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Prognostic relevance of β-catenin expression in T2-3N0M0 esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2010年第41期16卷 5195-5202页

作者： Dong-Rong Situ Yi Hu zhi-hua zhu Jian Wang Hao Long Tie-hua Rong Department of Thoracic Surgery Cancer CenterSun Yat-Sen UniversityGuangzhou 510060Guangdong ProvinceChina Department of Anesthe sia Cancer CenterSun Yat-Sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM: To study the expression of β-catenin in esophageal squamous cell carcinoma (ESCC) at stage T2-3N0M0 and its relation with the prognosis of ESCC patients. METHODS: Expression of β-catenin in 227 ESCC speci-mens was detected by immunohistochemistry (IHC). A reproducible semi-quantitative method which takes both staining percentage and intensity into account was applied in IHC scoring, and receiver operating char-acteristic curve analysis was used to select the cut-off score for high or low IHC reactivity. Then, correlation of β-catenin expression with clinicopathological features and prognosis of ESCC patients was determined. RESULTS: No significant correlation was observed between β-catenin expression and clinicopathological parameters in terms of gender, age, tumor size, tumor grade, tumor location, depth of invasion and pathologi-cal stage. The Kaplan-Meier survival curve showed that the up-regulated expression of β-catenin indicated a poorer post-operative survival rate of ESCC patients at stage T2-3N0M0 (P = 0.004), especially of those with T3 lesions (P = 0.014) or with stage ⅡB diseases (P = 0.007). Multivariate analysis also confirmed that β-catenin was an independent prognostic factor for the overall survival rate of ESCC patients at stage T2-3N0M0 (relative risk = 1.642, 95% CI: 1.159-2.327, P = 0.005). CONCLUSION: Elevated β-catenin expression level may be an adverse indicator for the prognosis of ESCC patients at stage T2-3N0M0, especially for those with T3 lesions or stage ⅡB diseases.

关键词： Esophageal squamous cell carcinoma β-catenin Prognosis Receiver operating characteristic curve Immunohistochemistry

Electroacupuncture exerts neuroprotective effects on ischemia/reperfusion injury in JNK knockout mice：the underlying mechanism

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Neural Regeneration Research 2018年第9期13卷 1594-1601页

作者： Chun-Xiao Wu Yi-Hui Feng Lu Yang zhu-Lian Zhan Xiu-Hong Xu Xiao-Ying Hu zhi-hua zhu Guo-Ping Zhou School of Traditional Chinese Medicine Southern Medical University Guangzhou Guangdong Province China Medical College of Acu-Moxi and Rehabilitation Guangzhou University of Chinese Medicine Guangzhou Guangdong Province China Central Hospital of Qingdao Qingdao Shandong Province China Traditional Chinese Medicine-Integrated Hospital the Affiliated Hospital of Southern Medical University Guangzhou Guangdong ProvinceChina Ruikang Hospital Affiliated to Guangxi College of Traditional Chinese Medicine Nanning Guangxi Zhuang Autonomous Region China

Simple regulation of c-Jun N-terminal kinase（JNK） or p38 mitogen-activated protein kinase（MAPK） pathways is not enough to trigger cell ***,activation of the stress activated pathway（JNK/p38 MAPK） together with inhibition of the growth factor activated extracellular signal-regulated kinase（ERK） pathway can promote cell *** hypothesized that inhibition of the JNK or p38 pro-apoptotic pathway and activating the ERK pathway could be the mechanism of anti-apoptosis following cerebral ischemia/reperfusion *** investigate the mechanism of the protective effect of electroacupuncture on cerebral ischemia/reperfusion injury in JNK knockout mice,mouse models of cerebral ischemia/reperfusion injury were established by Longa’s *** was conducted at acupoints Chize（LU5）,Hegu（LI4）,Sanyinjiao（SP6） and Zusanli（ST36） 1.5 hours after ischemia/reperfusion injury for 20 minutes,once a *** neurological function was evaluated using neurological deficit *** expression of phospho-extracellular signal-regulated kinase（p-ERK） and phospho-p38（p-p38） in JNK knockout mice was detected using double-labeling immunofluorescence and western blot *** m RNA expression of ERK and p38 was measured by quantitative real-time polymerase chain *** improved neurological function,increased the immunoreactivity and relative expression of p-ERK and reduced that of p-p38 in the cerebral cortex and hippocampus on the injured *** increased m RNA expression of ERK,but decreased that of p38 in the cerebral cortex and hippocampus on the injured *** conclusion,electroacupuncture upregulated the protective ERK pathway and inhibited the pro-apoptotic p38 pathway,thereby exerting a neuroprotective effect and improving the neurological function in JNK knockout mice.

关键词： nerve regeneration MAPKs signaling pathway cerebral ischemia/reperfusion stress-activated pathway growth factor-activatedpathway electroacupuncture apoptosis

Learnware:small models do big

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Science China(Information Sciences) 2024年第1期67卷 39-50页

作者： zhi-hua ZHOU zhi-Hao TAN National Key Laboratory for Novel Software Technology Nanjing University

There are complaints about current machine learning techniques such as the requirement of a huge amount of training data and proficient training skills,the difficulty of continual learning,the risk of catastrophic forgetting,and the leaking of data privacy/*** research efforts have been focusing on one of those concerned issues separately,paying less attention to the fact that most issues are entangled in *** prevailing big model paradigm,which has achieved impressive results in natural language processing and computer vision applications,has not yet addressed those issues,whereas becoming a serious source of carbon *** article offers an overview of the learnware paradigm,which attempts to enable users not to need to build machine learning models from scratch,with the hope of reusing small models to do things even beyond their original purposes,where the key ingredient is the specification which enables a trained model to be adequately identified to reuse according to the requirement of future users who know nothing about the model in advance.

关键词： artificial intelligence machine learning learnware

Molecular mechanism for the unusual enhancement of the second-step chemiluminescence production from the carcinogenic tetrabromohydroquinone and H2O_(2)

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Journal of Environmental Sciences 2024年第7期141卷 330-342页

作者： Zi-Han Wang Chun-hua huang zhi-Sheng Liu Li Mao Ben-Zhan zhu State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China College of Environment and Resources University of Chinese Academy of SciencesBeijing 100049China

We have found recently that two-step intrinsic hydroxyl radical(·OH)-dependent chemiluminescence(CL)could be produced by carcinogenic tetrahaloquinone and H_(2)O_(2).However,the first-step CL was too fast to clearly detect the stepwise generation of·OH and CL,and to distinguish the exact dividing point between the first-step and second-step *** we found that,extremely clear two-step intrinsic CL could be produced by the relative slow reaction of tetrabromohydroquinone(TBHQ)with H_(2)O_(2),which was directly dependent on the two-step·OH ***,the second-step,but not the first-step CL production of TBHQ/H_(2)O_(2)(CRET donor)was markedly enhanced by fluorescein(a typical xanthene dye,CRET acceptor)through a unique chemiluminescence resonance energy transfer(CRET)*** novel CRET system of TBHQ/H_(2)O_(2)/fluorescein was successfully applied for the sensitive detection of TBHQ with the detection limit as low as 2.5μmol/*** findings will help to develop more sensitive and highly efficient CL or CRET systems and specific CL sensor to detect the carcinogenic haloquinones,which may have broad environmental applications.

关键词： Two-step chemiluminescence Bromohydroquinone Hydrogen peroxide Hydroxyl radical CRET

Neural Network Based Scheduling for Variable-Length Packets in Gigabit Router with Crossbar Switch Fabric and Input Queuing

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Wuhan University Journal of Natural Sciences 2002年第3期7卷 313-318页

作者： Li Sheng\|hong, Xue zhi, Li Jian\|hua, zhu Hong\|wen Department of Electronic Engineering, Shanghai Jiaotong University, Shanghai 200030, China Department of Electronic Engineering Shanghai Jiaotong University Shanghai China

A high-speed and effective packet scheduling method is crucial to the performance of Gigabit routers. The paper studies the variable-length packet scheduling problem in Gigabit router with crossbar switch fabric and input queuing, and a scheduling method based on neural network is proposed. For the proposed method, a scheduling system structure fit for the variable-length packet case is presented first, then some rules for scheduling are given. At last, an optimal scheduling method using Hopfield neural network is proposed based on the rules. Furthermore, the paper discusses that the proposed method can be realized by hardware circuit. The simulation result shows the effectiveness of the proposed method.

关键词： Key words scheduling neural networks input queuing gigabit router

Application of the Robust Approach and Finite Element Analysis in Door System Static Design

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International Journal of Plant Engineering and Management 2010年第2期15卷 111-116页

作者： LI Chao ZHONG zhi-hua zhu Wu State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body Hunan University Changsha410082 P. R. China

The robust design approach based on Taguchi＇s design of experiment （DOE） coupled with the traditional finite element analysis （FEA） is applied to the static design of a sedan door. This method aims at shortening the design period, reducing the calculation cost and improving the competitive competence. First, the pe^ormance re- quirements, the control factors and the corresponding levels are determined to design a DOE table. Second, based on the schemes from the DOE table, sensitive control factors are distinguished from the results of the FEA method. Finally, the optimum design is chosen after comparisons and analyses of these performance response graphs. Performance results of the optimum design indicate that the application of the robust approach and FEA can greatly im- prove the quality of the door system, satisfy the requirements of products, underline the design purpose and shorten the design period.

关键词： robust approach Tagnchi's design door system DOE FEA

Synergistic catalysis of the N-hydroxyphthalimide on flower-like bimetallic metal-organic frameworks for boosting oxidative desulfurization

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Petroleum Science 2024年第1期21卷 674-682页

作者： Jing He Kun zhu Wei Jiang Dong-Ao zhu Lin-hua zhu Hai-Yan huang Wen-Shuai zhu hua-Ming Li Institute for Energy Research Jiangsu UniversityZhenjiang212013JiangsuChina College of Chemistry and Chemical Engineering Hainan Normal UniversityKey Laboratory of Water Pollution Treatment and Resource Reuse of Hainan ProvinceHaikou571158HainanChina

Synergic catalytic effect between active sites and supports greatly determines the catalytic activity for the aerobic oxidative desulfurization of fuel *** this work,Ni-doped Co-based bimetallic metal-organic framework(CoNi-MOF)is fabricated to disperse N-hydroxyphthalimide(NHPI),in which the whole catalyst provides plentiful synergic catalytic effect to improve the performance of oxidative desulfurization(ODS).As a bimetallic MOF,the second metal Ni doping results in the flower-like morphology and the modification of electronic properties,which ensure the exposure of NHPI and strengthen the synergistic effect of the overall *** with the monometallic Co-MOF and naked NHPI,the NHPI@CoNi-MOF triggers the efficient activation of molecular oxygen and improves the ODS performance without an *** sulfur removal of dibenzothiophene-based model oil reaches 96.4%over the NHPI@CoNi-MOF catalyst in 8 h of ***,the catalytic product of this aerobic ODS reaction is sulfone,which is adsorbed on the catalyst surface due to the difference in *** work provides new insight and strategy for the design of a strong synergic catalytic effect between NHPI and bimetallic supports toward high-activity aerobic ODS materials.

关键词： Metal-organic frameworks Doped Bimetallic N-hydroxyphthalimide Aerobic processes Oxidative desulfurization

Preparation of PVA/GO/h-BN Janus Film with High Thermal Conductivity and Excellent Flexibility via a Density Deposition Self-assembly Method

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Chinese Journal of Polymer Science 2024年第8期42卷 1217-1226页

作者： Fang-hua Luo zhi-Tao Dong Guo-hua Chen Chen Ma huai-Yuan Wang College of Chemistry and Chemical Engineering Northeast Petroleum UniversityDaqing 163318China College of Materials Science and Engineering Huaqiao UniversityXiamen 361000China School of Chemical Engineering and Technology and State Key Laboratory for Chemical Engineering Tianjin UniversityTianjin 300350China

Janus films with asymmetric physical/chemical properties have attracted con siderable attention due to their promising applications in personal thermal management,electronic skin s,sensors,actuators,***,traditional methods for fabricating Janus films conventionally need the assistance of an interface or auxiliary equipment,which are usually complex and ***,flexible poly(vinyl alcohol)(PVA)/graphene oxide(GO)/h-BN(recorded as PVA/GO/h-BN)Janus films with thermally,optically,and electrically anisotropic properties are fabricated by a simple density deposition self-assem bly method,which just utilizes the density difference between GO and h-BN during water *** results show that the two sides of the acquired Janus films have obvious asymmetric *** the original state of the PVA/GO/h-BN Janus films,the thermal conductivity of the GO side(10.06 W·m^(-1)·K^(-1))is generally lower than that of the h-BN side(10.48W·m^(-1)·K^(-1)).But after GO is reduced,the thermal conductivity of the rGO side reaches 12.17 W·m^(-1)·K^(-1),surpassing that of the h-BN *** addition,the relative reflectance of the h-BN side of Janus film is also significantly higher than that of the rGO side,and the su rface resistance difference between the two sides is about 4 orders of *** prepared PVA/GO/h-BN Janus films show great application potential in human thermal management,light conversion switches,and electronic *** study provides a simple and versatile strategy for fabricating Janus films with multifunctional(such as thermal,optical,and electrical)anisotropies.

关键词： Janus films PVA/GO/h-BN Density deposition self-assembly method

A Second-Order Image Denoising Model for Contrast Preservation

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1406-1427页

作者： Wei zhi Department of Mathematics University of AlabamaBox 870350TuscaloosaAL35487USA

In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in zhu(J Sci Comput 88:46,2021)for the design of a regularization *** to this new second-order derivative based regularizer,the model is able to alleviate the staircase effect and preserve image *** augmented Lagrangian method(ALM)is utilized to minimize the associated functional and convergence analysis is established for the proposed *** experiments are presented to demonstrate the features of the proposed model.

关键词： Image denoising Variational model Image contrast Augmented Lagrangian method(ALM)