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Multi-scale data joint inversion of minerals and porosity in altered igneous reservoirs—A case study in the South China Sea

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Petroleum Science 2024年第1期21卷 206-220页

作者： Xin-Ru wang Bao-zhi Pan Yu-Hang Guo Qing-Hui wang Yao Guan College of Geo-exploration Science and Technology Jilin UniversityChangchun130046JilinChina Research Institute CNOOC Ltd.-ShenzhenShenzhen518000GuangdongChina

There are abundant igneous gas reservoirs in the South China Sea with significant value of research,and lithology classification,mineral analysis and porosity inversion are important links in reservoir ***,affected by the diverse lithology,complicated mineral and widespread alteration,conventional logging lithology classification and mineral inversion become considerably *** the same time,owing to the limitation of the wireline log response equation,the quantity and accuracy of minerals can hardly meet the exploration requirements of igneous *** overcome those issues,this study takes the South China Sea as an example,and combines multi-scale data such as micro rock slices,petrophysical experiments,wireline log and element cutting log to establish a set of joint inversion methods for minerals and porosity of altered igneous ***,we define the lithology and mineral characteristics through core slices and mineral data,and establish an igneous multi-mineral volumetric *** we determine element cutting log correction method based on core element data,and combine wireline log and corrected element cutting log to perform the lithology classification and joint inversion of minerals and ***,it is always difficult to determine the elemental eigenvalues of different minerals in *** paper uses multiple linear regression methods to solve this ***,an integrated inversion technique for altered igneous formations was *** results show that the corrected element cutting log are in good agreement with the core element data,and the mineral and porosity results obtained from the joint inversion based on the wireline log and corrected element cutting log are also in good agreement with the core data from X-ray *** results demonstrate that the inversion technique is applicable and this study provides a new direction for the mineral inversion research of altered igneous formation

关键词： Joint inversion Altered igneous rock Element correction method Lithology identification Multi mineral volume model

Design of weak current measurement system and research on temperature impact

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Nuclear Science and Techniques 2024年第4期35卷 46-56页

作者： Chu-Xiang Zhao San-Gang Li Rong-Rong Su Li Yang Ming-Zhe Liu Qing-Yue Xue shan Liao zhi Zhou Qing-shan Tan Xian-Guo Tuo Yi Cheng College of Nuclear Technology and Automation Engineering Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China University of Science and Technology of China Hefei 230026China School of Physics and Electronic Engineering Sichuan University of Science and EngineeringZigong 643000China

A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization *** system incorporates a second-order low-pass filter circuit and the Kalman filtering algorithm to effectively filter out noise and minimize interference in the measurement *** conducted under normal temperature conditions has demonstrated the system's high precision ***,it was observed that temperature variations can affect the measurement *** were collected across temperatures ranging from -20 to 70℃,and a temperature correction model was established through linear regression fitting to address this *** feasibility of the temperature correction model was confirmed at temperatures of -5 and 40℃,where relative errors remained below 0.1% after applying the temperature *** research indicates that the designed measurement system exhibits excellent temperature adaptability and high precision,making it particularly suitable for measuring weak currents.

关键词： Weak current measurement system Neutron ionization chamber Kalman filter algorithm Temperature correction model

A thermo-mechanical damage constitutive model for deep rock considering brittleness-ductility transition characteristics

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Journal of Central South University 2024年第7期31卷 2379-2392页

作者： FENG Chen-chen wang zhi-liang wang Jian-guo LU zhi-tang LI Song-yu School of Civil and Hydraulic Engineering Hefei University of TechnologyHefei 230009China School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China

This paper developed a statistical damage constitutive model for deep rock by considering the effects of external load and thermal treatment temperature based on the distortion *** model parameters were determined through the extremum features of stress−strain ***,the model predictions were compared with experimental results of marble *** is found that when the treatment temperature rises,the coupling damage evolution curve shows an S-shape and the slope of ascending branch gradually decreases during the coupling damage evolution *** a constant temperature,confining pressure can suppress the expansion of *** the confining pressure increases the rock exhibits ductility characteristics,and the shape of coupling damage curve changes from an S-shape into a quasi-parabolic *** model can well characterize the influence of high temperature on the mechanical properties of deep rock and its brittleness-ductility transition characteristics under confining ***,it is suitable for sandstone and granite,especially in predicting the pre-peak stage and peak stress of stress−strain curve under the coupling action of confining pressure and high *** relevant results can provide a reference for further research on the constitutive relationship of rock-like materials and their engineering applications.

关键词： deep rock crack initiation threshold thermo-mechanical coupling statistical damage model distortion energy theory

Carrying Capacity and Coupling Coordination of Water and Land Resources Systems in Arid and Semi-arid Areas: A Case Study of Yulin City, China

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Chinese Geographical Science 2024年第5期34卷 931-950页

作者： ZHANG Qianxi CAO zhi wang Yongsheng HUANG Yijia Institute of Geographic Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

Quantitatively assessing the carrying capacity of water and land resources systems in arid and semi-arid areas is crucial for achieving the 2030 Sustainable Development *** this work,taking Yulin City in China as a case study and employing the Criteria Importance Through Intercriteria Correlation(CRITIC)method,a modified model of coupling degree was developed to evaluate the car-rying capacity of water and land resources systems endowment and utilization,as well as their coupling coordination degree from 2013 to *** findings indicate that the water and land resources of Yulin are diminishing due to declines in agriculture,higher industrial water use,and wetland ***,reallocating domestic water for ecological sustainability and reducing sloping farmland can mitigate this trend of ***,as the coupling coordination between water and land resources system endowment in Yulin continuously improved,the coupling coordination between water and land resources system utilization first decreased and then in-creased with 2016 as the turning ***,the carrying capacity of water and land resources systems,the coupling coordination degree between water and land resources system endowment,and the coupling coordination degree between water and land resources system utilization in Yulin exhibited the same pattern of being higher in the six northern counties than in the six southern ***-proving the water resources endowment is vital for the highly efficient use of water and land resources.

关键词： water and land resources systems carrying capacity coupling coordination human-earth system sustainable development Yulin City,China

Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： Ying-Ying Tan Ying-Ying Liu Yi-Yan Zhai Yi-Xuan wang zhi-shan Wu Antony Stalin Guo-Liang Cheng Bing Li Chao Wu zhi-Hong Huang shan Lu Xiao-Tian Fan Zheng Zhao Jia-Rui Wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology

Oncogenic MORC2 in cancer development and beyond

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Genes & Diseases 2024年第2期11卷 861-873页

作者： shan Zhang Ayao Guo Huan wang Jia Liu Chenshuang Dong Junyi Ren Guiling wang Key Laboratory of Cell Biology Department of Cell BiologyMinistry of Public Health and Key Laboratory of Medical Cell BiologyMinistry of EducationChina Medical UniversityShenyangLiaoning 110122China Department of Breast Surgery The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China

Microrchidia CW-type zinc finger 2(MORC2)is a member of the MORC superfamily of nuclear *** evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of downstream oncogenes or tumor *** present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target *** systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future.

关键词： Cancer development Hallmarks of cancer MORC2 Therapeutic target Treatment resistance

Creep damage evolution process of asphalt binder based on viscoelastic characteristics

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 497-506页

作者： Xiaofei Qi Shuang Tian Liyan shan Shuang Liu Yajie wang School of Transportation Science and Engineering Harbin Institute of TechnologyHarbin 150090China College of Water Conservancy&Architectural Engineering Shihezi UniversityShihezi 832003China

The creep damage evolution of asphalt binder plays a significant role in investigating the formation mechanism of *** rutting is the common distress at high temperatures for asphalt ***,the reliability of existing creep damage parameters is under questioned,and these parameters cannot accurately illustrate the change of intrinsic microstructure for asphalt *** this paper,a new test protocol was given access to study the evolution of viscoelastic parameters during creep *** was completed by inserting the frequency sweep during creep *** frequency sweep curve clusters were fitted by the generalized Kelvin-Voigt model for obtaining the change law of model *** on the change law and sensitivity analysis of model parameters,(E_(2)+E_(3))/2 was proposed as the creep damage *** to the curve of(E_(2)+E_(3))/2 versus loading time,two stages during the creep test could be identified:an approximate constant value in phase I and a linear decrease in phase *** differences about creep property of binders could be determined by this new proposed *** results not only ensure better understanding of the creep damage mechanism of binders,but also lay the theoretical foundation on predicting the anti-rutting performance of binders.

关键词： Asphalt binder Multi-stage creep test Damage variable Evolution law

Parent-offspring relationship recognition based on SSR and mtDNA confirmed resource supplement effect of Fenneropenaeus chinensis release

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Acta Oceanologica Sinica 2024年第2期43卷 156-160页

作者： Song Sun Ding Lyu Xianshi Jin Xiujuan shan Weiji wang Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture and Rural AffairsYellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdao 266071China Function Laboratory for Marine Fisheries Science and Food Production Processes Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China

The resource of Fenneropenaeus chinensis has declined sharply due to excessive fishing intensity,ecological changes and *** order to supplement the fishing yield and restore resources of ***,the relevant authorities have carried out the activities of stock enhancement and *** can increase biomass and recover ***,compared with increasing biomass,there were still few reports on its effect on the recovery of *** recovery is a process related to whether the released individuals can form a reproductive *** to now,there has been a lack of evidence whether the released *** can complete the entire life history,and form reproduction *** this study,gravid female shrimp after spawning migration were captured from coastal waters of Haiyang,Qingdao,and Yellow *** identifying parentage relationships using simple sequence repeat(SSR)and mtDNA haplotype,it was finally confirmed that there were eight released individuals in the recapture *** was confirmed for the first time that at least part of the released *** can complete overwintering and reproductive migration,and maintain the migration habits as their wild ***,we infered that the released shrimp can reproduce under natural conditions,these *** can form reproductive populations theoretically if without human *** results indicated that enhancenment and release activities have a positive effect on resource recovery.

关键词： Fenneropenaeus chinensis release simple sequence repeat(SSR) mtDNA resource supplement

Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

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Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI zhi-min wang Xia LIU Xia ZHAO Juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis