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Characterization of the Purified Glutathione S-transferases from Two Psocids Liposcelis bostrychophila and ***

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Agricultural Sciences in China 2010年第7期9卷 1008-1016页

作者： DOU Wei XIAO Li-sha NIU Jin-zhi jiang hong-bo WANG Jin-jun Key Laboratory of Entomology and Pest Control Engineering College of Plant Protection Southwest University Chongqing 400716 P.R. China

Glutathione S-transferases（GSTs） from Liposcelis bostrychophila Badonnel and ***（Enderlein）（Psocoptera：Liposcelididae） were purified by glutathione-agarose affinity chromatography,and characterized subsequently by their Michaelis-Menten kinetics toward the artificial substrates 1-chloro-2,4-dinitrobenzene（CDNB） and reduced glutathione（GSH）,*** specific activity of the purified GST toward CDNB was 2.3-fold higher in *** than in *** the specific activities of purified enzymes varied between the two species,the purification yields were ***-PAGE revealed one band at 23 kDa for both the *** of *** exhibited higher Michaelis-Menten constants（Km） but lower maximal velocity（Vmax） values than those of *** optimum pH for CDNB conjugation of *** and *** GSTs was 7.0 and 7.5,and optimum temperature was 35 and 40°C,*** kinetics showed that cibacron blue,curcumin,bromosulfalein,ethacrynic acid,and carbosulfan had excellent inhibitory effects on GSTs in both species,but the inhibitory effects of beta-cypermethrin,fenpropathrin,tetraethylthiuram disulfide,and diethyl maleate were not significant.

关键词： GSTs purification psocids xenobiotic compounds

Use of Capillary Electrophoresis in the Study of Interaction between dsDNA and Drug Molecules

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Chinese Chemical Letters 2006年第3期17卷 383-386页

作者： Juan Fang WU Ling Xin CHEN Guo An LUO Yong Suo LIU Yi Ming WANG zhi hong jiang Department of Chemistry Tsinghua University Beijing 100084 School of Chinese Medicine Hong Kong Baptist University Kowloon Tong Hong Kong

Two 17-mer dsDNA with different sequence characteristics were designed to investigate the binding characteristics of berberine, an anticancer drug with uncertain binding mode, and Hoechst 33258, a model DNA minor groove binder, with dsDNA, respectively by the capillary zone electrophoresis （CZE）. Kenndler model analysis revealed that Hoechst 33258 exhibited intermediate affinity with dsDNA, while there was only low affinity and some weak binding preference for AATT-containing to GGCC-containing dsDNA for berberine.

关键词： Capillary zone electrophoresis interaction berberine Hoechst 33258 DNA.

(±)-Atrachinenins A-C,Three Pairs of Caged C_(27) Meroterpenoids from the Rhizomes of Atractylodes chinensis

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Chinese Journal of Chemistry 2022年第4期40卷 460-466页

作者： Fei-Long Chen Dong-Li Liu Jing Fu Ji Yang Li-Ping Bai Wei Zhang zhi-hong jiang Guo-Yuan Zhu Key Laboratory of Quality Research in Chinese Medicine Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious DiseaseMacao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacaoChina

Comprehensive Summary(±)-Atrachinenins A—C(1—3),three meroterpenoids possessing novel C_(27) skeletons,were isolated from the rhizomes of Atractylodes chinensis.(±)-Atrachinenin A(1)possesses an unprecedented cage-like skeleton with a fused 6/6/5/5 tetracyclic system(decahy-dro-1,5:4a,7-dimethanobenzo[7]annulene),which may be formed by the intermolecular cyclization of(±)-atrachinenin C(3).

关键词： Atractylodes chinensis Terpenoids Phytochemistry Natural products TGF-β

2D NMR-based MatchNat Dereplication Strategy Enables Explosive Discovery of Novel Diterpenoid Alkaloids

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Chinese Journal of Chemistry 2022年第18期40卷 2169-2178页

作者： Tian-Peng Yin Yi Yu Qing-Hua Liu Ming-Yue Zhou Guo-Yuan Zhu Li-Ping Bai Wei Zhang zhi-hong jiang State Key Laboratory of Quality Research in Chinese Medicines Macao Institute for Applied Research in Medicine and HealthGuangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious DiseaseMacao University of Science and TechnologyTaipaMacaoChina Faculty of Bioengineering Zhuhai Campus of Zunyi Medical UniversityZhuhaiGuangdong519041 China

The tribe Delphineae,comprising two genera,Aconitum *** Delphinium L.,is the richest source of bioactive diterpenoid alkaloids(DAs),while their highly similar chemical structures create a major challenge for dereplication from complex *** solve the inefficient discovery process of natural DAs,a novel dereplication strategy based on pattern recognition of specific heteronuclear multiple bond correlation(HMBC)signals has been established in this *** strategy utilized the diagnostic signals in the HMBC spectra of C_(19)-DAs,which could indicate the structural *** newly designed software MatchNat allowed in silico recognition of C_(19)-DA *** developed dereplication system was demonstrated to be a practical strategy to dereplicate a variety of natural products from two Delphineae plants,including Aconitum vilmorinianum *** Delphinium pachycentrum *** compounds could be rapidly recognized from the mixture,and novel DAs were found with the aid of ***,targeted isolation led to the explosive discovery of a series of novel *** dereplication system has the potential to be adopted for dereplication of any other class of natural products and has shown promising application as a complementary tool in the nuclear magnetic resonance analysis of traditional Chinese medicines.

关键词： NMR spectroscopy Natural products Alkaloids Dereplication Aconitum

Consideration on immunotherapy of liver metastases of malignant tumors

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2374-2381页

作者： Chuang jiang zhi-hong Zhang Jia-Xin Li Division of Liver Surgery Department of General Surgery and Laboratory of Liver Surgeryand State Key Laboratory of Biotherapy and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of General Surgery Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

In this editorial,we comment on the article“Analysis of the impact of immuno-therapy efficacy and safety in patients with gastric cancer and liver metastasis”by Liu et al that was published in the recent issue of the World Journal of Gastroin-testinal *** has prompted us to think and summarize some thoughts on immunotherapy for malignant tumor liver *** plays a crucial role in the treatment of malignant tumors;however,the presence of liver metastases in advanced tumors may impact its *** patients with liver metastases can still benefit from immunotherapy,multiple clinical studies have indicated that,compared to other sites of metastasis,liver metastases may diminish the effectiveness of *** efficacy of immune checkpoint inhibitors in patients with liver metastases often fails to reach the ideal level,primarily due to the liver metastases exploiting the host's peripheral immune to-lerance mechanisms to promote systemic CD8(+)T cell exhaustion,resulting in a systemic immune-tolerant *** article aims to summarize the reasons for the decreased efficacy of immunotherapy following liver metastasis in various malignant tumors and propose potential clinical strategies for manage-ment.

关键词： Liver metastasis Immunotherapy Immune tolerance Cancer Treatment

Systemic immune-inflammation index combined with pediatric appendicitis score in assessing the severity and prognosis for paediatric appendicitis

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2565-2573页

作者： Li-Ming Guo zhi-Hui jiang hong-Zhen Liu Department of General Surgery Qingdao Women and Children’s HospitalQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Children's Hospital Affiliated to Shandong UniversityJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Jinan Children's HospitalJinan 250022Shandong ProvinceChina

BACKGROUND Pediatric appendicitis is a common cause of abdominal pain in children and is recognized as a significant surgical emergency.A prompt and accurate diagnosis is essential to prevent complications such as perforation and *** To investigate the predictive value of the systemic immune-inflammation index(SII)combined with the pediatric appendicitis score(PAS)for the assessment of disease severity and surgical outcomes in children aged 5 years and older with *** Clinical data of 104 children diagnosed with acute appendicitis were *** participants were categorized into the acute appendicitis group and chronic appendicitis group based on disease presentation and further stratified into the good prognosis group and poor prognosis group based on *** SII and PAS were measured,and a joint model using the combined SII and PAS was constructed to predict disease severity and surgical *** Significant differences were observed in the SII and PAS parameters between the acute appendicitis group and chronic appendicitis *** analysis showed associations among the SII,PAS,and disease severity,with the combined SII and PAS model demonstrating significant predictive value for assessing disease severity[aera under the curve(AUC)=0.914]and predicting surgical outcomes(AUC=0.857)in children aged 5 years and older with *** The study findings support the potential of integrating the SII with the PAS for assessing disease severity and predicting surgical outcomes in pediatric appendicitis,indicating the clinical utility of the combined SII and PAS model in guiding clinical decision-making and optimizing surgical management strategies for pediatric patients with appendicitis.

关键词： Systemic immune-inflammation index Pediatric appendicitis score Disease severity Surgical outcomes Risk factor Logistic regression Receiver operating characteristic analysis

Diagnostic significance of serum levels of serum amyloid A,procalcitonin,and high-mobility group box 1 in identifying necrotising enterocolitis in newborns

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2003-2011页

作者： Li-Ming Guo zhi-Hui jiang hong-Zhen Liu Lei Zhang Department of General Surgery Qingdao Women and Children’s HospitalQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Children's Hospital Affiliated to Shandong UniversityJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Jinan Children's HospitalJinan 250022Shandong ProvinceChina Department of Pediatric Surgery Qilu Hospital of Shandong University(Qingdao)Qingdao 260010Shandong ProvinceChina

BACKGROUND Necrotising enterocolitis(NEC)is a critical gastrointestinal emergency affecting premature and low-birth-weight *** amyloid A(SAA),procalcitonin(PCT),and high-mobility group box 1(HMGB1)have emerged as potential biomarkers for NEC due to their roles in inflammatory response,tissue damage,and immune *** To evaluate the diagnostic value of SAA,PCT,and HMGB1 in the context of NEC in *** The study retrospectively analysed the clinical data of 48 newborns diagnosed with NEC and 50 healthy newborns admitted to the ***,radiological,and laboratory findings,including serum SAA,PCT,and HMGB1 Levels,were collected,and specific detection methods were *** diagnostic value of the biomarkers was evaluated through statistical analysis,which was performed using chi-square test,t-test,correlation analysis,and receiver operating characteristic(ROC)*** The study demonstrated significantly elevated levels of serum SAA,PCT,and HMGB1 Levels in newborns diagnosed with NEC compared with healthy *** correlation analysis indicated strong positive correlations among serum SAA,PCT,and HMGB1 Levels and the presence of *** analysis revealed promising sensitivity and specificity for serum SAA,PCT,and HMGB1 Levels as potential diagnostic *** combined model of the three biomarkers demonstrating an extremely high area under the curve(0.908).CONCLUSION The diagnostic value of serum SAA,PCT,and HMGB1 Levels in NEC was *** biomarkers potentially improve the early detection,risk stratification,and clinical management of critical *** findings suggest that these biomarkers may aid in timely intervention and the enhancement of outcomes for neonates affected by NEC.

关键词： Serum amyloid A Procalcitonin High-mobility group box 1 Necrotising enterocolitis in newborns Serum biomarkers

Chemoselective and Living/Controlled Polymerization of Alkenyl Methacrylates by the Phosphonium Ylide/Organoaluminum Lewis Pairs

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Chinese Journal of Polymer Science 2024年第2期42卷 159-167,I0005页

作者： zhi-Kang Chen Wu-Chao Zhao Yi-Ling Zhao Cong-Lei Liu Liu-Yin jiang Yue-Tao Zhang hong-Ping Zhu State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Chemoselective,living/controlled polymerizations of allyl methacrylate(AMA) and vinyl methacrylate(VMA) with/without methyl methacrylate(MMA) by using the phosphonium ylide/organoaluminum based Lewis pairs(LPs) have been *** P-ylide-2/AIMe(BHT)_(2)(Pylide-2=Ph_(3)P=CHMe and BHT=2,6-iBu_(2)-4-MeC_(6)H_(2)O) was demonstrated to be superior by which homopolymers PAMAs(M_(n)=27.6-111.5kg/mol and ■=1.14-1.25) and PVMAs(M_(n)=28.4-78.4 kg/mol and ■=1.12-1.18) and block copolymers PMMA-b-PAMA,PAMA-b-PVMA,PAMA-bPMMA,PMMA-b-PAMA-b-PMMA,PAMA-b-PMMA-b-PAMA,and PAMA-b-PVMA-b-PAMA were *** the polymerizations,all of the monomers were reacted by the conjugated ester vinyl groups leaving intactly the nonconjugated acryloxy *** pendant acryloxy groups attached to the main chain enable further to post-functionalization by the AIBN-induced radical "thiol-ene" reaction using PhCH_(2)*** thiolether side group-containing polymers PAMA-SCH_(2)Ph and PAMA-SCH_(2)Ph-b-PMMA-b-PAMA-SCH_(2)Ph were thus prepared.

关键词： Phosphonium ylide Alkenyl methacrylate Chemoselectivity Living/controlled polymerization Post-functionalization

Growth of Ag/g-C_(3)N_(4) nanocomposites on nickel foam to enhance photocatalytic degradation of formaldehyde under visible light

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Journal of Environmental Sciences 2024年第3期137卷 432-442页

作者： Ze Wang zhi Huang jiang Yu Xiao Shao Weidong Peng Jie Yu Yinying jiang Department of Environmental Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Institute of New Energy and Low Carbon Technology Sichuan UniversityChengdu 610065China School of Agriculture and Environment University of Western AustraliaPerth 6907Western AustraliaAustralia Yibin Institute of Industrial Technology Sichuan UniversityYibin 644000China

Formaldehyde is a pollutant that significantly affects the indoor air ***,conventional remediation approaches can be challenging to deal with low-concentration formaldehyde in an indoor *** this study,Photocatalysts of Ag/graphitic carbon nitride(g-C_(3)N_(4))/Ni with 3D reticulated coral structure were prepared by thermal polymerization and liquid phase photo-deposition,using nickel foam(NF)as the *** demonstrated that when the Ag concentration was 3%,and the relative humidity was 60%,the Ni/Ag/g-C_(3)N_(4)showed the maximum degradation rate of formaldehyde at 90.19%under visible light irradiation,and the formaldehyde concentration after degradation was lower than the Hygienic standard stated by the Chinese *** porous structure of Ni/Ag/g-C_(3)N_(4)and the formation of Schottky junctions promoted the Adsorption efficiency and degradation of formaldehyde,while the nickel foam carrier effectively promoted the desorption of degradation ***,the degradation rate was only reduced by3.4%after 16 recycles,the three-dimensional porous structure extended the lifetime of the *** study provides a new strategy for the degradation of indoor formaldehyde at low concentrations.

关键词： Graphitic carbon nitride(g-C_(3)N_(4)) Nickel foam(NF) Ag Formaldehyde Photocatalysis