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等渗和低渗造影剂在冠状动脉介入诊疗中对肾功能影响的对比观察

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中国循环杂志 2011年第1期26卷 12-14页

作者：吴志勇漆红梅葛郁芝盛国太余茂生江西省人民医院心内一科江西省南昌市330006 南昌大学第一附属医院心内科

目的：对比观察等渗和低渗造影剂在冠状动脉介入诊疗中对肾功能影响。方法：根据患者心功能（NYHA分级）、糖尿病、年龄3项因素按“不平衡指数最小的原则”对2006-05至2009-05行冠状动脉介入诊疗的366例患者进行随机分组，将患者分为等... 详细信息

目的：对比观察等渗和低渗造影剂在冠状动脉介入诊疗中对肾功能影响。方法：根据患者心功能（NYHA分级）、糖尿病、年龄3项因素按“不平衡指数最小的原则”对2006-05至2009-05行冠状动脉介入诊疗的366例患者进行随机分组，将患者分为等渗造影剂组（n=161）与低渗造影剂组（n=205）。人选患者术前给予充分的生理盐水水化治疗，所有患者介入治疗前1天及治疗后第1～5天、术后14天分别检查肾功能指标，并同时观测尿量。了解肾功能变化及造影剂相关性肾损害（CIN）的发生情况。结果：在充分水化治疗的基础上，等渗造影剂组与低渗造影剂组患者在术后24—72h与术前相比均有不同程度的肌酐水平的升高，且这影响在术前肾功能不全患者中更为持久（达4～5天），但差异均没有达到统计学意义（P〉0．05）。同时，等渗造影剂组与低渗造影剂组之间在相应的时间段对肾功能影响和CIN发生率差异也均无统计学意义（P〉0．05）。结论：在充分水化治疗的基础上，等渗造影剂和低渗造影剂对。肾功能影响和造影剂肾病的发生无明显区别。水化治疗仍是降低CIN发生的经济、有效、副作用少的措施。

关键词：造影剂相关性肾损害水化治疗冠状动脉介入治疗

Fate of Nitrogen from Organic and Inorganic Sources in Rice-Wheat Rotation Cropping System

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Agricultural Sciences in China 2010年第7期9卷 1017-1025页

作者： CHEN Yi,wu Chun-yan,TANG Xu,YANG sheng-mao and WANG Jia-yu Institute of Environmental Resources and Soil Fertilizer,Zhejiang Academy of Agricultural Sciences,Hangzhou 310021,P.R.China [a] Institute of Environmental Resources and Soil Fertilizer Zhejiang Academy of Agricultural Sciences Hangzhou 310021 P.R. China

The lower availability of N is one of the most important limiting factors impeding crop yield enhancement among the various factors that affect crop yield under the multiple-cropping agroecosystem in *** this study,the recovery of a single application of 15N-labeled fertilizer or residues in rice-wheat cropping system was determined,in order to provide theoretical foundation for the nitrogen management in sustainable agricultural production.A continuous trace experiment was conducted for 15N microplots by using randomized block design with four treatments and four replications（T1 = 15N-labeled fertilizer with crop residue incorporation,T2 = 15N-labeled residues,T3 = 14N fertilizer to generate unlabeled crop residue,and T4 = 15Nlabeled fertilizer without crop residue incorporation）.Our results showed that,on average,17.17 and 12.01% of crop N was derived from N fertilizer and 15N-labeled residues,respectively during the first growing season,suggesting that approximately 82.83 or 87.99% of crop N was derived directly from soil N *** was a larger difference in the 15N recovery pattern in crop when N was applied as fertilizer or residues,i.e.,most of crop N derived from N fertilizer was absorbed in the first growing season（92.04%）,and the relevant value was 38.03% when 15N-labeled residues were *** implied that most of N fertilizer was recovered in the present cropping season,while a longer residue effect will be found for 15N-labeled ***,the average recovery of N fertilizer and N residue in the soil after the first growing season was 33.46 and 85.64%,*** recovery of applied N in soil when N was applied as residues was significantly higher than that when N was applied as *** was a larger difference in the total 15N recovery in plant and soil when N was applied as fertilizer or *** the end of the fifth or sixth cropping season,the total 15N recovery in plant and soil when N was applied as fertilizer or resi

关键词： crop residue fertilizer fate 15N isotope nitrogen fertilizer rice field

The Prokaryotic Expression and Bioactivity of the Recombinant Red Fire Ant Venom Allergen Sol i 4

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Agricultural Sciences in China 2009年第2期8卷 182-187页

作者： HAN Xue-qing LIN Xiang-mei CHEN Hong-jun ZHANG Yong-guo YE Gui-sheng wu Shao-qiang LI Jian CHEN Nai-zhong CHEN Yan ZHU Shui-fang Chinese Academy of Inspection and Quarantine Beijing 100029 P.R.China

The sting of red imported fire ant （RIFA） could cause serious allergic response in fraction of people. These allergic reactions are mainly caused by its venom, especially venom allergen Sol i 1-4. To produce large amount of RIFA venom allergen Sol i 4 for diagnosis of RIFA allergy and allergen-specific immunotherapy, the gene encoding this protein was amplified and cloned into the prokaryotic expression vector pET43, la. The recombinant plasmid was used to transform competent cells and the recombinant proteins were expressed in E. coll. SDS-PAGE and Western blotting analysis indicated that high-level expression of Sol i 4 protein was successfully achieved. Allergenic activity analysis of the recombinant allergen Sol i 4 was then performed on rabbit. The result showed that the recombinant protein obtained had significant allergenic activity. It indicated that the recombinant allergen Sol i 4 of RIFA venom was successfully expressed in E. coli, which provided foundation for further developing therapeutic and diagnosis reagents of RIFA allergy.

关键词： red imported fire ant recombinant allergen Sol i 4 expression activity

Single-qubit quantum classifier based on gradient-free optimization algorithm

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Chinese Physics B 2023年第10期32卷 241-247页

作者：张安琪王可伦吴逸华赵生妹 Institute of Signal Processing and Transmission Nanjing University of Posts and TelecommunicationsNanjing 210003China Key Laboratory of Broadband Wireless Communication and Sensor Network Technology Ministry of EducationNanjing 210003China

A single-qubit quantum classifier(SQC)based on a gradient-free optimization(GFO)algorithm,named the GFO-based SQC,is proposed to overcome the effects of barren plateaus caused by quantum ***,a rotation gate R_(X)(φ)is applied on the single-qubit binary quantum classifier,and the training data and parameters are loaded intoφin the form of vector *** cost function is decreased by finding the value of each parameter that yields the minimum expectation value of measuring the quantum *** algorithm is performed iteratively for all parameters one by one until the cost function satisfies the stop *** proposed GFO-based SQC is demonstrated for classification tasks in Iris and MNIST datasets and compared with the Adam-based SQC and the quantum support vector machine(QSVM).Furthermore,the performance of the GFO-based SQC is discussed when the rotation gate in the quantum device is under different types of *** simulation results show that the GFO-based SQC can reach a high accuracy in reduced ***,the proposed GFO algorithm can quickly complete the training process of the ***,the GFO-based SQC has a good performance in noisy environments.

关键词： single-qubit quantum classifier gradient-free parameters optimizing barren plateau quantum noise

An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction

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Science China(Life Sciences) 2020年第3期63卷 388-400页

作者： Mengxi Guo Chengliang Zhou Gufeng Xu Lin Tang Yechun Ruan Ying Yu Xianhua Lin Dandan wu Hao Chen Priscilla Yu Luyang Jin Yinyu Wang Yimei wu Kamran Ullah Tanzil Ur Rahman Xinmei Liu Jianzhong sheng Hsiao-Chang Chan Hefeng Huang Women’s Hospital Zhejiang University School of MedicineHangzhou 310058China International Peace Maternal and Child Health Hospital Shanghai Jiao Tong University School of MedicineShanghai 200030China Epithelial Cell Biology Research Center Faculty of MedicineSchool of Biomedical SciencesThe Chinese University of Hong KongHong KongChina Key Laboratory of Reproductive Genetics Ministry of Education(Zhejiang University)Hangzhou 310058China Department of Pathology and Pathophysiology Zhejiang University School of MedicineHangzhou 310058China Shanghai Key Laboratory of Embryo Original Disease Shanghai 20030China

The pathophysiology of preeclampsia(PE)remains *** spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide *** collected placental and umbilical artery samples from normotensive and PE *** receptor(MR)and its alternative splicing variant(ASV)expression and their biological effects on PE were *** MR ASV was found to be highly expressed in all PE samples and slightly expressed in about half of the normotensive samples(umbilical artery,~57.58%;placenta,~36.84%).The MR ASV expression was positively associated with blood pressure in both *** MR ASV protein changed the aldosterone-induced expression pattern of MR target genes related to ion exchanges and cell signaling *** MR ASV can also impair the proliferation,migration,and tube formation ability of endothelial *** findings indicate that MR ASV in PE placenta plays a pathogenic role in PE pathophysiology,especially in endothelial dysfunction,and the existence of the MR ASV in PE umbilical artery provides a new direction in the study of PE offspring with increased risk of cardiovascular diseases.

关键词： preeclampsia mineralocorticoid receptor alternative splicing variant offspring endothelial dysfunction

Genome-wide 5-Hydroxymethylcytosine Profiling Analysis Identifies MAP7D1 as A Novel Regulator of Lymph Node Metastasis in Breast Cancer

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Genomics, Proteomics & Bioinformatics 2021年第1期19卷 64-79页

作者： Shuang-Ling wu Xiaoyi Zhang Mengqi Chang Changcai Huang Jun Qian Qing Li Fang Yuan Lihong Sun Xinmiao Yu Xinmiao Cui Jiayi Jiang Mengyao Cui Ye Liu Huan-Wen wu zhi-Yong Liang Xiaoyue Wang Yamei Niu Wei-Min Tong Feng Jin Department of Surgical Oncology and Breast Surgery the First Affiliated Hospital of China Medical UniversityShenyang 110000China Department of Pathology Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeMolecular Pathology Research CenterChinese Academy of Medical SciencesBeijing 100005China State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Center for BioinformaticsInstitute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Beijing National Laboratory for Molecular Sciences(BNLMS) MOE Key Laboratory of Bioorganic Chemistry and Molecular EngineeringCollege of ChemistryPeking UniversityBeijing 100871China Center for Experimental Animal Research Institute of Basic Medical Sciences Chinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeMolecular Pathology Research CenterChinese Academy of Medical SciencesBeijing 100005China

Although DNA 5-hydroxymethylcytosine(5 hmC)is recognized as an important epigenetic mark in cancer,its precise role in lymph node metastasis remains *** this study,we investigated how 5 hmC associates with lymph node metastasis in breast *** with high expression of TET1 and TET2 proteins,large numbers of genes in the metastasis-positive primary tumors exhibit higher 5 hmC levels than those in the metastasis-negative primary *** contrast,the TET protein expression and DNA 5 hmC decrease significantly within the metastatic lesions in the lymph nodes compared to those in their matched primary *** genomewide analysis of 8 sets of primary tumors,we identified 100 high-confidence metastasis-associated5 hmC signatures,and it is found that increased levels of DNA 5 hmC and gene expression of MAP7 D1 associate with high risk of lymph node ***,we demonstrate that MAP7 D1,regulated by TET1,promotes tumor growth and *** conclusion,the dynamic5 hmC profiles during lymph node metastasis suggest a link between DNA 5 hmC and lymph node ***,the role of MAP7 D1 in breast cancer progression suggests that the metastasis-associated 5 hmC signatures are potential biomarkers to predict the risk for lymph node metastasis,which may serve as diagnostic and therapeutic targets for metastatic breast cancer.

关键词： 5-Hydroxymethylcytosine Breast cancer Lymph node metastasis MAP7D1 Biomarker

Annual Frequency of Tropical Cyclones Directly Affecting Guangdong Province:Prediction Based on LSTM-FC

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Journal of Tropical Meteorology 2022年第1期28卷 45-56页

作者： HU Ya-min CHEN Yun-zhu HE Jian LIU sheng-jun YAN Wen-jie ZHAO Liang WANG Ming-sheng LI zhi-hui WANG Juan-huai DONG Shao-rou LIU Xin-ru Guangdong Climate Center Guangzhou 510641 China School of Mathematics and Statistics Central South UniversityChangsha 410083 China State Key Laboratory of Numerical Modeling for Atmosphere Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029 China

Tropical cyclone(TC)annual frequency forecasting is significant for disaster prevention and mitigation in Guangdong *** on the NCEP-NCAR reanalysis and NOAA Extended Reconstructed global sea surface temperature(SST)V5 data in winter,the TC frequency climatic features and prediction models have been *** 1951-2019,353 TCs directly affected Guangdong with an annual average of about *** have experienced an abrupt change from abundance to deficiency in the mid to late 1980 with a slightly decreasing trend and a normal distribution.338 primary precursors are obtained from statistically significant correlation regions of SST,sea level pressure,1000hPa air temperature,850hPa specific humidity,500hPa geopotential height and zonal wind shear in *** those 338 primary factors are reduced into 19 independent predictors by principal component analysis(PCA).Furthermore,the Multiple Linear Regression(MLR),the Gaussian Process Regression(GPR)and the Long Short-term Memory Networks and Fully Connected Layers(LSTM-FC)models are constructed relying on the above 19 *** three different kinds of test sets from 2010 to 2019,2011 to 2019 and 2010 to 2019,the root mean square errors(RMSEs)of MLR,GPR and LSTM-FC between prediction and observations fluctuate within the range of 1.05-2.45,1.00-1.93 and 0.71-0.95 as well as the average absolute errors(AAEs)0.88-1.0,0.75-1.36 and 0.50-0.70,*** for the 2010-2019 experiment,the mean deviations of the three model outputs from the observation are 0.89,0.78 and 0.56,together with the average evaluation scores 82.22,84.44 and 88.89,*** prediction skill comparisons unveil that LSTM-FC model has a better performance than MLR and *** conclusion,the deep learning model of LSTM-FC may shed light on improving the accuracy of short-term climate prediction about TC *** current research can provide experience on the development of deep learning in this field and help to achieve furthe

关键词： tropical cyclone frequency long short-term memory network fully connected layers Gaussian process regression multiple linear regression

A new method for quantifying mitochondrial axonal transport

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Protein & Cell 2016年第11期7卷 804-819页

作者： Mengmeng Chen Yang Li Mengxue Yang Xiaoping Chen Yemeng Chen Fan Yang sheng Lu shengyu Yao Timothy Zhou Jianghong Liu Li Zhu Sidan Du Jane Y. wu University of Chinese Academy of Sciences Beijing 100049 China School of Electronic Science & Engineering Nanjing University Nanjing 210093 China State Key Laboratory for Brain & Cognitive Science Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Department of Neurology Center for Genetic Medicine Lurie Cancer Center Northwestern University Feinberg School of Medicine Chicago IL 60611 USA

Axonal transport of mitochondria is critical for neuronal survival and function. Automatically quantifying and analyzing mitochondrial movement in a large quantity remain challenging. Here, we report an efficient method for imaging and quantifying axonal mitochondrial trans- port using microfluidic-chamber-cultured neurons together with a newly developed analysis package named ＂MitoQuant＂. This tool-kit consists of an automated program for tracking mitochondrial movement inside live neuronal axons and a transient-velocity analysis program for analyzing dynamic movement patterns of mitochondria. Using this method, we examined axonal mitochondrial movement both in cultured mammalian neurons and in motor neuron axons of Drosophila in vivo. In 3 different paradigms （temperature changes, drug treatment and genetic manipulation） that affect mitochondria, we have shown that this new method is highly efficient and sensitive for detecting changes in mitochondrial movement. The method significantly enhanced our ability to quantitatively analyze axonal mitochondrial movement and allowed us to detect dynamic changes in axonal mltochondrial transport that were not detected by traditional kymographic analyses.

关键词： mitochondrial transport image processing and analysis FUS proteinopathy and mitochondrial transport defect

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珠江三角洲大暴雨的多普勒特征及形成机制

自然灾害学报 2009年第5期18卷 119-126页

作者：伍志方曾沁胡胜叶爱芬广州中心气象台广东广州510080

利用广州C INRAD-SA新一代多普勒天气雷达资料,结合天气形势分析,研究了华南地区夏季短时大暴雨的发生、发展过程,特别是中小尺度系统引发短时大暴雨不同发展阶段的多普勒特征以及辐合强度与短时大暴雨的关系,并对短时大暴雨的发展机制... 详细信息

利用广州C INRAD-SA新一代多普勒天气雷达资料,结合天气形势分析,研究了华南地区夏季短时大暴雨的发生、发展过程,特别是中小尺度系统引发短时大暴雨不同发展阶段的多普勒特征以及辐合强度与短时大暴雨的关系,并对短时大暴雨的发展机制进行了初步探讨。通过分析发现,短时大暴雨产生于低空强盛西南气流等有利条件下,近地层雨区附近的气旋式扰动有利于激发对流,抽吸作用、局地锋生对对流的维持和加强起到了十分重要的作用。在短时大暴雨发生初期及发展旺盛期,大多数都伴有逆风区、辐合带等多普勒特征,中气旋更是与高强度降水、地面强风等剧烈天气密切相关。

关键词：多普勒天气雷达短时大暴雨中气旋相对散度