Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging

作     者：Chuang Gao Zi-Jian Deng Dong Peng Yu-Shen Jin Yan Ma Yan-Yan Li Yu-Kun Zhu Jian-Zhong Xi Jie Tian Zhi-Fei Dai Chang-Hui Li Xiao-Long Liang 

作者机构：Department of Biomedical Engineering College of Engineering Peking University Institute of Automation Chinese Academy of Sciences Nanomedicine and Biosensor Laboratory School of Life Science and Technology Harbin Institute of Technology 

出 版 物：《Cancer Biology & Medicine》 (癌症生物学与医学（英文版）)

年 卷 期：2016年第13卷第3期

页      面：349-359页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by National Key Research and Development Program of China(Grant No.2016YFA0201400) State Key Program of National Natural Science of China(Grant No.81230036) National Natural Science Foundation for Distinguished Young Scholars(Grant No.81225011) National Natural Science Foundation of China(Grant No.21273014) the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(Grant No.81421004) 

主　　题：Indocyanine green magnetic nanoparticles photoacoustic tomography tumor imaging 

摘      要：Objective: Photoacoustic(PA) tomography(PAT) has attracted extensive interest because of its optical absorption contrast and ultrasonic detection. This study aims to develop a biocompatible and biodegradable PA contrast agent particularly promising for clinical applications in human ***: In this study, we presented a PA contrast agent: 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)](DSPE-PEG)-coated superparamagnetic iron oxide(SPIO) nanoparticles(NPs) loaded with indocyanine green(ICG). We used ICG and SPIO NPs because both drugs are approved by the U.S. Food and Drug Administration. Given the strong absorption of near-infrared laser pulses, SPIO@DSPE-PEG/ICG NPs with a uniform diameter of ~28 nm could significantly enhance PA ***: We demonstrated the contrast enhancement of these NPs in phantom and animal experiments, in which the in vivo circulation time of SPIO@DSPE-PEG/ICG NPs was considerably longer than that of free ICG. These novel NPs also displayed a high efficiency of tumor ***: SPIO@DSPE-PEG/ICG NPs are promising PAT contrast agents for clinical applications.