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Effectiveness and safety of splenectomy for gastric carcinoma:A meta-analysis

World Journal of Gastroenterology 2009年第42期15卷 5352-5359页

作者： Kun Yang xin-Zu chen Jian-Kun Hu Bo Zhang zhi-xin chen Jia-Ping chen Department of Gastrointestinal Surgery West China Hospital Sichuan University No. 37 Guo Xue Xiang Chengdu 610041 Sichuan Province China

AIM： To evaluate the impact of splenectomy on longterm survival, postoperative morbidity and mortality of patients with gastric cancer by performing a metaanalysis METHODS： A search of electronic databases to identify randomized controlled trials in The Cochrane Library trials register, Mediine, CBMdisc （Chinese Biomedical Database） and J-STAGE, etc was performed. Data was extracted from the studies by 2 independent reviewers. Outcome measures were survival, postoperative morbidity and mortality and operation-related events. The meta-analyses were performed by RevMan 4.3. RESULTS： Three studies comprising 466 patients were available for analysis, with 231 patients treated by gastrectomy plus splenectomy. Splenectomy could not increase the 5-year overall survival rate [RR = 1.17, 95% confidence interval （CI） 0.97-1.41]. The postoperative morbidity （RR = 1.76, 95% CI 0.82-3.80） or mortality （RR = 1.58, 95% CI 0.45-5.50） did not suggest any significant differences between the 2 groups. No significant differences were noted in terms of number of harvested lymph nodes, operation time, length of hospital stay and reoperation rate. Subgroup analyses showed splenectomy did not increase the survival rate for proximal and whole gastric cancer. No obvious differences were observed between the 2 groups when stratified by stage. Sensitivity analyses indicated no significant differences regarding the survival rates （P 〉 0.05）. CONCLUSION： Splenectomy did not show a beneficial effect on survival rates compared to splenic preservation. Routinely performing splenectomy should not be recommended.

关键词： Gastric cancer Splenectomy Survival rate Morbidity Operative surgical procedure Postoperative period Treatment outcome

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Possible mechanism for hepatitis B virus X gene to induce apoptosis of hepatocytes

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World Journal of Gastroenterology 2005年第28期11卷 4351-4356页

作者： Sheng-Jun Zhang Hong-Ying chen zhi-xin chen Xiao-Zhong Wang Department of Gastroenterology Union Hospital of Fujian Medical University Fuzhou 350001 Fujian Province China

AIM： To investigate the possible mechanism for HBV X gene to induce apoptosis of hepatocyte HL-7702 cells.METHODS： HBV X gene eukaryon expression vector pcDNA3-X was established and transfected into HL-7702 cells by lipid-mediated transfection, including transient and stable transfection. Positive clones were screened by incubating in the selective medium with 600 μg/mL G418 and named HL-7702/HBV-encoded X protein （HBx） cells. The expressions of Fas/FasL, Bax/Bcl-2, and c-myc mRNA were measured by semi-quantitative RT-PCR in HL-7702/HBx and control group, respectively.RESULTS： RT-PCR analysis confirmed that HBV X gene was transfected into HL-7702 cells successfully. By semiquantitative RT-PCR analysis, Bax and c-myc mRNA levels in HL-7702/HBx cells of transient transfection were significantly higher than those in control, FasL and c-myc mRNA levels in HL-7702/HBx cells of stable transfection were significantly higher than those in control, whereas the Bcl-2 mRNA levels in HL-7702/HBx cells of transient and stable transfection were significantly lower than thosein control.CONCLUSION： HBV X gene may promote the apoptosis of hepatocytes by regulating the expressions of Fas/FasL, Bax/Bcl-2, and c-myc gene in a dose-dependent manner.

关键词： Hepatitis B virus X gene Apoptosis Geneexpression

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Cost-effectiveness analysis of chemotherapy for advancedgastric cancer in China

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World Journal of Gastroenterology 2008年第17期14卷 2715-2722页

作者： xin-Zu chen Kun Jiang Jian-Kun Hu Bo Zhang Hong-Feng Gou Kun Yang zhi-xin chen Jia-Ping chen Department of Gastrointestinal Surgery and Multidisciplinary Treatment Team of Gastrointestinal TumorsWest China Hospital Sichuan University Chengdu 610041Sichuan Province China Department of Integrated Western and TraditionalChinese Medicine West China Hospital Sichuan UniversityChengdu 610041 Sichuan Province China Department of Oncology West China HospitalSichuan University Chengdu 610041 Sichuan Province China

AIM： To assess the economics of various chemotherapeutic regimens for advanced gastric cancer （AGC）, and to select the best cost-effective regimen for the common Chinese patients. METHODS： Data source used in this study was the Chinese Biomedical Disk Database. Patients were diagnosed as AGC and any regimen was eligible. Outcome measures included median survival time （MST） and percentage of complete and partial response （CR＋PR）. Economic statistics was per capita direct medical cost （DMC） of a single cycle. TreeAge Pro Healthcare 2007 software was used to carry out costeffectiveness and incremental cost-effectiveness analysis. Sensitivity analyses were applied by altering willingness- to-pay and annual discount rate, and also re-analyzed by excluding the studies with apparent heterogeneity. RESULTS： Seven retrospective economics studies on 760 patients were included. S-fluorouracil-based regimens were universal, and also some new agents were involved, such as docetaxel, paclitaxel, andoxaliplatin. By processing analysis, we could recommend etoposide, leucovorin and 5-fluorouracil （ELF） regimen as preference, with a DMC/MST ratio of 2543 RBM/11.7 mo and a DMC/CR＋PR ratio of 2543 RMB/53.3%. Uraciltegafur, etoposide and cisplatin （FEP） or 5-fluorouracil, adrimycin/epirubin and mitomycin （FAM） regimens could be regarded as optional first-line chemotherapy for AGC in common Chinese patients. With no regard for willingness-to-pay, the docetaxel, cisplatin and 5-fluorouracil （DCF） regimen could be chosen as either a first- or a second-line chemotherapy, with a DMC/CR＋PR ratio of 9979 RMB/56.3%. CONCLUSION： 5-fluorouracial regimens are still considered the mainstream for AGC, while new agents such as taxanes are optional. More randomized clinical trials are required before any mandatory recommendation of certain regimens for patients with AGC in China is made.

关键词： Advanced gastric cancer Chemotherapy 5-fluorouracil Taxanes Cost-effectiveness

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Fluorescence detection of hydroxyl radical generated from oxygen reduction on Fe/N/C catalyst

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Science China Chemistry 2020年第2期63卷 198-202页

作者： Li-Na chen Wen-Song Yu Tao Wang Xiao-Dong Yang Hui-Juan Yang zhi-xin chen Tan Wang Na Tian zhi-You Zhou Shi-Gang Sun State Key Laboratory of Physical Chemistry of Solid Surfaces Innovation Center of Chemistry for Energy MaterialsCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China College of Materials Science&Engineering Huaqiao UniversityXiamen 361021China Institute of Advanced Electrochemical Energy School of Materials Science and EngineeringXi'an University of TechnologyXi'an 710048China

Pyrolyzed Fe/N/C catalyst has been considered as the most promising candidate to replace Pt for oxygen reduction reaction(ORR) in fuel ***,poor stability of Fe/N/C catalyst,mainly attributed to the oxidation corrosion by aggressive ·OH radical,severely hampers its ***,the exact mechanism for generation of ·OH is unclear ***,we developed a fluorescent method to effectively detect ·OH generated from ORR on Fe/N/C catalyst by using coumarin as a fluorescent probe.A great difference in potential dependence between ·OH and H2O2 generated from the ORR was observed,which suggests that ·OH is not generated from the decomposition of H2O2 as traditional viewpoint.

关键词： oxygen reduction reaction Fe/N/C catalysts radical coumarin fluorescent probe

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Novel Ba_(0.5)Sr_(0.5)Fe_(0.8)Zn_(0.2)O_(3-δ) membranes for POM

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Chinese Chemical Letters 2009年第2期20卷 250-252,F0003页

作者： Hui Xia Luo Ling Hui Yu xin zhi chen Hai Hui Wang Jtirgen Caro The Key Lab of Enhanced Heat Transfer and Energy Conservation of Chinese Ministry of Education School of Chemistry & Chemical Engineering South China University of Technology Guangztwu 510640 China Institute of Physical Chemistry and Electrochemistry Leibniz University Hannover Callinstr. 3-34 D-30179 Hannover Germany

A novel cobalt-free perovskite based on Ba0.5Sr0.5Fe0.8Zn0.2O3-δ （BSFZ） were prepared by EDTA-citric acid method. The lattice constants of the BSFZ perovskite were characterized by in situ high-temperature X-ray diffraction （HTXRD）. The thermal expansion coefficient of BSFZ is 10.5×10^-6 K^-1, which is lower than that of cobalt-based perovskite materials. The BSFZ membrane was also used to construct reactors for the partial oxidation of methane （POM） to syngas. Results show that the BSFZ membrane can be operated for the POM reaction for more than 100 h without any fractures. The CO selectivity of 97% is obtained. The steady oxygen permeation flux reaches around 2.5 mL/min cm^2 during POM reaction.

关键词： Membrane Oxygen separation Mixed conductor Perovskite POM

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Effect of IL-10 on the expression of HSC growth factors in hepatic fibrosis rat

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World Journal of Gastroenterology 2005年第31期11卷 4788-4793页

作者： Mei-Na Shi Wei-Da Zheng Li-Juan Zhang zhi-xin chen Xiao-Zhong Wang Department of Gastroenterology Union Hospital of Fujian Medical University Fuzhou 350001 Fujian Province China

AIM： To study the effect of IL-10 on the expression of growth factors - transforming growth factor-β1 （TGF-β1）, epidermal growth factor （EGF）, hepatocyte growth factor （HGF）and platelet-derived growth factor （PDGF） of hepatic stellate cells （HSCs） of hepatic fibrosis rat and the anti-fibrogenic role of exogenous IL-10. METHODS： Hepatic fibrosis was induced by CCI4 administration intra-peritoneally. Sixty clean male Sprague-Dawley （SD） rats were randomly divided into three groups： normal control group （GN, 8 rats）, hepatic fibrosis model group （GC, 28 rats） and IL-10 treated group （GI, 24 rats）. At the beginning of the 7^th and 11^th wk, rats in each group were routinely perfused with pronase E and type IV collagenase through a portal vein catheter and the suspension obtained from the liver was spun by centrifugation with 11% Nycodenz density gradient to isolate HSCs. Histological examination was used to determine the degree of hepatic fibrosis. RT-PCR was employed to analyze mRNA expression from freshly isolated cells. Immunocytochemistry was performed to detect protein expression in primary cultured HSCs. RESULTS： Rat hepatic fibrosis was developed with the increase of injection frequency of CCl4, and HSCs were successfully isolated. At the 7^th and 11^th wk, TGF-β1, EGF, and HGF mRNA in GC increased obviously compared with GN （P = 0.001/0.042, 0.001/0.001, 0.001/0.001） and GI （P= 0.001/0.007, 0.002/0.001, 0.001/0.001）. For TGF-β1, no difference was observed between GI and GN. For EGF, mRNA level in GI increased compared with GN during the 7^th wk （P= 0.005） and 11^th wk （P= 0.049）. For HGF, mRNA level in GI decreased compared with GN at the 7^th wk （P = 0.001） and 11^th wk （P= 0.021）. Between these two time points, TGF-β1 expression at the 7^th wk was higher than that of the 11^th wk （P = 0.049）, but for EGF, the former was lower than the latter （P = 0.022）. As for PDGF mRNA, there was no significant difference between thesegroups, but difference seemed to exist i

关键词： Hepatic fibrosis Hepatic stellate cells Interleukin-10 Transforming growth factor-131 Epidermal growth factor Hepatocyte growth factor Platelet-derived growth factor

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Relationship between transforming growth factorβ1 and antifibrotic effect of interleukin-10

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World Journal of Gastroenterology 2006年第15期12卷 2357-2362页

作者： Mei-Na Shi Yue-Hong Huang Wei-Da Zheng Li-Juan Zhang zhi-xin chen Xiao-Zhong Wang Department of Gastroenterology Union Hospital of Fujian Medical UniversityFuzhou 350001 Fujian Province China

AIM： To study the effect of interleukin-10 （IL-10） on the expression of transforming growth factor β1 （TGF-β1） in hepatic fibrosis rats and the anti-fibrotic role of exogenous IL-10. METHODS： Hepatic fibrosis was induced by carbon tetrachloride administered （CCh） intraperitoneally. The experiment was performed in two stages. In the first stage, 60 SD rats were divided randomly into normal control group I（GNI, n = 8）, hepatic fibrosis group（GC, n = 28）and IL-10 intervened group（GI, n = 24）. At the beginning of the 7^th and 11^th wk, hepatic stellate cells （HSCs） were isolated, reverse transcription-polymerase chain reation （RT-PCR） and immunocytochemistry were performed to detect the expression of TGF-β1 in HSCs. Histological examination was used to determine the degree of hepatic fibrosis. In the second stage, 47 SD rats were divided randomly into normal control group 2 （GN2, n = 6）and CCh group（GZ, n = 41）. At the end of the 9th week, rats in GZ group were allocated randomly into model group（GM, n = 9）, IL-10 treatment group（GT, n = 9） and recovered group （GR, n = 9）. At the end of the 12^th week, all rats were sacrificed. RT-PCR and immuno- histochemistry were performed to detect the expression of TGF-β1 in liver tissue. ELISA was used to assay serum TGF-β1 levels. RESULTS： Hepatic fibrosis developed in rats with the increase of the injection frequency of CCI4. In the first stage, hepatic fibrosis developed and HSCs were isolated successfully. At the 7^th and 11^th week, TGF-β1 mRNA in GC group increased significantly compared with that in GN1（P = 0.001/0.042） and GI groups（P = 0.001/0.007）, whereas there was no significant difference between the two groups. The levels of TGF-β1 at the beginning of the 7^th wk was higher than that of the 11^th wk （P = 0.049）.Immunocytochemistry results of TGF-β1 were consistent with the above findings. In the second stage, TGF-β1 increased significantly in GM group compared to GN2. Alter treatment with IL-10, TGF-β1 declined obvio

关键词： Hepatic fibrosis Hepatic stellate cells Interleukin-10 Transforming growth factor-β1

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Expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor and its intervention by interleukin-10 in experimental hepatic fibrosis

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World Journal of Gastroenterology 2003年第6期9卷 1287-1291页

作者： Xiao-Zhong Wang zhi-xin chen Li-Juan Zhang Yun-xin chen Dan Li Feng-Lin chen Yue-Hong Huang Department of Gastroenterology,Affiliated Union Hospital,Fujian Medical University,Fuzhou,350001,Fujian Province,China Department of Gastroenterology Affiliated Union Hospital Fujian Medical University Fuzhou 350001 Fujian Province China. drwangxz@***

AIM: To study the expression of IGF-1 and IGF-1R and its intervention by interleuldn-10 in the course of experimental hepatic ***: Hepatic fibrosis was induced in rats by carbon tetrachloride intoxication and liver specimens were taken from the rats administered CCl4 with or without IL-10 treatment and the animals of the control *** for insulin-like growth factor-1 (IGF-1)and IGF-1 receptor(IGF-1R) were demonstrated by immunohistochemistry, and their intensities were evaluated in different animal ***: The positive levels for IGF-1 and IGF-1R were increased with the development of hepatic fibrosis, with the positive signals localized in cytoplasm and/or at the plasmic membrane of hepatocytes. The positive signals of IGF-1 and IGF-1R were observed more frequently (P<0.01) in the CCl4-treated group (92.0 % and 90.0 %) compared to those in the control group. The positive signals decreased significantly (P<0.05) in IL-10-treated group. The responses in IGF-1 and IGF-1R expression correlated with the time of IL-10 ***: The expression of IGF-1 and IGF-1R immunoreactivities in liver tissue seems to be up-regulated during development of hepatic fibrosis induced by CC14, and exogenic IL-10 inhibits the responses.

关键词：肝纤维化胰岛素样生长因子-1 受体白细胞介素-10

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Global, regional, and national burden of gallbladder and biliary diseases from 1990 to 2019

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2564-2578页

作者： Zhong-Zhuan Li Lin-Jing Guan Rong Ouyang zhi-xin chen Guo-Qing Ouyang Hai-xing Jiang Department of Gastroenterology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Gastroenterology Liuzhou Workers’Hospital(The Fourth Affiliated Hospital of Guangxi Medical University)Liuzhou 545007Guangxi Zhuang Autonomous RegionChina Department of Abdomen Ultrasound Nanning Sixth People’s HospitalNanning 530002Guangxi Zhuang Autonomous RegionChina Department of General Surgery Liuzhou People’s Hospital Affiliated to Guangxi Medical UniversityLiuzhou 545006Guangxi Zhuang Autonomous RegionChina

BACKGROUND Gallbladder and biliary diseases(GABDs)are a major public health *** To analysis the cause-specific incidence,prevalence,and years lived with disability(YLDs)and its temporal trends of GABDs at the global,regional,and national *** on GABD were available from the Global Burden of Disease study *** The estimated annual percentage change(EAPC)was used to quantify temporal trend in GABD age-standardized incidence rates(ASIRs),age-standardized prevalence rate(ASPR),and age-standardized YLD rate(ASYR)by region,*** analyzed the relationship between the GABD burden and country development level using the human development index(HDI).RESULTS In 2019,the incident cases of GABD were 52003772,with an ASIR of 63432/100000 ***,the number of incident cases and ASIR of GABD increased 97%and 58.9%between 1990 and ***,the ASPR and ASYR decreased from 1990 to 2019,the number of prevalent and YLDs cases *** highest ASIR was observed in Italy,and the highest ASPR and ASYR was observed in United *** highest burden of GABD was found in low-SDI region,and the burden in female was significantly higher than males.A generally negative correlation(ρ=-0.24,P<0.05)of GABD with the EAPC and human development index(HDI)(in 2021)were observed for ***’s more,no correlation in ASPR(ρ=-0.06,P=0.39)and ASYR(ρ=-0.07,P=0.36)of GABD with the EAPC and HDI(in 2021)were observed,*** GABD remain a major global public health challenge;however,the burden of GABD varies ***,the number of incident cases and ASIR of GABD increased between 1990 and *** results of our study provide insight into the global disease burden of GABD and may assist policymakers in formulating effective policies to mitigate modifiable risk factors.

关键词： Gallbladder and biliary diseases,incidence,prevalence,years lived with disability The Global Burden of Diseases study Estimated annual percentage changes

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环境友好非均相多金属氧酸盐-金催化剂Au/BW_(11)/Al_2O_3上环辛烯分子氧绿色环氧化研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第12期17卷 1000-1012页

作者： Umsa JAMEEL Ming-qiao ZHU xin-zhi chen Yi LIU Zhang-fa TONG Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological Engineering Zhejiang University Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology School of Chemistry and Chemical Engineering Guangxi University

目的:环氧化物是多种有机合成反应的重要中间体,也可作为环氧树脂、染料和表面活性剂的原料。传统的环氧化存在催化剂分离难、氧化剂成本高和过程含有溶剂等缺点。本文旨在探讨纳米金和多金属氧酸盐负载非均相催化剂用于无溶剂条件下环... 详细信息

目的:环氧化物是多种有机合成反应的重要中间体,也可作为环氧树脂、染料和表面活性剂的原料。传统的环氧化存在催化剂分离难、氧化剂成本高和过程含有溶剂等缺点。本文旨在探讨纳米金和多金属氧酸盐负载非均相催化剂用于无溶剂条件下环辛烯环氧化的反应条件对催化性能的影响。创新点:1.把纳米金颗粒和多金属氧酸盐(即BW11)结合并负载在固体载体上制备出了一种新型复合催化剂材料;2.采用分子氧作为氧化剂而不是传统的有机酸或者过氧酸;3.在温和条件下可获得良好的转化率和较高的环氧化物选择性;4.催化反应体系未使用有机溶剂;5.催化剂稳定并可循环使用。方法:1.根据文献中所述方法制备BW11;2.采用标准沉积沉淀法合成Au/Al2O3;3.采用湿式浸渍法制备催化剂Au/BW11/Al2O3;4.环辛烯环氧化使用叔丁基过氧化氢(TBHP)作为引发剂,氧气作为氧化剂,在高压反应釜中进行反应;5.采用扫描电镜和X射线衍射等对催化剂进行表征。结论:1.提高焙烧温度可改善催化反应性能;2.随着催化剂量增加到0.2 g,转化率也随之增加(图8);3.反应的最佳温度为80°C(表1);4.随着反应时间的增加直到24 h,转化率逐渐增加,环氧化物选择性也增加到约87%(图9);5.催化剂可适用于多种氧化剂(表2);6.无溶剂下转化率和选择性相对较大(表3);7.催化剂可以有效活化分子氧和环辛烯;8.催化剂可以再生,在使用三次后,其活性损失不大。

关键词：纳米金多金属氧酸盐环辛烯环氧化分子氧

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