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Responses of soil ammonia oxidizers to a short-term severe mercury stress

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Journal of Environmental Sciences 2015年第12期27卷 8-13页

作者： zhi-feng zhou Yu-Rong Liu Guo-Xin Sun Yuan-Ming Zheng College of Resources and Environment Southwest University State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of Sciences

The responses of soil ammonia-oxidizing archaea（AOA） and ammonia-oxidizing bacteria（AOB） to mercury（Hg） stress were investigated through a short-term incubation *** with four different concentrations of Hg（CK,Hg25,Hg50,and Hg100,denoting 0,25,50,and 100 mg Hg/kg dry soil,respectively）,samples were harvested after 3,7,and 28 day *** showed that the soil potential nitrification rate（PNR） was significantly inhibited by Hg stress during the ***,lower abundances of AOA（the highest in CK： 9.20 × 10~7 copies/g dry soil; the lowest in Hg50： 2.68 × 10~7 copies/g dry soil） and AOB（the highest in CK： 2.68 × 10~7 copies/g dry soil; the lowest in Hg50：7.49 × 10~6 copies/g dry soil） were observed only at day 28 of incubation（P 〈 0.05）.Moreover,only the community structure of soil AOB obviously shifted under Hg stress as seen through DGGE profiles,which revealed that 2-3 distinct AOB bands emerged in the Hg treatments at day *** summary,soil PNR might be a very useful parameter to assess acute Hg stress on soil ecosystems,and the community structure of soil AOB might be a realistic biological indicator for the assessment of heavy metal stress on soil ecosystems in the future.

关键词： Mercury (Hg) Potential nitrification rate (PNR) Amonia oxidizers Abundance Community structure

Sleep disorders in Alzheimer’s disease:the predictive roles and potential mechanisms

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Neural Regeneration Research 2021年第10期16卷 1965-1972页

作者： Huang Kuang Yu-Ge Zhu zhi-feng zhou Mei-Wen Yang Fen-Fang Hong Shu-Long Yang Department of Physiology College of MedicineNanchang UniversityNanchangJiangxi ProvinceChina Department of Nurse Nanchang University HospitalNanchangJiangxi ProvinceChina Department of Experimental Teaching Center Nanchang UniversityNanchangJiangxi ProvinceChina

Sleep disorders are common in patients with Alzheimer’s disease,and can even occur in patients with amnestic mild cognitive impairment,which appears before Alzheimer’s *** disorders further impair cognitive function and accelerate the accumulation of amyloid-βand tau in patients with Alzheimer’s *** present,sleep disorders are considered as a risk factor for,and may be a predictor of,Alzheimer’s disease *** that sleep disorders are encountered in other types of dementia and psychiatric conditions,sleep-related biomarkers to predict Alzheimer’s disease need to have high specificity and ***,we summarize the major Alzheimer’s disease-specific sleep changes,including abnormal non-rapid eye movement sleep,sleep fragmentation,and sleep-disordered breathing,and describe their ability to predict the onset of Alzheimer’s disease at its earliest *** the mechanisms underlying these sleep changes is also crucial if we are to clarify the role of sleep in Alzheimer’s *** paper therefore explores some potential mechanisms that may contribute to sleep disorders,including dysregulation of the orexinergic,glutamatergic,andγ-aminobutyric acid systems and the circadian rhythm,together with amyloid-β*** review could provide a theoretical basis for the development of drugs to treat Alzheimer’s disease based on sleep disorders in future work.

关键词： Alzheimer’s disease amyloid-βaccumulation circadian rhythm GABAergic system glutamatergic system non-rapid eye movement sleep orexinergic system sleep disorders sleep fragmentation sleep-disordered breathing

Roles of pattern recognition receptors in diabetic nephropathy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第3期21卷 192-203页

作者： zhi-feng zhou Lei JIANG Qing ZHAO Yu WANG Jing zhou Qin-kai CHEN Jin-lei LV The First Clinical Medical College of Nanchang University Nanchang 330006China Department of Nephrology the First Affiliated Hospital of Nanchang UniversityInstitute of Molecular Immunology of Kidney Disease of Nanchang UniversityNanchang 330006China

Diabetic nephropathy(DN)is currently the most common complication of *** is considered to be one of the leading causes of end-stage renal disease(ESRD)and affects many diabetic *** pathogenesis of DN is extremely complex and has not yet been clarified;however,in recent years,increasing evidence has shown the important role of innate immunity in DN *** recognition receptors(PRRs)are important components of the innate immune system and have a significant impact on the occurrence and development of *** this review,we classify PRRs into secretory,endocytic,and signal transduction PRRs according to the relationship between the PRRs and subcellular *** can recognize related pathogen-associated molecular patterns(PAMPs)and danger-associated molecular patterns(DAMPs),thus triggering a series of inflammatory responses,promoting renal fibrosis,and finally causing renal *** this review,we describe the proposed role of each type of PRRs in the development and progression of DN.

关键词： Diabetic nephropathy Innate immunity Pattern recognition receptor Pathogenesis

Studies on the biosynthesis of arteannuin——Ⅳ.The biosynthesis of arteanniuin and arteannuin B by the leaf homogenate of Artemisia annua L.

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Chinese Journal of Chemistry 1993年第5期11卷 457-463页

作者： WANG,Yu XIA,zhi-Qiang zhou,feng-Yi WU,Yu-Lin HUANG,Jing-Jian WANG,zhi-Zhong Shanghai Institute of Organtic Chemistry,Chinese Academy of Siciences,Shanghai 200032

Arteannuic acid and(-)11R,13-d(?)ydroarteannuic acid are the key intermediates in the biosynthesis of arteannuin by the leaf homogenate of Artemisia annua L.,and arteannuic acid and epoxyarteannuic acid are the interm... 详细信息

关键词： The biosynthesis of arteanniuin and arteannuin B by the leaf homogenate of Artemisia annua L Studies on the biosynthesis of arteannuin

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自适应访问模式的缓存替换策略

北京邮电大学学报 2016年第3期39卷 44-48,53页

作者：黄智濒周锋马华东北京邮电大学智能通信软件与多媒体北京市重点实验室北京100876

针对组竞争仅考虑访问请求序列的替换结果而没有考虑请求的访存特征这个问题,提出了基于堆栈距离频度的复杂加权法在线识别访问模式的方法以及自适应访问模式的缓存管理替换算法,基本思想是依据在线识别的访问请求模式特征自动调整其插... 详细信息

针对组竞争仅考虑访问请求序列的替换结果而没有考虑请求的访存特征这个问题,提出了基于堆栈距离频度的复杂加权法在线识别访问模式的方法以及自适应访问模式的缓存管理替换算法,基本思想是依据在线识别的访问请求模式特征自动调整其插入策略.在Simics中,对选自SPEC CPU2000/2006的18个测试程序及组合负载的实验结果表明,该算法的缺失率相对于DIP、RRIP、TADIP和PIPP都有显著降低.

关键词：访问模式替换算法多核共享末级缓存组竞争

Normal carcinoembryonic antigen indicates benefit from perioperative chemotherapy to gastric carcinoma patients

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World Journal of Gastroenterology 2012年第29期18卷 3910-3916页

作者： Shi Chen Ying-Bo Chen Yuan-Fang Li Xing-Yu feng zhi-Wei zhou Xiu-Hong Yuan Chao-Nan Qian State Key Laboratory of Oncology in South China Sun Yat-sen Univer- sity Cancer Center Guangzhou 510060 Guangdong Province China

AIM:To evaluate pretreatment serum carcinoembryonic antigen(CEA) as a predictor of survival for patients with locally advanced gastric cancer receiving perioperative ***:We retrospectively studied a cohort of 228 gastric cancer patients who underwent D2 gastrectomy combined with chemotherapy at the Sun Yat-sen University Cancer Center between January 2005 and December *** them,168 patients received 6-12 cycles of oxaliplatin-based adjuvant(post-operative) chemotherapy,while 60 received perioperative chemotherapy(2 cycles of FOLFOX6 or XELOX before surgery and 4-10 cycles after surgery).Serum CEA was measured using an enzyme *** followup lasted until December ***:In the group that had elevated serum CEA,the difference in survival time between patients receiving perioperative chemotherapy and those receiving adjuvant chemotherapy had no statistical significance(P > 0.05).However,in the group that had normal serum CEA,patients receiving perioperative chemotherapy had a longer survival *** multivariate analysis,T staging and lymph node metastatic rate were independent prognostic factors for the *** chemotherapy improved the overall survival of patients who had a normal pretreatment CEA level(P = 0.070).CONCLUSION:Normal pretreatment serum CEA is a predictor of survival for patients receiving perioperative chemotherapy.

关键词： Carcinoembryonic antigen Perioperative chemotherapy Prognosis Gastric adenocarcinoma Survival

Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： feng He Sitong Chen Ruili zhou Hanyu Diao Yangyang Han Xiaodong Wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

Effects of MICA expression on the prognosis of advanced non-small cell lung cancer and the efficacy of CIK therapy

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Effects of MICA expression on the prognosis of advanced non-...

A low redox potential and long life organic anode material for sodium-ion batteries

第13届全国肺癌学术大会

作者： Yu Chen Gen Lin Zeng-qing Guo zhi-feng zhou zhi-yong He Yun-bin Ye Department of Medical Oncology Fujian Provincial Cancer HospitalFujian Medical University Teaching Hospital Fujian Key Laboratory of Translational Cancer Medicine Fujian Provincial Key Laboratory of Tumor Biotherapy Laboratory of Immuno-Oncology Fujian Provincial Cancer HospitalFujian Medical University Teaching Hospital

＜正＞Objective:To investigate the clinical significance of the expression of MHG classⅠchain-related gene A（MICA） in patients with advanced non-small cell lung cancer and explore the relationship between MICA expression and the efficacy of cytokine-induced killer cell（GIK） therapy for treating advanced non-small cell lung ***: We obtained data on 222 patients with advanced non-small cell lung cancer（stageⅢ-Ⅳ）,

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： zhi Li Yang Wei Kang zhou Xin Huang Xing zhou Jie Xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries