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Eosinophil extracellular traps in respiratory ailment:Pathogenic mechanisms and clinical translation

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第3期10卷 213-224页

作者： Shun-Yu Wu Bo-Yu Cai Tian-Yu Wang zhi-wen cao Hu Peng Huan-Hai Liu Department of Otolaryngology The Second Affiliated Hospital of the Naval Military Medical University(Shanghai Changzheng Hospital)ShanghaiChina

Background:Eosinophilic extracellular traps(EETs)are reticular complexes comprising deoxyribonucleic-Acid(DNA)fibers and granule ***:EETs play a crucial role in antimicrobial host responses and are pathogenic when overproduced or under *** created by eosinophils appear to enable vital immune responses against extra-cellular pathogens,nevertheless,trap overproduction is evident in ***&Methods:As considerably research is performed,new data affirmed that EETs can alter the outcome of respiratory ***:We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic,unresolved ***:Whether EETs can be used as a prospective brand-new target for the diagnosis,treatment and prognosis of respiratory ailments is a scientific theme worth ***:We probe into the disclosure and specificity of EETs produced in reaction to various stimuli and propose a role for those frameworks in ailment pathogenesis and the establishment of chronic,unresolved inflammation.

关键词： cytolysis degranulation eosinophil extracellular traps eosinophils respiratory ailments

微波辅助制备不规则Co3O4花球及其电化学性能

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精细化工 2018年第4期35卷 658-661页

作者：王珏文志刚曹茂启黔南民族师范学院化学化工学院

以六水合硝酸钴、苯甲酰丙酮为原料,利用微波法合成了Co3O4花球前驱体,并在500℃空气条件下锻烧得到不规则Co3O4花球。通过XRD、SEM、TEM对不规则Co3O4花球的微观结构和表面形貌进行了表征。电化学测试结果表明,不规则Co3O4花球负极材料... 详细信息

以六水合硝酸钴、苯甲酰丙酮为原料,利用微波法合成了Co3O4花球前驱体,并在500℃空气条件下锻烧得到不规则Co3O4花球。通过XRD、SEM、TEM对不规则Co3O4花球的微观结构和表面形貌进行了表征。电化学测试结果表明,不规则Co3O4花球负极材料在0.1 A/g的电流密度下,首次充电比容量达到816 m A·h/g,循环100圈后,比容量保持率为89.2%;倍率性能测试结果表明,电流密度从0.1 A/g增加到1 A/g时,比容量有一定的衰减,但电流密度恢复到0.1 A/g时,比容量几乎恢复到原来的水平;阻抗测试结果表明,不规则Co3O4花球负极材料循环前内阻为335Ω,50圈循环后内阻减小到240Ω。制备的不规则Co3O4花球具有较高的充电比容量、良好的循环性能和倍率性能。

关键词：不规则Co3O4花球负极材料金属有机骨架微波有机电化学与工业

我国图书馆新媒体服务研究展望——基于高被引论文的分析

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图书馆论坛 2017年第9期37卷 62-69,78页

作者：王知津曹文振南开大学商学院信息资源管理系福建船政交通职业学院图书馆

图书馆新媒体服务作为新兴研究领域,对其发展趋势进行梳理和展望有着重要的意义,但因文章质量参差不齐、研究深度不一,目前存在困难。高被引文献既能反映出文章质量,也能体现出对后续研究的指导和借鉴作用。文章引入高被引文献分析方法... 详细信息

图书馆新媒体服务作为新兴研究领域,对其发展趋势进行梳理和展望有着重要的意义,但因文章质量参差不齐、研究深度不一,目前存在困难。高被引文献既能反映出文章质量,也能体现出对后续研究的指导和借鉴作用。文章引入高被引文献分析方法,对图书馆新媒体服务研究的代表性文献进行筛选和探讨。文献计量和相关分析的结果表明:56篇具有代表性的图书馆新媒体服务研究文献在2013年以后集中出现,以微信为主要平台进行研究,有明显的核心期刊集聚效应和高下载次数特点,部分关键词呈现出共词特征,但是否由高影响力作者和机构发表、是否有基金项目支持与研究的影响力关系不大。图书馆新媒体服务研究趋势包括:有望持续成为研究热点,由高校图书馆为引领机构,创造更加均等的研究机会;以微信应用为主要研究平台,随着新技术的应用不断深化;高水平成果继续向核心期刊集聚。

关键词：图书馆新媒体服务研究展望高被引论文微信公众平台

The Protection of Buthus martensi Karsch Venom Against Influenza Infection In MDCK Cells

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The Protection of Buthus martensi Karsch Venom Against Influ...

Experimental Observing Damage Evolution in Cement Pastes Exposed to External Sulfate Attack by in situ X-ray Computed Tomography

第二届中国青年学者微生物遗传学学术研讨会

作者： wen-Ian Wu, Ju Liang, Xiu-lin Xu, Yong-gang Sha, zhi-jian cao, wen-xin Li College of Life Sciences, Wuhan University, Wuhan 430072, China College of Chemistry, Wuhan University, Wuhan 430072, China

Influenza virus infection induces an increase in free radical production in host cells. Experiments were performed to determine whether the Buthus martensi Karsch (BmK) scorpion venom inhibited influenza viral infection in cultures of Madin-Darby canine kidney (MDCK) cells. At the early hours of infection, we detected various intracellular biochemical parameters in influenza virus infected MDCK cells, focused on the level of radical oxygen specials (ROS), superoxide dismutase (SOD) and glutathione (GSH). It was found that the venom could remarkably decrease the viral hemagglutinin titer. Further results showed that the introduction of venom restrained the excessive generation of intracellular ROS aroused by influenza virus. Measurement of total GSH content suggested that venom could help cells maintain a more reduced state and elevate the tolerance of cells against oxidative stress. Consistent with the GSH levels, the venom appeared to increase the total SOD activity. Together, the data suggest that the venom may enhance antiviral response and protect against oxidative stress induced by influenza infection.

关键词： venom influenza ROS GSH SOD.

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 164-170页

作者： WU Min cao Kailei XIAO Weirong YU Zetai cao Jierong DING Qingjun LI Jinhui China Railway Construction Corporation Harbour and Channel Engineering Bureau Group Co. LTDZhuhai 519000China Con-struction Headquarters of Zhoushan Liuheng Bridge Phase II Project Zhoushan 316000China China Railway Construction Bridge En-gineering Bureau Group Co. LTDTianjin 300000China State Key Laboratory of Silicate Material for Architecture(Wuhan University of Technology) Wuhan 430070China College of Materials Science and Engineering Wuhan Textile UniversityWuhan 430200China

The paper presents experimental investigation results of crack pattern change in cement pastes caused by external sulfate attack(ESA).To visualize the formation and development of cracks in cement pastes under ESA,an X-ray computed tomography(X-ray CT)was used,i e,the tomography system of Zeiss Xradia 510 *** results indicate that X-CT can monitor the development process and distribution characteristics of the internal cracks of cement pastes under ESA with attack *** addition,the C3A content in the cement significantly affects the damage mode of cement paste specimens during sulfate *** damage of ordinary Portland cement(OPC)pastes subjected to sulfate attack with high C3A content are severe,while the damage of sulfate resistant Portland cement(SRPC)pastes is much smaller than that of OPC ***,a quadratic function describes the correlation between the crack volume fraction and development depth for two cement pastes immermed in sulfate solution.

关键词： concrete external sulfate attack damage evolution situ X-ray computed tomography

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming cao Yao-wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

土-结构相互作用体系合成模态阻尼比的振动台模型试验研究

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力学季刊 2003年第1期24卷 75-80页

作者：吕西林张之颖曹文清同济大学土木工程防灾国家重点实验室上海200092

本文籍振动台模型试验,研究了SSI体系的合成模态阻尼比问题。文中首先阐明了在SSI体系直接动力分析中应采用合成模态阻尼比的观点,研究了合成模态阻尼比的实测确定方法。并在不同工况下,通过对模型不同部位测点的传递函数、基本频率、... 详细信息

本文籍振动台模型试验,研究了SSI体系的合成模态阻尼比问题。文中首先阐明了在SSI体系直接动力分析中应采用合成模态阻尼比的观点,研究了合成模态阻尼比的实测确定方法。并在不同工况下,通过对模型不同部位测点的传递函数、基本频率、基本合成模态阻尼比等实测数据考察,验证了SSI体系合成模态的存在性、合成模态阻尼比与相同应变下不考虑相互作用的单纯地基土体或刚性地基结构阻尼比的差异性及其在递增动力作用下的变化规律。

关键词： SSI体系振动台试验传递函数合成模态阻尼比

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury