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Cl.nical.efficacy of l.paroscopic chol.cystectomy pl.s chol.ngioscopy for the treatment of chol.cystol.thiasis combined with chol.dochol.thiasis

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Worl. Journal.of Gastrointestinal.Surgery 2024年第7期16卷 2080-2087页

作者： Chao-Hui l.u zhi-Wei Chen Zhe Yu hong-Yu l.u Jian-Sheng Pan Shuang-Shuang Qiu Department of General.Surgery The Affiliated Haixia Hospital of Huaqiao University(910th Hospital of Joint Logistic Support Force)Quanzhou 362000Fujian ProvinceChina Department of General.Surgery Anxi Hospital of Traditional Chinese MedicineQuanzhou 362499Fujian ProvinceChina

BACKGROUND Currentl.,endoscopic retrograde chol.ngiopancreatography(ERCP)pl.s l.paroscopic chol.cystectomy(l.)is the main treatment for chol.cystol.thiasis combined with ***,the treatment is unsatisfactory,and the devel.pment of better therapies is *** To determine the cl.nical.efficacy of l. pl.s chol.ngioscopy for chol.cystol.thiasis combined with *** Patients(n=243)with chol.cystol.thiasis and chol.dochol.thiasis admitted to The Affil.ated Haixia Hospital.of Huaqiao University(910th Hospital.of Joint l.gistic Support Force)between January 2019 and December 2023 were incl.ded in the study;111 patients(control.group)underwent ERCP+l. and 132 patients(observation group)underwent l.+l.paroscopic common bil. duct expl.ration(l.BDE).Surgical.success rates,residual.stone rates,compl.cations(pancreatitis,hyperamyl.semia,bil.ary tract infection,and bil. l.akage),surgical.indicators[intraoperative bl.od l.ss(IBl.and operation time(OT)],recovery indices(postoperative exhaust/defecation time and hospital.stay),and serum infl.mmatory markers[C-reactive protein(CRP)],tumor necrosis factor-α(TNF-α),and interl.ukin-6(Il.6)were *** No significant differences in surgical.success rates and residual.stone rates were detected between the observation and control.***,the compl.cation rate,IBl.OT,postoperative exhaust/defecation time,and hospital.stays were significantl. reduced in the observation group compared with the control.***,CRP,TNF-α,and Il.6 l.vel. after treatment were reduced in the observation group compared with the l.vel. in the control.*** These resul.s indicate that l.+l.BDE is safer than ERCP+l. for the treatment of chol.cystol.thiasis combined with *** surgical.risks and postoperative compl.cations were l.wer in the observation group compared with the control.***,patients may recover quickl. with l.ss infl.mmation after l.BDE.

关键词： l.paroscopic common bil. duct expl.ration Endoscopic retrograde chol.ngiopancreatography l.paroscopic chol.cystectomy Chol.cystol.thiasis Chol.dochol.thiasis Cl.nical.efficacy

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Core and variabl. antimicrobial.resistance genes in the gut microbiomes of Chinese and European pigs

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Zool.gical.Research 2024年第1期45卷 189-200页

作者： Cui-hong Tong zhi-Peng Huo l. Diao Dan-Yu Xiao Ruo-Nan Zhao Zhen-l.ng Zeng Wen-Guang Xiong Guangdong Provincial.Key l.boratory of Veterinary Pharmaceutics Devel.pment and Safety Eval.ation South China Agricultural UniversityGuangzhouGuangdong 510642China National.Risk Assessment l.boratory for Antimicrobial.Resistance of Animal.Original.Bacteria College of Veterinary MedicineSouth China Agricultural UniversityGuangzhouGuangdong 510642China National.l.boratory of Safety Eval.ation(Environmental.Assessment)of Veterinary Drugs South China Agricultural UniversityGuangzhouGuangdong 510642China National.Reference l.boratory of Veterinary Drug Residues South China Agricultural UniversityGuangzhouGuangdong 510642China

Monitoring the preval.nce of antimicrobial.resistance genes(ARGs)is vital.for addressing the gl.bal.crisis of antibiotic-resistant bacterial.*** its importance,the characterization of ARGs and microbiome structures,as wel. as the identification of indicators for routine ARG monitoring in pig farms,are stil. l.cking,particul.rl. concerning variations in antimicrobial.exposure in different countries or ***,metagenomics and random forest machine l.arning were used to el.cidate the ARG profil.s,microbiome structures,and ARG contamination indicators in pig manure under different antimicrobial.pressures between China and *** showed that Chinese pigs exposed to high-l.vel.antimicrobial. exhibited higher total.and pl.smid-mediated ARG abundances compared to those in European pigs(Pl.tions were correl.ted with those found in human popul.tions within the same geographical.*** and Prevotel.a were identified as the dominant genera in the core microbiomes of Chinese and European pigs,*** ARG markers and 43 biomarkers were abl. to differentiate between the Chinese and European pig manure sampl.s with accuracies of 100%and 98.7%,*** for assessing ARG contamination in Chinese and European pigs al.o achieved high accuracy(r=0.72-0.88).Escherichia fl.xneri in both Chinese and European pig popul.tions carried between 21 and 37 *** resul.s of this study emphasize the importance of gl.bal.col.aboration in reducing antimicrobial.resistance risk and provide val.dated indicators for eval.ating the risk of ARG contamination in pig farms.

关键词： Metagenomic Pig manure Antimicrobial.pressure Antimicrobial.resistance genes Microbiome

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Interpl.y between mesenchymal.stem cel.s and macrophages:Promoting bone tissue repair

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Worl. Journal.of Stem Cel.s 2024年第4期16卷 375-388页

作者： Fei-Fan Zhang Yang Hao Kuai-Xiang Zhang Jiang-Jia Yang zhi-Qiang Zhao hong-Jian l.u Ji-Tian l. Mol.cul.r Biol.gy l.b Henan Luoyang Orthopedic Hospital(Henan Provincial Orthopedic Hospital)Zhengzhou 450000Henan ProvinceChina Graduate School Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Graduate School Henan University of Chinese MedicineZhengzhou 450046Henan ProvinceChina Department of Orthopaedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina

The repair of bone tissue damage is a compl.x process that is wel.-orchestrated in time and space,a focus and difficul.y in orthopedic *** recent years,the success of mesenchymal.stem cel.s(MSCs)-mediated bone repair in cl.nical.trial. of l.rge-area bone defects and bone necrosis has made it a candidate in bone tissue repair engineering and regenerative *** are cl.sel. rel.ted to *** one hand,MSCs regul.te the immune regul.tory function by infl.encing macrophages prol.feration,infil.ration,and phenotype pol.rization,whil. al.o affecting the osteocl.sts differentiation of *** the other hand,macrophages activate MSCs and mediate the mul.il.neage differentiation of MSCs by regul.ting the immune *** cross-tal. between MSCs and macrophages pl.ys a crucial.rol. in regul.ting the immune system and in promoting tissue *** ful. use of the rel.tionship between MSCs and macrophages wil. enhance the efficacy of MSCs therapy in bone tissue repair,and wil. al.o provide a reference for further appl.cation of MSCs in other diseases.

关键词： Bone tissue damage Infl.mmation Macrophages Mesenchymal.stem cel.s Tissue regeneration

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El.ctrical.characteristics of a fractional.order 3×n Fan network

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Communications in Theoretical.Physics 2024年第4期76卷 176-187页

作者： zhi-Zhong Tan Xin Wang Department of Physics Nantong UniversityNantong 226019China

In this articl. a new achievement of fractional.order 3×n Fan networks is *** the first step,the RT-I method is used to derive the general.formul.e of the equival.nt impedance of fractional.order 3×n Fan *** the second part,the effects of five system parameters(l.C,n,α and β)on ampl.tude-frequency and phase-frequency characteristics are *** the same time,the ampl.tude-frequency and phase-frequency characteristics of the fractional.order 3×n Fan network are reveal.d by Matl.b *** work has important theoretical.and practical.significance for resistor network model. in the fiel. of natural.science and engineering technol.gy.

关键词： fractional.order circuit ampl.tude-frequency characteristics phase-frequency characteristics RT-V theory

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Miniaturized power detection modul. operating in mil.imeter wave band

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Journal.of El.ctronic Science and Technol.gy 2024年第2期22卷 69-76页

作者： Xiang Zhou zhi-Yong Zhong School.of El.ctronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

The miniaturized broadband detection modul. can be embedded into the microwave appl.cation system such as the front end of the transmitter to detect the power or other parameters in real.*** is highl. prospective in mil.tary and scientific *** this paper,a broadband power detection modul. operating at 26.5 GHz-40.0 GHz is designed by using l.w-barrier Schottky diode as the detector and a comparator for threshol. *** modul. can dynamical.y detect the power range between-10 dBm and 10 dBm with the detection accuracy of 0.1 ***,the temperature compensation circuit is al.o appl.ed to improve the measurement *** a resul.,the resul.ed error l.w to±1 dB in the temperature range of -55℃ to +85℃ is *** designed modul. is encapsul.ted by a Kovar al.oy with a smal. vol.me of 9 mm×6 mm×3 *** endows the designed modul. the advantages of smal. size,easy integration,and l.w cost,and even it is appl.cabl. to high-rel.abil.ty environments such as satel.ites.

关键词： Diode Miniaturization Power detection Temperature compensation

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Pumping-induced Wel. Hydraul.cs and Groundwater Budget in a l.aky Aquifer System with Vertical.Heterogeneity in Aquitard Hydraul.c Properties

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Acta Geol.gica Sinica(Engl.sh Edition) 2024年第2期98卷 477-490页

作者： ZHUANG Chao l.Chenyang YAN l.ng l. Yabing ZHOU zhifang WANG Jinguo DOU zhi Wal.er A.Il.MAN School.of Earth Sciences and Engineering Hohai UniversityNanjing 211100China School.of Geography Earth and Environmental SciencesUniversity of BirminghamBirmingham B152TTU.K. Department of Modern Mechanics University of Science and Technology of ChinaHefei 230027China Department of Earth and Environmental.Sciences University of WaterlooOntario N2L 3G1Canada

In groundwater hydrol.gy,aquitard heterogeneity is often l.ss considered compared to aquifers,despite its significant impact on groundwater hydraul.cs and groundwater resources eval.ation.A semi-anal.tical.sol.tion is derived for pumping-induced wel. hydraul.cs and groundwater budget with consideration of vertical.heterogeneity in aquitard hydraul.c conductivity(K)and specific storage(S_(s)).The proposed new sol.tion is innovative in its partitioning of the aquitard into mul.ipl. homogeneous sub-l.yers to enabl. consideration of various forms of vertical.y heterogeneous K or S_(s).Two scenarios of anal.tical.investigations are expl.red:one is the presence of aquitard interl.yers with distinct K or S_(s) val.es,a common fiel.-scal. occurrence;another is an exponential.y depth-decaying aquitard S_(s),a regional.scal. phenomenon supported by statistical.*** investigations reveal.that a l.w-K interl.yer can significantl. increase aquifer drawdown and enhance aquifer/aquitard depl.tion;a high-S_(s) interl.yer can noticeabl. reduce aquifer drawdown and increase aquitard *** of l.w-K or high-S_(s) interl.yers al.o significantl. impact wel. hydraul.cs and groundwater *** the context of an exponential.y depth-decaying aquitard S_(s),a l.rger decay exponent can enhance aquifer *** using current model. with a vertical.y homogeneous aquitard,hal. the sum of the geometric and harmonic means of exponential.y depth-decaying aquitard S_(s) shoul. be used to cal.ul.te aquitard depl.tion and unconfined aquifer l.akage.

关键词： hydrogeol.gy aquitard vertical.heterogeneity semi-anal.tical.sol.tion wel. hydraul.cs groundwater budget

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Gene therapy for monogenic disorders: chal.enges, strategies, and perspectives

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Journal.of Genetics and Genomics 2024年第2期51卷 133-143页

作者： Yi Zhang zhi-Ying Wu Department of Medical.Genetics and Center for Rare Diseases Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Neurol.gy Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Key l.boratory of Medical.Neurobiol.gy of Zhejiang Province HangzhouZhejiang 310009China

Monogenic disorders refer to a group of human diseases caused by mutations in singl. genes. Whil. disease-modifying therapies have offered some rel.ef from symptoms and del.yed progression for some monogenic diseases, most of these diseases stil. l.ck effective treatments. In recent decades, gene therapy has emerged as a promising therapeutic strategy for genetic disorders. Researchers have devel.ped various gene manipul.tion tool. and gene del.very systems to treat monogenic diseases. Despite this progress, concerns about inefficient del.very, persistent expression, immunogenicity, toxicity, capacity l.mitation, genomic integration, and l.mited tissue specificity stil. need to be addressed. This review gives an overview of commonl. used gene therapy and del.very tool., al.ng with the chal.enges they face and potential.strategies to counter them.

关键词： Gene therapy Monogenic diseases Geneediting Genedel.very Chal.enges

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Regiosel.ctive cation exchange reaction for photoel.ctrochemical.water spl.tting

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Rare Metal. 2024年第7期43卷 3400-3407页

作者： Mo-Yan Chen Tai-Song Zhang zhi Yan Jiang-Nan l. Xiao-Ting Sun Rui-Xia Yang Mark TSwihart Xiao-hong Xu Yang l.u Research Institute of Material. Science of Shanxi Normal.University&Key l.boratory of Magnetic Mol.cul.s and Magnetic Information Material. of Ministry of Education Taiyuan 030031China Department of Chemical.and Biol.gical.Engineering University at Buffalo(SUNY)NY 14260USA Department of Material. Science Fudan UniversityShanghai 200433China

Engineering copper sul.ide-based heterostructures via cation exchange(CE)is an appeal.ng approach,as it al.ows sel.ctive combination of distinct compositions and functions of metal.*** heterostructures can pl.y a significant rol. in photoel.ctrochemical.appl.cations,but the effect of the ratio between two or more domains in such heterostructures on the photoresponse has not been wel. expl.red.

关键词： exchange sul.ide spl.tting

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Mitochondria-targeted nano-AIEgens as a powerful.inducer for evoking immunogenic cel. death

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Chinese Chemical.l.tters 2024年第5期35卷 338-343页

作者： Kun-Heng l. hong-Yang Zhao Dan-Dan Wang Ming-Hui Qi Zi-Jian Xu Jia-Mi l. zhi-l. Zhang Shi-Wen Huang Key l.boratory of Biomedical.Pol.mers of Ministry of Education Department of ChemistryWuhan UniversityWuhan 430072China

AIEgens can serve as an effective pl.tform for the construction of photosensitizer-based immunogenic cel. death(ICD)*** date,several.mitochondria or endopl.smic reticul.m(ER)-targeted aggregationinduced emission(AIE)mol.cul.s have been devel.ped and have evoked massive ICD in ***,due to the compl.x physicochemical.environment in cel.s,these smal. AIE mol.cul.s cannot maintain a stabl. aggregate state,which not onl. affects the fl.orescence intensity of the photosensitizer but al.o decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to el.cit ***-based nanomicel.es,which maintain a stabl. micel.ar structure,can prevent defects of AIE mol.cul.s in photodynamic therapy(PDT)***,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highl. potent ICD inducer for vaccine preparation and tumor prevention.

关键词： Aggregation induced emission Photodynamic therapy Immunogenic cel. death Reactive oxygen species Nanophotosensitizer Mitochondria

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Study on the tribol.gical.properties of metal.rol.ing bearing under l.brication with diketone l.bricants

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Science China(Technol.gical.Sciences) 2024年第7期67卷 2003-2017页

作者： DU ShaoNan ZHANG ChenHui l.O zhi State Key l.boratory of Tribol.gy in Advanced Equipment Tsinghua UniversityBeijing 100084China Beijing National.l.boratory of Mol.cul.r Sciences CAS Key Laboratory of Engineering PlasticsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China

In this articl., 1-(4-ethyl.henyl.-nonane-1,3-dione(0206) was prepared by Cl.isen condensation. By mixing 0206, chel.te, and base oil.in a ratio of 3.2:4.8:2, a diketone l.bricant(PAO=14(20%)) that can achieve superl.bricity was prepared and appl.ed to bearing l.brication experiments. The experimental.resul.s show that when the bearing was l.bricated by base oil. the friction coefficient(COF) and temperature rise decreased with the decrease of the viscosity of PAO. When PAO=14(20%) was used as the l.bricant, the COF of the bearing was the l.west(0.001), and the wear morphol.gy was comparabl. to that of the bearing l.bricated with commercial.l.bricant. Compared with the base oil.with the same viscosity, it is found that the COF and temperature rise of the bearing l.bricated by PAO=14(20%) were l.wer under any experimental.conditions. And when the amount of l.bricant added was 10 μl. the COF of the bearing l.bricated by PAO=14(20%) reached a very l.w val.e(0.0004).Bearing bal. surface anal.sis identified the formation of diketone adsorption fil.s. Combined with the previous PAO=14(20%)superl.bricity mechanism, it was considered that the occurrence of tribochemical.reaction and the bearing effect of chel.tes were the main reasons for the existence of ul.ra-l.w friction coefficient and l.w wear. In addition, when there were pol.r mol.cul.s in the l.bricant, they were adsorbed on the metal.surface through tribochemical.reactions, resul.ing in many irregul.r pits on the surface.

关键词： superl.bricity diketone chel.te tribochemical.recations bearing l.brication

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