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New insight into surface properties of LB film of an amphiphilic terpolymer

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Chinese Chemical Letters 2011年第2期22卷 241-244页

作者： Xiu Li Yue Fang Ma, zhi fei dai Meng Liu Lei Xing Hai Yan Fan Zhan Wen Xing Shao Qin Liu Nanobiotechnology Division State Key Laboratory of Urban Water Resources and Environment School of Sciences Harbin Institute of Technology Harbin 150001 China Received 4 June 2010

Amphiphilic terpolymer（TPR） exhibits good film-forming behavior on pure water observed by means ofπ-A *** gain insight into physical properties of TPR,the films have been deposited on silicon substrates at different surface pressure by Langmuir-Blodgett（LB） *** was found that the increase in peak intensities of stretching mode was due to orderly packing of the *** contact angles increased with increasing surface pressure,indicating an increase in hydrophobicity due to dense packing of chains of *** cyclic voltammetric measurements indicated that TPR showed good current shielding effect for *** a word,LB films of TPR can produce a variety of structures with varied topography,enabling us to control not only the functionality of the surface,but also the interfacial transport characteristics.

关键词： Terpolymer Monolayer Langmuir-Blodgett film Surface

PREPARATION OF POLYELECTROLYTE MULTILAYER COATED MICROBUBBLES FOR USE AS ULTRASOUND CONTRAST AGENT

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Chinese Medical Sciences Journal 2008年第2期23卷 103-107页

作者： Zhan-wen Xing Heng-te Ke Shao-qin Liu zhi-fei dai Jin-rui Wang Ji-bin Liu Nanomedicine and Biosensor Laboratory Bio-X Center Harbin Institute of Technology Harbin 150080 Department of Ultrasonography Third Hospital Peking University Beijing 100083 Ultrasound Research and Education Institute Thomas Jefferson University Hospital Philadelphia 19107 USA

Objeelive To prepare and characterize polyelectrolyte multilayer film coated microbubbles for use as ultrasound contrast agent （UCA） and evaluate its effects in ultrasonic imaging on normal rabbit＇s fiver parenchyma. Methods Perfluorocarbon （PFC）-containing microbubbles （ST68-PFC） were prepared by sonication based on suffactant （ Span 60 and Tween 80）. Subsequently, the resulting ST68-PFC microbubbles were coated using oppositely charged polyelectrolytes by microbubble-templated layer-by-layer self-assembly technique via electrostatic interaction. The enhancement effects in ultrasonic imaging on normal rabbit＇s liver parenchyma were assessed. Results The obtained microbubbles exhibited a narrow size distribution. The polyelectrolytes were successfully assembled onto the surface of ST68-PFC microbubbles. In vivo experiment showed that polyelectrolyte multilayer film coated UCA effectively enhanced the imaging of rabbit＇s liver parenchyma. Conclusions The novel microbubbles UCA coated with polyelectrolyte multilayer, when enabled more function, has no obvious difference in enhancement effects compared with the pre-modified microbubbles. The polymers with chemically active groups （ such as amino group and carboxyl group） can be used as the outermost layer for attachment of targeting ligands onto microbubbles, allowing selective targeting of the microbubbles to combine with desired sites.

关键词： microbubbles ultrasound contrast agent layer-by-layer self-assembly technique polyelectrolyte

Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging

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Cancer Biology & Medicine 2016年第3期13卷 349-359页

作者： Chuang Gao Zi-Jian Deng Dong Peng Yu-Shen Jin Yan Ma Yan-Yan Li Yu-Kun Zhu Jian-Zhong Xi Jie Tian zhi-fei dai Chang-Hui Li Xiao-Long Liang Department of Biomedical Engineering College of Engineering Peking University Institute of Automation Chinese Academy of Sciences Nanomedicine and Biosensor Laboratory School of Life Science and Technology Harbin Institute of Technology

Objective: Photoacoustic(PA) tomography(PAT) has attracted extensive interest because of its optical absorption contrast and ultrasonic detection. This study aims to develop a biocompatible and biodegradable PA contrast agent particularly promising for clinical applications in human ***: In this study, we presented a PA contrast agent: 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)](DSPE-PEG)-coated superparamagnetic iron oxide(SPIO) nanoparticles(NPs) loaded with indocyanine green(ICG). We used ICG and SPIO NPs because both drugs are approved by the U.S. Food and Drug Administration. Given the strong absorption of near-infrared laser pulses, SPIO@DSPE-PEG/ICG NPs with a uniform diameter of ~28 nm could significantly enhance PA ***: We demonstrated the contrast enhancement of these NPs in phantom and animal experiments, in which the in vivo circulation time of SPIO@DSPE-PEG/ICG NPs was considerably longer than that of free ICG. These novel NPs also displayed a high efficiency of tumor ***: SPIO@DSPE-PEG/ICG NPs are promising PAT contrast agents for clinical applications.

关键词： Indocyanine green magnetic nanoparticles photoacoustic tomography tumor imaging

光谱辐射照度国际关键比对装置、方法与结果分析

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光谱学与光谱分析 2025年第1期45卷 1-7页

作者：代彩红王彦飞李玲吴志峰谢一航中国计量科学研究院光学与激光计量科学研究所北京100029

基于高温黑体辐射源和双光栅光谱辐射比较测量系统,中国计量科学研究院自主研制了新一代光谱辐射照度国家基准装置,波长范围覆盖230~2550 nm,以一组稳定的卤钨灯作为副基准灯组,保存和传递光谱辐射照度量值。黑体的温度溯源至铂-碳Pt-C... 详细信息

基于高温黑体辐射源和双光栅光谱辐射比较测量系统,中国计量科学研究院自主研制了新一代光谱辐射照度国家基准装置,波长范围覆盖230~2550 nm,以一组稳定的卤钨灯作为副基准灯组,保存和传递光谱辐射照度量值。黑体的温度溯源至铂-碳Pt-C和铼-碳Re-C共晶点黑体,在3021 K采用钨碳-碳WC-C共晶点黑体进行验证。采用新基准装置,2017年-2019年NIM参加国际计量局组织的光谱辐射照度国际关键比对CCPR-K1.a,比对由全俄光学物理学测量研究院(VNIIOFI)主导,共有12个实验室参加。比对结果表明:除少数实验室外,在250~290、300~1300、1500~2500 nm波长范围,各参比实验室之间的一致性分别为±2.0%、±1.0%和±2.0%。在紫外、可见和近红外波段,NIM与国际比对参考值的平均相对偏差分别为0.13%、0.28%和0.15%。在250~2500 nm全波段,NIM与国际比对参考值的平均相对偏差为0.17%,与2004年平均相对偏差0.9%相比,测量能力提升显著。

关键词：光谱辐射照度国际比对高温黑体测量不确定度国家基准

QSBR Study on the Anaerobic Biodegradation of Chlorophenols

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1183-1188页

作者： YANG Da-Sen dai You-zhi LI Jian-Hua ZHU fei Department of Environmental Engineering Xiangtan Umversity Hunan 411105 China

18 Physicochemical and quantum chemical parameters of 12 kinds of chlorophenols are calculated in this paper. QSBR （quantitative structure-biodegradability relationship） study is performed using simca statistical software by PLS regression analysis method on anaerobic biodegradation data （logKb）, and the QSBR model is developed with favorable prediction. The model shows that the size and energy of the molecule are the dominant factors affecting the anaerobic biodegradation of chlorophenols. And the degradation rate constants （logKb） increase with the increase of core-core repulsion （CCR）, average molecular polarizability （α）, total surface area （TSA）, heat of formation （HOF） and total energy （TE）. while decrease with the increase of molecular connectivity index （^1X^V）, relative molecular mass （Mw） and electronic energy （EE）.

关键词： chlorophenols anaerobic biodegradation QSBR optimal model

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan Xu Kang He Chang-Qing Liu Li-fei Song Zheng-zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

The tail risk safe haven property of China's energy futures against US market implied volatility

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Journal of Management Science and Engineering 2024年第2期9卷 271-291页

作者： Xingyu dai Peng-fei dai Qunwei Wang zhi-Yi Ouyang College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing211106China Research Center for Soft Energy Science Nanjing University of Aeronautics and AstronauticsNanjing211106China School of Management Wuhan University of TechnologyWuhan430070China Research Institute of Digital Governance and Management Decision Innovation Wuhan University of TechnologyWuhan430070China Huafu Fund Management Co. Ltd.ShanghaiChina

This paper analyses the tail risk contagion of US market implied volatility(USIV)on China's energy futures(CEF)markets,exploring how to utilize operations in the CEF to achieve a safe *** CEF characteristics to simultaneously take both long-/short-positions and engage in long-/short-run investment horizons,this paper defines eight different CEF safe haven attributes to counteract the tail risk of extreme increases in *** trading data from March 27,2018,to October 30,2023,the empirical results show that,first,in the analysis of the entire sample period,China's coking coal futures can serve as a weak safe haven,aiding long-position investors in mitigating the tail risks associated with US gold and stock market implied *** coal futures also assist short-position investors in countering US stock market implied volatility tail ***,in the sub-period analysis,the safe haven attributes of CEF exhibit strong heterogeneity and asymmetry across different ***,the time span during which CEF exhibits a particular safe haven attribute does not persist for an extended period.

关键词： China's energy futures Safe havenImplied volatility Multi-timescale analysis Cross-quantilogram model

Optimization of water and nitrogen management for surge-root irrigated apple trees in the Loess Plateau of China

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Journal of Integrative Agriculture 2021年第1期20卷 260-273页

作者： dai zhi-guang fei Liang-jun ZENG Jian HUANG De-liang LIU Teng nstitute of Water Resources Research Xi’an University of TechnologyXi’an 710048P.R.China School of Hydraulic and Ecological Engineering Nanchang Institute of TechnologyNanchang 330099P.R.China

The Loess Plateau is one of the main regions for growing apple trees in China, but a shortage of water resources and low utilization of nitrogen have restricted its agricultural development. A 2-year field experiment was conducted which included three levels of soil water content(SWC), 90–75%, 75–60%, and 60–45% of field capacity, and five levels of nitrogen application(N(app)), 0.7, 0.6, 0.5, 0.4 and 0.3 kg/plant. The treatments were arranged in a strip-plot design with complete randomized blocks with three replications. For both years, the water and N(app) had significant(P<0.05) effects on leaf area index(LAI), yield, water use efficiency(WUE) and nitrogen partial factor productivity(NPFP) while the interaction effect of water and N(app) on yield, WUE and NPFP was significant(P<0.05) in 2018, and not in 2017. For the same SWC level, WUE first increased, then decreased as N(app) increased, while NPFP tended to decrease, but the trend of LAI with different N(app) was closely related to SWC. At the same N(app), the LAI increased as SWC increased, while the WUE and NPFP first increased, then decreased, but the yield showed different trends as the SWC increased. The dualistic and quadric regression equations of water and N(app) indicate that the yield, WUE and NPFP cannot reach the maximum at the same time. Considering the coupling effects of water and N(app) on yield, WUE and NPFP in 2017 and 2018, the SWC level shall be controlled in 75–60% of field capacity and the N(app) is 0.45 kg/plant, which can be as the suitable strategy of water and N(app) management for the maximum comprehensive benefits of yield, WUE and NPFP for apple trees in the Loess Plateau and other regions with similar environments.

关键词： surge-root irrigation yield water use efficiency nitrogen partial factor productivity

Stability analysis of layered slopes in unsaturated soils

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Frontiers of Structural and Civil Engineering 2022年第3期16卷 378-387页

作者： Guangyu dai fei ZHANG Yuke WANG Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing 210098China Jiangsu Province's Geotechnical Research Center Nanjing 210098China College of Water Conservancy Engineering Zhengzhou UniversityZhengzhou 450001China

This study presents stability analyses of layered soil slopes in unsaturated conditions and uses a limit equilibrium method to determine the factor of safety involving suction stress of unsaturated ***-dimensional steady infiltration and evaporation conditions are considered in the stability *** example of a two-layered slope in clay and silt is selected to verify the used method by comparing with the results of other *** analyses are conducted to explore the influences of the matric suction on the stability of layered soil *** obtained results show that larger suction stress provided in unsaturated clay dominates the stability of the layered ***,the location and thickness of the clay layer have significant influences on slope *** the water level decreases,the factor of safety reduces and then increases gradually in most ***/evaporation can obviously affect the stability of unsaturated layered slopes,but their influences depend on the soil property and thickness of the lower soil layer.

关键词： slope stability suction stress unsaturated soil layered slope limit equilibrium