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High Speed Sintering:Assessing the Influence of Energy Input on Microstructure and Mechanical Properties of Polyether Block Amide(PEBA)Parts

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Chinese Journal of Polymer Science 2024年第5期42卷 675-682,I0004,I0010页

作者： Jiang-Tao Sun zhi-Yong Fan Yi-Wei Mao Wei Li Wei Zhu Dao-Sheng Cai Qing-song Wei State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074China State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430074China National Engineering Research Centre for High Efficiency Grinding Hunan UniversityChangsha410082China Wuhan EasyMFG Technology CO. LTDWuhan430074China

High speed sintering,a new powder-bed fusion additive manufacturing technology,utilizes infrared lights(IR)to intensely heat and melt polymer *** presence of defects such as porosity,which is associated with particle coalescence,is highly dependdent on the level of energy *** study investigate the influcence of energy input on porosity and its subsequent effects on the mechanical properties and microstructures of PEBA *** parts were manufactured with a variety of lamp powers,resulting in a range of energy input levels spanning from low to ***,they underwent testing using Archimedes’method,followed by tensile *** porosity,mechanical characteristics,and energy input exhibit a strong correlation;inadequate energy input was the primary cause of pore *** the reduced IR light power resulted in the following outcomes:porosity,ultimate tensile strength,and elongation of 1.37%,7.6 MPa,and 194.2%,*** the energy input was further increased,the porosity was reduced to as low as 0.05%and the ultimate tensile strength and elongation were increased to their peak values of 233.8%and 9.1 MPa,respectively.

关键词： High speed sintering Additive manufacturing Energy input Powder bed fusion PEBA

Tuning microstructures of TC4 ELI to improve explosion resistance

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Defence Technology（防务技术） 2024年第3期33卷 78-99页

作者： Changle Zhang Yangwei Wang Lin Wang Zixuan Ning Guoju Li Dongping Chen zhi-Wei Yan Yuchen song Xucai Wang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China National Key Laboratory of Science and Technology on Materials under Shock and Impact Beijing 100081China State Key Laboratory of Explosive Science and Technology Beijing Institute of TechnologyBeijing 100081China Aerospace Information Research Institute Chinese Academy of SciencesBeijing 100094China School of Aeronautical Engineering Zhengzhou University of AeronauticsHenan ProvinceZhengzhou 450046China Shanxi Jiangyang Chemical Co. Ltd.Shanxi ProvinceTaiyuan 030041China Shandong Institute of Non-metallic Materials Shandong ProvinceJinan 250031China

A reasonable heat treatment process for TC4 ELI titanium alloy is crucial to tune microstructures to improve its explosion ***,there is limited investigation on tuning microstructures of TC4 ELI to improve explosion ***,the current challenge is quantifying microstructural changes'effects on explosion resistance and incorporating microstructural changes into finite element *** work aims to tune microstructures to improve explosion resistance and elucidate their anti-explosion mechanism,and find a suitable method to incorporate microstructural changes into finite element *** this work,we systematically study the deformation and failure characteristics of TC4 ELI plates with varying microstructures using an air explosion test and LS-DYNA finite element *** Johnson-Cook(JC)constitutive parameters are used to quantify the effects of microstructural changes on explosion resistance and incorporate microstructural changes into finite element *** of the heat treatment,one plate has equiaxed microstructure and the other has bimodal *** convex of the plate after the explosion has a quadratic relationship with the charge mass,and the simulation results demonstrate high reliability,with the error less than 17.5%.Therefore,it is feasible to obtain corresponding JC constitutive parameters based on the differences in microstructures and mechanical properties and characterize the effects of microstructural changes on explosion *** bimodal target exhibits excellent deformation *** response of bimodal microstructure to the shock wave may be more intense under explosive *** well-coordinated structure of the bimodal target enhances its resistance to deformation.

关键词： Microstructure Finite element modelling Parameter optimization Failure characteristics Explosion resistance

Mental retardation,seizures and language delay caused by new SETD1B mutations:Three case reports

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World Journal of Clinical Cases 2024年第2期12卷 383-391页

作者： Le Ding Li-Wan Wei Tai-song Li jing Chen Department of Neurology Children’s Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Chigene(Beijing)Translational Medical Research Center Co.Ltd.Beijing 101111China

BACKGROUND The SETD1B gene is instrumental in human intelligence and nerve *** in the SETD1B gene have been linked in recent studies to neurodevelopmental disorders,seizures,and language *** SUMMARY This study aimed to analyze the clinical manifestations and treatment of three patients suffering from mental retardation,epilepsy,and language delay resulting from a new mutation in the SETD1B *** individuals with these symptoms were selected,and their clinical symptoms,gene test results,and treatment were *** article discusses the impact of the SETD1B gene mutation on patients and outlines the treatment *** the three patients(two females and one male,aged 8,4,and 1,respectively),all exhibited psychomotor retardation,attention deficit,and hyperactivity disorder,and two had *** treatment with sodium tripolyvalproate halted the seizures in the affected child,although mental development remained somewhat *** exome sequencing revealed new mutations in the SETD1B gene for all patients,specifically with c.5473C>T(***1825trp),c.4120C>T(***1374*,593),c.14_15insC(***5Hisfs*33).CONCLUSION Possessing the SETD1B gene mutation may cause mental retardation accompanied by seizures and language *** the exact mechanism is not fully understood,interventions such as drug therapy,rehabilitation training,and family support can assist patients in managing their symptoms and enhancing their quality of ***,genetic testing supplies healthcare providers with more precise diagnostic and therapeutic guidance,informs families about genetic disease risks,and contributes to understanding disease pathogenesis and drug research and development.

关键词： Neurodevelopmental disorder Seizure SETD1B gene Whole-exome sequencing New mutation Case report

Rheological study of methane gas hydrates in the presence of micron-sized sand particles

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Chinese Journal of Chemical Engineering 2024年第6期70卷 149-161页

作者： Bohui Shi Shangfei song Yuchuan Chen Shunkang Fu Lihao Liu Xinyao Yang Haihao Wu Guangjin Chen jing Gong National Engineering Research Center of Oil and Gas Pipeline Transportation Safety MOE Key Laboratory of Petroleum EngineeringBeijing Key Laboratory of Urban Oil and Gas Distribution TechnologyChina University of Petroleum-BeijingBeijing 102249China China's Oil and Gas Exploration and Development Company(CNODC) Beijing 100034China China National Petroleum Corporation Mozambique LDA MaputoMozambique PipeChina West East Pipeline Company Shanghai 200122China

Natural gas hydrates,intricate crystalline structures formed by water molecules and small gas molecules,have emerged as a significant and globally impactful clean energy ***,their commercial exploitation faces challenges,particularly operational disruptions caused by sand-related *** the rheological properties of hydrate slurry,especially in the presence of micron-sized sand particles,is imperative for ensuring the flow assurance of subsea hydrate *** study extensively investigates the rheological properties of sand-containing hydrate *** findings reveal that these slurries exhibit non-Newtonian fluid characteristics,including yield stress,thixotropy,and shear-thinning ***-like elastic features are observed in sand-containing hydrate slurries before yielding,transitioning to viscous behavior after *** with a minimal amount of sand,both static yield stress and yield strain experience substantial changes,correlating with the increase in sand *** research conclusively establishes the thixotropic nature of sand-hydrate slurries,where the viscosity decay rate is directly influenced by the shear *** insights aim to contribute comprehensively to the development of effective flow assurance strategies,ensuring the safe and stable operation of subsea hydrate exploitation.

关键词： Natural gas hydrate production Sand-containing hydrate slurries Yield stress Thixotropy Shear-thinning behavior

Prevalence of sensitization to weed pollens of Humulus scandens,Artemisia vulgaris,and Ambrosia artemisiifolia in northern China

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第3期14卷 240-246页

作者： Guo-dong HAO Yi-wu ZHENG Birgitte GJESING Xing-ai KONG jing-yuan WANG zhi-jing song Xu-xin LAI Nan-shan ZHONG Michael D.SPANGFORT Department of Allergy Tangshan Gongren Hospital Research Asia Pacific ALK-Abelló A/S State Key Laboratory of Respiratory Diseases Guangzhou Medical University

Objective:Weed pollens are common sources of allergens *** prevalence of weed pollen sensitization is not yet fully known in *** purpose of this study was to investigate the prevalence of sensitization to weed allergens from Artemisia,Ambrosia,and Humulus in northern ***:A total of 1144 subjects(aged from 5 to 68 years) visiting our clinic from June to October 2011 underwent intradermal testing using a panel of 25 allergen *** with positive skin responses to any pollen were further tested for their serum concentrations of IgE antibodies against Artemisia vulgaris,Ambrosia artemisiifolia,and Humulus scandens,and against the purified allergens,Art v 1 and Amb a ***:Of 1144 subjects,170 had positive intradermal reactions to pollen and 144 donated serum for IgE *** prevalence of positive intradermal responses to pollens of Artemisia sieversiana,Artemisia annua,***,and *** was 11.0%,10.2%,3.7%,and 6.6%,*** the intradermal positive subjects,the prevalence of specific IgE antigens to *** was 58.3%,to *** 14.7%,and to *** 41.0%.The prevalence of specific IgE antigens to the allergen Art v 1 was 46.9%,and to Amb a 1 was 11.2%.The correlation between the presence of IgE antibodies specific to *** and to the Art v 1 antigen was very *** with *** specific IgE also had *** specific IgE,but with relatively high levels of *** IgE *** were no correlations between the presence of IgE antibodies to *** and *** or to *** and ***:The intradermal prevalence of weed pollen sensitization among allergic subjects in northern China is about 13.5%.Correlations of specific IgE antibodies suggest that pollen allergens from Artemisia and Humulus are independent sources for primary sensitization.

关键词：临床医学诊断学实验室生物化学

Sensitizing photoactive metal-organic frameworks via chromophore for significantly boosting photosynthesis

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Chinese Chemical Letters 2024年第5期35卷 519-522页

作者： Lihua Ma song Guo zhi-Ming Zhang Jin-Zhong Wang Tong-Bu Lu Xian-Shun Zeng School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Institute for New Energy Materials and Low Carbon Technologies School of Material Science&EngineeringTianjin University of TechnologyTianjin 300384China

Photosensitization related to energy/electron transfer process is of great importance to natural ***,we proposed a promising strategy to improve the sensitizing ability of the typical photoactive MOFs(UiO-Ir)by engineering its metal coordination center with NBI(1,8-naphthalenebenzimidizole)*** resulting MOFs(UiO-Ir-NBI)exhibited a strong sensitizing ability for significantly boosting ***,the catalytic yield of 2-chloroethyl ethyl sulfoxide with UiO-Ir-NBI can reach 99%,over 6 times higher than that with UiO-Ir(16.4%).Moreover,UiO-Ir-NBI exhibited an excellent catalytic stability and a broad substrate tolerance,highlighting its great application *** investigations revealed that the strong visible light absorption,long excited state lifetime and efficient electron-hole separation of UiO-Ir-NBI greatly contributed to harvesting visible light and facilitating interface electron/energy transfer for efficient solar energy *** work provides a new horizon to boost photosythesis of MOFs by engineering their metal sensitizing centers at a molecular level.

关键词： Metal-organic framework Photocatalysis Excited state Strong visible absorption Iridium complex

Improving mathematical model of burden distribution and correcting chute angle to cope with fluctuation of stock line

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Journal of Iron and Steel Research(International) 2024年第2期31卷 342-356页

作者： Jian-sheng Chen Wen-guo Liu Hao Guo Wang Ding Qing-guo Xue jing-song Wang Hai-bin Zuo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China MCC Capital Engineering&Research Incorporation Limited Beijing100176China Hunan Valin Xiangtan Iron and Steel Co. Ltd.Xiangtan411101HunanChina

Accurate evaluations of the burden distribution are of critical importance to stabilize the operation of blast *** mathematical model and discrete element method(DEM)are two attractive methods for predicting burden *** on DEM,the initial velocities of the pellet,sinter,and coke were calculated,and the velocity attenuations of the above three particles between the burden and the chute were *** initial velocity and velocity attenuation were applied to a mathematical model for improving the ***,based on the improved model,a scheme for rectifying the chute angles was proposed to address the fluctuation of the stock line and maintain a stable burden *** validity of the scheme was confirmed via a stable burden distribution under different stock *** mathematical model has been successfully applied to evaluate the online burden distribution and cope with the fluctuation of the stock line.

关键词： Burden distribution Mathematical model Discrete element method Velocity attenuation Stock line fluctuation

Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 55-64页

作者： Xu-Yun Wang Wen-jing Xu Bo-Nan Li Tian-song Sun Wen Sheng Department of Andrology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Dermatology The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha410021China School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha410208China Andrology Laboratory Hunan University of Chinese MedicineChangsha410208China School of Rehabilitation Medicine and Health Care Hunan University of MedicineHuaihua418000China School of Traditional Chinese Medicine Hunan University of MedicineHuaihua418000China

Objective:To examine the effect of icariin plus curcumol on prostate cancer cells PC3 and elucidate the underlying ***:We employed the Cell Counting Kit 8 assay and colony formation assay to assess cell viability and *** expression was analyzed using monodansylcadaverine *** and Western blot analyses were used to evaluate protein expressions related to autophagy,pyroptosis,and the mTOR *** damage was examined using the lactate dehydrogenase ***,cathepsin B and NLRP3 were detected by ***:Icariin plus curcumol led to a decrease in PC3 cell proliferation and an enhancement of *** levels of LC3-Ⅱ/LC3-Ⅰand beclin-1 were increased,while the levels of p62 and mTOR were decreased after treatment with icariin plus *** changes were reversed upon overexpression of ***,3-methyladenine resulted in a decrease in inflammatory cytokines,pyroptosis-related protein levels,and lactate dehydrogenase concentration,compared to the icariin plus curcumol *** cathepsin B reversed the regulatory effects of icariin plus ***:Icariin plus curcumol demonstrates great potential as a therapeutic agent for castration-resistant prostate cancer by enhancing autophagy via the mTOR pathway and promoting pyroptosis mediated by cathepsin *** findings provide valuable insights into the molecular mechanisms underlying the therapeutic potential of icariin and curcumol for prostate cancer treatment.

关键词： Icariin Curcumol Autophagy mTOR Cathepsin B Pyroptosis Prostate cancer

X-ray excited Mn^(2+)-doped persistent luminescence materials with biological window emission for in vivo bioimaging

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Journal of Rare Earths 2024年第1期42卷 28-35,I0001页

作者： Hanrun Zheng Lin Liu Yi’ang Li Rui Rong Liang song Junpeng Shi jing Teng Xia Sun Yun Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China University of the Chinese Academy of Sciences Beijing100049China Xiamen Hospital of Traditional Chinese Medicine Xiamen361015China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China

In recent years,persistent luminescence materials(PLMs)excited by X-rays and emitting in biological windows have received extensive attention in the field of high-sensitivity *** metal Mn^(2+)is an ideal emission center,but few studies focus on Mn^(2+)-doped PLMs with X-ray excitation and biological window ***,we report a Mn^(2+)-doped PLM,LiYGeO_(4):Mn^(2+)(LYGM),with excellent biological window persistent luminescence *** excitation by UV,LYGM produces a durable biological window of persistent luminescence emission at 660 nm for up to 20 *** *** can be repeatedly excited by X-rays,resulting in long-term biological window persistent luminescence *** addition,we obtain LYGM around 200 nm in diameter by ball milling and centrifugation and improve its biocompatibility by surface modification to apply it to in vivo imaging in *** LYGM are injected into mice through the tail vein,in situ excitation of X-rays can be *** the persistent luminescence decays,LYGM can be re-excited for repeated ***,LYGM shows potential prospects for in vivo deep tissue and long-term bioimaging.

关键词： Persistent luminescence X-ray Biological window In vivo imaging Rare earths