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CD 147 receptor is essential for TFF3-mediated signaling regulating colorectal cancer progression

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2521-2535页

作者： Hong-Yong Cui Shi-Jie Wang Fei Song Xu cheng Gang nan Yu Zhao Mei-Rui Qian Xi chen Jia-Yue Li Fen-Ling Liu Yu-Meng Zhu Ruo-Fei Tian Bin Wang Bin Wu Yang Zhang Xiu-Xuan Sun Ting Guo Xiang-Min Yang Hai Zhang Ling Li Jing Xu Hui-Jie Bian Jian-Li Jiang zhi-nan chen National Translational Science Center for Molecular Medicine and Department of Cell Biology Fourth Military Medical UniversityXi'anChina Department of Urology Shenzhen Institute of Translational MedicineThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's HospitalShenzhenChina Medical Research Institute School of MedicineWuhan UniversityWuhanChina College of Chemistry and Materials Science Northwest UniversityXi'anChina National Facility for Protein Science Shanghai Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of SciencesShanghaiChina Medical Research Center Southern University of Science and Technology HospitalShenzhenChina

Major gaps in understanding the molecular mechanisms of colorectal cancer(CRC)progression and intestinal mucosal repair have hampered therapeutic development for gastrointestinal *** factor 3(TFF3)has been reported to be involved in CRC progression and intestinal mucosal repair;however,how TFF3 drives tumors to become more aggressive or metastatic and how TFF3 promotes intestinal mucosal repair are still poorly ***,we found that the upregulated TFF3 in CRC predicted a worse overall survival ***3 deficiency impaired mucosal restitution and ***147,a membrane protein,was identified as a binding partner for *** binding to CD147,TFF3 enhanced CD147-CD44s interaction,resulting in signal transducer and activator of transcription 3(STAT3)activation and prostaglandin G/H synthase 2(PTGS2)expression,which were indispensable for TFF3-induced migration,proliferation,and ***2-derived PGE2 bound to prostaglandin E2 receptor EP4 subtype(PTGER4)and contributed to TFF3-stimulated CRC *** NMR studies of the TFF3-CD147 interaction revealed the key residues critical for TFF3 binding and the induction of PTGS2 *** ability of TFF3 to enhance mucosal restitution was weakened by a PTGS2 *** of TFF3-CD147 signaling using competitive inhibitory antibodies or a PTGS2 inhibitor reduced CRC lung metastasis in *** findings bring strong evidence that CD147 is a novel receptor for TFF3 and PTGS2 signaling is critical for TFF3-induced mucosal restitution and CRC progression,which widens and deepens the understanding of the molecular function of trefoil factors.

关键词： TFF3 colorectal impaired

Optimal geometrical configuration and oxidation state of cobalt cations in spinel oxides to promote the performance of Li-O_(2) battery

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nano Research 2024年第1期17卷 221-227页

作者： Yu Zhang Shuting Zhang Mengwei Yuan Yufeng Li Rong Liu Caiyun nan chen chen Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Energy Conversion and Storage Materials Institution College of ChemistryBeijing Normal UniversityBeijing 100875China X-ray diffraction Lab Analytical and Testing CenterBeijing Normal UniversityBeijing 100875China

Co_(3)O_(4) is considered as one of promising cathode catalysts for lithium oxygen(Li-O_(2))batteries,which contains both tetrahedral Co^(2+)sites(Co^(2+)Td)and octahedral Co^(3+)sites(Co^(3+)Oh).It is important to reveal the effect of optimal geometric configuration and oxidation state of cobalt ion in Co_(3)O_(4) to improve the performance of Li-O_(2) ***,through regulating the synthesis process,Co^(2+)and Co^(3+)sites in Co_(3)O_(4) were replaced with Zn and Al atoms to form materials with a unique Co *** Li-O_(2) batteries based on ZnCo_(2)O_(4) showed longer cycle life than that of CoAl_(2)O_(4),suggesting that in Co_(3)O_(4),the Co^(3+)Oh site is a relatively better geometric configuration than Co^(2+)Td site for Li-O_(2) *** calculations revealed that Co^(3+)Oh sites provide higher catalysis activity,regulating the adsorption energy of the intermediate LiO_(2) and accelerating the kinetics of the reaction in batteries,which further leads to the change of the morphology of the discharge product and ultimately improves the electrochemical performance of the batteries.

关键词： lithium oxygen(Li-O_(2))batteries geometrical configuration oxidation state lithium peroxide

Updated roles of the gut microbiota in exploring shrimp etiology, polymicrobial pathogens, and disease incidence

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Zoological Research 2024年第4期45卷 910-923页

作者： Jin-Bo Xiong Hao-nan Sha Jiong chen State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products School of Marine SciencesNingbo UniversityNingboZhejiang 315211China Key Laboratory of Aquacultural Biotechnology Ministry of EducationSchool of Marine SciencesNingbo UniversityNingboZhejiang 315211China Laboratory of Biochemistry and Molecular Biology School of Marine SciencesNingbo UniversityNingboZhejiang 315211China

Litopenaeus vannamei is the most extensively cultured shrimp species globally,recognized for its scale,production,and economic ***,its aquaculture is plagued by frequent disease outbreaks,resulting in rapid and massive *** research often lags behind the emergence of new diseases,leaving the causal agents of some shrimp diseases unidentified and leading to nomenclature based on symptomatic presentations,especially in cases involving co-and polymicrobial *** data on shrimp disease statuses remain *** this review,we summarize current knowledge on shrimp diseases and their effects on the gut ***,we also propose a workflow integrating primary colonizers,“driver”taxa in gut networks from healthy to diseased states,disease-discriminatory taxa,and virulence genes to identify potential polymicrobial *** examine both abiotic and biotic factors(e.g.,external and internal sources and specific-disease effects)that influence shrimp gut microbiota,with an emphasis on the“holobiome”concept and common features of gut microbiota response to diverse *** excluding the effects of confounding factors,we provide a diagnosis model for quantitatively predicting shrimp disease incidence using disease common-discriminatory taxa,irrespective of the causal *** to the conservation of functional genes used in designing specific primers,we propose a practical strategy applying qPCR-assayed abundances of disease common-discriminatory functional *** review updates the roles of the gut microbiota in exploring shrimp etiology,polymicrobial pathogens,and disease incidence,offering a refined perspective for advancing shrimp aquaculture health management.

关键词： Shrimp disease Gut microbiota Polymicrobial pathogens Diagnosis model Disease common-discriminatory taxa Disease prediction

Revolution in thermoelectric cooling using PbSe thermoelectrics by grid plainification

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Science China Materials 2024年第5期67卷 1672-1673页

作者： Xiao-Lei Shi Qingfeng Liu zhi-Gang chen School of Chemistry and Physics ARC Research Hub in Zero-emission Power Generation for Carbon Neutralityand Centre for Materials ScienceQueensland University of TechnologyBrisbaneQueensland4000Australia State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing211816China

Thermoelectric materials and devices enable direct conversion between heat and electricity,holding potential applications in thermoelectric power generation,localized cooling,and electronic thermal management[1].Howev... 详细信息

关键词： enable thermoelectric constrained

Localization for mixed near-field and far-field sources under impulsive noise

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Journal of Systems Engineering and Electronics 2024年第2期35卷 302-315页

作者： GAO Hongyuan ZHANG Yuze DU Ya’nan chenG Jianhua chen Menghan College of Information and Communication Engineering Harbin Engineering UniversityHarbin 150001China College of Intelligent Systems Science and Engineering Harbin Engineering UniversityHarbin 150001China

In order to solve the problem that the performance of traditional localization methods for mixed near-field sources(NFSs)and far-field sources(FFSs)degrades under impulsive noise,a robust and novel localization method is *** eliminating the impacts of impulsive noise by the weighted out-lier filter,the direction of arrivals(DOAs)of FFSs can be estimated by multiple signal classification(MUSIC)spectral peaks *** on the DOAs information of FFSs,the separation of mixed sources can be ***,the estimation of localizing parameters of NFSs can avoid two-dimension spectral peaks search by decomposing steering *** Cramer-Rao bounds(CRB)for the unbiased estimations of DOA and range under impulsive noise have been *** experiments verify that the proposed method has advantages in probability of successful estimation(PSE)and root mean square error(RMSE)compared with existing localization *** can be concluded that the proposed method is effective and reliable in the environment with low generalized signal to noise ratio(GSNR),few snapshots,and strong impulse.

关键词： source localization far-field source(NFS) near-field source(FFS) impulsive noise Cramer-Rao bound(CRB)

Aspirin suppresses hepatocellular carcinoma progression by inhibiting platelet activity

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2742-2756页

作者： Li-Jun Zhao zhi-Yin Wang Wei-Ting Liu Li-Li Yu Hao-nan Qi Jie Ren chen-Guang Zhang Hematology Laboratory The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang 453100Henan ProvinceChina Xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy School of Medical TechnologyXinxiang Medical UniversityXinxiang 453003Henan ProvinceChina School of Public Health Xinxiang Medical UniversityXinxiang 453003Henan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common malignant liver disease in the ***(PLTs)are known to play a key role in the maintenance of liver homeostasis and the pathophysiological processes of a variety of liver *** is the most classic antiplatelet ***,the molecular mechanism of platelet action and whether aspirin can affect HCC progression by inhibiting platelet activity need further *** To explore the impact of the antiplatelet effect of aspirin on the development of *** Platelet-rich plasma,platelet plasma,pure platelet,and platelet lysate were prepared,and a coculture model of PLTs and HCC cells was ***-8 analysis,apoptosis analysis,Transwell analysis,and real-time polymerase chain reaction(RT-PCR)were used to analyze the effects of PLTs on the growth,metastasis,and inflammatory microenvironment of ***-PCR and Western blot were used to detect the effects of platelet activation on tumor-related signaling *** was used to block the activation and aggregation of PLTs both in vitro and in vivo,and the effect of PLTs on the progression of HCC RESULTS PLTs significantly promoted the growth,invasion,epithelial-mesenchymal transition,and formation of an inflammatory microenvironment in HCC *** PLTs promoted HCC progression by activating the mitogenactivated protein kinase/protein kinase B/signal transducer and activator of transcription three(MAPK/AKT/STAT3)signaling ***,aspirin inhibited HCC progression in vitro and in vivo by inhibiting platelet *** PLTs play an important role in the pathogenesis of HCC,and aspirin can affect HCC progression by inhibiting platelet *** results suggest that antiplatelet therapy has promising application prospects in the treatment and combined treatment of HCC.

关键词： Platelets Antiplatelet therapy Hepatocellular carcinoma Aspirin Antitumor

Regioselective cation exchange reaction for photoelectrochemical water splitting

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Rare Metals 2024年第7期43卷 3400-3407页

作者： Mo-Yan chen Tai-Song Zhang zhi Yan Jiang-nan Lv Xiao-Ting Sun Rui-Xia Yang Mark TSwihart Xiao-Hong Xu Yang Liu Research Institute of Materials Science of Shanxi Normal University&Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education Taiyuan 030031China Department of Chemical and Biological Engineering University at Buffalo(SUNY)NY 14260USA Department of Materials Science Fudan UniversityShanghai 200433China

Engineering copper sulfide-based heterostructures via cation exchange(CE)is an appealing approach,as it allows selective combination of distinct compositions and functions of metal *** heterostructures can play a significant role in photoelectrochemical applications,but the effect of the ratio between two or more domains in such heterostructures on the photoresponse has not been well explored.

关键词： exchange sulfide splitting

Immunological and metabolic characteristics of the Omicron variants infection

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Signal Transduction and Targeted Therapy 2023年第2期8卷 784-794页

作者： Jiejie Geng Xu Yang Kun Wang Ke Wang Ruo chen zhi-nan chen Chuan Qin Guizhen Wu Youchun Wang Ke Xu Peng Du Jiangning Liu Shirui chen Tao Zhang Xiuxuan Sun Ting Guo Ying Shi Zheng Zhang Ding Wei Peng Lin Qingyi Wang Jing Yuan Jiuxin Qu Jin Zou Yingxia Liu Hongzhou Lu Ping Zhu Huijie Bian Liang chen Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital Fourth Military Medical UniversityXi’an 710032China Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthKey Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100871China MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Preven-tionChinese Center for Disease Control and PreventionBeijing 100871China Division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)and WHO Collaborating Center for Standardization and Evaluation of BiologicalsBeijing 102629China Beijing Institute of Biotechnology Beijing 100871China School of Basic Medicine Fourth Military Medical UniversityXi’an 710032China The Third People’s Hospital of Shenzhen Shenzhen 518112China School of Medicine Shanghai UniversityShanghai 200444China

The Omicron variants of SARS-CoV-2,primarily authenticated in November 2021 in South Africa,has initiated the 5th wave of global ***,we systemically examined immunological and metabolic characteristics of Omicron variants *** found Omicron resisted to neutralizing antibody targeting receptor binding domain(RBD)of wildtype *** could hardly be neutralized by sera of Corona Virus Disease 2019(COVID-19)convalescents infected with the Delta *** mass spectrometry on MHC-bound peptidomes,we found that the spike protein of the Omicron variants could generate additional CD8+T cell epitopes,compared with *** epitopes could induce robust CD8+T cell ***,we found booster vaccination increased the cross-memory CD8+T cell responses against *** regulome analysis of Omicron-specific T cell showed a metabolic profile that promoted the response of memory T ***,a greater fraction of memory CD8+T cells existed in Omicron stimulated peripheral blood mononuclear cells(PBMCs).In addition,CD147 was also a receptor for the Omicron variants,and CD147 antibody inhibited infection of ***147-mediated Omicron infection in a human CD147 transgenic mouse model induced exudative alveolar *** together,our data suggested that vaccination booster and receptor blocking antibody are two effective strategies against Omicron.

关键词： infection inhibited neutral

Ecological effect of the plantation of Sabina vulgaris in the Mu Us Sandy Land,China

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Journal of Arid Land 2024年第1期16卷 14-28页

作者： nan Weige DONG zhibao ZHOU Zhengchao LI Qiang chen Guoxiang School of Geography and Tourism Shaanxi Normal UniversityXi'an 710062China Shaanxi Key Laboratory of Ecological Restoration in Shaanbei Mining Area Yulin UniversityYulin 719000China College of Prataculture Gansu Agricultural UniversityLanzhou 730070China

Vegetation restoration through artificial plantation is an effective method to combat desertification,especially in arid and semi-arid *** study aimed to explore the ecological effect of the plantation of Sabina vulgaris on soil physical and chemical properties on the southeastern fringe of the Mu Us Sandy Land,*** collected soil samples from five depth layers(0-20,20-40,40-60,60-80,and 80-100 cm)in the *** plantation plots across four plantation ages(4,7,10,and 16 years)in November 2019,and assessed soil physical(soil bulk density,soil porosity,and soil particle size)and chemical(soil organic carbon(SOC),total nitrogen(TN),available nitrogen(AN),available phosphorus(AP),available potassium(AK),cation-exchange capacity(CEC),salinity,p H,and C/N ratio)*** results indicated that the soil predominantly consisted of sand particles(94.27%-99.67%),with the remainder being silt and *** plantation age increased,silt and very fine sand contents progressively *** 16 years of planting,there was a marked reduction in the mean soil particle *** initial soil fertility was low and declined from 4 to 10 years of planting before witnessing an *** positive correlations were observed for the clay,silt,and very fine sand(mean diameter of 0.000-0.100 mm)with SOC,AK,and p *** contrast,fine sand and medium sand(mean diameter of 0.100-0.500 mm)showed significant negative correlations with these *** findings ascertain that the plantation of *** requires 10 years to effectively act as a windbreak and contribute to sand fixation,and needs 16 years to improve soil physical and chemical ***,these improvements were found to be highly beneficial for vegetation restoration in arid and semi-arid *** research can offer valuable insights for the protection and restoration of the vegetation ecosystem in the sandy lands in China.

关键词： Sabina vulgaris plantation age soil physical and chemical properties soil particle size soil fertility vegetation restoration Mu Us Sandy Land