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Chinese Medical Journal 2021年第5期134卷 576-578页

作者： Xin-Xin Zhu Zong-Hao Feng lin-zhi liu Yan Zhang Department of Obstetrics and Gynecology Peking University First HospitalBeijing 100034China Department of Obstetrics and Gynecology Beijing Tsinghua Changgung HospitalBeijing 102218China

This study investigated the effect of liraglutide(an analog of human glucagon-like peptide-1[GLP-1])on the proliferation of Ishikawa(IK)and human endometrial carcinoma(HEC)-IB endometrial cancer(EC)cell lines,identified whether liraglutide enhances the anti-tumor effect of progesterone,and explored the role of liraglutide in progesterone receptor(PGR)expression in EC cell lines and potential pathways.

关键词： endometrial cancer progesterone

Comparison Between the Effects of 2-Selenium Bridged β-Cyclodextrin and Ebselen on Treating SHRsp Stroke

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Chemical Research in Chinese Universities 2008年第3期24卷 322-329页

作者： JIA zhi-dan lin Feng liu Lei MU Ying YAN Gang-lin LUO Gui-min Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education Jilin University Changchun 130021 P R. China

A glutathione peroxidase（GPX） mimic, 2-selenium bridged β-cyclodextrin（2-SeCD）, was synthesized. In order to examine its role and mechanism in treating stroke we chose stroke-prone spontaneously hypertensive rats（SHRsp） as animal model. 56 SHRsps of 8-week olds were randomly divided into several groups： test groups （low, moderate, high dose of 2-SeCD） and control groups（positive and negative）. After onset of the stroke, the rats in test groups were orally administrated with different amounts of 2-SeCD, the positive control group with ebselen, and the negative control group with drinking water. The treatment lasted two weeks, followed by observation of the rats for 10 days, meanwhile blood pressure, biochemical parameters of plasma, and the contents of nitric oxide（NO） and malondialdehyde（MDA） in plasma and brain were determined. The results show that there were significant differences in contents of NO and MDA in plasma and brain between the test groups（high, moderate dose of 2-SeCD） and negative control group. The NO contents of the test groups were obviously higher than that of the negative control group （P〈0.01）. The MDA contents of the test groups（high, moderate dose of 2-SeCD） were obviously lower than that of the negative control group（P〈0.01）. The mechanism of 2-SeCD in treating stroke was discussed, which maybe related to the increase of NO and the decrease of MDA in plasma and brain tissue, but the exact mechanism should be further studied. Moreover, the tendencies of changes in systolic blood pressure, contents of NO and MDA, and other physiological parameters for the test groups were shown to be much better than the corresponding parameters for the positive group（the group with ebselen）（P〈0.05）, indicating that the treatment effect of 2-SeCD is better than that of ebselen.

关键词： 2-Selenium bridged β-cyclodextrin Glutathione peroxidase Enzyme mimic Stroke Stroke-prone spontaneously hypertensive rat Nitric oxide Malondialdehyde

Thermal-sprayed coating of optimally mixed ceramic powders on stainless steel with enhanced corrosion resistance

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Journal of Iron and Steel Research International 2018年第2期25卷 207-212页

作者： Ping-hu Chen zhi-lin liu Rui-qing Li Chang-jun Qiu Xiao-qian Li College of Mechanical and Electrical Engineering CentralSouth University Changsha 410083 Hunan China State Key Laboratory of High Performance ComplexManufacturing Central South University Changsha 410083Hunan China Light Alloy Research Institute Central South UniversityChangsha 410083 Hunan China College of Mechanical Engineering University of SouthChina Hengyang 421001 Hunan China

Three different groups of ceramic powders for the thermal-swayed coating were firstly prepared using sintering and ball milling. Then, these powders were separately deposited on three stainless steel substrates, followed by individual corrosion resistance examination. Microstructural characterization showed that the levels of micro-void and micro-crack at the bonding interface （between coating and substrate） depended on the proportions of different ceramic particles. Meanwhile, a significantly enhanced corrosion resistance was reproducibly observed in one group of as-coated samples that have the optimal combination of given ceramic powders. Furthermore, the mechanism of corresponding enhanced corrosion resistance was discussed. It was found that the optimal ceramic powders for the present thermal-sprayed coating should contain 30.2 wt% SiO2, 54 wt% Cr2O3, 6.8 wt% Al2O3, 4.8 wt% CaO and 1.8 wt% TiO2. The corrosion velocities of such samples in the 3.5 vol.% HCl, 15 wt% NaOH and 5 wt% NaCl solutions were 3.74, 2.98 and 0.50 g h-1 m-2 for 168, 336 and 336 h, respectively.

关键词： Ceramic powder Thermal-sprayed coating Bonding interface Corrosion resistance

Malignant acanthosis nigricans with Leser–Trélat sign and tripe palms:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5632-5638页

作者： Ning Wang Peng-Jie Yu zhi-lin liu Sheng-Mao Zhu Cheng-Wu Zhang Graduate School Qinghai UniversityXining 810016Qinghai ProvinceChina Department of Gastrointestinal Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

BACKGROUND Acanthosis nigricans(AN),Leser–Trélat sign,and tripe palm are all skin *** date,reports of these appearing as a paraneoplastic syndrome in a gastric cancer patient are quite *** SUMMARY We report the case of a 61-year-old man with darkened skin color in the face and torso with no obvious inducement after 1 year of treatment for Riehl’s *** had 40 brown maculopapular eruptions on his face and the top of his head with obvious *** wart-like hyperkeratosis with dark brown pigmentation was also observed on both sides of the *** had papillomalike lesions on the face,around the orbit,and on the *** bilateral palms had small,smooth,papillary projections with millet-like *** examination of the skin showed that the patient was suffering from AN,tripe palms,and Leser–Trélat *** showed the patient’s cardia was affected,and pathological biopsy revealed that he had moderate-to-poorly differentiated *** tomography test results showed that his cardia wall had *** on these histological and skin characteristics,the patient was diagnosed with gastric cancer with AN,tripe palms,and Leser–Trélat *** Researchers should follow up on patients with malignant AN,Leser–Trélat sign,and tripe palms.

关键词： Acanthosis nigricans Leser-Trélat sign Tripe palms Paraneoplastic syndrome Gastric cancer Case report

A Novel CA4P Polymeric Nanoparticle for Murine Hepatoma Therapy

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Chinese Journal of Polymer Science 2023年第8期41卷 1223-1229,I0007页

作者： zhi-lin liu Xi-Tong Ren Yue Huang Jia-Li Sun Xiao-Shuang Wang Meng-Fei Zheng lin-Jie Cui Xue-Fei Zhang Zhao-Hui Tang Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China No.1 Department of Neurology China-Japan Union Hospital of Jilin UniversityChangchun 130033China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education and Key Laboratory of Polymeric Materials&Application Technology of Hunan Province College of ChemistryXiangtan UniversityXiangtan 411105China

Combretastatin A4 phosphate(CA4P)is a potent vascular disrupting agent with good water ***,it is only effective at high doses,which decreases clinical ***,we designed stable CA4P polymeric nanoparticles(CA4P NPs)consisting of various cholesterol derivatives,and with a drug loading efficacy of 93%.The nanoparticles released CA4P in a sustained manner and achieved a 72%inhibition rate in the murine H22 liver tumor model,which was about 2.9-fold higher than that of free CA4P(24.6%).Furthermore,the carrier components of CA4P NPs were metabolized to arginine,cholesterol,ethanol and poly(ethylene glycol)in vivo;therefore,the CA4P NPs are safe and have significant potential for clinical translation.

关键词： CA4P polymeric nanoparticle Cholesterol derivatives Vascular disrupting agent Phosphate-guanidine coordination Drug controlled release

Functional Amphiphilic Poly(2-oxazoline)Block Copolymers as Drug Carriers:the Relationship between Structure and Drug Loading Capacity

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Chinese Journal of Polymer Science 2021年第7期39卷 865-873页

作者： Si Dong Sheng Ma zhi-lin liu Li-Li Ma Yu Zhang Zhao-Hui Tang Ming-Xiao Deng Wan-Tong Song College of Chemistry Northeast Normal UniversityChangchun 130024China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China

Poly(2-oxazoline)(POx)is a kind of polymeric amides that can be viewed as conformational isomers of polypeptides with excellent cyto-and hemo-compatibility,and is promising to be used as drug ***,the drug loading capacity(DLC)of POx for many drugs is still low except several hydrophobic ones including paclitaxel(PTX).Herein,we prepared a series of amphiphilic POx block copolymers with various functional groups,and investigated the relationship between functional structures and the *** POxs with benzyl,carboxyl,and amino groups in the side-chain were synthesized based on a poly(2-methyl-2-oxazoline)-block-poly(2-buty1-2-oxazoline-co-2-buteny1-2-oxazoline)(PMeOx-P(nBuOx-co-ButenOx),PMBEOx)precursor,followed by click reaction between vinyl and the 2-phenylethanethiol,thioglycolic acid and *** thin-film hydration method,eight commonly used drugs with various characteristics were encapsulated within these functional POx *** found that amine-containing drugs were more easily encapsulated by POx with carboxyl groups,while amine functionalities in POx enhanced the loading capacity of drugs with carboxyl *** addition,n-n interactions resulted in enhanced DLC of most drugs,except several hydrophobic drugs with aromatic to total carbon ratios less than *** general,we could successfully encapsulate all the selected drugs with a DLC%over 10%using properly selected functional *** above results confirm that the DLC of polymeric carriers can be adjusted by modifying the functional groups,and the prepared series of functional POxs provide an option for various drug loadings.

关键词： Poly(2-oxaozoline) Polymeric micelles Drug loading π-πInteraction Electrostatic interaction

IL-2-loaded Polypeptide Nanoparticles for Enhanced Anti-cancer Immunotherapy

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Chinese Journal of Polymer Science 2023年第7期41卷 1059-1068页

作者： Xiao-Shuang Wang Zhao-Shi Zheng Meng-Fei Zheng Di Wang Hong-Lei Zhang Zhen-Qian Zhang zhi-lin liu Zhao-Hui Tang Xue-Mei Han No.1 Department of Neurology China-Japan Union Hospital of Jilin UniversityChangchun130033China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China Jilin Biomedical Polymers Engineering Laboratory Changchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education and Key Laboratory of Polymeric Materials&Application Technology of Hunan Province Xiangtan UniversityXiangtan411105China

Interleukin 2 (IL-2) is widely used as an active immunotherapeutic agent in clinical metastatic cancers. However, its therapeutic concentrations do not last long due to its short half-life. Thus, only a transient proliferation of the anti-cancer CD8+ T cells can be achieved, resulting in poor efficacy. Therefore, the aim of this work was to create a system that promotes CD8+ T cell proliferation at the tumor site using IL-2 persistently present and activates an anti-cancer immune response. This goal was achieved by the design of the IL-2-loaded polypeptide nanoparticles (P-IL-2) where methoxy poly(ethylene glycol) block poly-[(N-2-hydroxyethyl)-aspartamide] phenylboronic acid was used to encapsulate IL-2 through boron-nitrogen coordination with poly(L-lysine). P-IL-2 significantly prolonged the circulation time of IL-2 and achieved a selective drug release at the tumor site in the presence of high levels of reactive oxygen species, thus activating an anti-cancer immune response and exerting a better anti-cancer effect. The half-life of P-IL-2 was 3.15-fold higher than that of IL-2, and the quantity of CD8+ T cells after using P-IL-2 was 1.89-fold higher than that after using IL-2. In addition, the combination of P-IL-2 and anti-CTLA-4 monoclonal antibody resulted in an enhanced immune activation. Hence, this work provides a new approach to improve the efficacy of IL-2 in anti-cancer immunotherapy.

关键词： Polypeptide Phenylboronic acid Boron-nitrogen coordination Interleukin 2 ROS-responsive

Mechanical properties and wear resistance of medium entropy Fe40Mn40Cr10Co10/TiC composites

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Transactions of Nonferrous Metals Society of China 2019年第7期29卷 1484-1494页

作者： Jian-ying WANG Jing-hua FANG Hai-lin YANG zhi-lin liu Rui-di LI Shou-xun JI Yun WANG Jian-ming RUAN State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Institute of Materials and Manufacturing Brunel University LondonUxbridgeMiddlesex UB8 3PHU. K.

The Fe40Mn40Cr10Co10/TiC (volume fraction of TiC, 10%) composites were synthesized in combination of ball milling and spark plasma sintering (SPS) in the present work. Mechanical properties and wear resistance of the Fe40Mn40Cr10Co10/TiC composites were individually investigated. It was found that TiC particles homogenously distributed in the Fe40Mn40Cr10Co10/TiC composite after being sintered at 1373 K for 15 min. Meanwhile, grain refinement was observed in the as-sintered composite. Compared with the pure Fe40Mn40Cr10Co10 medium entropy alloy (MEA) matrix grain, addition of 10% TiC particles resulted in an increase in the compressive strength from 1.571 to 2.174 GPa, and the hardness from HV 320 to HV 872. Wear resistance results demonstrated that the friction coefficient, wear depth and width of the composite decreased in comparison with the Fe40Mn40Cr10Co10 MEA matrix. Excellent mechanical properties and wear resistance could offer the Fe40Mn40Cr10Co10/TiC composite a very promising candidate for engineering applications.

关键词： TiC Fe40Mn40Cr10Co10/TiC composites mechanical properties wear resistance spark plasma sintering

Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension

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World Journal of Gastroenterology 2024年第13期30卷 1859-1870页

作者： Rong Chen ling Luo Yun-zhi Zhang Zhen liu An-lin liu Yi-Wen Zhang Department of Infectious Diseases Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Portal hypertension(PHT),primarily induced by cirrhosis,manifests severe symptoms impacting patient *** transjugular intrahepatic portosystemic shunt(TIPS)is a critical intervention for managing PHT,it carries risks like hepatic encephalopathy,thus affecting patient survival *** our knowledge,existing prognostic models for post-TIPS survival in patients with PHT fail to account for the interplay among and collective impact of various prognostic factors on ***,the development of an innovative modeling approach is essential to address this *** To develop and validate a Bayesian network(BN)-based survival prediction model for patients with cirrhosis-induced PHT having undergone *** The clinical data of 393 patients with cirrhosis-induced PHT who underwent TIPS surgery at the Second Affiliated Hospital of Chongqing Medical University between January 2015 and May 2022 were retrospectively *** were selected using Cox and least absolute shrinkage and selection operator regression methods,and a BN-based model was established and evaluated to predict survival in patients having undergone TIPS surgery for *** Variable selection revealed the following as key factors impacting survival:age,ascites,hypertension,indications for TIPS,postoperative portal vein pressure(post-PVP),aspartate aminotransferase,alkaline phosphatase,total bilirubin,prealbumin,the Child-Pugh grade,and the model for end-stage liver disease(MELD)*** on the above-mentioned variables,a BN-based 2-year survival prognostic prediction model was constructed,which identified the following factors to be directly linked to the survival time:age,ascites,indications for TIPS,concurrent hypertension,post-PVP,the Child-Pugh grade,and the MELD *** Bayesian information criterion was 3589.04,and 10-fold cross-validation indicated an average log-likelihood loss of 5.55 with a standard deviation of *** model’s acc

关键词： Bayesian network Cirrhosis Portal hypertension Transjugular intrahepatic portosystemic shunt Survival prediction model

TSC prediction and dynamic control of BOF steelmaking with state-of-the-art machine learning and deep learning methods

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Journal of Iron and Steel Research International 2024年第1期31卷 174-194页

作者： Tian-yi Xie Cai-dong Zhang Quan-lin Zhou zhi-qiang Tian Shuai liu Han-jie Guo Material Technology Research Institute Hesteel GroupShijiazhuang050023HebeiChina Tangsteel Company Hesteel GroupTangshan063611HebeiChina School of Artificial Intelligence Beijing Technology and Business UniversityBeijing100048China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing100083China

Mathematical(data-driven)models based on state-of-the-art(SOTA)machine learning and deep learning models and data collected from 12,786 heats were established to predict the values of temperature,sample,and carbon(TSC)test,including temperature of molten steel(TSC-Temp),carbon content(TSC-C)and phosphorus content(TSC-P),which made prepa-ration for eliminating the TSC *** maximize the prediction accuracy of the proposed approach,various models with different inputs were implemented and compared,and the best models were applied to the production process of a Hesteel Group steelmaking plant in China in the *** number of tabular features(hot metal information,scrap,additives,blowing practices,and preset values)was expanded,and time series(off-gas profiles and blowing practice curves)that could reflect the entire steelmaking process were introduced as ***,the latest machine learning models(LightGBM,CatBoost,TabNet,and NODE)were used to make predictions with tabular features,and the best coefficient of determination R^(2)values obtained for TSC-P,TSC-C and TSC-Temp predictions were 0.435(LightGBM),0.857(Cat-Boost)and 0.678(LightGBM),respectively,which were higher than those of classic models(backpropagation and support vector machine).Then,making predictions was performed by using SOTA time series regression models(SCINet,Dlinear,Informer,and MLSTM-FCN)with original time series,SOTA image regression models(NesT,CaiT,ResNeXt,and GoogLeNet)with resized time series,and the proposed Concatenate-Model and Parallel-Model with both tabular features and time *** optimization and comparisons,it was finally determined that the Concatenate-Model with MLSTM-FCN,SCINet and Informer as feature extractors performed the best,and its R^(2)values for predicting TSC-P,TSC-C and TSC-Temp reached 0.470,0.858 and 0.710,*** field test accuracies for TSC-P,TSC-C and TSC-Temp were 0.459,0.850 and 0.685,respectively.A related importance analysis was carri

关键词： BOF steelmaking In-blow prediction TSC test Machine learning Deep learning Field application