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Influence of tanshinone on N-methyl-D-aspartate receptor 1 protein expression in a rat model of spinal cord ischemia/reperfusion injury

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Neural Regeneration Research 2009年第1期4卷 10-14页

作者： Li Zhang Xiang Lin yong Fu Guangrui nie Qiqing Zeng Department of Traumatology & Orthopedics Fujian College of Traditional Chinese Medicine Fuzhou 350003 Fujian Province China

BACKGROUND： Tanshinone has been previously shown to be involved in the prevention and treatment of cerebral ischemia/reperfusion injury. In addition, excitatory amino acid-mediated neu- rotoxicity may induce neuronal damage following spinal cord ischemia/reperfusion injury. OBJECTIVE： To explore the interventional effect of tanshinone on N-methyl-D-aspartate receptor 1 （NMDAR1） protein expression in a rat model of spinal cord ischemia/reperfusion injury. DESIGN, TIME AND SETTING： A randomized molecular biology experiment was conducted at the Traumatology ＆ Orthopedics Laboratory of Fujian Hospital of Traditional Chinese Medicine （Key Laboratory of State Administration of Traditional Chinese Medicine） between September 2007 and May 2008. MATERIALS： A total of 88 Sprague Dawley rats were randomly divided into a sham operation （n = 8）, model （n = 40）, and tanshinone （n = 40） groups. Thirty minutes after ischemia, rats in the model and tanshinone groups were observed at hour 0.5, 1, 4, 8, and 12 following perfusion, with eight rats for each time point. METHODS： Abdominal aorta occlusion was performed along the right renal arterial root using a Scoville-Lewis clamp to induce spinal cord ischemia. Blood flow was recovered 30 minutes following occlusion to establish models of spinal cord ischemia/reperfusion injury. Abdominal aorta occlusion was not performed in the sham operation group. An intraperitoneal injection of tanshinone ⅡA sulfonic sodium solution （0.2 L/g） was administered to rats in the tanshinone group, preoperatively. In addition, rats in the sham operation and model groups were treated with an intraperitoneal injection of the same concentration of saline, preoperatively. MAIN OUTCOME MEASURES： NMDAR1 protein expression in the anterior horn of the spinal cord, accumulative absorbance, average absorbance, and area of positive cells were detected in the three groups through immunohistochemistry. RESULTS： All 88 rats were included in the final analysis.

关键词： spinal cord ischemia/reperfusion injury tanshinone N-methyI-D-aspartate receptor 1

RELATIVE BRIGHTNESS INDEX AND IT’S CLIMATIC SIGNIFICANCE FROM LACUSTRINE SEDIM ENT OF NAPAHAI LAKE,NORTHWESTERN YUNNAN PLATEAU,CHINA

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Chinese Geographical Science 2002年第3期12卷 58-62页

作者： yong Yin Nian-qiao Fang Chao-yong Hu Hao-gang nie Zun-li Qing The Key Laboratory of Coast & Island Development Nanjing University Nanjing P. R. China China University of Geosciences Beijing P. R. China China University of Geosciences Wuhan P. R. China

Information on the palaeoenvironm ent from Late Pleistocene to Holocen e in northwestern Yannan Plateau has been deduced from a study of a 28.81m-long core taken from Napahai *** results from Relative Brightness In-dex(RBI )as well as those from the lithological analyses of bulk sediments,total organic carbon and granulometric analy-ses have been used to reconstruct the environmental and climatic evoluti on of the *** ages were provided by three 14 C *** record suggested a climate fluctuation between warm-dry a nd cool-wet from ca.57to 32ka B.P.,which led a shallowing and swamping of the l *** water level again increased quickly at ca.32ka B.P.,reached it’ s peak during LGM(Last Glacial Maximum,ca.18-20ka B.P.)and remained relative high until ca.15ka *** high wa-ter level at LGM is attributed to cold-wet *** area experienced an abrupt and unstable climatic ch anges dur-ing the transition period from15to 10ka *** a dominated littoral en ***-dry climate led to the contrac-tion of the lake during the Holocene a nd reed-swamps became *** a minor wet-cool pulse during the L ate Holocene,the modern climate became to be established.

关键词： Relative Brightress Index total organic carbon particle size palaeoclimate Napahai Lake

Generating large steady-state optomechanical entanglement by the action of Casimir force

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Science China(Physics,Mechanics & Astronomy) 2014年第12期57卷 2276-2284页

作者： nie Wen Jie LAN Yue Heng LI yong ZHU Shi Yao Department of Physics Tsinghua University Beijing Computational Science Research Center Department of Applied Physics East China Jiaotong University

In this paper, we study an optomechanical device consisting of a Fabry-P6rot cavity with two dielectric nanospheres trapped near the cavity mirrors by an external driving laser. In the condition where the distances between the nanospheres and cavity mirrors are small enough, the Casimir force helps the optomechanical coupling to induce a steady-state optomechanical entanglement of the mechanical and optical modes in a certain regime of parameters. We investigate in detail the dependence of the steady- state optomechanical entanglement on external control parameters of the system, i.e., the effective detuning, the pump powers of the cavity, the cavity decay rate and the wavelength of the driving field. It is found that the large steady-state optomechanical entanglement, i.e. EN = 5.76, can be generated with experimentally feasible parameters, i.e. the pump power P = 18.2 μW, the cavity decay rate K = 0.5 MHz and the wavelength of the laser AL=1064 nm, which should be checked by optical measurement.

关键词： optomechanics Casimir effect entanglement

Electroacupuncture promotes the recovery of motor neuron function in the anterior horn of the injured spinal cord

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Neural Regeneration Research 2015年第12期10卷 2033-2039页

作者： Jian-hui Yang Jian-guo Lv Hui Wang Hui-yong nie Rehabilitation Center First Affiliated Hospital of Health Science CenterXi’an Jiaotong University

Acupuncture has been shown to lessen the inflammatory reaction after acute spinal cord injury and reduce secondary ***,the mechanism of action remains *** this study,a rat model of spinal cord injury was established by compressing the T8-9 segments using a modified Nystrom ***-four hours after injury,Zusanli（ST36）,Xuanzhong（GB39）,Futu（ST32）and Sanyinjiao（SP6）were stimulated with *** with spinal cord injury alone were used as *** 2,4 and 6 weeks after injury,acetylcholinesterase（ACh E）activity at the site of injury,the number of medium and large neurons in the spinal cord anterior horn,glial cell line-derived neurotrophic factor（GDNF）m RNA expression,and Basso,Beattie and Bresnahan locomotor rating scale scores were greater in the electroacupuncture group compared with the control *** results demonstrate that electroacupuncture increases ACh E activity,up-regulates GDNF m RNA expression,and promotes the recovery of motor neuron function in the anterior horn after spinal cord injury.

关键词： nerve regeneration spinal cord injury electroacupuncture spine injury secondaryinjury acupoint motor neurons acetylcholinesterase glial cell line-derived neurotrophic factor inclined board test Basso, Beattie and Bresnahan locomotor rating scale functional recovery neuralregeneration

Fractal　and　chaotic　phenomena　of　seismic　dissipated　energy　in　an　energy　system　of　engineering　struct

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Acta Seismologica Sinica(English Edition) 1998年第4期11卷 479-486页

作者： Cui, Yu-Hong nie, yong-An Yan, Zong-Da Wu, Guo-You Department of Mechanics Tianjin University Tianjin China Seismological Bureau of Tianjin Tianjin China

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ＦｒａｃｔａｌａｎｄｃｈａｏｔｉｃｐｈｅｎｏｍｅｎａｏｆｓｅｉｓｍｉｃｄｉｓｓｉｐａｔｅｄｅｎｅｒｇｙｉｎａｎｅｎｅｒｇｙｓｙｓｔｅｍｏｆｅｎｇｉｎｅｅｒｉｎｇｓｔｒｕｃｔｕｒｅｓＹＵ－ＨＯＮＧＣＵＩ１）（崔玉红）ＹＯＮＧ－ＡＮＮＩＥ２）（聂永安）Ｚ...

关键词： phenomena 崔玉 Fractal

Progress in Mechanism of Astragalus membranaceus and Its Chemical Constituents on Multiple Sclerosis

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Chinese Journal of Integrative Medicine 2023年第1期29卷 89-95页

作者： PENG yong DENG Xiang YANG Shan-shan nie Wei TANG Yan-dan Department of Neurology Affiliated First Hospital of Hunan Traditional Chinese Medical CollegeZhuzhouHunan Province412000China

The primary chemical components of Astragalus membranaceus include polysaccharides,saponins,flavonoids,and amino *** studies have shown that Astragalus membranaceus has multiple functions,including improving immune function and exerting antioxidative,anti-radiation,anti-tumor,antibacterial,antiviral,and hormone-like *** membranaceus and its extracts are widely used in clinical practice because they have obvious therapeutic effects against various autoimmune diseases and relatively less adverse *** sclerosis(MS)is an autoimmune disease of central nervous system(CNS),which mainly caused by immune disorder that leads to inflammatory demyelination,inflammatory cell infiltration,and axonal degeneration in the *** this review,the authors analyzed the clinical manifestations of MS and experimental autoimmune encephalomyelitis(EAE)and focused on the efficacy of Astragalus membranaceus and its chemical components in the treatment of MS/EAE.

关键词： Astragalus membranaceus chemical components multiple sclerosis experimental autoimmune encephalomyelitis immunoregulation

Recent progress and application of materials life cycle assessment in China

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Progress in Natural Science:Materials International 2011年第1期21卷 1-11页

作者： Zuo-ren nie,Feng GAO,Xian-zheng GONG,zhi-hong WANG,Tie-yong ZUO College of Materials Science and Engineering,Beijing University of Technology,Beijing 100124,China College of Materials Science and Engineering Beijing University of Technology Beijing 100124 China

Life cycle assessment(LCA) is a technique for systematically analyzing the environmental impacts and resources used throughout a target’s life cycle,*** raw material acquisition,via production and use phases,to waste *** is an effective tool that gives a detailed information of environmental profiles of a material or a *** importantly,the value of life cycle thinking lies in its ability to provide the decision-making basis for sustainable development,making the products, industries and even the whole industry chain act more in line with the principles of sustainable *** recent developments of LCA methods and applications of materials life cycle assessment in China were *** the sections on LCA methodology,the data quality analysis,the impact of land use and abiotic resource depletion as well as the weakness in life cycle impact assessment were *** relation to the applications,the Chinese materials database(SinoCenter Database) and several representative case studies such as life cycle analysis of civilian buildings and metal production in China were introduced.

关键词： materials life cycle assessment LCIA methodology

Rational design of bimetallic atoms supported on C3N monolayer to break the linear relations for efficient electrochemical nitrogen reduction

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Nano Research 2022年第9期15卷 8656-8664页

作者： Riming Hu Yanan Yu yongcheng Li Yiran Wang Jiaxiang Shang yong nie Xuchuan Jiang Institute for Smart Materials&Engineering University of JinanJinan 250022China Shandong college of Tourism and Hospitality Jinan 250200China Qinghai Provincial Key Laboratory of New Light Alloys Qinghai Provincial Engineering Research Center of High-Performance Light Metal Alloys and FormingQinghai UniversityXining 810016China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Linear relations between the adsorption free energies of nitrogen reduction reaction(NRR)intermediates limit the catalytic activity of single atom catalysts(SACs)to reach the optimal *** improvements in NRR activity require the balance of binding strength of reaction ***,we have investigated the C_(3)N-supported monometallic(M/C_(3)N)and bimetallic(M_(1)M_(2)/C_(3)N)atoms for the electrochemical NRR by using density functional theory(DFT)*** results show that this linear relation does exist for SACs because all the intermediates bind to the same site on M/C_(3)*** the synergistic effect of the two atoms in M_(1)M_(2)/C_(3)N can create a more flexible adsorption site for intermediates,which results in the decoupling of adsorption free energies of key ***,the fundamental limitation of scaling relations on limiting potentials is broken *** notably,the optimal limiting potential is increased from−0.63 V for M/C_(3)N to−0.20 V for M_(1)M_(2)/C_(3)*** addition,the presence of bimetallic atoms can also effectively inhibit the hydrogen evolution reaction(HER)as well as improve the stability of the *** study proposes that the introduction of bimetallic atoms into C_(3)N is beneficial to break the linear relations and develop efficient NRR electrocatalysts.

关键词： nitrogen reduction reaction linear relations bimetallic atoms C_(3)N density functional theory

Evaluation indices of sour flavor for apple fruit and grading standards

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Journal of Integrative Agriculture 2018年第5期17卷 994-1002页

作者： YAN Zhen ZHENG Li-jing nie Ji-yun LI zhi-xia CHENG Yang Laboratory of Quality & Safety Risk Assessment for Fruit (Xingcheng) Ministry of Agriculture/Institute of Pomology Chinese Academy of Agricultural Sciences Xingcheng 125100 P.R. China Beijing Agriculture Technology Extension Station Beijing 100029 P.R. China

In order to establish grading standards of evaluation indices for sour flavor of apples, 10 indices of samples from 106 apple cultivars were tested, including： malic acid（Mal）, oxalic acid（Oxa）, citric acid（Cit）, lactic acid（Lac）, succinic acid（Suc）, fumaric acid（Fum）, total organic acids（To A, the sum of the six organic acids tested）, titratable acid（TiA）, acidity value（AcV）, and pH value. For most of the cultivars studied（85.8%）, the order of the organic acid contents in apples was Mal〉Oxa〉Cit〉Lac〉Suc〉Fum. Mal was the dominant organic acid, on average, accounting for 94.5% of To A. Among the 10 indices, the dispersion of pH value was the smallest with a coefficient of variation of only 8.2%, while the coefficients of variation of the other nine indices were larger, ranging between 31 and 66%. There were significant linear relationships between Mal and two indices（ToA and AcV） as well as between ToA and AcV. There were significant logarithmic relationships between pH value and four indices： Mal, TiA, ToA, and AcV. All the equations had very high fitting accuracy and can be used to accurately predict related indices. According to this study, Mal, ToA, and AcV of apple were normally distributed, TiA was close to normally distributed, whereas pH value had a skewed distribution. Using the fitted normal distribution curves, the grading standards of Mal, TiA, ToA, and AcV were established. The grading node values of pH value were obtained using the logarithmic relationship between pH value and Mal. The grading standards of these five indices can be used to evaluate the sour flavor of apple. This study provides a scientific basis for evaluating apple flavor and selecting apple cultivars.

关键词： apple organic acid sour flavor evaluation indices grading standard