournier’s gangrene(FG)is a fulminant infection in the external genital region and *** present study explored the clinical features of FG originating from the anorectal region,from primary conditions such as anal fistulas and ***:A retrospective analysis was performed in order to identify the factors associated with clinical outcomes in FG patients derived from two hospitals—the Sixth Affiliated Hospital of Sun Yat-sen University and People’s Hospital Affiliated to Fujian University of Traditional Chinese—over the period from May 2013 to April ***:Sixty FG patients were included in this *** common causative microorganisms cultured were Escherichia coli *** and perirectal regional involvement was evident in 52 and 59 cases,respectively,although the perineum was unaffected in 7 cases(12%),as confirmed by imaging examination and surgical *** with early radical debridement and broad-spectrum antibiotic therapy is effective with an acceptably sepsis mortality(1.7%).Ten patients underwent protective *** patient underwent an orchidectomy and required urinary ***:FG originating from the anorectal region can be rapidly progressive and *** can spread superiorly to the genital region without the involvement in perineal *** aggressive surgical debridement of nonviable tissue is essential for satisfactory outcomes and a protective colostomy is not mandatory.

关键词： Fournier’s gangrene perianal abscess anal fistula protective colostomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pretreatment with intestinal trefoil factor alleviates stress-induced gastric mucosal damage via Akt signaling

引用

World Journal of Gastroenterology 2020年第48期26卷 7619-7632页

作者： Yun Huang Meng-Meng Wang zhi-zhou yang Yi Ren Wei Zhang Zhao-Rui Sun Shi-Nan Nie Nantong Hospital Affiliated to Nanjing University of Chinese Medicine Nantong 226001Jiangsu ProvinceChina Department of Emergency Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002Jiangsu ProvinceChina Department of Emergency Medicine Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

BACKGROUND Stress-related gastric mucosal damage or ulcer remains an unsolved issue for critically ill *** ulcer prophylaxis has been part of routine intensive care,but uncertainty and controversy still ***-secreted with mucins,intestinal trefoil factor(ITF)is reported to promote restitution and regeneration of intestinal mucosal epithelium,although the mechanism remains *** To elucidate the protective effects of ITF on gastric mucosa and explore the possible *** We used a rat model of gastric mucosal damage induced by water immersion restraint stress and lipopolysaccharide-treated human gastric epithelial cell line to investigate the potential effects of ITF on damaged gastric mucosa both in vivo and in *** ITF promoted the proliferation and migration and inhibited necrosis of gastric mucosal epithelia in *** also preserved the integrity of gastric mucosa by upregulating expressions of occludin and zonula *** the rat model,pretreatment with ITF ameliorated the gastric mucosal epithelial damage and facilitated mucosal *** protective effects of ITF were confirmed to be exerted via activation of Akt signaling,and the specific inhibitor of Akt signaling LY249002 reversed the protective *** ITF might be a promising candidate for prevention and treatment of stressinduced gastric mucosal damage,and further studies should be undertaken to verify its clinical feasibility.

关键词： Intestinal trefoil factor Water immersion restraint stress Gastric mucosa Epithelium integrity Akt signaling pathway

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Generation of functional hepatocyte-like cells from human bone marrow mesenchymal stem cells by overexpression of transcription factor HNF4α and FOXA2

引用

Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 546-556页

作者： Pei-Yi Xie Xiao-Jun Hu Ruo-Mi Guo Xiao-Chun Meng Peng-Fei Pang zhi-yang zhou Dan Li Hong Shan Guangdong Provincial Engineering Research Center of Molecular Imaging the Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China Department of Radiology the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510655China Interventional Medicine Center the Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China Interventional Radiology Institute Sun Yat-sen UniversityZhuhai 519000China Department of Radiology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Background: Our previous study showed that overexpression of hepatocyte nuclear factor 4α(HNF4α) could directly promote mesenchymal stem cells(MSCs) to differentiate into hepatocyte-like cells. However, the efficiency of hepatic differentiation remains low. The purpose of our study was to establish an MSC cell line that overexpressed HNF4α and FOXA2 genes to obtain an increased hepatic differentiation efficiency and hepatocyte-like cells with more mature hepatocyte functions. Methods: Successful establishment of high-level HNF4α and FOXA2 co-overexpression in human induced hepatocyte-like cells(hi Hep cells) was verified by flow cytometry, immunofluorescence and RT-PCR. Measurements of albumin(ALB), urea, glucose, indocyanine green(ICG) uptake and release, cytochrome P450(CYP) activity and gene expression were used to analyze mature hepatic functions of hi Hep cells. Results: hi Hep cells efficiently express HNF4α and FOXA2 genes and proteins, exhibit typical epithelial morphology and acquire mature hepatocyte-like cell functions, including ALB secretion, urea production, ICG uptake and release, and glycogen storage. hi Hep cells can be activated by CYP inducers. The percentage of both ALB and α-1-antitrypsin(AAT)-positive cells was approximately 72.6%. The expression levels of hepatocyte-specific genes( ALB, AAT, and CYP1A1) and liver drug transport-related genes( ABCB1, ABCG2, and SLC22A18) in hi Hep cells were significantly higher than those in MSCs-Vector cells. The hi Hep cells did not form tumors after subcutaneous xenograft in BALB/c nude mice after 2 months. Conclusion: This study provides an accessible, feasible and efficient strategy to generate hi Hep cells from MSCs.

关键词： Mesenchymal stem cells Hepatocyte nuclear factor Hepatic differentiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Arctigenin attenuates paraquat-induced human lung epithelial A549 cell injury by suppressing ROS/p38 mitogen-activated protein kinases-mediated apoptosis

引用

World Journal of Emergency Medicine 2022年第5期13卷 373-378页

作者： Chao Liu Zhao-rui Sun Meng-meng Wang zhi-zhou yang Wei Zhang Yi Ren Xiao-qin Han Rui Liu Quan Li Shi-nan Nie Department of Emergency Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002China

BACKGROUND:Paraquat(PQ)-induced acute lung injury(ALI)and pulmonary fi brosis are common diseases with high mortality but without eff ective antidotes in emergency *** previous study has proved that arctigenin suppressed pulmonary fibrosis induced by *** wondered whether arctigenin could also have a protective eff ect on PQ-induced ***:A PQ-induced A549 cell injury model was used,and the effect of arctigenin was determined by a cell counting kit-8(CCK-8)cell viability *** addition,terminal deoxynucleotidyl transferase(TdT)-mediated dUTP nick-end labelling(TUNEL)staining assays and mitochondrial membrane potential assays were performed to evaluate the level of cell *** generation of reactive oxygen species(ROS)was refl ected by dihydroethidium(DHE)staining and a 2’,7’-dichlorodihy drofluorescein diacetate(DCFH-DA)***,immunoblotting studies were used to assess the expression of mitogen-activated protein kinases(MAPKs)and p38 ***:Arctigenin attenuated PQ-induced inhibition of A549 cell viability in a dose-dependent *** also significantly reduced PQ-induced A549 cell apoptosis,as refl ected by the TUNEL assay and mitochondrial membrane potential assay,which may result from suppressed ROS/p38 MAPK signaling because we found that arctigenin dramatically suppressed ROS generation and p38 MAPK ***:Arctigenin could attenuate PQ-induced lung epithelial A549 cell injury in vitro by suppressing ROS/p38 MAPK-mediated cell apoptosis,and arctigenin might be considered a potential candidate drug for PQ-induced ALI.

关键词： Paraquat A549 cells Arctigenin Reactive oxygen species Mitogen-activated protein kinases Apoptosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A low redox potential and long life organic anode material for sodium-ion batteries

引用

Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： zhi Li yang Wei Kang zhou Xin Huang Xing zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Association between gestational anemia in different trimesters and neonatal outcomes:a retrospective longitudinal cohort study

引用

World Journal of Pediatrics 2021年第2期17卷 197-204页

作者： Chang-Fa Sun Han Liu Yan-Hui Hao Hong-Tao Hu zhi-yang zhou Ke-Xin Zou Xin-Mei Liu Jian-Zhong Sheng Guo-Lian Ding He-Feng Huang The International Peace Maternity and Child Health Hospital School of MedicineShanghai Jiao Tong University910 Hengshan RoadShanghai 200030China Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina Department of Pathology and Pathophysiology School of MedicineZhejiang UniversityHangzhouChina Department of Gynecology and Obstetrics The First Affiliated Hospital of Nanjing Medical UniversityNanjingChina

Background Previous studies investigated the association between gestational anemia and neonatal ***,few studies explored whether the effects of gestational anemia could be eliminated by subsequent correction of anemia in the later stages of *** study aimed to investigate the relationship between anemia in different trimesters and neonatal *** The study was conducted in Shanghai,China,with a sample of 46,578 pregnant women who delivered between January 1,2016 and July 1,2019.A multivariable logistic regression model was adopted to analyse the associations between maternal anemia and neonatal *** The incidence of gestational anemia was 30.2%,including 4.4%in the first trimester,9.6%in the second trimester,and 16.2%in the third *** 24.5%(507/2066)of anemia that occurred in the first trimester and 29.6%(1320/4457)that occurred in the second trimester could be corrected in the later stages of *** occurring in the first trimester was associated with small for gestational age[odds ratio(OR)1.46;95%confidence interval(CI)1.20-1.78]and with fetal distress(OR 1.23;95%CI 1.08-1.40).Anemia corrected in the first trimester also was associated with a higher risk of small for gestational *** Gestational anemia is a public health problem in China impacting neonatal *** in pregnancy could be corrected in only about a quarter of the *** in the first trimester,whether corrected or not,still led to lower birth weight;therefore,the prevention of anemia prior to pregnancy is important.

关键词： Hemoglobin Iron deficiency Low birth weight Preterm birth Small for gestational age

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Investigation of the correlation between MODS score and incidence of stress ulcer

Investigation of the correlation between MODS score and inci...

引用

第七次全国中毒与危重症救治学术年会、第二届宝安急危重症高峰论坛、国家级继续项目“心肺复苏与急危重症学习班”

作者： LIN Jin-feng yang zhi-zhou Shinan Nie Jingling Hosp Dept EmergencyNanjing UnivSch Med

BACKGROUND:To predict the incidence of stress ulcer among multiple organ dysfunction syndrome（MODS）patients,which can provide basis for ***:Clinical data of two hundred and sixty-two patients who conform to the MODS diagnosis criterionadmitted to our EICU from August 2008 to August 2012 was investigated in the retrospective *** MODS patients were evaluated with MODS score criterion of *** to the diagnosis criterion of stress ulcer,the stress ulcer was *** between the score with incidence of stress ulcer was studied by rank *** ability of MODS score to predict the incidence of stress ulcer was estimated with *** critical value was obtained by Youden *** Correlation coefficient was 0.693（P<0.01）.The area under the ROC was0.793（P<0.01）.The optimization critical value to predict the incidence of stress ulcer was ***:The incidences of stress ulcer can be predicted by MODS score to some *** ulcer prophylaxis is necessary when the MODS score is above 9.

关键词： stress ulcer multiple organ dysfunction syndrome severity score correlation prophylaxis intensive care unit retrospective study incidence

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

氧化锆基氧传感器对抽气(空气)系统的低真空测量

引用

无机材料学报 1999年第6期14卷 963-968页

作者：孙成文陈深杨芝洲中国科学院上海硅酸盐研究所上海200050

应用Y2O3稳定ZrO2氧浓差电池，在600～800℃测定了抽气（空气）系统（0．1～10－3MPa）中氧对大气氧的浓差电动势．实验得出，电池电动势E与被抽真空系统残余气压p的对数有线性关系：E＝RT／4F1n（pair／p），线性方程斜率和理论值RT／4... 详细信息

应用Y2O3稳定ZrO2氧浓差电池，在600～800℃测定了抽气（空气）系统（0．1～10－3MPa）中氧对大气氧的浓差电动势．实验得出，电池电动势E与被抽真空系统残余气压p的对数有线性关系：E＝RT／4F1n（pair／p），线性方程斜率和理论值RT／4F接近，误差5％．测量电动势灵敏度随压力降低而增加，因此适宜用于低真空测量．

关键词：低真空测量氧化锆氧传感器氧浓差电池真空度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

某高层住宅建筑非封闭天井火灾危险性分析

引用

消防科学与技术 2017年第7期36卷 950-953页

作者：杨志舟苏州市消防支队江苏苏州222000

以某非封闭天井式高层住宅为研究对象,该住宅存在非封闭式天井外廊与建筑之间距离不满足规范规定值的消防设计问题。设置三种不同的工况,采用FDS进行火灾风险评估模拟。结果显示,三种模型的烟气运动规律及热辐射情况相似,且实际模型下... 详细信息

以某非封闭天井式高层住宅为研究对象,该住宅存在非封闭式天井外廊与建筑之间距离不满足规范规定值的消防设计问题。设置三种不同的工况,采用FDS进行火灾风险评估模拟。结果显示,三种模型的烟气运动规律及热辐射情况相似,且实际模型下的住宅内人员可在安全疏散时间内疏散完毕。在综合模拟结果与现有消防设施的基础上,提出加强消防安全的建议。

关键词：非封闭天井烟气运动人员疏散数值模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laser‑Induced Highly Stable Conductive Hydrogels for Robust Bioelectronics

引用

Nano-Micro Letters 2025年第3期17卷 117-120页

作者： Yibo Li Hao zhou Huayong yang Kaichen Xu State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310058People’s Republic of China

Despite the promising progress in conductive hydrogels made with pure conducting polymer,great challenges remain in the interface adhesion and robustness in longterm *** address these challenges,*** Hwan Ko and Taek-Soo Kim’s team introduced a laserinduced phase separation and adhesion method for fabricating conductive hydrogels consisting of pure poly(3,4-ethylenedioxythiophene):polystyrene sulfonate on polymer *** laser-induced phase separation and adhesion treated conducting polymers can be selectively transformed into conductive hydrogels that exhibit wet conductivities of 101.4 S cm^(−1)with a spatial resolution down to 5μ***,they maintain impedance and charge-storage capacity even after 1 h of *** micropatterned electrode arrays demonstrate their potential in long-term in vivo signal recordings,highlighting their promising role in the field of bioelectronics.

关键词： Laser processing Conductive hydrogels Stable interface Bio-interfacing electrodes Bioelectronic application

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：