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Dynamic response mechanism and precursor characteristics of gneiss rockburst under different initial burial depths

Journal of Mountain Science 2024年第3期21卷 1004-1018页

作者： liu Dongqiao SUN Jie MENG Wen HE Manchao ZHANG Chongyuan LI Ran CAO Binghao State Key Laboratory for Tunnel Engineering China University of Mining and TechnologyBeijing 100083China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesInstitute of GeomechanicsChinese Academy of Geological SciencesBeijing 100081China School of Mechanics and Civil Engineering China University of Mining and TechnologyBeijing 100083China

To investigate the influence mechanism of geostress on rockburst characteristics,three groups of gneiss rockburst experiments were conducted under different initial geostress conditions.A high-speed photography system and acoustic emission(AE)monitoring system were used to monitor the entire rockburst process in real *** experimental results show that when the initial burial depth increases from 928 m to 1320 m,the proportion of large fracture scale in rockburst increases by 154.54%,and the AE energy increases by 565.63%,reflecting that the degree and severity of rockburst increase with the increase of burial *** then,two mechanisms are proposed to explain this effect,including(i)the increase of initial geostress improves the energy storage capacity of gneiss,and then,the excess energy which can be converted into kinetic energy of debris ejection increases,consequently,a more pronounced violent ejection phenomenon is observed at rockburst;(ii)the increase of initial geostress causes more sufficient plate cracks of gneiss after unloading ofσh,which provides a basis for more severe ejection of ***’s more,a precursor with clear physical meaning for rockburst is proposed under the framework of dynamic response process of crack ***,potential value in long term rockburst warning of the precursor obtained in this study is shown via the comparison of conventional precursor.

关键词： Traffic Engineering Gneiss Rockburst Crack propagation Excess energy Precursor characteristic

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普惠金融稳定器与加速器效应研究——基于企业融资约束视角

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统计研究 2024年第6期41卷 71-85页

作者：梁洁莹刘小勇张展培广东财经大学智能财会管理学院华南理工大学经济与金融学院

厘清普惠金融缓解中小企业融资约束的机制,对破解中小企业融资难题和实现高质量发展具有重要意义。本文构建了一个包含准入、效度和特定化配比三种普惠金融维度的动态随机一般均衡模型,探究普惠金融如何通过影响企业融资约束,进而影响... 详细信息

厘清普惠金融缓解中小企业融资约束的机制,对破解中小企业融资难题和实现高质量发展具有重要意义。本文构建了一个包含准入、效度和特定化配比三种普惠金融维度的动态随机一般均衡模型,探究普惠金融如何通过影响企业融资约束,进而影响经济增长和稳定。模型稳态分析显示,普惠金融准入、效度和特定化配比的改善分别通过降低企业破产风险、降低外部融资溢价和增加贷款补贴以缩减企业存贷利差,缓解企业融资约束,促进经济增长。其中,效度的作用最为明显。动态效应分析显示,效度和特定化配比有利于抑制经济负面冲击造成的企业破产概率提升和信贷缩减,平抑冲击造成的经济波动,发挥稳定器作用;准入有利于加速企业自有资本积累和融资成本下降,放大经济正面冲击带来的经济增长,发挥加速器作用。据此,从长期来看应着力构建和完善普惠金融市场化服务体系,促进普惠金融多维度协调发展;从短期来看应注重建立应对经济波动的普惠金融方案,加强经济冲击识别和不同普惠金融政策工具的择时运用。

关键词：普惠金融融资约束稳定器与加速器效应动态随机一般均衡模型

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糖皮质激素治疗抗中性粒细胞胞质抗体相关性血管炎的变迁与展望

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中华内科杂志 2024年第9期63卷 829-834页

作者：梁锦坚刘海俊戴冽中山大学孙逸仙纪念医院风湿免疫科广州520120 广州医科大学附属番禺中心医院风湿免疫科广州511400

目前糖皮质激素(以下简称激素)仍是治疗抗中性粒细胞胞质抗体相关性血管炎(AAV)的基石, 但激素相关不良反应, 尤其是感染会导致AAV不良预后。如何更精准地应用激素治疗AAV, 在保证疗效的同时尽可能减少副作用是临床实践的难点, 亦是近... 详细信息

目前糖皮质激素(以下简称激素)仍是治疗抗中性粒细胞胞质抗体相关性血管炎(AAV)的基石, 但激素相关不良反应, 尤其是感染会导致AAV不良预后。如何更精准地应用激素治疗AAV, 在保证疗效的同时尽可能减少副作用是临床实践的难点, 亦是近年国际AAV指南关注及更新的重点。本文结合近年国际AAV指南关于激素治疗AAV, 尤其是肉芽肿性多血管炎和显微镜下多血管炎的更新, 强调诱导缓解期快速激素减量、维持期尽量减停激素及预防感染(尤其是肺孢子虫病)的理念, 并提出未来激素治疗的趋势(如低剂量诱导缓解, 甚至无激素诱导及维持缓解)及目前激素治疗尚待解决的问题(如激素冲击的指征、具体剂量)。

关键词：抗中性粒细胞胞质抗体相关性血管炎治疗糖皮质激素类感染

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Oncogenic MORC2 in cancer development and beyond

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Genes & Diseases 2024年第2期11卷 861-873页

作者： Shan Zhang Ayao Guo Huan Wang Jia liu Chenshuang Dong Junyi Ren Guiling Wang Key Laboratory of Cell Biology Department of Cell BiologyMinistry of Public Health and Key Laboratory of Medical Cell BiologyMinistry of EducationChina Medical UniversityShenyangLiaoning 110122China Department of Breast Surgery The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110001China

Microrchidia CW-type zinc finger 2(MORC2)is a member of the MORC superfamily of nuclear *** evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of downstream oncogenes or tumor *** present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target *** systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future.

关键词： Cancer development Hallmarks of cancer MORC2 Therapeutic target Treatment resistance

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Polyethylene glycol (PEG) as a benign solvent for Knoevenagel condensation

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Chinese Chemical Letters 2008年第9期19卷 1043-1046页

作者： Yang liu Jun liang Xiu Hong liu Ji Cai Fan zhi Cai Shang Department of Chemistry Zhejiang University Hangzhou 310027 China

The Knoevenagel condensation of aromatic aldehydes with active methylene compound proceeded efficiently in polyethylene glycol at room temperature with L-proline as catalyst. The yield is high and the products had E-isomer dominantly. Polyethylene glycol containing L-proline could be recycled and reused for several times without noticeably decreasing in productivity.

关键词： Polyethylene glycol L-Proline Knoevenagel condensation

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Spatiotemporal evolution and assembly processes of ammonia-oxidizing prokaryotic communities in 1 000-year-old coastal reclaimed soils

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Pedosphere 2024年第4期34卷 709-725页

作者： Sarfraz HUSSAIN Yifan YIN Senlin liu Shanshan YAN Dongjie CHEN Hui CAO Feng WANG Key Laboratory of Agricultural Environmental Microbiology Ministry of Agriculture and Rural AffairsCollege of Life SciencesNanjing Agricultural UniversityNanjing 210095China Institute of Eco-Environmental Sciences Ningbo Academy of Agricultural SciencesNingbo 315040China

Coastal marshes are transitional areas between terrestrial and aquatic *** are sensitive to climate change and anthropogenic *** recent decades,the reclamation of coastal marshes has greatly increased,and its effects on microbial communities in coastal marshes have been studied with great *** of these studies have explained the short-term spatiotemporal variation in soil microbial community ***,the impact of reclamation on the community composition and assembly processes of functional microbes(e.g.,ammonia-oxidizing prokaryotes)is often *** this study,using quantitative polymerase chain reaction and the Ion S5™XL sequencing platform,we investigated the spatiotemporal dynamics,assembly processes,and diversity patterns of ammonia-oxidizing prokaryotes in 1000-year-old reclaimed coastal salt *** taxonomic and phylogenetic diversity and composition of ammonia oxidizers showed apparent spatiotemporal variations with soil *** null modelling-based analysis showed that across all sites,the archaeal ammonia-oxidizing community was assembled by a deterministic process(84.71%),and deterministic processes were also dominant(55.2%)for ammonia-oxidizing bacterial communities except for communities at 60 years of *** assembly process and nitrification activity in reclaimed soils were positively *** abundance of the amoA gene and changes in ammonia-oxidizing archaeal and bacterial diversities significantly affected the nitrification activity in reclaimed *** findings suggest that long-term coastal salt marsh reclamation affects nitrification by modulating the activities of ammonia-oxidizing microorganisms and regulating their community structures and assembly *** results provide a better understanding of the effects of long-term land reclamation on soil nitrogen-cycling microbial communities.

关键词： ammonia oxidizer beta nearest taxon index coastal salt marshes community assembly deterministic process nitrification rate stochastic process

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Drivers of spatial structure in thinned forests

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Forest Ecosystems 2024年第2期11卷 202-213页

作者： Zichun Wang Yaoxiang Li Guangyu Wang Zheyu Zhang Ya Chen Xiaoli liu Rundong Peng College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin150040China Department of Forest Resources Management University of British ColumbiaVancouverCanada

Background:As is widely known,an increasing number of forest areas were managed to preserve and enhance the health of forest ***,previous research on forest management has often overlooked the importance of ***:Our objectives were to define the direction of structure-based forest ***,we investigated the relationships between forest structure and the regeneration,growth,and mortality of trees under different thinning ***,the drivers of forest structural change were ***:On the basis of 92 sites selected from northeastern China,with different recovery time (from 1 to 15years) and different thinning intensities (0–59.9%) since the last *** component analysis (PCA)identified relationships among factors determining forest spatial *** structural equation model (SEM)was used to analyze the driving factors behind the changes in forest spatial structure after ***:Light thinning (0–20%trees removed) promoted forest regeneration,and heavy thinning (over 35% of trees removed) facilitated forest ***,only moderate thinning (20%–35%trees removed) created a reasonable spatial *** dead trees were clustered,and they were hardly affected by thinning ***,thinning intensity,recovery time,and altitude indirectly improve the spatial structure of the forest by influencing diameter at breast height (DBH) and canopy ***:Creating larger DBH and canopy area through thinning will promote the formation of complex forest structures,which cultivates healthy and stable forests.

关键词： Thinning Natural secondary forest Spatial structure Dynamic changes Growth factors Structural equation modeling

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The Caching and Pricing Strategy for Information-Centric Networking with Advertisers’Participation

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China Communications 2024年第3期21卷 283-295页

作者： Zheng Quan Yan Wenliang Wu Rong Tan Xiaobin Yang Jian Yuan liu Xu Zhenghuan Laboratory for Future Networks Department of AutomationUniversity of Science and Technology of ChinaHefei 230026China Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefei 230088China Institute of Advanced Technology University of Science and Technology of ChinaHefei 230088China Suzhou Nuclear Power Research Institute Suzhou 215004China National Engineering Laboratory for Public Safety Risk Perception and Control by Big Data(NEL-PSRPC) China Academy of Electronics and Information Technology of CETCBeijing 100041China

As users’access to the network has evolved into the acquisition of mass contents instead of IP addresses,the IP network architecture based on end-to-end communication cannot meet users’***,the Information-Centric Networking(ICN)came into *** a technical point of view,ICN is a promising future network *** and customizing a reasonable pricing mechanism plays a positive role in promoting the deployment of *** current research on ICN pricing mechanism is focused on paid ***,we study an ICN pricing model for free content,which uses game theory based on Nash equilibrium to *** this work,advertisers are considered,and an advertiser model is established to describe the economic interaction between advertisers and ICN *** solution can formulate the best pricing strategy for all ICN entities and maximize the benefits of each *** extensive analysis and numerical results show that the proposed pricing framework is significantly better than existing solutions when it comes to free content.

关键词： advertisers cache free content Information-Centric Networking pricing strategy

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In-situ analysis and genetic investigation of Li-bearing minerals in McDermitt clay-type lithium deposit,Nevada,USA

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Acta Geochimica 2024年第3期43卷 478-488页

作者： Yi Cui Hanjie Wen Zhengbing Zhou Kunyue Ling Lin Xu Shirong liu Fei Xu School of Earth Sciences East China University of TechnologyNanchang 330013China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China School of Earth Sciences and Resources Chang’an UniversityXi’an 710054China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China State Key Laboratory of Environmental Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China

Clay-type Li deposits are poised to play a pivotal role in addressing the surging global demand for *** McDermitt clay-type Li deposit,located in Nevada,is the largest Li deposit in the United States,with Li hosted by a clay-rich sequence of smectite-dominated intervals and illite-dominated intervals,***,the occurrence of Li and the genesis of Li-bearing minerals within smectite-dominated intervals have not been thoroughly investigated in previous ***,we studied the mineralogy,the in-situ Li distribution,and the bonding environments of Li within the smectite intervals using a combination of instru-mental techniques including scanning electron microscope,transmission electron microscope,time-of-flight secondary ion mass spectrometry,and nuclear magnetic *** results indicate that the smectite exhibits low crystallinity characteristics of lacustrine clay authigenesis and is com-monly found tofill the interstices among volcanic minerals or envelop them;Li is mainly hosted by Mg-smectite rather than the volcanic *** the tuffaceous sediment samples,the volcanic glass has undergone a transformation,resulting in its complete disappearance and alteration into clay *** to the octahedral sites of Mg-smectite bounded in Li,it is referred to be *** interpret that the hectorite’s precipitation occurs in a high saline-alkaline water environment,a result of McDermitt *** conclusion can be supported by the coexistence of spherulitic calcite and ***,this study confirms hectorite as the main Li-bearing mineral and increases the understanding of the genetic model of hectorite formation in intracontinental caldera basins.

关键词： McDermitt caldera Lithium occurrence Tuffaceous sediments Mineralogy Hectorite neoformation

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Haploidentical hematopoietic cell transplantation with or without an unrelated cord blood unit for adult acute myeloid leukemia:a multicenter,randomized,open-label,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2669-2678页

作者： Biqi Zhou Jia Chen Tianhui liu Yishan Ye Yanming Zhang Yiyang Ding Hong liu MingQing Zhu Xiao Ma Xiaoli Li Longfei Zhao zhihong Lin He Huang Yang Xu Depei Wu National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhouChina Institute of Blood and Marrow Transplantation Collaborative Innovation Center of HematologySoochow UniversitySuzhouChina Bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Department of Hematology The Affiliated Huai’an Hospital of Xuzhou Medical University and The Second People’s Hospital of Huai’anHuai’anChina Soochow Hopes Hematology Hospital SuzhouChina Department of Hematology Hygeia Suzhou Yongding HospitalSuzhouChina

Coinfusion of unrelated cord blood(UCB)units in haploidentical hematopoietic cell transplantation(haplo-HCT)(haplo-cord HCT)for hematopoietic malignancies showed promising results in previous reports,but the efficiency of haplo-cord HCT in acute myeloid leukemia(AML)still lacks sufficient *** multicenter,randomized,phase 3 trial(*** NCT03719534)aimed to assess the efficacy and safety of haplo-cord HCT in AML patients.A total of 268 eligible patients aged 18-60 years,diagnosed with measurable residual disease in AML(excluding acute promyelocytic leukemia),with available haploidentical donors and suitable for allotransplantation,were randomly allocated(1:1)to receive haplo-cord HCT(n=134)or haplo-HCT(n=134).The 3-year overall survival(OS)was the primary endpoint in this *** median follow-up was 36.50 months(IQR 24.75-46.50).The 3-year OS of Haplo-cord HCT group was better than haplo-HCT group(80.5%,95%confidence interval[CI]:73.7-87.9 vs.67.8%95%CI 60.0-76.5,p=0.013).Favorable progression-free survival(70.3%,95%CI 62.6-78.8 vs.57.6%,95%CI 49.6-67.0,p=0.012)and cumulative incidence of relapse(12.1%,95%CI 12.0-12.2 vs.30.3%,95%CI 30.1-30.4,p=0.024)were observed in haplo-cord HCT *** 3-4 adverse events(AEs)within two years posttransplantation in the two groups were ***-cord HCT patients exhibited a faster cumulative incidence of neutrophil recovery(p=0.026)and increased T-cell reconstitution in the early period ***-cord HCT can improve OS in AML patients without excessive AEs,which may exert additional benefits for recipients of haplo-HCT.

关键词： hematopoietic acute phase

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