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Healthcare-associated Pneumonia： Clinical Features and Retrospective Analysis Over 10 Years

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Chinese Medical Journal 2015年第20期128卷 2707-2713页

作者： Fei Qi Guo-Xin Zhang Dan-Yang She zhi-Xin liang ren-Tao Wang Zhen Yang liang-An Chen Jun-Chang Cui Department of Respiratory Medicine Chinese People's Liberation Army General Hospital Beijing 100853 China

Background： Healthcare-associated pneumonia （HCAP） is associated with drug-resistant pathogens and high mortality, and there is no clear evidence that this is due to inappropriate antibiotic therapy. This study was to elucidate the clinical features, pathogens, therapy, and outcomes of HCAP, and to clarify the risk factors for drug-resistant pathogens and prognosis. Methods： Retrospective observational study among hospitalized patients with HCAP over 10 years. The primary outcome was 30-day all-cause hospital mortality after admission. Demographics （age, gender, clinical features, and comorbidities）, dates of admission, discharge and/or death, hospitalization costs, microbiological results, chest imaging studies, and CURB-65 were analyzed. Antibiotics, admission to Intensive Care Unit （ICU）, mechanical ventilation, and pneumonia prognosis were recorded. Patients were dichotomized based on CURB-65 （lowvs. high-risk）. Results： Among 612 patients （mean age of 70.7 years）, 88.4% had at least one comorbidity. Commonly detected pathogens were Acinetobacter baumannii, Pseudomonas aeruginosa, and coagulase-negative staphylococci. Initial monotherapy with 13-1actam antibiotics was the most common initial therapy （50%）. Mean age, length of stay, hospitalization expenses, ICU admission, mechanical ventilation use, malignancies, and detection rate for P. aeruginosa, and Staphylococcus aureus were higher in the high-risk group compared with the low-risk group. CURB-65 ≥3, malignancies, and mechanical ventilation were associated with an increased mortality. Logistic regression analysis showed that cerebrovascular diseases and being bedridden were independent risk factors for HCAR Conclusion： Initial treatment of HCAP with broad-spectrum antibiotics could be an appropriate approach. CURB-65 〉3, malignancies, and mechanical ventilation may result in an increased mortality.

关键词： Acinetobacter Baumannii Antibiotic Resistance Community-acquired Pneumonia CURB-65 Healthcare-associatedPneumonia Pseudomonas Aeruginosa

基于WRI曲线图的截瘫FES行走稳定性评估新方法

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中国生物医学工程学报 2005年第1期24卷 118-121页

作者：明东万柏坤胡勇梁智仁天津大学生物医学工程系香港大学骨科学系

本研究介绍了利用步行器倾翻指数 (WRI)曲线图来评估截瘫功能性电刺激 (FES)行走稳定性的新方法。其主要构件是一套基于标准步行器的测试系统 ,该系统可以实时获得三维上肢支撑力数据 ,进而转化成行走过程中的纵向和侧向WRI曲线图来显... 详细信息

本研究介绍了利用步行器倾翻指数 (WRI)曲线图来评估截瘫功能性电刺激 (FES)行走稳定性的新方法。其主要构件是一套基于标准步行器的测试系统 ,该系统可以实时获得三维上肢支撑力数据 ,进而转化成行走过程中的纵向和侧向WRI曲线图来显示量化的行走稳定性水平。有关实验校准和临床测试结果均表明新方法在稳定性评估方面有很好的临床应用前景 ,并有望在截瘫FES设计及康复训练中发挥作用。

关键词：定性评估曲线图 FES 新方截瘫功能性电刺激临床应用前景测试系统行走过程临床测试发挥作用康复训练稳定性步行器

Boosting charge extraction and efficiency of inverted perovskite solar cells through coordinating group modification at the buffer layer/cathode interface

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Nano Research 2025年第1期18卷 415-423页

作者： zhiqing liang Ziqiu ren Ziyu Wang Nan Yan Ling Li Bo Zhang Yanlin Song College of Chemistry Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy DevicesShaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and EngineeringShaanxi Normal UniversityXi’an 710119China Key Laboratory of Green Printing Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyNational Laboratory for Molecular Sciences(BNLMS)Beijing 100190China

In inverted perovskite solar cells (PSCs),effective modification of the interface between the metalcathode and electron transport layer (ETL) is crucial forachieving high performance and stability. Herein, sulfonatedbathocuproine, commonly known as disodium bathocuproinedisulfonate (BCDS), was employed as a cathode buffer layerto address the interfacial issues at the [6,6]-phenyl-C61-butyricacid methyl ester (PCBM)/Ag interface. BCDS possesses theability to form coordinate bonds with Ag electrodes. Theutilization of the BCDS buffer layer enhanced the chargeextraction capability at the cathode interface whilesimultaneously achieving interfacial defect passivation,improving interfacial contact and increasing the built-in electricfield. Consequently, a power conversion efficiency (PCE) of25.06% was achieved. Furthermore, owing to the excellent filmforminguniformity of BCDS on PCBM, the stability of thedevice was also improved. After storage in dry air for morethan 2000 h, the device maintained 96% of its initial efficiency. This work underscores the remarkable potential of tailoringcoordination groups to enhance charge extraction efficiency at the ETL-cathode interface, unveiling a promising newfrontier in buffer layer development and performance optimization strategies for PSCs.

关键词： perovskite solar cells buffer layer bathocuproine disulfonate coordination group modification electron transport layer(ETL)-cathode interface

Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease

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Neural Regeneration Research 2025年第11期20卷 3193-3206页

作者： Ling-Xiao Yi Hui ren Woon Genevieve Saw Li Zeng Eng King Tan zhi Dong Zhou National Neuroscience Institute Singapore Nanyang Technology University Singapore Department of Neurology Singapore General HospitalSingapore Signature Research Program in Neuroscience and Behavioral Disorders Duke-NUS Medical SchoolSingapore

The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative *** the detailed pathogenesis accounting for dopaminergic neuron degeneration in Parkinson's disease is still unclear,the advancement of stem cell approaches has shown promise for Parkinson's disease research and *** induced pluripotent stem cells have been commonly used to generate dopaminergic neurons,which has provided valuable insights to improve our understanding of Parkinson's disease pathogenesis and contributed to anti-Parkinson's disease *** current review discusses the practical approaches and potential applications of induced pluripotent stem cell techniques for generating and differentiating dopaminergic neurons from induced pluripotent stem *** benefits of induced pluripotent stem cell-based research are *** dopaminergic neuron differentiation protocols from induced pluripotent stem cells are *** emerging three-dimension-based brain organoid models compared with conventional two-dimensional cell culture are ***,limitations,challenges,and future directions of induced pluripotent stem cell–based approaches are analyzed and proposed,which will be significant to the future application of induced pluripotent stem cell-related techniques for Parkinson's disease.

关键词： dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches

用于截瘫FES行走的三维上肢力动态测量系统

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实验力学 2005年第1期20卷 90-96页

作者：明东万柏坤胡勇梁智仁天津大学生物医学工程系香港大学骨科学系

功能性电刺激(FES)技术已被广泛用于截瘫病人行走能力的恢复,但作为评估截瘫FES行走效率的重要指标,三维上肢力状况的研究至今仍十分有限,亟待深入开展。本文研制出了一套可用于截瘫FES行走的三维上肢力动态测量系统,该系统在一个标准... 详细信息

功能性电刺激(FES)技术已被广泛用于截瘫病人行走能力的恢复,但作为评估截瘫FES行走效率的重要指标,三维上肢力状况的研究至今仍十分有限,亟待深入开展。本文研制出了一套可用于截瘫FES行走的三维上肢力动态测量系统,该系统在一个标准步行器框架上装备有 12个应力应变片电桥,通过专用的隔离放大及A/D转换装置与计算机相连,经过标定后,截瘫FES行走时的上肢支撑力数据就可以被系统实时获得并显示。测力系统在应变片位置的确定以及“冗余-优化”方法的采用等多个方面保证了测量的可靠性和准确性,后续的校准实验显示系统的非线性、交互干扰和力学精度误差分别小于 2. 901%, 3. 188%和 1. 01%。研究中,一例截瘫患者作为志愿者按照正常的FES行走训练程序进行了相关测试,以验证新系统在行走能力评估方面的临床前景,结果表明其可用于: 1)截瘫FES行走效率的评估; 2)病人自我训练的控制指导; 3)作为反馈信号选择一种有效的FES模式和阵列。

关键词：动态测量系统 FES 截瘫上肢三维行走能力转换装置隔离放大测力系统显示系统训练程序能力评估信号选择应变片电刺激功能性步行器计算机 A/D 支撑力准确性可靠性非线性志愿者新系统 S模式病人

“塑料模具设计”辅助多媒体教学软件设计与制作

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广东工业大学学报（社会科学版） 2002年第B6期2卷 92-93页

作者：梁志仁张永俊广东工业大学机电工程学院，广东广州510090

综合运用等工具开发“塑料模具设计”辅助多媒体教学软件，介绍了软件总体开发思路，素材选择，材质处理等。

关键词：塑料模具 CAI 多媒体教学

基于危势轨迹图的截瘫FES行走步态分析新技术研究

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信息与控制 2005年第3期34卷 274-278页

作者：明东万柏坤胡勇靳世久梁智仁天津大学精密仪器与光电子工程学院天津300072 香港大学骨科学系香港999077

提出了危势轨迹图技术新概念,并以此为基础进行截瘫功能性电刺激(FES)行走的步态信息分析和处理.危势轨迹图技术是利用步行器倾翻指数作为评估因子来直观显示截瘫患者在行走过程中步态稳定性的时空表现,其核心构件为一套基于12导联应变... 详细信息

提出了危势轨迹图技术新概念,并以此为基础进行截瘫功能性电刺激(FES)行走的步态信息分析和处理.危势轨迹图技术是利用步行器倾翻指数作为评估因子来直观显示截瘫患者在行走过程中步态稳定性的时空表现,其核心构件为一套基于12导联应变片电桥网络的步行器测力系统.通过相应的系统校准和临床测试结果表明,该技术是集测量、处理、显示、分析功能于一体而形成的一个较完整的研究手段,可用于截瘫的临床康复指导,并有望为未来FES闭环反馈控制系统的研制奠定基础.

关键词：危势轨迹图截瘫功能性电刺激步态步行器测力系统

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang liang Bei Hu Longlong ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren Wenlu Li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(Li and Jia,2023).

关键词： death specialized barrier