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Enabling topical and long-term anti-radical properties for percutaneous coronary intervention-related complications by incorporating teMPOL into electrospun nanofibers

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Science China Materials 2021年第3期64卷 769-782页

作者： jian Lu Rui Wang li Shen Jiasheng yin Guilian liu Han Chen Fei Xu qilin Wu Changhuai ye Xiang Fei Junbo ge Meifang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInternational Joint Laboratory for Advanced Fiber and Low-dimension MaterialsDonghua UniversityShanghai201620China Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesShanghai200032China

Scavenging reactive oxygen species(ROS)by antioxidants has been demonstrated as the most effective strategy for preventing percutaneous coronary intervention(PCI)-related ***,topical and long-term delivery of ROS antioxidants to a specific vascular tissue is proven to be a great ***,an ROS scavenger of 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl(teMPOL)is incorporated into electrospun nanofibers with a tunable loading amount to achieve its topical applicability and long-term antiradical *** functions of such teMPOL-loaded electrospun membranes are evaluated by cell proliferation,ROS-scavenging capability,monocyte adhesion,cell migration,inflammatory molecule secretion and mRNA expression in *** optimizing the loading amount of teMPOL,such an electrospun membrane presents a superior ROS-scavenging and anti-inflammation performance for both endothelial cells and *** expression of endothelial prothrombogenic molecules and the migration of vascular smooth muscle cells(VSMCs)are also effectively ***,it is bravely predicted that the topical use of such a teMPOL-loaded electrospun system will be a promising pathway for the anti-restenosis therapy,especially when used as a novel coating on stent for long-term and topical delivery of antioxidant drugs.

关键词： percutaneous coronary interventions reactive oxygen species teMPOL electrospinning topical release

Implementation and research of integrated curriculum of immunology

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Medical Bulletin of Shanghai Jiaotong University 2015年第1期27卷 103-107页

作者： Guang-jie CHEN Xiao-yin NIU li-hua jianG ye-bin XI Hai-liang ge Department of Immunology and Microbiology Shanghai Jiao Tong University School of Medicine

In order to get adapted to the teaching reform in Shanghai Jiao Tong University School of Medicine,and promote the integration of the teaching of basic and clinical medicine for medical students,the integrated curriculum of host defense and immunity integrates medical immunology with the morphological structure and histogenesisof the immune system. In this paper,we focus on the different integration medical immunology curriculum in the world and our unique integrated immunology curriculum. This paper introduces the condition of host defense and immunity both at home and abroad and its status and role in the integrated curriculum system in School of Medicine,and summarizes the contents,experience and improvement measures for the implementation of host defense and immunity.

关键词： integrated curriculum immunology teaching reform

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796例大肠息肉的临床、内镜及病理观察

中南大学学报（医学版） 2005年第4期30卷 463-466页

作者：李伏娥叶红军李坚王俊萍刘永革余光银尹为华北京大学深圳医院消化内科深圳518036

目的:探讨大肠息肉患者的年龄,息肉的发生部位、大小和息肉的病理类型以及息肉癌变的相关规律.方法:对电子肠镜检查中检出的大肠息肉患者的临床表现、内镜及病理资料进行分析.结果:在7 276例肠镜检查患者中,发现大肠息肉796例,其中男性... 详细信息

目的:探讨大肠息肉患者的年龄,息肉的发生部位、大小和息肉的病理类型以及息肉癌变的相关规律.方法:对电子肠镜检查中检出的大肠息肉患者的临床表现、内镜及病理资料进行分析.结果:在7 276例肠镜检查患者中,发现大肠息肉796例,其中男性521例,女性275例,检出率10.94%;年龄30～69岁占82.29%;腺瘤性、炎性、增生性、幼年性息肉分别占43.84%,42.09%,11.06%,1.51%;息肉部位分别为盲肠3.29%、升结肠11.88%,横结肠4.89%,降结肠11.58%,乙状结肠26.05%,直肠42.32%.796例中有35例发生癌变,癌变率4.4%.绒毛状腺瘤、混合性腺瘤、管状腺瘤癌变率为29.73%,11.11%,4.86%;息肉直径≤0.5 cm,未发现癌变;0.6～1.0 cm,癌变率1.3%;1.1～1.9 cm,癌变率7.4%;≥2.0 cm,癌变率25.6%.结论:30～69岁大肠息肉发病率较高,男性较女性更易患大肠息肉;息肉好发部位为左半结肠;病理类型以腺瘤性息肉、炎性息肉较常见;左半结肠息肉、直径≥2.0 cm息肉、绒毛状腺瘤容易癌变;大肠息肉不论大小应尽可能予以切除,全瘤送检.内镜切除大肠息肉可预防息肉癌变.

关键词：大肠息肉内镜病理

基于Andersen模型探讨卒中二级预防药物依从性的影响因素

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现代预防医学 2022年第12期49卷 2293-2297+2304页

作者：赵燕李辉张吉玉邢立莹殷黎黄富林娄阁刘世炜内蒙古医科大学公共卫生学院公共卫生学系中国疾病预防控制中心控烟办公室宁波市疾病预防控制中心健康促进科山东省疾病预防控制中心慢性非传染性疾病防制所辽宁省疾病预防控制中心慢性非传染性疾病预防控制所湖南省疾病预防控制中心慢性非传染性疾病预防控制科北京市朝阳区疾病预防控制中心传染病与地方病控制科

目的分析卒中二级预防措施中药物治疗依从性的影响因素。方法基于Andersen卫生服务利用模型构建卒中二级预防药物依从性影响因素的理论框架，通过二分类logistic回归模型对卒中二级预防药物依从性的影响因素进行分析。结果 617名卒中... 详细信息

目的分析卒中二级预防措施中药物治疗依从性的影响因素。方法基于Andersen卫生服务利用模型构建卒中二级预防药物依从性影响因素的理论框架，通过二分类logistic回归模型对卒中二级预防药物依从性的影响因素进行分析。结果 617名卒中患者被纳入本次研究中，患者平均年龄（67±8.16）岁，男性占比50.1%，药物依从比为67.9%。多因素logistic回归模型结果显示，女性、参与城镇职工医疗保险、年均收入2万元以上与二级预防药物依从有关，年龄在70岁以上、有心脏病史和血脂异常病史、MRS评分25分与二级预防药物不依从有关。结论卒中二级预防药物依从性偏低，高龄、心脏病史、血脂异常史和较高MRS评分与药物不依从有关，应加强对具有上述影响因素的卒中患者提供预防性干预。

关键词： Andersen模型卒中二级预防药物依从性影响因素

Towards a global One Health index: a potential assessment tool for One Health performance

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Infectious Diseases of Poverty 2022年第3期11卷 12-26页

作者： Xiao-Xi Zhang Jing-Shu liu Le-Fei Han Shang Xia Shi-Zhu li Odel Yli Kokouvi Kassegne Min li Kun yin qin-qin Hu Le-Shan Xiu Yong-Zhang Zhu liang-yu huang Xiang-cheng Wang Yi Zhang Han-qing Zhao Jing-Xian yin Tian-ge jiang qin li Si-wei Fei Si-yu Gu Fu-Min Chen Nan Zhou Zi-Le cheng Yi Xie Hui-Min li Jin Chen Zhao-yu Guo Jia-Xin Feng lin Ai Jing-Bo Xue qian ye liz Grant Jun-Xia Song geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou School of Global Health Chinese Center for Tropical Diseases ResearchShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China One Health Center Shanghai Jiao Tong University-The University of EdinburghShanghaiPeople’s Republic of China National Institute of Parasitic Diseases at Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research) NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Centre for Tropical DiseasesShanghaiPeople’s Republic of China Shanghai Legislative Research Institute ShanghaiPeople’s Republic of China Zhuhai Branch ESPREBeijing Normal University Zhuhai CampusZhuhaiGuangdongPeople’s Republic of China Global Health Academy The University of EdinburghEdinburghUK Food and Agriculture Organization of the United Nations RomeItaly Global Academy of Agriculture and Food Systems The University of EdinburghEdinburghUK Swiss Tropical and Public Health Institute AllschwilSwitzerland University of Basel BaselSwitzerland

Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently ***:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the ***:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be ***:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the

关键词： Antimicrobial resistance Cell-like framework Climate change Food security Global One Health index(GOHI) Global performance assessment Governance Zoonotic diseases

凋亡相关基因的整合分析及基因表达芯片的制备

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生物化学与生物物理进展 2008年第12期35卷 1451-1460页

作者：黄茉莉孙道春娄雅欣尹燕斌李川昀张勇高歌王升启伯晓晨魏丽萍李松岗北京大学生物信息中心北京大学生命科学学院北京大学蛋白质工程和植物基因工程国家重点实验室北京100871 北京放射医学研究所北京100850 中国医学科学院肿瘤研究所肿瘤医院细胞和分子生物实验室北京100021

利用IPI和genBank,收集了与凋亡相关的5333条基因序列,用一定的标准,整合筛选得到1384个凋亡相关的基因.通过亚细胞定位、组织表达差异显著性分析、自然正义/反义RNA对预测、基因簇在pathway上的定位、蛋白质/蛋白质相互作用等方面的分... 详细信息

利用IPI和genBank,收集了与凋亡相关的5333条基因序列,用一定的标准,整合筛选得到1384个凋亡相关的基因.通过亚细胞定位、组织表达差异显著性分析、自然正义/反义RNA对预测、基因簇在pathway上的定位、蛋白质/蛋白质相互作用等方面的分析发现,一些基因只在一个组织里显著差异表达,一些基因存在自然正义/反义RNA对现象,一些基因簇同时位于多条pathway等重要信息.同时,制作了一张凋亡相关基因的寡核苷酸芯片,并且对于一对NAIF1表达质粒转染前后的HeLa样品,通过该芯片的筛选,得到24个差异表达的基因.发现NAIF1过表达诱导的细胞凋亡,伴随了PAX2、PDCD8、PDCD10、DFFA、CASP7等基因表达的显著变化,同时还发现,U58668,该mRNA没有任何基因或蛋白质的注释信息,当camptothecin诱导U937细胞系凋亡时上调,在这里的NAIF1过表达诱导的HeLa细胞系中也上调(上述数据结果见http://***:2005/chip).

关键词：凋亡生物信息 NAIF1 生物芯片

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透射法测量丰中子核~8He的去中子截面

高能物理与核物理 2007年第1期31卷 52-55页

作者：李琛叶沿林詹文龙肖国青徐瑚珊郭忠言王建松孙志宇李加兴王猛陈志强江栋兴郑涛华辉李智焕李湘庆葛愉成吴翠娥庞丹阳楼建玲卢飞范凤英北京大学技术物理系和教育部重离子物理重点实验室北京100871 中国科学院近代物理研究所兰州730000

利用HIRFL提供的50MeV／U ^13C束流轰击Be靶，通过RIBLL选择出丰中子放射性核8He．利用透射法测量了^8He的去双中子截面和去四中子截面．利用Ogawa等人的理论结合原有^8He的反应总截面数据，得到^8He的核芯为^8He的结论．

关键词：丰中子去双中子截面去四中子截面透射法

中能区丰中子核^(11)li的反应总截面的测量(英文)

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高能物理与核物理 2007年第12期31卷 1102-1105页

作者：李琛叶沿林詹文龙肖国青徐瑚珊郭忠言王建松孙志宇李加兴王猛陈志强江栋兴郑涛华辉李智焕李湘庆葛愉成庞丹阳楼建玲卢飞范凤英吕林辉北京大学技术物理系教育部重离子物理重点实验室北京100871 中国科学院近代物理研究所兰州730000

利用HIRFL提供的50MeV/u的^(13)C束流轰击Be靶,通过RIBLL选择出放射性核素^(11)li.实验采用透射法测量了25—45MeV/u的^(11)li在^(28)Si靶上的反应总截面.采用双参数Gauss密度分布形式,利用Glauber模型很好地拟合了高能和中能区的^(11)L... 详细信息

利用HIRFL提供的50MeV/u的^(13)C束流轰击Be靶,通过RIBLL选择出放射性核素^(11)li.实验采用透射法测量了25—45MeV/u的^(11)li在^(28)Si靶上的反应总截面.采用双参数Gauss密度分布形式,利用Glauber模型很好地拟合了高能和中能区的^(11)li实验数据,并从密度分布中提取了核的物质均方根半径.

关键词： Glauber模型透射法反应总截面

Consensus of clinical diagnosis and treatment for non-functional pancreatic neuroendocrine neoplasms with diameter<2 cm

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Journal of Pancreatology 2023年第3期6卷 87-95页

作者： Wu Wenming Cai Shouwang Chen Rufu Fu Deliang ge Chunlin Hao Chunyi Hao Jihui huang Heguang jian zhixiang Jin Gang li Fei li Haimin li Shengping li weiqin liYixiong liang Tingbo liu Xubao lou Wenhui Miao Yi Mou Yiping Peng chenghong qin Renyi Shao chenghao Sun Bei Tan Guang Wang Huaizhi Wang Lei Wang wei Wang weilin wei Junmin Wu Heshui Wu zheng yan Changqing yang yinmo yin Xiaoyu yu Xianjun yuan Chunhui Zhao yupei Department of general Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China Department of Hepatobiliary Surgery PLA General HospitalBeijing 100853China Department of general Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Pancreatic Surgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Department of Hepatobiliary and Pancreatic Surgery Hunnan Division of The First Hospital of China Medical UniversityShenyang 110167China Department of Hepato-Pancreato-Biliary Surgery Peking University Cancer Hospital&InstituteBeijing 100142China Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of general Surgery Fujian Medical University Union HospitalFuzhou 350001China Department of general Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510000China Department of Hepatobiliary Pancreatic Surgery Changhai Hospital Affiliated to Navy Medical University(Second Military Medical University)Shanghai 200433China Department of general Surgery Xuanwu HospitalCapital Medical UniversityBeijing 100053China Department of Hepatobiliary Surgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Hepatobiliary and Pancreatic Surgery Sun Yat-Sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060China Department of Critical Care Medicine Jinling HospitalMedical School of Nanjing UniversityNanjing 210002China Department of general Surgery Xiangya HospitalCentral South UniversityChangsha 410008China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department

In clinical practice,pancreatic neuroendocrine neoplasms(pNENs)with a diameter smaller than 2 cm are commonly referred to as small *** to their generally favorable biological characteristics,the diagnosis and treatment of small pNENs differ from other pNENs and are somewhat *** response to this,the Chinese Pancreatic Surgery Association,Chinese Society of Surgery,Chinese Medical Association have developed a consensus on the diagnosis and treatment of small pNENs,which is based on evidence-based medicine and expert *** consensus covers various topics,including concepts,disease assessment,treatment selection,follow-up,and other relevant aspects.

关键词： 2 cm Clinical diagnosis Non-functional pancreatic neuroendocrine neoplasms Treatment