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World Journal of Gastrointestinal Oncology 2024年第9期16卷 3747-3751页

作者： De-Hui li Rui-Qi Feng Oncology DepartmentⅡ The First Affiliated Hospital of Hebei University of Chinese Medicine(Hebei Province Hospital of Chinese Medicine)Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology ResearchShijiazhuang 050000Hebei ProvinceChina Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina

This review comments on the article“To explore the mechanism of Yigong San anti-gastric cancer and immune regulation”.We are interested that the article applied network pharmacology and bioinformatics techniques to elucidate the mechanism of action of Yigong Sang,a traditional Chinese medicine(TCM),in the treatment of gastric cancer(GC).The mechanism of action of Yigong Sang in the treatment of GC has not yet been elucidated because it is composed of multiple Chinese medicines with multiple components and multiple *** emergence of network pharmacology and bioinformatics analysis helps explain the mechanism of action of TCM in preventing and treating GC,and provides a possibility for TCM to transform from empirical to evidence-based *** is of great significance for the application of TCM in oncology,new drug development,formula optimization,and the improvement of clinical efficacy.

关键词： Gastric cancer Traditional Chinese medicine Mechanism Network pharmacology Bioinformatics New technology

Whole-process case management effects on mental state and selfcare ability in patients with liver cancer

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 833-841页

作者： Man-Di Ju Qin Qin Meng li Department of Internal Medicine of Abdominal Oncology Hubei Cancer HospitalWuhan 430070Hubei ProvinceChina Department of Hepatological Surgery Wuhan No.1 HospitalWuhan 430000Hubei ProvinceChina Department of Nursing General Hospital of the Yangtze River ShippingWuhan 430014Hubei ProvinceChina

BACKGROUND Regarding the incidence of malignant tumors in China,the incidence of liver cancer ranks fourth,second only to lung,gastric,and esophageal *** case fatality rate ranks third after lung and cervical *** a previous study,the whole-process management model was applied to patients with breast cancer,which effectively reduced their negative emotions and improved treatment adherence and nursing *** In this single-center,randomized,controlled study,60 randomly selected patients with liver cancer who had been admitted to our hospital from January 2021 to January 2022 were randomly divided into an observation group(n=30),who received whole-process case management on the basis of routine nursing mea-sures,and a control group(n=30),who were given routine nursing *** compared differences between the two groups in terms of anxiety,depression,the level of hope,self-care ability,symptom distress,sleep quality,and quality of *** Post-intervention,Hamilton anxiety scale,Hamilton depression scale,memory symptom assessment scale,and Pittsburgh sleep quality index scores in both groups were lower than those pre-intervention,and the observation group had lower scores than the control group(Plity assessment scale-revision in Chinese,and quality of life measurement scale for patients with liver cancer scores in both groups were higher than those pre-intervention,with higher scores in the observation group compared with the control group(Pliver cancer,alleviate symptoms and problems,and improve the level of hope,self-care ability,sleep quality,and quality of life,as well as provide feasible nursing alternatives for patients with liver cancer.

关键词： liver cancer Mental state Self-care ability Whole-process case management life quality Nursing

System Reliability Analysis Method Based on T-S FTA and HE-BN

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1769-1794页

作者： Qing Xia Yonghua li Dongxu Zhang YufengWang School of Mechanical Engineering Dalian Jiaotong UniversityDalian116028China School of Locomotive and Rolling Stock Engineering Dalian Jiaotong UniversityDalian116028China

For high-reliability systems in military,aerospace,and railway fields,the challenges of reliability analysis lie in dealing with unclear failure mechanisms,complex fault relationships,lack of fault data,and uncertainty of fault *** overcome these problems,this paper proposes a reliability analysismethod based on T-S fault tree analysis(T-S FTA)and Hyper-ellipsoidal Bayesian network(HE-BN).The method describes the connection between the various systemfault events by T-S fuzzy gates and translates them into a Bayesian network(BN)*** the advantages of T-S fault tree modeling with the advantages of Bayesian network computation,a reliability modeling method is proposed that can fully reflect the fault characteristics of complex *** describe the degree of failure of the event in the form of interval *** knowledge and experience of experts are fused with the D-S evidence theory to obtain the initial failure probability interval of the BN root ***,the Hyper-ellipsoidal model(HM)constrains the initial failure probability interval and constructs a HE-BN for the system.A reliability analysismethod is proposed to solve the problem of insufficient failure data and uncertainty in the degree of *** failure probability of the system is further calculated and the key components that affect the system’s reliability are *** proposedmethod accounts for the uncertainty and incompleteness of the failure data in complex multi-state systems and establishes an easily computable reliability model that fully reflects the characteristics of complex faults and accurately identifies system *** feasibility and accuracy of the method are further verified by conducting case studies.

关键词： System reliability D-S evidence theory hyper-ellipsoidal bayesian network T-S fault tree

One-pot synthesis of li_3VO_4@C nanofibers by electrospinning with enhanced electrochemical performance for lithium-ion batteries

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Science Bulletin 2017年第15期62卷 1081-1088页

作者： Ruihuan Qin Gaoqi Shao Junxian Hou zhi Zheng Tianyou Zhai Huiqiao li State Key Laboratory of Material Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology (HUST) Department of Composite Materials and Engineering College of Materials Science and Engineering Hebei University of Engineering

Electrospinning is firstly used to one-pot synthesis of li3VO4@C nanofibers in a large scale. Although with the presence of organic sources in synthesis process, the pure phase li3VO4 with superior nanofibrous morphology is still successfully obtained through adjusting different heat treatment processes and different vanadium sources. The prepared li3VO4@C nanofibers exhibit a unique structure in which nanosized li3VO4 particles are uniformly embedded in amorphous carbon matrix. Compared with liBVO4/C powder, li3VO4@C nanofibers display enhanced reversible capacity of 451 mAhg^-1 at 40mAg^-1 with an increased initial coulombic efficiency of 82.3%, and the capacity can remain at 394 mAh g ^-1 after 100 cycles. This superior electrochemical performance can be attributed to its unique structure which ensures a high reactivity by nanosized li3VO4, more stable electrode/electrolyte interface by carbon encapsulation, improved electronic conductivity and buffered volume changes by flexible carbon matrix. The electrospinning technology provides an effective method to obtain high performance li3VO4 as a promising anode material for lithium-ion batteries.

关键词： lithium vanadium oxide Electrospinning lithium-ion batteries Anode Carbon nanocomposite

韧性治理何以实现:城市社区应急管理的困境与因应

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理论导刊 2024年第5期 69-78页

作者：李智张桃梅河海大学公共管理学院南京211100

“与风险共存”是现代社会的基本特征。风险社会突发事件的高度复杂性和不确定性提升了应急管理的战略定位。社区作为突发事件的第一现场,是实现风险消解和危机应对的重要关口,也是国家治理体系和治理能力现代化建设的关键场域。针对传... 详细信息

“与风险共存”是现代社会的基本特征。风险社会突发事件的高度复杂性和不确定性提升了应急管理的战略定位。社区作为突发事件的第一现场,是实现风险消解和危机应对的重要关口,也是国家治理体系和治理能力现代化建设的关键场域。针对传统应急管理有效性不足的问题,韧性治理作为一种新型治理理念,具有抗逆力、恢复力和适应力三重价值指向,契合了社区应急管理的现实需要。基于韧性治理议题和治理要素维度,搭建“主体—制度—过程—能力”的韧性社区治理分析框架,通过分析社区突发公共事件的治理实践,发现社区在应急管理中存在主体支撑薄弱、制度保障乏力、过程管理粗疏和能力供给不足的缺陷。依据韧性社区治理向度,城市社区应急管理应重视社会动员、健全社区参与机制,加强顶层设计、推动预案执行落实,优化流程管理、注重程序适应变通,强化资源保障、推动技术治理嵌入。

关键词：风险社会韧性治理城市社区应急管理

Concomitant treatment of ureteral calculi and ipsilateral pelvic sciatic nerve schwannoma with transperitoneal laparoscopic approach: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1947-1953页

作者： Yang Xiong Jin li Han-Jie Yang Department of Urology Pingxiang People’s HospitalPingxiang 337000Jiangxi ProvinceChina

BACKGROUND Schwannomas are rare peripheral neural myelin sheath tumors that originate from Schwann *** the different types of schwannomas,pelvic sciatic nerve schwannoma is extremely *** preoperative diagnosis of pelvic schwannomas is difficult,and surgical resection is the gold standard for its definite diagnosis and *** SUMMARY We present a case of pelvic schwannoma arising from the sciatic nerve that was detected in a 40-year-old man who underwent computed tomography for intermittent right lower back pain caused exclusively by a right ureteral ***,successful transperitoneal laparoscopic surgery was performed for the intact removal of the stone and en bloc resection of the *** total operative time was 125 min,and the estimated blood loss was *** surgical procedure was *** patient was discharged on postoperative day 5 with the simultaneous removal of the urinary ***,the patient presented with motor and sensory disorders of the right lower limb,caused by partial damage to the right sciatic *** tumor recurrence was observed at the postoperative *** Histopathological examination of the specimen confirmed the diagnosis of a ***,laparoscopic surgery is safe and feasible for concomitant extirpation of pelvic schwannomas and other pelvic and abdominal diseases that require surgical treatment.

关键词： Schwannoma Sciatic nerve Laparoscopy Ureteral calculi Pelvic neoplasms Case report

基于时间触发机制的温控负荷集群综合惯性控制研究

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全球能源互联网 2024年第3期7卷 325-335页

作者：周特周梦李继东周盛强李治韩杨张宁天府永兴实验室新型电力系统研究中心四川省成都市610213 清华四川能源互联网研究院四川省成都市610042 电子科技大学机械与电气工程学院四川省成都市621000 国家电网有限公司北京市西城区100032 国网四川省电力公司广安供电公司四川省广安市638500

面对新型电力系统的低惯量趋势,规模庞大而位置分散的温控负荷在参与电力系统频率响应的同时,能够为电网提供虚拟惯量和一次调频支撑将是提升电网频率安全的新思路。为此,以集中-分布式调控框架下的温控负荷集群为研究对象,首先在详细... 详细信息

面对新型电力系统的低惯量趋势,规模庞大而位置分散的温控负荷在参与电力系统频率响应的同时,能够为电网提供虚拟惯量和一次调频支撑将是提升电网频率安全的新思路。为此,以集中-分布式调控框架下的温控负荷集群为研究对象,首先在详细分解控制层调控中心、协调层聚合商、响应层温控负荷终端三者在辅助调频过程中的采样、计算、控制、执行一系列实时任务的基础上,设计了事件触发与时间触发相结合的温控负荷集群终端异步响应机制,实现温控负荷集群功率遵从综合惯性控制律的效果。随后,对所提综合惯性控制下温控负荷集群参与调频的电力系统进行频率响应建模,并进一步利用改进劳斯近似实现系统降阶,从而获得系统频率响应关键特征的时域解析表达式。最后,通过仿真算例验证了所提基于时间触发机制的温控负荷集群综合惯性控制的有效性,并分析了采用改进劳斯近似对系统模型降阶的可行性。

关键词：温控负荷需求响应电力系统频率响应综合惯性控制虚拟惯量控制频率下垂控制

Meiotic transcriptional reprogramming mediated by cell-cell communications in humans and mice revealed by scATACseq and scRNA-seq

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Zoological Research 2024年第3期45卷 601-616页

作者： Hai-Quan Wang Xiao-Long Wu Jing Zhang Si-Ting Wang Yong-Juan Sang Kang li Chao-Fan Yang Fei Sun Chao-Jun li State Key Laboratory of Reproductive Medicine and Offspring Health Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Medical School Nanjing UniversityNanjingJiangsu 210093China Zhejiang University School of Medicine HangzhouZhejiang 310016China Department of Urology and Andrology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhouZhejiang 310000China Model Animal Research Center of Medical School Nanjing UniversityNanjingNanjingJiangsu 210093China liangzhu Laboratory Zhejiang UniversityHangzhouZhejiang 311121China

Meiosis is a highly complex process significantly influenced by transcriptional ***,studies on the mechanisms that govern transcriptomic changes during meiosis,especially in prophase I,are ***,we performed single-cell ATAC-seq of human testis tissues and observed reprogramming during the transition from zygotene to pachytene *** event,conserved in mice,involved the deactivation of genes associated with meiosis after reprogramming and the activation of those related to spermatogenesis before their functional ***,we identified 282 transcriptional regulators(TRs)that underwent activation or deactivation subsequent to this *** suggested that physical contact signals from Sertoli cells may regulate these TRs in spermatocytes,while secreted ENHO signals may alter metabolic patterns in these *** results further indicated that defective transcriptional reprogramming may be associated with non-obstructive azoospermia(NOA).This study revealed the importance of both physical contact and secreted signals between Sertoli cells and germ cells in meiotic progression.

关键词： Single-cell RNA-seq Single-cell ATAC-seq Spermatogenesis Meiosis Transcriptional reprogramming Cell-cell communication

Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4014-4027页

作者： li Wang Zhe Zhang Hai-Zhang Ma Department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Emergency Medicine The First People’s Hospital of Linping District HangzhouHangzhou 311100Zhejiang ProvinceChina Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Cholangiocarcinoma(CCA)is a lethal malignancy with limited treatment options and poor *** PEA3 subfamily of E26 transformation specific genes:ETV1,ETV4,and ETV5 are known to play significant roles in various cancers by influencing cell proliferation,invasion,and *** To analyze PEA3 subfamily gene expression levels in CCA and their correlation with clinical parameters to determine their prognostic value for *** The expression levels of PEA3 subfamily genes in pan-cancer and CCA data in the cancer genome atlas and genotype-tissue expression project databases were analyzed with R language *** curve and receiver operating characteristic analyses were performed using the SurvMiner,Survival,and Procr language *** gene expression profiling interactive analysis 2.0 database was used to analyze the expression levels of PEA3 subfamily genes in different subtypes and stages of *** Gestalt was used to perform the gene ontology/Kyoto encyclopedia of genes and genomes(GO/KEGG)analysis,and STRING database analysis was used to determine the genes and proteins related to PEA3 subfamily *** ETV1,ETV4,and ETV5 expression levels were significantly increased in *** were significant differences in ETV1,ETV4,and ETV5 expression levels among the different subtypes of CCA,and predictive analysis revealed that only high ETV1 and ETV4 expression levels were significantly associated with shorter overall survival in patients with ***/KEGG analysis revealed that PEA3 subfamily genes were closely related to transcriptional misregulation in *** vitro and in vivo experiments revealed that PEA3 silencing inhibited the invasion and metastasis of CCA *** The expression level of ETV4 may be a predictive biomarker of survival in patients with CCA.

关键词： PEA3 subfamily Cholangiocarcinoma The cancer genome atlas ETV4 The prognosis Prognostic biomarker

Adenosine triphosphate mediates the pain tolerance effect of manual acupuncture at Zusanli(ST36) in mice

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Journal of Traditional Chinese Medicine 2024年第4期44卷 660-669页

作者： li Zhongzheng ZHAO Yadan Ma Weigang Zhang Yonglong XU zhifang XI Qiang li Yanqi QIN Siru ZHANG Zichen WANG Songtao ZHAO Xue liU Yangyang GUO Yi GUO Yongming Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese MedicineTianjin 301617China National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin 301617China Department of Acupuncture and Moxibustion Qingdao Hiser Hospital Affiliated of Qingdao University(Qingdao Traditional Chinese Medicine Hospital)Qingdao 266033China School of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China School of Acupuncture and Moxibustion and Tuina Tianjin University of Traditional Chinese MedicineTianjin 301617China

OBJECTIVE:To investigate the mechanisms behind the effects of acupuncture in Traditional Chinese Medicine,we delved into the adenosine triphosphate/peripheral purinergic P2X receptor 3(ATP/P2X3)receptor signaling system as an indicator of the body's energy state,commonly referred to as"Qi".METHODS:The tail-flick test was utilized to explore the impact of acupuncture on pain tolerance threshold(PTT)in mice,while also assessing adenosine(ADO)levels and adenylate energy charge(EC)at Zusanli(ST36).The study further investigated the dose-depen.ent effects of acupuncture on PTT and ADO levels at Zusanli(ST36).To shed light on the underlying mechanisms of acupuncture's effects,the study examined the impact of ATP,a P2X3 receptor antagonist,and adenosine disodium on PTT following acupuncture ***:Acupuncture at Zusanli(ST36)led to significant improvements in PTT in mice,with the most effective interventions being twirling for 2 min and needle retention for 28 *** interventions also resulted in significant increases in ATP *** effects of acupuncture were further augmented by administration of different doses of ATP at Zusanli(ST36),and pretreatment with a P2X3 receptor antagonist decreased *** EC peaked at 30 min after intraperitoneal injection of ATP,and pretreatment with various doses of *** 30 min prior to acupuncture increased PTT in a dose-depen.ent ***,pretreatment with an *** intramuscular injection of adenosine disodium enhanced the effects of ***:This research provides compelling evidence that ATP is involved in the regulation of PTT through acupuncture,revealing new avenues for achieving enhanced clinical outcomes.

关键词： acupuncture point ST36(Zusanli) adenosine triphosphate receptors,purinergic P2X3 energy state