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Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2038-2059页

作者： Xiang-Hui Wan Guo-Bing jin Qun Yang ji-Long Hu zhi-Liang Liu Jun Rao Can Wen Peng-Ling Li Xi-Mei Yang Bo huang Xiao-Zhong Wang jiangxi Medical College Nanchang UniversityNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina jiangxi Key Laboratory of Translational Research for Cancer Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Abdominal Surgery Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Pathology Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Science and Education Section Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Children’s HospitalNanchang 330006Jiangxi ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina jiangxi Province Key Laboratory of Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Heterogeneous ribonucleoprotein A1(hnRNPA1)has been reported to enhance the Warburg effect and promote colon cancer(CC)cell proliferation,but the role and mechanism of the miR-490-3p/hnRNPA1-b/PKM2 axis in CC have not yet been *** To investigate the role and mechanism of a novel miR-490-3p/hnRNPA1-b/PKM2 axis in enhancing the Warburg effect and promoting CC cell proliferation through the PI3K/AKT *** Paraffin-embedded pathological sections from 220 CC patients were collected and subjected to immunohistochemical analysis to determine the expression of *** relationship between the expression values and the clinicopathological features of the patients was *** in mRNA expression were analyzed using quantitative real-time polymerase chain reaction,while differences in protein expression were analyzed using western *** proliferation was evaluated using the cell counting kit-8 and 5-ethynyl-2’-deoxyuridine assays,and cell cycle and apoptosis were detected using flow cytometric *** targeted binding of miR-490-3p to hnRNPA1-b was validated using a dual luciferase reporter *** Warburg effect was evaluated by glucose uptake and lactic acid production *** The expression of hnRNPA1-b was significantly increased in CC tissues and cells compared to normal controls(P<0.05).Immunohistochemical results demonstrated significant variations in the expression of the hnRNPA1-b antigen in different stages of CC,including stage I,II-III,and ***,the clinicopathologic characterization revealed a significant correlation between hnRNPA1-b expression and clinical stage as well as T ***1-b was found to enhance the Warburg effect through the PI3K/AKT pathway,thereby promoting proliferation of HCT116 and SW620 ***,the proliferation of HCT116 and SW620 cells was inhibited when miR-490-3p targeted and bound to hnRNPA1-b,effectively blocking the Warburg ***

关键词： Heterogeneous ribonucleoprotein A1-b MiR-490-3p Colon cancer Alternative splicing Warburg effect

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Efficacy of Ganshuang granules(肝爽颗粒)on non-alcoholic fatty liver and underlying mechanism:a network pharmacology and experimental verification

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Journal of Traditional Chinese Medicine 2024年第1期44卷 122-130页

作者： zhi Guoguo SHAO Bingjie ZHENG Tianyan ji Shaoxiu LI jingwei DANG Yanni LIU Feng WANG Dong School of Basic Medicine Chengdu University of Traditional Chinese MedicineChengdu 611137China Shanxi Buchang Pharmaceutical Company LimitedXi’an 712000China

OBJECTIVE:To investigate the potential pharmacological mechanisms of Ganshuang granules(肝爽颗粒,GSG)in treating non-alcoholic fatty liver(NAFLD).METHODS:All the active components and targets of GSG were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis ***-Protein interaction network,Kyoto Encyclopedia of Genes and Genomes and Gene Ontology function annotation of common targets were analyzed to predict the mechanisms of action of GSG in the treatment of ***,the mouse models of NAFLD were constructed in a diet-induced manner and treated with *** levels of interleukin 6(IL-6),tumor necrosis factor-alpha(TNF-α)and phosphatidylinositol 3-kinase/protein kinase B(PI3K/AKT)pathway-related proteins in the liver of mice in each group were measured by enzyme linked immunosorbent assay and Western blot,***:Network pharmacology revealed a total of 159 potential targets of GSG for the treatment of *** enrichment analysis indicated that the PI3K/AKT signaling pathway may be involved during GSG treatment of *** experiments showed that the significantly decreased alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,total cholesterol,triglyceride and low-density lipoprotein cholesterol levels in NAFLD model mice serum after GSG treatment,as well as the expression levels of IL-6 and TNF-αin the ***,drug intervention increased the protein expression levels of phosphorylated-PI3K(P-PI3K)and P-AKT in the liver of the model group mice,and decreased the protein expression level of sterol regulatory element-binding protein ***:We found that GSG is effective in treating NAFLD and the potential therapeutic targets may be involved in PI3K/AKT signaling pathway.

关键词： fatty liver alcoholic network pharmacology models animal phosphatidylinositol 3-kinase proto-oncogene proteins c-akt signal transduction Ganshuang granules

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Long-term prognosis and its associated predictive factors in patients with eosinophilic gastroenteritis

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World Journal of Gastroenterology 2024年第2期30卷 146-157页

作者： Kai-Wen Li Ge-Chong Ruan Shuang Liu Tian-Ming Xu Ye Ma Wei-Xun Zhou Wei Liu Peng-Yu Zhao zhi-Rong Du ji Li jing-Nan Li Department of Gastroenterology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Allergy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Radiology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Affairs Office Chinese Academy of Medical Sciences and Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Eosinophilic gastroenteritis(EGE)is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal *** remain the most common treatment ***,disease relapse and glucocorticoid dependence remain notable *** date,few studies have illuminated the prognosis of EGE and risk factors for disease *** To describe the clinical characteristics of EGE and possible predictive factors for disease relapse based on long-term *** This was a retrospective cohort study of 55 patients diagnosed with EGE admitted to one medical center between 2013 and *** records were collected and ***-Meier curves and log-rank tests were conducted to reveal the risk factors for long-term relapse-free survival(RFS).RESULTS EGE showed a median onset age of 38 years and a slight female predominance(56.4%).The main clinical symptoms were abdominal pain(89.1%),diarrhea(61.8%),nausea(52.7%),distension(49.1%)and vomiting(47.3%).Forty-three(78.2%)patients received glucocorticoid treatment,and compared with patients without glucocorticoid treatments,they were more likely to have elevated serum immunoglobin E(IgE)(86.8%vs 50.0%,P=0.022)and descending duodenal involvement(62.8%vs 27.3%,P=0.046)at *** a median follow-up of 67 mo,all patients survived,and 56.4%had at least one *** variables at baseline might have been associated with the overall RFS rate,including age at diagnosis24 kg/m^(2)(HR 0.3922,95%CI:0.1916-0.8027,P=0.014),disease duration from symptom onset to diagnosis>3.5 mo(HR 2.4725,95%CI:1.220-5.0110,P=0.011),vomiting(HR 3.1259,95%CI:1.5246-6.4093,P=0.001),total serum IgE>300 KU/L at diagnosis(HR 0.2773,95%CI:0.1204-0.6384,P=0.022)and glucocorticoid treatment(HR 6.1434,95%CI:2.8446-13.2676,P=0.003).CONCLUSION In patients with EGE,younger onset age,longer disease c

关键词： Eosinophilic gastroenteritis Prognosis Relapse Glucocorticoid Glucocorticoid dependence

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Myelin oligodendrocyte glycoprotein-associated transverse myelitis after SARS-CoV-2 infection:A case report

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World Journal of Radiology 2024年第9期16卷 446-452页

作者： jian-Rong Zheng Jun-Lei Chang Jun Hu zhi-jian Lin Kai-hua Lin Bi-hua Lu Xu-Hui Chen zhi-Gang Liu Department of Neurology Peking University Shenzhen HospitalShenzhen 518000Guangdong ProvinceChina Department of Neurology Shenzhen Xinhua HospitalShenzhen 518000Guangdong ProvinceChina Institute of Biomedicine and Biotechnology Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518000Guangdong ProvinceChina Department of Neurology The Sixth People’s Hospital of Foshan Nanhai DistrictFoshan 528000Guangdong ProvinceChina Laboratory of Functional Chemistry and Nutrition of Food Northwest A&F UniversityYangling 712100Shaanxi ProvinceChina

BACKGROUND Cases of myelin oligodendrocyte glycoprotein(MOG)antibody-related disease have a history of coronavirus disease 2019 infection or its vaccination before disease *** acute respiratory syndrome virus 2(SARS-CoV-2)infection has been considered to be a trigger of central nervous system autoimmune *** SUMMARY Here we report a 20-year male with MOG-associated transverse myelitis after a SARS-CoV-2 *** patient received a near-complete recovery after standard immunological *** Attention should be paid to the evaluation of typical or atypical neurological symptoms that may be triggered by SARS-CoV-2 infection.

关键词： Myelin oligodendrocyte glycoprotein antibody-associated encephalomyelitis Myelin oligodendrocyte glycoprotein antibody-associated disease SARS-CoV-2 COVID-19 Case report

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Analysis of risk factors for postoperative anxiety and depression in endometriosis patients with reproductive intention

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World Journal of Psychiatry 2024年第9期14卷 1364-1374页

作者： Chun-Mei Wu Cai-hua Li You-Yan Fang huan Wu Dong-Mei ji Ping Zhou Yun-Xia Cao Ye He Zhao-Lian Wei Department of Obstetrics and Gynecology the First Affiliated Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Obstetrics and Gynecology Huaibei People's Hospital of Anhui ProvinceHuaibei 235000Anhui ProvinceChina

BACKGROUND The occurrence of postoperative depression and anxiety in patients with endomet-riosis(EMS)not only causes psychological distress,but may also harm their physical *** To explore the postoperative depression status,and its influencing factors,of EMS patients with reproductive *** A total of 321 EMS patients with reproductive intent were *** the self-rating anxiety scale and self-rating depression scale,EMS patients with anxiety or depression were distinguished.A clinical model for predicting anxiety or depression in EMS patients was constructed and evaluated using a nomogram,receiver operating characteristic curve,and calibration *** The results of the single factor analysis showed that smoking,coffee,EMS stage,chronic pelvic pain,and sexual discomfort may be related to ***,smoking,drinking,spouse,annual household income and EMS stage may be related to depression in EMS *** logistic regression illustrated that smoking,coffee,chronic pelvic pain and sexual discomfort may be inde-pendent risk factors for anxiety in EMS patients,while smoking,EMS stage(Phase III and Phase IV),spouse and high annual household income may be independent risk factors for depression in EMS ***,the models used to predict the risk of anxiety or depression in EMS patients have good predictive *** The anxiety and depression of EMS patients may be related to many *** clinical treatment,additional attention should be paid to the psychological status of EMS patients.

关键词： Endometriosis Reproductive intention Anxiety Depressed

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10H2DA improves PCOS through autophagy-mediated mitochondrial fission dependent on the maintenance of calcium homeostasis between endoplasmic reticulum and mitochondria

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Food Science and Human Wellness 2024年

作者： ji-Cheng huang Liang Yue Bai-Yu Li zhi-Song Chen Yu-Si Wang Zhan-Peng Yue Bin Guo State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases， Key Laboratory for Zoonosis Research of the Ministry of Education， and College of Veterinary Medicine， jilin University Reproductive Medical Center， the Second Hospital of jilin University

Polycystic ovarian syndrome （PCOS） is the most principal reason for infertility in reproductive women， but no versatile treatment is feasible. Although trans-10-Hydroxy-2-decenoic acid （10H2DA） exhibits the anti-inflammatory， anti-cancerous and immunomodulatory properties， its role in improving PCOS remains elusive. This present study examined the effects of 10H2DA on the estrous cycle， ovarian morphology， reproductive hormone， glucose and insulin tolerances of PCOS mice， analyzed the binding between 10H2DA and free fatty acid receptor 4 （FFAR4）， and explored the regulation of 10H2DA on the c-Jun N-terminal kinase （JNK）/JUN （Jun proto-oncogene） signaling， cytosolic calcium ion (Ca2+)， endoplasmic reticulum （ER） Ca2+release， mitochondrial Ca2+， mitochondrial function， autophagy， lysosomal acidification， mitochondrial fission， secretion function and apoptosis of ovarian granulosa cells （GCs） using enzyme-linked immunosorbent assay， flow cytometry. western blotting， molecular docking， various fluorescent probes or plasmid， etc. The results found that 10H2DA alleviated the symptom of PCOS mice through improving the secretion dysfunction of GCs and protecting GCs against apoptosis. After binding to FFAR4 and inactivation of JNK/JUN signaling， 10H2DA restricted the release of ER Ca2+through targeting ryanodine receptors （RYRs） which had been identified as the downstream targets of JUN， diminished cytosolic Ca2+accumulation and prevented Ca2+influx into mitochondria via adjusting the mitochondrial calcium uptake 1 （MICU1） and mitochondrial calcium uniporter （MCU）. Concurrently， 10H2DA kept the integrity of mitochondrial function through maintaining mitochondrial Ca2+homeostasis and suppressed the discharge of mitochondrial reactive oxygen species （mtROS） into the cytosol through blocking the mitochondrial permeability transition pore opening to avoid the lipid peroxidation and ameliorate the secretory function and apoptosis of GCs. Furthermore， 10H2DA rescued the defective

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基于ε-约束方法的增广Lagrangian多目标协同进化算法

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系统工程与电子技术 2002年第9期24卷 33-37页

作者：关志华寇纪淞李敏强天津大学系统工程研究所天津300072

介绍了一种利用协同进化算法求解多目标优化问题的算法。这种算法首先采用ε- 约束方法对多目标优化问题进行处理 ,使其转化为一个单目标带约束的优化问题 ;然后 ,采用增广Lagrangian方法把这个单目标约束优化问题转化成一个存在鞍点的... 详细信息

介绍了一种利用协同进化算法求解多目标优化问题的算法。这种算法首先采用ε- 约束方法对多目标优化问题进行处理 ,使其转化为一个单目标带约束的优化问题 ;然后 ,采用增广Lagrangian方法把这个单目标约束优化问题转化成一个存在鞍点的二人零和博弈问题 ;最后 ,利用协同进化的思想 ,用两个种群分别表示目标函数和约束这两个局中人 ,对这个二人零和博弈问题求解。进化过程中的选择、重组和变异算子均采用简单遗传算法(SGA)的机制。通过对两个实验测试问题的研究可以看出 ,这种算法比其它同类进化算法所得的结果要精确、稳定。

关键词： ε-约束方法增广Lagrangian方法协同进化博弈理论多目标优化理论

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基于FPGA和行折叠的稀疏矩阵向量乘优化

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计算机工程与科学 2024年第8期46卷 1340-1348页

作者：周智高建花计卫星北京理工大学计算机学院北京100081

稀疏矩阵向量乘(SpMV)是科学与工程计算中的一个关键内核。由于稀疏矩阵中不规则的数据分布和SpMV计算中不规则的访存操作,SpMV在多核CPU和GPU等设备上的性能与这些设备的理论峰值还具有较大差距。现有的CPU和GPU由于在架构上受到限制,... 详细信息

稀疏矩阵向量乘(SpMV)是科学与工程计算中的一个关键内核。由于稀疏矩阵中不规则的数据分布和SpMV计算中不规则的访存操作,SpMV在多核CPU和GPU等设备上的性能与这些设备的理论峰值还具有较大差距。现有的CPU和GPU由于在架构上受到限制,导致它们无法很好地利用稀疏矩阵的特殊结构来加速SpMV计算,而现场可编程门阵列(FPGA)可以通过自定义电路实现高效的并行运算,能够更好地处理稀疏矩阵的计算和存储问题。基于FPGA提出了一种SpMV优化方法,该优化方法基于高级综合的流式处理引擎,采用了一种自适应多行折叠的SpMV优化策略。该方法通过行折叠减少了处理引擎中零元的无效存储和计算,从而提升了基于FPGA的SpMV计算性能。实验结果表明,相比于现有的FPGA实现方案,设计的基于行折叠优化的数据流引擎实现了最高1.78倍和平均1.15倍的加速。

关键词：稀疏矩阵向量乘现场可编程门阵列高级综合行折叠

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Identification of NR3C2 as a functional diagnostic and prognostic biomarker and potential therapeutic target in non‐small cell lung cancer

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Cancer Innovation 2024年第4期3卷 67-86页

作者： Yuan‐yuan Sun Hai‐cheng Gao Peng Guo Na Sun Chan Peng zhi‐hua Cheng jing Gu jin‐yi Liu Fei Han Department of Clinical Pharmacy Jilin University School of Pharmaceutical SciencesChangchunChina Institute of Toxicology College of Preventive MedicineArmy Medical UniversityChongqingChina Department of Hepatobiliary Surgery Third Affiliated Hospital of Chongqing Medical UniversityChongqingChina Breast and Thyroid Surgery Southwest HospitalArmy Medical UniversityChongqingChina College of Pharmaceutical Sciences Southwest UniversityChongqingChina Vascular Surgery Department General Surgery CenterFirst Hospital of Jilin UniversityChangchunChina Department of Toxicology School of Public HealthChongqing Medical UniversityChongqingChina Laboratory of Reproductive Biology Chongqing Medical UniversityChongqingChina

Background:Non‐small cell lung cancer(NSCLC),including the lung squamous cell carcinoma(LUSC)and lung adenocarcinoma(LUAD)subtypes,is a malignant tumor type with a poor 5‐year survival *** identification of new powerful diagnostic biomarkers,prognostic biomarkers,and potential therapeutic targets in NSCLC is urgently ***:The UCSC Xena,UALCAN,and GEO databases were used to screen and analyze differentially expressed genes,regulatory modes,and genetic/epigenetic alterations in *** UCSC Xena database,GEO database,tissue microarray,and immunohistochemistry staining analyses were used to evaluate the diagnostic and prognostic ***‐of‐function assays were performed to examine the *** ESTIMATE,TIMER,Linked Omics,STRING,and DAVID algorithms were used to analyze potential molecular ***:NR3C2 was identified as a potentially important molecule in ***3C2 is expressed at low levels in NSCLC,LUAD,and LUSC tissues,which is significantly related to the clinical indexes of these *** operating characteristic curve analysis suggests that the altered NR3C2 expression patterns have diagnostic value in NSCLC,LUAD,and especially LUSC *** NR3C2 expression levels can help predict poor prognosis in NSCLC and LUAD patients but not in LUSC *** results have been confirmed both with database analysis and real‐world clinical samples on a tissue *** number variation contributes to low NR3C2 expression levels in NSCLC and LUAD,while promoter DNA methylation is involved in its downregulation in *** NR3C2 promoter methylation sites have high sensitivity and specificity for LUSC diagnosis with clinical application ***3C2 may be a key participant in NSCLC development and progression and is closely associated with the tumor microenvironment and immune cell ***3C2 co‐expressed genes are involved in many cancer‐related signaling pathways,further supporting a potentially si

关键词： diagnosis and prognosis expression regulation function immune cell infiltration non‐small cell lung cancer NR3C2 therapeutic target tumor microenvironment

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Effects of connected automated vehicle on stability and energy consumption of heterogeneous traffic flow system

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Chinese Physics B 2024年第3期33卷 291-301页

作者：申瑾赵建东刘华清姜锐余智鑫 School of Systems Science Beijing Jiaotong UniversityBeijing 100044China Key Laboratory of Transport Industry of Big Data Application Technologies for Comprehensive Transport Beijing Jiaotong UniversityBeijing 100044China School of Maritime and Transportation Ningbo UniversityNingbo 315000China

With the development of intelligent and interconnected traffic system,a convergence of traffic stream is anticipated in the foreseeable future,where both connected automated vehicle(CAV)and human driven vehicle(HDV)will *** order to examine the effect of CAV on the overall stability and energy consumption of such a heterogeneous traffic system,we first take into account the interrelated perception of distance and speed by CAV to establish a macroscopic dynamic model through utilizing the full velocity difference(FVD)***,adopting the linear stability theory,we propose the linear stability condition for the model through using the small perturbation method,and the validity of the heterogeneous model is verified by comparing with the FVD *** nonlinear theoretical analysis,we further derive the KdV-Burgers equation,which captures the propagation characteristics of traffic density ***,by numerical simulation experiments through utilizing a macroscopic model of heterogeneous traffic flow,the effect of CAV permeability on the stability of density wave in heterogeneous traffic flow and the energy consumption of the traffic system is *** analysis reveals emergent traffic *** experimental findings demonstrate that as CAV permeability increases,the ability to dampen the propagation of fluctuations in heterogeneous traffic flow gradually intensifies when giving system perturbation,leading to enhanced stability of the traffic ***,higher initial traffic density renders the traffic system more susceptible to congestion,resulting in local clustering effect and stop-and-go traffic ***,the total energy consumption of the heterogeneous traffic system exhibits a gradual decline with CAV permeability *** evidence has demonstrated the positive influence of CAV on heterogeneous traffic *** research contributes to providing theoretical guidance for future CAV applic

关键词： heterogeneous traffic flow CAV linear stability nonlinear stability energy consumption

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