检索结果-南通市图书馆

Rare Metals 2019年第11期38卷 1070-1077页

作者： zhi-li hu Qiu Pang Ming-liang Dai hubei Key Laboratory of Advanced Technology of Automobile Components Wuhan University of TechnologyWuhan 430070China hubei Collaborative Innovation Center for Automotive Components Technology Wuhan University of TechnologyWuhan 430070China School of Mechanical and Electrical Engineering Wuhan Donghu UniversityWuhan 430212China

Zigzag line is a common defect in friction stir welding(FSW) *** formation mechanism of the zigzag line in Al-Cu alloy FSW joint and its influence on the microstructure and mechanical properties during post weld heat treatment(PWHT) were studied by scanning electron microscopy(SEM),microhardness and tensile *** is found that the occurrence of zigzag line for PWHT joint is determined by PWHT process which in nature depends on residual stress and thermal stress of FSW *** optimization of PWHT process to reduce the residual and thermal stress can trigger for the deterioration of mechanical properties of PWHT joints with zigzag *** obvious decrease of tensile properties is observed for T6-450 and T6-495 joints although zigzag line appears in the *** determines the sizes of zigzag line cracks and consequently determines the fracture location and characteristics of FSW joint.

关键词： Friction stir welding Post weld heat treatment Zigzag line Mechanical properties

Mechanical behaviors and energy absorption properties of Y/Cr and Ce/Cr coated open-cell nickel-based alloy foams

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2018年第8期37卷 650-661页

作者： zhi-li hu Qiu Pang Guo-Qiang Ji Gao-hui Wu State Key Laboratory of Advanced Welding and Joining HarbinInstitute of TechnologyHarbin 150001China hubei Key Laboratory of Advanced Technology of Automobile Components Wuhan University of TechnologyWuhan 430070China School of Mechanical and Electrical Engineering Wuhan Donghu UniversityWuhan 430212China Materials Test Department China National Analytical CenterGuangzhou 510070China

In this study, Y-and Ce-modified Cr coatings applied by pack cementation method were prepared on the surface of open-cell nickel-based alloy foam. The morphologies and microstructures of Y- and Ce-modified Cr coatings with various Y and Ce contents were investigated in detail. Then, the effects of Y and Ce addition on the mechanical properties of open-cell nickel-based alloy foams were analyzed and compared. Simultaneously, the energy absorption capacity and energy absorption efficiency of the Y- and Ce-modified Cr coated alloy foams were discussed and compared at the room and high temperatures. The results show that Cr coatings containing minor amounts of rare earth element （Y and Ce） are well adhered to the nickel-based foam struts. Especially, the microstructure of the 2 wt% Ce-modified Cr coating is denser and uniform. In addition, the compressive strength and plateau stress of Y- and Ce-modified Cr coated alloy foams firstly increase and then decrease by increasing the Y and Ce contents at room and high temperatures. The energy absorption capacity of Y/Cr and Ce/Cr coated alloy foams increases linearly with the strains increasing. The Ce/Cr coated alloy foams can absorb more energy than Y/Cr coated alloy foams in the plateau and densification regions at room temperature. Compared to those at room temperature, the Y- and Ce-modified Cr coated alloy foams show higher energy absorption efficiency when deforma- tion within 10%-30% at high temperature.

关键词： Open-cell nickel-based alloy foam Y-modified Cr coating Ce-modified Cr coating Pack cementation Mechanical properties

A new integrated model of deformation resistance and its application in prediction of rolling force of a thick plate

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第4期31卷 882-893页

作者： Shun-hu Zhang Yan li li-zhi Che Wen-hao Tian Shagang School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

The prediction accuracy of existing models of the rolling force of a thick plate is always very *** address this problem,a high-precision genetic algorithm-backpropagation network(GA-BP)model of deformation resistance was built,and its integration with the traditional fitted model was further ***,a novel rolling force model was obtained by embedding the integration model of deformation resistance in the original model of rolling *** to this research idea,the industrial data are normalized at *** this basis,the interactions among the process parameters were disclosed through the variance analysis,and then described by various virtual *** factors are set as part of input ***,the optimal structure of the GA-BP model of deformation resistance was determined and an integration model of deformation resistance was ***,a novel rolling force model is obtained by substituting the traditional fitted deformation resistance into the Sims model with the integration model of the deformation *** results proves that the introduction of virtual factors can increase the hit rate of±5%from 75.8%to 78%and can reduce the root mean square error from 4.72%to 4.48%.Besides,it is found that the mean relative error of the traditional fitted deformation resistance is 0.142,while that of the modified deformation resistance is only *** addition,the mean relative error in the original rolling force model is 0.145,while that of the present model is only 0.03.

关键词： Integration model-Deformation resistance Variance analysis Virtual factor Genetic algorithm-backpropagation network model

Antitumor Effect of Apcin on Endometrial Carcinoma via p21-Mediated Cell Cycle Arrest and Apoptosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第3期44卷 623-632页

作者： Ke NI Zi-li li zhi-yong hu li HONG Department of Obstetrics and Gynecology Renmin Hospital of Wuhan UniversityWuhan430060China Institute of Reproductive Health Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Endometrial carcinoma(EC)is a prevalent gynecological malignancy characterized by increasing incidence and mortality *** underscores the critical need for novel therapeutic *** such potential target is cell division cycle 20(CDC20),which has been implicated in *** study investigated the effect of the CDC20 inhibitor Apcin on EC and elucidated the underlying mechanism *** The effects of Apcin on EC cell proliferation,apoptosis,and the cell cycle were evaluated using CCK8 assays and flow *** sequencing(RNA-seq)was subsequently conducted to explore the underlying molecular mechanism,and Western blotting and coimmunoprecipitation were subsequently performed to validate the *** studies were performed to evaluate the antitumor effects in *** analysis was also conducted to identify CDC20 as a potential therapeutic target in *** Treatment with Apcin inhibited proliferation and induced apoptosis in EC cells,resulting in cell cycle *** associated with apoptosis and the cell cycle were activated following treatment with ***,Apcin treatment led to the upregulation of the cell cycle regulator p21,which was verified to interact with CDC20 and consequently decrease the expression of downstream cyclins in EC *** vivo experiments confirmed that Apcin treatment significantly impeded tumor *** CDC20 expression was observed in EC tissue than in nonmalignant tissue,and increased CDC20 expression in EC patients was associated with shorter overall survival and progress free *** CDC20 is a novel molecular target in EC,and Apcin could be developed as a candidate antitumor drug for EC treatment.

关键词： endometrial carcinoma CDC20 apoptosis cell cycle arrest p21 BBC3

Metal/covalent organic frameworks for aqueous rechargeable zinc-ion batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第1期67卷 247-259页

作者： hu Hong Xun Guo Jiaxiong Zhu Zhuoxi Wu Qing li Chunyi zhi Department of Materials Science and Engineering City University of Hong KongHong Kong 999077China

lithium-ion batteries(liBs)have become one of the most successful energy storage systems due to their high operating voltage,high energy density,and long cycle ***,with the widespread use of liBs in recent decades,lithium resources are at risk of being ***,it is necessary to find a substitute for liBs to meet the needs of future large-scale energy storage *** of their competitiveness,low cost,and high safety,aqueous rechargeable zinc-ion batteries(ARZIBs)are regarded as promising components in the post-lithium-ion-battery *** the tunable composition,ordered porous channels,and controllable structure of metal-organic frameworks(MOFs)and covalent organic frameworks(COFs),these frameworks are viewed as potential materials for developing high-performance *** this review,we focus on the recent developments in the applications of MOF-/COF-based materials in ARZIBs,including in electrode materials,anode modifications,separators,and solid *** then focus on the critical factors and optimization techniques of MOF-/COF-based materials that affect the performance of ***,we conclude with some projections for the expansion of ARZIBs containing MOF-/COF-based materials.

关键词： metal/covalent organic frameworks aqueous zinc-ion batteries electrode materials anode modifications separators electrolytes

Production of CCHF Virus-like Particle by a Baculovirus-Insect Cell Expression System

在线全文

学校读者我要写书评

暂无评论

Virologica Sinica 2011年第5期26卷 338-346页

作者： Zhao-rui Zhou Man-li Wang Fei Deng Tian-xian li zhi-hong hu hua-lin Wang State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China

Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is a tick-born virus of the Nairovirus genus within the Bunyaviridae family,which is widespread and causes high *** nucleocapsid of CCHFV is comprised of N proteins that are encoded by the S *** this research,the N protein of CCHFV was expressed in insect cells using a recombinant *** an electron microscope,Virus-like Particles (VLPs) with various size and morphology were observed in cytoplasmic vesicles in the infected ***-gradient purification of the cell lysate indicated that the VLPs were mainly located in the upper fraction after ultracentrifugation,which was confirmed by Western blot analysis and immuno-electron microscopy (IEM).

关键词： Crimean-Congo hemorrhagic fever virus (CCHFV) Virus-like Particle (VLP) Nucleocapsid (N)protein

The role of lipid metabolism in osteoporosis:Clinical implication and cellular mechanism

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第4期11卷 220-233页

作者： Jing Zhang Wenhui hu zhi Zou Yuheng li Fei Kang Jianmei li Shiwu Dong College of Bioengineering Chongqing UniversityChongqing 400044China Department of Biomedical Materials Science College of Biomedical EngineeringArmy Medical University(Third Military Medical University)Chongqing 400038China State Key Laboratory of Trauma and Chemical Poisoning Army Medical University(Third Military Medical University)Chongqing 400038China

In recent years,researchers have become focused on the relationship between lipids and bone metabolism ***,many diseases related to lipid metabolism dis-orders,such as nonalcoholic fatty liver disease,atherosclerosis,obesity,and menopause,are associated with osteoporotic *** has been clinically observed in humans that these lipid metabolism disorders promote changes in osteoporosis-related indicators bone mineral density and bone ***,similar osteoporotic phenotype changes were observed in high-fat and high-cholesterol-induced animal *** lipid metabolism(such as increased oxidized lipids and elevated plasma cholesterol)affects bone microenvironment ho-meostasis via cross-organ communication,promoting differentiation of mesenchymal stem cells to adipocytes,and inhibiting commitment towards ***,disturbances in lipid metabolism affect the bone metabolism balance by promoting the secretion of cyto-kines such as receptor activator of nuclear factor-kappa B ligand by osteoblasts and stimulating the differentiation of ***,this review addresses the possible link be-tween lipid metabolism disorders and osteoporosis and elucidates the potential modulatory mechanisms and signaling pathways by which lipid metabolism affects bone metabolism *** also summarize the possible approaches and prospects of intervening lipid meta-bolismforosteoporosistreatment.

关键词： Bone homeostasis Cross-organ communication lipid metabolism Osteoclast Osteoporosis

Tetraethylenepentamine-functionalized magnetic mesoporous composites as a novel adsorbent for the removal Cr(Ⅲ)-ethylenediaminetetraacetic acid in complex solution

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第4期68卷 16-26页

作者： zhi hu Jiahong Wang Tongtong Sun School of Environmental Science and Engineering Shaanxi University of Science&TechnologyXi'an 710021China Shaanxi Key Laboratory of Green Preparation and Functionalization of Inorganic Materials Xi'an 710021China

A novel tetraethylenepentamine(TEPA) functionalized magnetic mesoporous silica adsorbent(FNMs/TEPA) was prepared for the adsorption of Cr(Ⅲ)-ethylenediaminetetraacetic acid(EDTA)from wastewater. The characterization of the prepared adsorbent certified that TEPA was modified onto the magnetic mesoporous silicon(FNMs), while FNMs/TEPA maintained the ordered mesoporous and pristine magnetic properties. The batch adsorption experiments demonstrated that TEPA significantly enhanced the removal capacity of the adsorbent for Cr(Ⅲ)-EDTA. FNMs/TEPA exhibited an excellent adsorption property(13.84 mg·g-1) at p H 4.0. Even in the presence of high concentrations of coexisting ions and organic acids, the adsorption performance of FNMs/TEPA was stable. Experimental characterization and DFT demonstrated that the adsorption of Cr(Ⅲ)-EDTA was ascribed to the electrostatic interaction, hydrogen bonding, and complexation between Cr(Ⅲ)-EDTA and amino groups on the adsorbent surface. The analysis of the independent gradient model(IGM) shows that electrostatic interaction is the main mode of action in the adsorption process. Moreover, FNMs/TEPA demonstrated remarkable reusability in three regeneration cycles. These findings indicated that FNMs/TEPA possessed excellent application prospects in the disposal of wastewater containing Cr(Ⅲ)-EDTA.

关键词： TEPA functionalized magnetic mesoporous silicon Adsorption Cr(III)-EDTA Density functional theory calculations

在线全文

学校读者我要写书评

暂无评论

整车湿热环境下大气暴露试验失效问题分析

环境技术 2024年第1期42卷 42-46页

作者：冯拓李秋魁李志虎贺丽丽张浩悦王旭昕晋飞合众新能源汽车股份有限公司嘉兴314500

汽车内外饰使用了大量的高分子材料,由于材料本身分子结构存在一些弱点,在综合环境(光、热、水和氧气等)因素作用下,易产生老化问题。为提高整车内外饰零部件的老化性能,本文通过对多款车型的大气暴露试验问题进行了分类,对失效原因进... 详细信息

汽车内外饰使用了大量的高分子材料,由于材料本身分子结构存在一些弱点,在综合环境(光、热、水和氧气等)因素作用下,易产生老化问题。为提高整车内外饰零部件的老化性能,本文通过对多款车型的大气暴露试验问题进行了分类,对失效原因进行了分析,并提出从标准要求、材料选型、试验验证、开发流程、生产过程的一致性等各个方面进行质量管控的措施。

关键词：大气暴露试验湿热环境老化失效分析

Learning Sequential and Structural Dependencies Between Nucleotides for RNA N6-Methyladenosine Site Identification

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第10期11卷 2123-2134页

作者： Guodong li Bowei Zhao Xiaorui Su Dongxu li Yue Yang zhi Zeng Lun hu Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of ScienceUrumqi 830011China College of Computer Xi’an Jiaotong UniversityXi’an 710049China IEEE

N6-methyladenosine(m6A)is an important RNA methylation modification involved in regulating diverse biological processes across multiple ***,the identification of m6A modification sites provides valuable insight into the biological mechanisms of complex diseases at the post-transcriptional *** a variety of identification algorithms have been proposed recently,most of them capture the features of m6A modification sites by focusing on the sequential dependencies of nucleotides at different positions in RNA sequences,while ignoring the structural dependencies of nucleotides in their threedimensional *** overcome this issue,we propose a cross-species end-to-end deep learning model,namely CR-NSSD,which conduct a cross-domain representation learning process integrating nucleotide structural and sequential dependencies for RNA m6A site ***,CR-NSSD first obtains the pre-coded representations of RNA sequences by incorporating the position information into single-nucleotide states with chaos game representation *** then constructs a crossdomain reconstruction encoder to learn the sequential and structural dependencies between *** minimizing the reconstruction and binary cross-entropy losses,CR-NSSD is trained to complete the task of m6A site *** experiments have demonstrated the promising performance of CR-NSSD by comparing it with several state-of-the-art m6A identification ***,the results of cross-species prediction indicate that the integration of sequential and structural dependencies allows CR-NSSD to capture general features of m6A modification sites among different species,thus improving the accuracy of cross-species identification.

关键词： Cross-domain reconstruction cross-species prediction N6-methyladenosine(m6A)modification site RNA sequence sequential and structural dependencies