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Dual Isoflurane-induced Preconditioning Improves Neuroprotection in Rat Brain In Vitro and the Role of Extracellular Signal-regulated Protein Kinase

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Chinese Medical Sciences Journal 2011年第1期26卷 36-42页

作者： Sheng Wang Su-xiang Guo zhi-gang dai Xi-wei Dong Yang Liu Shan Jiang zhi-ping Wang Department of Anesthesiology Affiliated Hospital of Shihezi Medical School Shihezi University Shihezi 832008 China Anesthesiology Key Laboratory of Jiangsu Province Xuzhou 221002 China

Objective To test the ability of isoflurane-induced preconditioning against oxygen and glucose dep- rivation （OGD） injury in vitro. Methods Rat hippocampal slices were exposed to 1 volume percentage （vol%）, 2vo1% or 3vo1% isoflurane respectively for 20 minutes under normoxic conditions （95% O2/5% CO2） once or twice （12 slices in each group） before OGD, with 15-minute washout after each exposure. During OGD experiments, hippocampus slices were bathed with artificial cerebrospinal fluid （ACSF） lacking glucose and perfused with 95% N2 and 5% CO2 for 14 minutes, followed by a 30-minute reperfusion in normal ACSF. The CA1 population spike （PS） was measured and used to quantify the degree of neuronal function recovery after OGD. To assess the role of mitogen-activated protein kinases （MAPKs） in isoflurane preconditioning, U0126, an inhibitor of extracellular signal-regulated protein kinase （ERK1/2）, and SB203580, an inhibitor of p38 MAPK, were used before two periods of 3vol% isoflurane exposure. Results The degree of neuronal function recovery of hippocampal slices exposed to 1 vol%, 2vol%, or 3vol% isoflurane once was 41.88%±9.23%, 55.05%±11.02%, or 63.18%±10.82% respectively. Moreover, neuronal function recovery of hippocampal slices exposed to 1 vol%, 2vo1%, or 3vo1% isoflurane twice was 53.75%±12.04%, 63.50%±11.06%, or 76.25%±12.25%, respectively. Isoflurane preconditioning increased the neuronal function recovery in a dose-dependent manner. U0126 blocked the preconditioning induced by dual exposure to 3vo1% isoflurane （6.13%±1.56%, P〈0.01） and ERK1/2 activities. Conclusions Isoflurane is capable of inducing preconditioning in hippocampal slices in vitro in a dose-dependent manner, and dual exposure to isoflurane with a lower concentration is more effective in triggering preconditioning than a single exposure. Isoflurane-induced neuroprotection might be involved with ERK 1/2 activities.

关键词： electrophysiology hippocampal slice isoflurane preconditioning oxygen andglucose deprivation mitogen-activated protein kinase

丙泊酚麻醉对颅脑损伤手术患者脑保护作用的系统评价

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中国现代医学杂志 2015年第34期25卷 44-50页

作者：葛明月王胜代志刚何艳辉石河子大学新疆石河子843200 石河子大学医学院第一附属医院麻醉科新疆石河子843200

目的系统评价丙泊酚静脉麻醉对颅脑损伤患者的脑保护作用。方法计算机检索Cochrane协作网麻醉组专业协作组数据库、MEDLINE、Pubmed、EMbase和中国期刊全文数据库,同时手工检索图书馆馆藏期刊,收集丙泊酚用于颅脑损伤手术患者麻醉的随... 详细信息

目的系统评价丙泊酚静脉麻醉对颅脑损伤患者的脑保护作用。方法计算机检索Cochrane协作网麻醉组专业协作组数据库、MEDLINE、Pubmed、EMbase和中国期刊全文数据库,同时手工检索图书馆馆藏期刊,收集丙泊酚用于颅脑损伤手术患者麻醉的随机对照试验,评价研究的质量、提取指标数据,并采用Rev Man 5.3软件进行Meta分析。结果纳入14个研究,共1021例颅脑损伤手术患者,结果显示丙泊酚能降低患者血清炎性因子CRP、IL-6、TNF、以及S100β和NSE,并能降低颅内压和升高脑氧分压。结论丙泊酚用于颅脑损伤手术患者的麻醉具有明显的脑保护作用。

关键词：丙泊酚颅脑损伤神经保护系统评价

压力控制容量保证通气中不同吸气流速对单肺通气患者呼吸功能的影响

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中国现代医学杂志 2020年第1期30卷 87-92页

作者：陈平邵秀芝代志刚殷姜文石河子大学医学院第一附属医院麻醉科

目的探讨在压力控制容量保证通气下不同吸气流速对胸科单肺通气患者呼吸功能的影响。方法择期行单侧肺病损切除术的单肺通气全身麻醉患者75例。随机分为3组,吸气流速30 L/min组(A组),吸气流速50 L/min组(B组),吸气流速70 L/min组(C组),... 详细信息

目的探讨在压力控制容量保证通气下不同吸气流速对胸科单肺通气患者呼吸功能的影响。方法择期行单侧肺病损切除术的单肺通气全身麻醉患者75例。随机分为3组,吸气流速30 L/min组(A组),吸气流速50 L/min组(B组),吸气流速70 L/min组(C组),每组25例。分别于单肺通气前5 min(T0)、单肺通气后30 min(T1)、60 min(T2)、120 min(T3)记录气道峰压(Ppeak)、气道平台压(Pplat)并行血气分析,计算动态肺顺应性(Cdyn)、死腔率(VD/VT)、氧合指数(Pa O2/Fi O2)和分流率(Qs/Qt)。结果不同时间点的动脉血二氧化碳分压(PaCO2)、动脉血氧分压(PaO2)、动脉血氧饱和度(SaO2)、中心静脉血氧饱和度(ScvO2)、Ppeak、Pplat、呼气末正压(PEEP)、VD/VT、Cdyn、PaO2/Fi O2、Qs/Qt有差异(P<0.05);3组间PaCO2、Ppeak、Pplat、PEEP、VD/VT、Cdyn有差异(P<0.05);3组间PaCO2、Ppeak、Pplat、PEEP、VD/VT变化趋势有差异(P<0.05)。结论在压力控制容量保证的单肺通气中,适当增加吸气流速可以在降低气道压的同时促使更有效的气体弥散,减少死腔率并改善肺动态顺应性。

关键词：单肺通气吸气流速压力控制死腔率肺动态顺应性

腹横肌阻滞对老年结肠癌患者应激及术后认知功能的影响

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中国现代医学杂志 2019年第2期29卷 63-69页

作者：赵春辉高元丽代志刚王胜石河子大学医学院第一附属医院麻醉科新疆石河子832008

目的对行结肠癌手术的老年患者实施腹横肌阻滞(TAP),探讨其对应激反应及术后认知功能的影响。方法选择拟在全身麻醉(以下简称全麻)下行结肠癌手术的老年患者50例,随机分为腹横肌阻滞联合全麻组和单纯全麻组。腹横肌阻滞联合全麻组于入室... 详细信息

目的对行结肠癌手术的老年患者实施腹横肌阻滞(TAP),探讨其对应激反应及术后认知功能的影响。方法选择拟在全身麻醉(以下简称全麻)下行结肠癌手术的老年患者50例,随机分为腹横肌阻滞联合全麻组和单纯全麻组。腹横肌阻滞联合全麻组于入室后10 min常规进行双侧肋缘下TAP。测定入室10 min、麻醉诱导后5 min、切皮5 min、切皮2 h及手术结束即刻的血糖(GLU)、C-反应蛋白(CRP)浓度。测定术前1 d、入室10 min、手术结束即刻、术后1和2 d血清中神经元特异性烯醇化酶(NSE)含量。采用蒙特利尔认知评定量表(MoCA)、简易精神状态量表(MMSE)进行认知评估,记录两组患者围手期发生认知功能损伤的情况。结果两组患者平均动脉压、心率静态视觉模拟评分、GLU、NSE、MoCA及MMSE评分比较,差异有统计学意义(P <0.05);两组患者不良反应发生率比较,差异有统计学意义(P <0.05);两组患者术后静脉自控镇痛泵按压次数比较,差异有统计学意义(P <0.05);两组患者术后1 d术后认知功能障碍发生率比较,差异有统计学意义(P <0.05)。结论 TAP应用于老年结肠癌手术患者,可降低机体围手术期不良应激反应及认知功能损伤的发生率。

关键词：腹横肌阻滞/神经肌肉阻滞结肠肿瘤认知障碍应激障碍,创伤后老年

细胞外信号蛋白调节激酶5在异氟醚后处理减轻大鼠海马脑片缺氧无糖损伤中的作用

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中国现代医学杂志 2017年第21期27卷 1-6页

作者：崔迪王胜葛明月王芹殷姜文代志刚司军强石河子大学医学院第一附属医院麻醉科新疆石河子832008 石河子大学医学院生理教研室新疆石河子832000

目的探讨异氟醚后处理大鼠海马脑片缺氧无糖(OGD)损伤神经保护机制中细胞外信号蛋白调节激酶5(ERK5)的作用。方法使用雄性SD大鼠,将其麻醉后取出海马组织,制成离体脑片,然后随机进行正常对照组(Con组)、损伤组(OGD组)和药物处理组的处... 详细信息

目的探讨异氟醚后处理大鼠海马脑片缺氧无糖(OGD)损伤神经保护机制中细胞外信号蛋白调节激酶5(ERK5)的作用。方法使用雄性SD大鼠,将其麻醉后取出海马组织,制成离体脑片,然后随机进行正常对照组(Con组)、损伤组(OGD组)和药物处理组的处理。采用花粉活力染色(TTC)法评价各组脑片损伤程度,采用碘化丙啶(PI)染色法检测海马CA1区神经细胞凋亡程度,采用实时荧光定量聚合酶链反应(q RT-PCR)测定细胞外调节蛋白激酶信使核糖核酸(ERK5 m RNA)的表达,采用Western blot法检测ERK5蛋白的表达与磷酸化水平。结果与Con组比较,OGD组脑片损伤程度升高、海马CA1区凋亡细胞增多,海马组织内ERK5 m RNA和p-ERK5表达升高(P<0.05);XMD组阻断ERK5 m RNA和p-ERK5表达,脑片损伤程度升高、海马CA1区凋亡细胞增多(P<0.05)。与OGD、1.5%ISPOC和4.5%ISPOC组比较,3.0%ISPOC组脑片损伤程度减轻、海马CA1区凋亡细胞减少,海马组织内ER K5 m R N A和p-ER K5表达升高(P<0.05)。与3.0%ISPO C组比较,XMD阻断ISPOC海马组织内ERK5 m RNA和p-ERK5表达,脑片损伤程度升高、海马CA1区凋亡细胞增多(P<0.05)。结论一定浓度的异氟醚后处理大鼠海马脑片对抗O GD损伤的保护性机制可能与上调ER K5 m R N A和ERK5磷酸化水平有关。

关键词：麻醉药异氟醚后处理细胞外信号调节MAP激酶类脑缺血海马

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氨基磺酸法合成反应型表面活性剂的进展

邵阳高等专科学校学报 2001年第3期14卷 195-198页

作者：姚志钢戴云信邵阳高等专科学校化学工程系，湖南邵阳422001

对氨基磺酸法合成反应型表面活性剂的进展进行了较详细介绍，并对今后的发展提出了建议。

关键词：反应型表面活性剂氨基磺酸硫酸酯化

活性炭负载杂多酸(PW_(12)C)催化合成1,4-丁二醇双马来酸AEO_2双酯

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邵阳学院学报（自然科学版） 2004年第1期1卷 64-67页

作者：姚志钢戴云信邵阳学院化学与材料科学工程系湖南邵阳422000

以 1,4 -丁二醇 ,马来酸酐 ,十二醇聚氧乙烯醚 (AEO2 )为原料 ,合成了一种结构新型的化合物——— 1,4 -丁二醇双马来酸AEO2 双酯 ,此化合物的合成由两步酯化反应组成 ,酯化反应Ⅰ采用正交实验 ,确定最优工艺条件为 :n(马来酸酐 ) :n(1,... 详细信息

以 1,4 -丁二醇 ,马来酸酐 ,十二醇聚氧乙烯醚 (AEO2 )为原料 ,合成了一种结构新型的化合物——— 1,4 -丁二醇双马来酸AEO2 双酯 ,此化合物的合成由两步酯化反应组成 ,酯化反应Ⅰ采用正交实验 ,确定最优工艺条件为 :n(马来酸酐 ) :n(1,4 -丁二醇 ) =2 .15 :1.0 0 ,反应时间 1h ,催化剂用量ω(乙酸钠 ) =1.0 % .酯化反应Ⅱ采用活性炭负载杂多酸(PW1 2 C)为催化剂 ,该催化剂的最优制备条件为 :m(PW1 2 ) :m(C) ==4 :6 ,回流时间 4h ,烘干温度 15 0℃ ,烘干时间4h .酯化反应Ⅱ采用均匀实验优化工艺条件 ,最优工艺条件为 :n(1,4 -丁二醇双马来酸单酯 ) :n(AEO2 ) =1.0 0 :2 .15 ,反应温度 15 0℃ ,反应时间 14h ,催化剂用量ω(PW1 2 C) =1.5 % ,对每步合成的产物结构用IR和

关键词：活性炭 1,4-丁二醇双马来酸AEO2双酯马来酸酐负载杂多酸酯化交联剂表面活性剂

C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu Zhong-Shang dai Guo-Zhong Gong Min Zhang Department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and Department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(P<0.01).Notably,CXCR5+CD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin dai Xuefeng Liu Xin Ma Shaojie Tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity