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MicroRNA21 Meets Neuronal TLR8: Non-canonical Functions of MicroRNA in Neuropathic Pain

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Neuroscience Bulletin 2019年第5期35卷 949-952页

作者： zhi-hong wang Tong Liu Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience Soochow University Suzhou 215021 China College of Life Sciences Yanan University Yanan 716000 China

Toll-like receptors (TLRs) are well-known as patternrecognition receptors in the immune system for recognizing pathogen-associated and damage-associated molecular patterns [1]. TLRs play an essential role in the innate and adaptive immune responses. To date, 10 functional TLRs have been identified in humans (TLR1–TLR10) and 12 in mice (TLR1–TLR9 and TLR11–TLR13)[1]. TLRs are evolutionarily conserved type I transmembrane proteins and comprise an ectodomain characterized by leucine-rich repeats mediating the recognition of ligands, a transmembrane region, and cytosolic Toll-interleukin (IL)-1 receptor domains that activate the downstream signaling pathways [1].

关键词： MicroRNA21 Neuronal TLR8 Neuropathic Pain

COSSET＋： Crowdsourced Missing Value Imputation Optimized by Knowledge Base

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Journal of Computer Science & Technology 2017年第5期32卷 845-857页

作者： hong-zhi wang zhi-Xin Qi Ruo-Xi Shi Jian-Zhong Li hong Gao School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China

Missing value imputation with crowdsourcing is a novel method in data cleaning to capture missing values that could hardly be filled with automatic approaches. However, the time cost and overhead in crowdsourcing are high. Therefore, we have to reduce cost and guarantee the accuracy of crowdsourced imputation. To achieve the optimization goal, we present COSSET+, a crowdsourced framework optimized by knowledge base. We combine the advantages of both knowledge-based filter and crowdsourcing platform to capture missing values. Since the amount of crowd values will affect the cost of COSSET+, we aim to select partial missing values to be crowdsourced. We prove that the crowd value selection problem is an NP-hard problem and develop an approximation algorithm for this problem. Extensive experimental results demonstrate the efficiency and effectiveness of the proposed approaches.

关键词： crowdsourcing missing value imputation knowledge base optimization

EntityManager： Managing Dirty Data Based on Entity Resolution

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Journal of Computer Science & Technology 2017年第3期32卷 644-662页

作者： Xue-Li Liu hong-zhi wang Jian-Zhong Li hong Gao Massive Data Computing Laboratory Harbin Institute of Technology Harbin 150001 China

Data quality is important in many data-driven applications, such as decision making, data analysis, and data mining. Recent studies focus on data cleaning techniques by deleting or repairing the dirty data, which may cause information loss and bring new inconsistencies. To avoid these problems, we propose EntityManager, a general system to manage dirty data without data cleaning. This system takes real-world entity as the basic storage unit and retrieves query results according to the quality requirement of users. The system is able to handle all kinds of inconsistencies recognized by entity resolution. We elaborate the EntityManager system, covering its architecture, data model, and query processing techniques. To process queries efficiently, our system adopts novel indices, similarity operator and query optimization techniques. Finally, we verify the efficiency and effectiveness of this system and present future research challenges.

关键词： dirty data entity resolution uncertain attribute query processing query optimization

Giant Hydroureteronephrosis Associated with Ipsilateral Inguinal Hernia and Contralateral Hydronephrosis:a Case Study

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Chinese Medical Sciences Journal 2010年第4期25卷 243-245页

作者： zhi-qiang wang Xiao-hong Dong Bai-zhi Yang Xiu-hong wang Department of Urology Shouguang Hospital of Traditional Chinese Medicine Shouguang 262700 China

GIANT hydronephrosis is a rare urological entity. It was first defined as the presence of more than 1000 mL of fluid in the collecting sys-tem.1 That disease is seen more often in males

关键词： heminephroureterectomy hydroureteronephrosis inguinal hernia

FrepJoin:an efficient partition-based algorithm for edit similarity join

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Frontiers of Information Technology & Electronic Engineering 2017年第10期18卷 1499-1510页

作者： Ji-zhou LUO Sheng-fei SHI hong-zhi wang Jian-zhong LI School of Computer Science and Technology Harbin Institute of Technology Guangdong Key Laboratory of Popular High Performance Computers Key Laboratory of Service Computing and Application

String similarity join(SSJ) is essential for many applications where near-duplicate objects need to be found. This paper targets SSJ with edit distance constraints. The existing algorithms usually adopt the filter-andrefine framework. They cannot catch the dissimilarity between string subsets, and do not fully exploit the statistics such as the frequencies of characters. We investigate to develop a partition-based algorithm by using such *** frequency vectors are used to partition datasets into data chunks with dissimilarity between them being caught easily. A novel algorithm is designed to accelerate SSJ via the partitioned data. A new filter is proposed to leverage the statistics to avoid computing edit distances for a noticeable proportion of candidate pairs which survive the existing filters. Our algorithm outperforms alternative methods notably on real datasets.

关键词： String similarity join Edit distance Filter and refine Data partition Combined frequency vectors

O2iJoin： An Efficient Index-Based Algorithm for Overlap Interval Join

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Journal of Computer Science & Technology 2018年第5期33卷 1023-1038页

作者： Ji-Zhou Luo Sheng-Fei Shi Guang Yang hong-zhi wang Jian-Zhong Li School of Computer Science and Technology Harbin Institute of Technology Harbin 150001 China Guangdong Key Laboratory of Popular High Performance Computers Key Laboratory of Service Computing and Application Shenzhen 518000 China

Time intervals are often associated with tuples to represent their valid time in temporal relations, where overlap join is crucial for various kinds of queries. Many existing overlap join algorithms use indices based on tree structures such as quad-tree, B＋-tree and interval tree. These algorithms usually have high CPU cost since deep path traversals are unavoidable, which makes them not so competitive as data-partition or plane-sweep based algorithms. This paper proposes an efficient overlap join algorithm based on a new two-layer flat index named as Overlap Interval Inverted Index （i.e., O2i Index）. It uses an array to record the end points of intervals and approximates the nesting structures of intervals via two functions in the first layer, and the second layer uses inverted lists to trace all intervals satisfying the approximated nesting structures. With the help of the new index, the join algorithm only visits the must-be-scanned lists and skips all others. Analyses and experiments on both real and synthetic datasets show that the proposed algorithm is as competitive as the state-of-the-art algorithms.

关键词： overlap interval join temporal relation overlap inverted index join algorithm

Characterization of the Purified Glutathione S-transferases from Two Psocids Liposcelis bostrychophila and ***

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Agricultural Sciences in China 2010年第7期9卷 1008-1016页

作者： DOU Wei XIAO Li-sha NIU Jin-zhi JIANG hong-bo wang Jin-jun Key Laboratory of Entomology and Pest Control Engineering College of Plant Protection Southwest University Chongqing 400716 P.R. China

Glutathione S-transferases（GSTs） from Liposcelis bostrychophila Badonnel and ***（Enderlein）（Psocoptera：Liposcelididae） were purified by glutathione-agarose affinity chromatography,and characterized subsequently by their Michaelis-Menten kinetics toward the artificial substrates 1-chloro-2,4-dinitrobenzene（CDNB） and reduced glutathione（GSH）,*** specific activity of the purified GST toward CDNB was 2.3-fold higher in *** than in *** the specific activities of purified enzymes varied between the two species,the purification yields were ***-PAGE revealed one band at 23 kDa for both the *** of *** exhibited higher Michaelis-Menten constants（Km） but lower maximal velocity（Vmax） values than those of *** optimum pH for CDNB conjugation of *** and *** GSTs was 7.0 and 7.5,and optimum temperature was 35 and 40°C,*** kinetics showed that cibacron blue,curcumin,bromosulfalein,ethacrynic acid,and carbosulfan had excellent inhibitory effects on GSTs in both species,but the inhibitory effects of beta-cypermethrin,fenpropathrin,tetraethylthiuram disulfide,and diethyl maleate were not significant.

关键词： GSTs purification psocids xenobiotic compounds

Modification and refinement effects of Sb and Sr on Mg_(17)Al_(12) and Mg_2Si phases in Mg-12Al-0.7Si alloy

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China Foundry 2016年第5期13卷 310-315页

作者： zhi-wen wang hong-xia wang Jia-lin Gong Ming Li Wei-li Cheng Wei Liang Key Laboratory of lnterface Science and Engineering in Advanced Materials Taiyuan University of Technology Ministry of Education Taiyuan 030024 Shanxi China

The effects of Sb and Sr on the modification and refinement of Mg17Al12 and Mg2Si phases in Mg- 12Al-0.7Si alloy were investigated and compared. The microstructure and mechanical properties of Mg-12Al0.7Si alloy and its modification mechanism by Sb and Sr were investigated using a scanning electron microscope （SEM）, an energy dispersive spectrometer （EDS）, X-ray diffraction （XRD） and differential thermal analysis （DTA）. The results indicate that by adding 0.5wt.% Sb to the Mg-12Al-0.7Si alloy, the Mg17Al12 phase was refined and broken into some discontinuous island structures. However, some network Mg17Al12 phases still can be detected in Mg-12Al-0.7Si-0.09Sr alloy. Therefore, Sb performs better in modification and refinement of Mg17Al12 phase than does Sr. Small amounts of fine polygonal shaped Mg2Si phases were found in Mg-12AI-0.7Si-0.5Sb alloy, while the morphology of Mg2Si phases in Mg-12Al-0.7Si-0.09Sr alloy changed from the coarse Chinese script shapes to fine granule and irregular polygonal shapes, indicating that the effects of modification and refinement on Mg2Si phase are more significant by adding 0.09wt.% Sr than 0.5wt.% Sb. The ultimate tensile strengths of the Sb and Sr modified Mg-12Al-0.7Si alloys were considerably increased both at room temperature and at 200 ℃.

关键词： magnesium alloy Sb Sr Mg17Al12 phase Mg2Si phase

Effects of Limiting Amino Acids on Rumen Fermentation and Microbial Community In vitro

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Agricultural Sciences in China 2008年第12期7卷 1524-1531页

作者： wang Meng-zhi wang hong-rong CAO Heng-chun LI Guo-xiang ZHANG Jie College of Animal Science and Technology Yangzhou University Yangzhou 225009 P.R.China

Three goats fitted with cannula were used to provide rumen liquor to investigate the effects of limiting amino acids on rumen fermentation and microbial community in vitro. The removal method was used in the current experiments. Treatments are total essential amino acid （TEAA）, His-removal, Lys-removal, Met-removal, and branch chain amino acid （BCAA）- removal. Results indicated that, pH-value ranged between 5.9 and 6.8, with the highest mean value for the group with BCAA-removal （6.54） in the culture. Concentration of NH3-N ranged between 10.99 to 30.51 mg 100 mL^-1, with the group of TEAA recording the highest average NH3-N concentration （17.85 mg 100 mL^-1）. Yields of microbial protein and limiting degree on microbial growth varied with treatments （P 〈 0.01）, and the lowest accrued in treatment with BCAA-removal （0.1389, 0.1772, and 0.3161 mg mL^-1 for bacteria, protozoa, and mixed microbes, respectively）, compared to the group with TEAA, microbial production of mixed microbes decreased by 44.52%. As for micro-flora, protozoa to bacteria ratio was the lowest for the group with Lys-removal （89.12%）, while the highest for the group with BCAA-removal （127.60%）（P 〈 0.01）. Furthermore, PCR-SSCP analysis revealed that, microbial profile subjected to substrates within bacteria and protozoa groups. It was therefore concluded that, dietary amino acid influenced both rumen fermentation and microbial characteristics.

关键词： limiting amino acids rumen microbes limiting degree,