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NUMERICAL SIMULATION OF BATOID LOCOMOTION

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Journal of Hydrodynamics 2011年第5期23卷 594-600页

作者： CHEN Wei-shan WU zhi-jun liu jun-kao SHI Sheng-jun ZHOU Yang State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin 150001 China

The hydrodynamics of batoid swimming motions is investigated using the three-dimensional simulation of a self-propelled body in still water. The kinematics of batoid swimming is characterized by large amplitude undulations of the pectoral fins while the middle part of the body remains straight. The majority of the thrust is generated by pectoral fins. Linear and quadratic amplitude variations are used for the pectoral fins in analyzing the locomotion of the batoid. Navier-Stokes equations are used to solve the unsteady fluid flow. A user defined function and a dynamic mesh method are applied to track the batoid locomotion. The mean swimming velocities of 1.6 BL/s and 1.3 BL/s are achieved, respectively, with thrust coefficients of 0.13 in and 0.095 in the dynamical simulation, where BL/s is the body length per second. The maximum propulsive efficiency 19% is achieved when the frequency of the undulation is 2.2 Hz in both amplitude variations.

关键词： batoid fish undulation pectoral fin dynamical simulation

Microstructure and creep properties of high Cr resisting weld metal alloyed with Co

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第10期11卷 756-760页

作者： Xue WANG Liang-fei ZHAN Qian-gang PAN zhi-jun liu Hong liu Yong-shun TAO School of Power and Mechanical Engineering Wuhan University Wuhan 430072 China DongFang Boiler Group Co. Ltd. Zigong 643001 China

A 9% Cr ferritic steel weld metal containing 1% Co, partially substituted for nickel, was prepared by submerged arc welding (SAW) processing. The microstructure and creep properties of the weld metal were investigated. The microstructure exhibited a fully tempered martensitic structure free of δ-ferrite. The creep properties of the obtained weld metal were inferior to those of the P92 base metal at 600 and 650 °C. The values of A and n for weld metal in the Norton power law constitution at 650 °C are 1.1×10?21 and 8.1, respectively.

关键词： 9Cr steels Weld metal Microstructure Creep properties

Effect of Human Cytomegalovirus Infection on Nerve Growth Factor Expression in Human Glioma U251 Cells

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Biomedical and Environmental Sciences 2009年第4期22卷 354-358页

作者： HAI-TAO WANG BIN WANG zhi-jun liu zhi-QIANG BAI LING LI HAI-YAN liu DONG-MENG QIAN zhi-YONG YAN XU-XIA SONG Department of Microbiology Qingdao Medical College and Key Laboratory of Medicine and Biotechnology of Qingdao Qingdao University Medical College Qingdao 266071 Shandong China Qingdao Center for Disease Control and Prevention Qingdao 266033 Shandong China LRB 270E University of Massachusetts Medical School Worcester MA. 01605 USA

Objective To explore the change of endogenic nerve growth factor （NGF） expression in human glioma cells infected with human cytomegalovirus （HCMV）. Methods U251 cells were cultured in RPMI 1640 culture medium and infected with HCMV AD 169 strain in vitro to establish a cell model of viral infection. Morphologic changes of U251 cells were observed under inverted microscope before and after infection with HCMV. Expression of NGF gene and protein of cells was detected by RT-PCR and Western blotting before and after infection with HCMV. Results The cytopathic effects of HCMV-infected cells appeared on day 5 after infection. However, differential NGF expression was evident on day 7. NGF expression was decreased significantly in U251 cells on day 7 after infection in comparison with control group （P〈0.05）. Conclusion HCMV can down-regulate endogenous NGF levels in human glioma cell line U251.

关键词： Human cytomegalovirus U251 cells Nerve growth factor

Limited thoracoplasty and free musculocutaneous flap transposition for postpneumonectomy empyema: A case report

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World Journal of Clinical Cases 2021年第27期9卷 8114-8119页

作者： Qian-Qian Huang Zhong-Liang He Yong-Yong Wu zhi-jun liu Operating Room Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Cardiothoracic Surgery Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina

BACKGROUND Empyema is a severe complication following pneumonectomy that is associated with high morbidity and mortality *** there are a wide variety of treatment options,successful management remains challenging when this condition is combined with a large cavity in very thin patients who had previously undergone a posterolateral *** SUMMARY We reported the case of a thin,63-year-old man with a progressive pulmonary cyst who underwent left pneumonectomy via posterolateral thoracotomy 23 years *** an initially uneventful postoperative course,he was readmitted with empyema and a large cavity 21 years after *** was successfully treated with limited thoracoplasty,followed by free vastus lateralis musculocutaneous flap *** This case highlights that the treatment mode of limited thoracoplasty and free vastus lateralis musculocutaneous flap transposition is safe and effective for the management of postpneumonectomy empyema with a large cavity in thin patients who had previously undergone a posterolateral thoracotomy.

关键词： Pneumonectomy Postpneumonectomy empyema Thoracoplasty Free muscle flap Surgical treatment Case report

Using the SELDI ProteinChip System to Detect Changes in Protein Expression in Vero Cells after Infection

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中国病毒学 2007年第1期22卷 68-73页

作者： zhi-jun liu Bin WANG zhi-yong YAN Xu-xia SONG Dong-meng QIAN zhi-qiang BAI Department of Microbiology Qingdao Medical College and Key Laboratory of Medicine and Biotechnology of Qingdao Qingdao University Medical College Qingdao 266021China

人的疱疹单一的病毒(HSV-1 ) 1 引起美容，眼睛，并且 encephalitic 疾病并且与潜伏的感染和癌症被联系。这里，我们开发了由使用 SELDI 蛋白质薄片在在 vitro 有教养的 Vero 房间检测蛋白质表示的变化在蛋白质水平学习 HSV-1 感染的致... 详细信息

人的疱疹单一的病毒(HSV-1 ) 1 引起美容，眼睛，并且 encephalitic 疾病并且与潜伏的感染和癌症被联系。这里，我们开发了由使用 SELDI 蛋白质薄片在在 vitro 有教养的 Vero 房间检测蛋白质表示的变化在蛋白质水平学习 HSV-1 感染的致病的一个工具。在有为 12， 24 或 48 h 的 HSV-1 和文化的感染以后，房间被收获并且 lysed。IMAC3 数组被用于 SELDI-TOF-MS 在感染前后检测 proteomic 差别。薄片检测了一系列差别表示蛋白质山峰。有趣地，在 16 912 Da 的山峰和 17 581 Da 与 ISG15 的分子的团精确相应，它可以在感染的过程期间参予抗病毒的活动。因此，我们获得了的结果能用作一个基础学习在病毒和它的主人之间的 HSV-1 和相互作用的致病。另外，他们能为 HSV-1 感染的治疗在新治疗学的目标的发现帮助。关键词 SELDI 蛋白质薄片 - Vero 房间 - HSV-1 - 蛋白质表达式 CLC 数字 R373 基础项目：中国(30540075 ) 的国家自然科学基础；

关键词： SELDI Protein Chip Vero Cells HSV-1 Protein Expression

Preparation of Optically Active Alkoxy-serines from Amino-amide Racemate Catalyzed by Escherichia coli Cells with Peptidase B Activity

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Chemical Research in Chinese Universities 2013年第1期29卷 95-98页

作者： WANG zhi-yuan liu jun-zhong XU Li-sheng ZHANG Hong-juan liu Qian JIAO Qing-cai State Key Laboratory of Pharmaceutical Biotechnology School of Life Science Nanjing University Nanjing 210093 P. R. China

Alkoxy-L-serines are useful for peptide syntheses. The demand for alkoxy-L-serines in the pharmaceutical industries continues to increase because of their multiple physiological effects. In this research, an improved method for alkoxy-L-serines synthesis is reported. A series of substrates, DL-fl-alkoxy-a-amino propionamides, was used for the synthesis of alkoxy-serines catalyzed by Escherichia coli cells with peptidase B（PepB） activity. The results show that PepB has a high resolution activity with DL-fl-alkoxy-a-amino propionamides as substrate. Reaction conditions were optimized, i.e., DL-β-methoxy-a-amino propionamide as substrate at pH=9.0, 40 ℃ and 14 h, and the optimal reaction concentration is 400 mmol/L. The results also show that divalent metal cations exhibit different effects on the PepB activity, for example, Zn2＋ and Cu2＋ can obviously inhibit the activity of PepB, whereas Co2＋, Ca2＋, Mn〉 and Mg2＋ at low concentrations can activate PepB. This research provides access to enantiomerically enriched and valuable alkoxy-L-serines from a simple amino-amide racemate.

关键词： Alkoxy-serine DL-β-Alkoxy-a-amino propionamide Enzymatic resolution Peptidase B

Neuropsychiatric issues after stroke: Clinical significance and therapeutic implications

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World Journal of Psychiatry 2020年第6期10卷 125-138页

作者： Shuo Zhang Michael Xu zhi-jun liu Juan Feng Yan Ma Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Clinical Medicine International Education SchoolChina Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Ultrasound Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

A spectrum of neuropsychiatric disorders is a common complication from *** disorders after stroke have negative effects on functional recovery,increasing the rate of mortality and disability of stroke *** the vital significance of maintaining physical and mental health in stroke patients,neuropsychiatric issues after stroke have raised concerns by clinicians and *** mini-review focuses on the most common non-cognitive functional neuropsychiatric disorders seen after stroke,including depressive disorders,anxiety disorders,post-traumatic stress disorder,psychosis,and psychotic *** each condition,the clinical performance,epidemiology,identification of the therapeutic implication,and strategies are reviewed and discussed;the main opinions and perspectives presented here are based on the latest controlled studies,meta-analysis,or updated systematic *** the absence of data from controlled studies,consensus recommendations were provided accordingly.

关键词： Stroke Neuropsychiatric disorders Depression Anxiety Post-traumatic stress disorder Psychosis

Effect of dimethyl fumarate on rats with chronic pancreatitis

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Asian Pacific Journal of Tropical Medicine 2016年第3期9卷 256-259页

作者： Wen-Xian Zhang Jian-Hong Zhao Fu-Min Ping zhi-jun liu jun-Xia Gu Xin-Qing Lu Affiliated Hospital of Hebei University of Engineering

Objective:To discuss the effect of dimethyl fumarate(DMF) on rats with L-arginine induced chronic pancreatitis(CP).Methods:Male Wistar rats were given DMF treatment(25 mg/kg) by oral lavage method;then Wistar rats were given the intraperitoneal injection of L-arginine for 5times(250 mg/100 kg,twice per time,each interval of 1 h) for building of CP *** were divided into control group,CP group,DMF group and CP+DMF *** in CP+DMF group were given the oral intragastric administration of DMF(25 mg/kg),while rats in control group and CP group were given the equal volume of normal *** weight of rats was evaluated and the intraperitoneal glucose tolerance test was performed(IPGTT,2 g/kg).The islet of rats was isolated and then flow cytometry was employed to evaluate the quality and activity of ***,the histology of non-endocrine tissues and levels of myeloperoxidase(MPO) and malondialdchyde(MDA) were ***:Compared with control group,the weight of rats in CP group was significantly reduced at week 2,4 and 6;the blood glucose significantly increased,AUC increased,the histopathological scores of pancreatic atrophy,acinar injury,edema and cellular infiltration increased,levels of MDA and MPO increased,the islet equivalent and islet activity decreased at 0.30,60,120 and 180 *** with CP group,the weight of rats in CP+DMF group significantly increased at week 2,4 and 6;the blood glucose significantly *** decreased,the histopathological scores of pancreatic atrophy,acinar injury,edema and cellular infiltration decreased,levels of MDA and MPO decreased,the islet equivalent and islet activity increased at 0,30.60,120 and 180 ***:DMF treatment can improve CP induced by L-argininc and islet function in rats.

关键词： Dimethyl fumarate Chronic pancreatitis Rats Mechanism

HCMV Infection Depress NGF Expression in Human Glioma Cells

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Virologica Sinica 2009年第3期24卷 209-214页

作者： Hai-tao WANG Bin WANG zhi-jun liu zhi-qiang BAI Ling LI Dong-meng QIAN zhi-yong YAN Xu-xia SONG Department of Microbiology Qingdao Medical College and Key Laboratory of Medicine and Biotechnology of Qingdao Qingdao University Medical College Qingdao 266071 China Qingdao Center for Disease control and Prevention Qingdao 266033 China RB 270E University of Massachusetts Medical School Worcester MA. 01605 USA

Human cytomegalovirus （HCMV） is the most common cause of congenital infection, resulting in birth defects such as microcephaly. In this study, RT-PCR and Western Blotting were performed to quantify the regulation of endogenic nerve growth factor expression in neuroglia ceils by HCMV infection. The results showed that basal, endogenous NGF expression in U251 was unchanged during early HCMV infection. NGF expression is strongly down-regulated during the latent phase of infection. These results suggest that HCMV can depress the NGF expression in U251 cells.

关键词： Human cytomegalovirus (HCMV) U251 cell Nerve growth factor (NGF)