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Debates in pediatric obstructive sleep apnea treatment

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2021年第3期7卷 194-200页

作者： zhi-fei xu Xin Ni Respiratory Department Beijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthChina Department of Otolaryngology Head and Neck SurgeryBeijing Children’s HospitalCapital Medical UniversityNational Center for Children’s HealthChina

Pediatric obstructive sleep apnea(OSA)is among the most common sleep-disordered breathing(SDB)diseases in *** high prevalence and multiple systemic complications lead to increasing numbers of children and families affected by *** diagnosis and effective intervention in children with this condition is extremely important in improving their *** major approaches in the treatment of OSA in children are to eliminate the causes of upper airway obstruction and prevent and treat *** the specific individual differences in children’s growth and development,as well as the diversity of etiologies in children’s OSA,pediatric treatment strategies need to be precise,multidisciplinary,and ***-line clinical treatment consists of surgical(adenotonsillectomy)and non-surgical therapies[including anti-inflammatory medications and non-invasive ventilation(NIV)].However,a considerable controversy exists concerning the indications,treatment standards,and the evaluation of the efficacy of the aforementioned treatment *** this review,reviews and assessment of literature studies and multidisciplinary clinical experience were performed to analyze the application of each treatment and discuss controversial issues and future research *** suggest that the above interventions should be tailored to each child’s needs,comorbidities,and the availability and expertise of the *** ideal case is when a multidisciplinary team of doctors together with the patients and their parents,or guardians,have a thorough discussion regarding the benefits and risks of all available treatment options and all agree on an effective treatment plan.

关键词： Pediatric Obstructive sleep apnea Treatment

Sleep Duration and Factors Related to Sleep Loss in 3-14-Year-Old Children in Beijing： A Cross-Sectional Survey

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Chinese Medical Journal 2018年第15期131卷 1799-1807页

作者： Xiao-Dan Li Jun Tai zhi-fei xu Gui-Xiang Wang Yun-Xiao Wu Jiang-Nan Du Jie Zhang Xiao-Xia Peng Xin Ni Department of Otorhinolaryngology-Head and Neck Surgery Beijing Children's Hospital Capital Medical University Beijing 100045 China Department of Respiratory Beijing Children's Hospital Capital Medical University Beijing 100045 China Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University Beijing 100045 China Center for Clinical Epidemiology and Evidence-based Medicine Beijing children's Hospital Capital Medical University Beijing 100045 China

Background： It is known that short sleep duration adversely affects children＇s behavior and physical development. This study aimed to investigate the status of sleep duration in 3-14-year-old children in Beijing and explore the related factors of sleep loss with them. Methods： In this study, a cross-sectional study of random stratified cluster sampling was conducted on 3-14-year-old children and adolescents in Beijing. According to the proportion of children in each district and school, the final cohort included a total of 11 kindergartens, 7 primary schools, and 8 junior high schools from 7 districts of Beijing. Children of sampled classes were included, and their parents were invited to fill a series of questionnaires including the simplified Chinese version of Pediatric Sleep Questionnaire, Sleep Questionnaire Scale, and Hong Kong-Children Sleep Questionnaire about the performance of the last 6 months. Results： Out of the total 11,420 questionnaires, 9198 questionnaires were valid and effective with the response rate of 80.54%. The age of the investigated children was 8.8 ± 3.8 years, including 4736 males and 4462 females. The daily sleep duration of children in Beijing was 9.7 ± 0.7 h. The prevalence of sleep loss （〈9 h/day） of children in Beijing was 11.8%. The daily sleep duration of children aged 〈6, 6 ≤ age 〈11, and ≥11 years was 9.7 ± 0.6 h, 9.6 ± 0.6 h, and 9.5 ± 0.8 h, respectively. The sleep duration reduced significantly in children aged ≥11 years as compared to younger children in Beijing which was mainly contributed by the variation tendency of sleep duration on weekdays. The multivariate logistic regression analysis identified factors associated with sleep loss （P 〈 0.05）： male （odds ratio [OR] = 1.32, 95% confidence interval [CI ]： 1.15-1.51 ）, age ≥11 years （OR = 2.37, 95% CI： 1.92-2.93）, overweight （OR = 1.34, 95% CI： 1.17-1.54）, family history of snoring （OR - 1.35, 95% CI： 1.13-1.61 ） and activities before bedtime with watching TV （OR = 1.24, 95

关键词： Child Cross-Sectional Survey Sleep Duration

Overview of in-situ oxygen production technologies for lunar resources

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 233-255页

作者： Youpeng xu Sheng Pang Liangwei Cong Guoyu Qian Dong Wang Laishi Li Yusheng Wu zhi Wang College of Materials Science and Engineering Shenyang University of TechnologyShenyang 110870China CAS Key Laboratory of Green Process and Engineering National Engineering Research Center for Green Recycling of Strategic Metal ResourcesInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

The rich resources and unique environment of the Moon make it an ideal location for human expansion and the utilization of extraterrestrial ***,crucial for supporting human life on the Moon,can be extracted from lunar regolith,which is highly rich in oxygen and contains polymetallic *** oxygen and metal extraction can be achieved using existing metallurgical ***,the ample reserves of water ice on the Moon offer another means for oxygen *** paper offers a detailed overview of the leading technologies for achieving oxygen production on the Moon,drawing from an analysis of lunar resources and environmental *** delves into the principles,processes,advantages,and drawbacks of water-ice electrolysis,two-step oxygen production from lunar regolith,and one-step oxygen production from lunar *** two-step methods involve hydrogen reduction,carbothermal reduction,and hydrometallurgy,while the one-step methods encompass fluorination/chlorination,high-temperature decomposition,molten salt electrolysis,and molten regolith electrolysis(MOE).Following a thorough comparison of raw materials,equipment,technology,and economic viability,MOE is identified as the most promising approach for future in-situ oxygen production on the *** the corrosion characteristics of molten lunar regolith at high temperatures,along with the Moon's low-gravity environment,the development of inexpensive and stable inert anodes and electrolysis devices that can easily collect oxygen is critical for promoting MOE technology on the *** review significantly contributes to our understanding of in-situ oxygen production technologies on the Moon and supports upcoming lunar exploration initiatives.

关键词： lunar resources in-situ oxygen production space metallurgy molten lunar regolith electrolysis

Sleep Duration and Related Factors among Chinese children:A Cross-sectional Study

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Sleep Duration and Related Factors among Chinese children:A ...

A low redox potential and long life organic anode material for sodium-ion batteries

中国睡眠研究会第十届全国学术年会

作者： Jun Tai Xiao-dan Li Gui-xiang Wang Yun-xiao Wu Jiang-nan Du Jie Zhang Xiao-xia Peng zhi-fei xu Xin Ni Department of Otorhinolaryngology-Head and Neck Surgery Beijing Children's HospitalCapital Medical University Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck SurgeryBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityCapital Medical University Center for Clinical Epidemiology and Evidence-based Medicine Beijing children's HospitalCapital Medical University Respiratory Department Beijing Children's HospitalCapital Medical University

Background It is known short sleep duration adversely affects children’s behavior and physical *** duration and sleep habit vary substantially in children with different ages,areas and ***,our understanding on the sleep duration in Chinese children remains *** present study investigated the status of sleep durations in Chinese children and explored factors related to sleep *** A randomized,stratified,multi-stage cluster sampling method encompassed 11420 children in 25 schools from 7 districts in *** aged 3 to 14 years were included,and their parents were invited to fill sleep habit related questionnaires about the performance of the last 3 *** The final cohort included 4736 boys and 4462 girls with a mean age of 8.8±3.8 *** mean sleep durationof children ≥12 years of age was 9.4 h,which was significantly lower than those ＜ 12 years old（9.7 h）;this was in agreement with the trend of sleep durations of *** weekends and holidays,the sleep duration was approximately 10 h for most children and similar in all age ***（male）,age（≥12-year group）,overweight,and suburban residence were significantly correlated with sleep loss in children（p＜ 0.001）.A significantly high proportion of children with sleep loss displayed sleepiness during sitting and reading（19.1%）,in the car（31.4%）,in the afternoon（20.7%）,and after lunch（17.5%）.Conclusions The sleep duration reduced significantly in children ≥12 years of age as compared to younger children in *** such as gender（male）,age（≥12-year group）,overweight,and suburban residence are related to sleep *** ≥12 years of age older with sleep loss were likely to experience daytime sleepiness.

关键词： Chinese children sleep duration sleepiness sleep loss

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： zhi Li Yang Wei Kang Zhou Xin Huang Xing Zhou Jie xu Taoyi Kong Junwei Lucas Bao Xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

Deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang Zeng Jun-Hong Wu Dan-Dan xu Kang He Chang-Qing Liu Li-fei Song Zheng-zhi Wu Qian-Qian Jiang Shao-Yu Liang Department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical Department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

Background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κB,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(ABCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XDH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

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充内压端封闭异厚度薄圆柱壳的塑性分析

清华大学学报(自然科学版) 1982年第1期 71-82页

作者：费志中徐秉业工程力学系

本文研究充内压端封闭异厚度薄圆柱壳的极限分析问题。在多数壳体问题中，弯矩和薄膜力并不是同时重要的，因此在屈服条件中，可以不考虑力矩和薄膜力之间的相互影响。本文根据两矩弱作用的屈服条件以及相关联的流动法则，找到了上述问... 详细信息

本文研究充内压端封闭异厚度薄圆柱壳的极限分析问题。在多数壳体问题中，弯矩和薄膜力并不是同时重要的，因此在屈服条件中，可以不考虑力矩和薄膜力之间的相互影响。本文根据两矩弱作用的屈服条件以及相关联的流动法则，找到了上述问题的完全解。

关键词：圆柱壳应力场极限分析薄壳结构圆板内压塑性分析结构分析

A mechanical reinforced and antifreezing polyacrylate hydrogel electrolyte for high-performance zinc-ion batteries

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Nano Research 2025年第1期18卷 341-350页

作者： Zili Zhang Ruolin Wang Hongfei Lu Di Zhang Yu Zhao Jing xu Bin Sun zhi-Min Dang Yang Jin School of Electrical and Information Engineering Zheng Zhou UniversityZhengzhou 450001China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The operation of aqueous zinc-ion batteries in flexible energy storage field is plagued by the uncontrollable growth of Zn-dendrite and inevitable freeze of water below 0 ℃.Therefore,it is necessary to design a hydrogel electrolyte with good mechanical property and freezing resistance to uniform the Zn-deposition and resist flexibility loss at low *** find that the mechanical property(strength and toughness)of hydrogel electrolyte has a significant impact on the suppression of dendrite growth and the uniform deposition of zinc ***,a polyacrylate hydrogel is prepared in one step by ultraviolet(UV)curing method with Zn(CF_(3)SO_(3))_(2)salt and polyvinyl alcohol(PVA)addition to increase the antifreezing ability and mechanical *** adsorption of water molecules by 2-hydroxyethyl acrylate(HEA)and PVA reduces the freezing point of the hydrogel,which is beneficial for enhancing the electrochemical stability at low *** this basis,the Zn-symmetrical battery with hydrogel electrolyte has a long lifespan of 4710 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2)at room ***,the hydrogel electrolyte exhibits an outstanding stability at low temperature of^(-2)0 ℃,the lifespan of symmetrical battery reaches to 4000 h at 0.5 mA·cm^(-2)and 0.5 mAh·cm^(-2).The assembled full cell with NaV3O8·1.5H_(2)O(NVO)cathode and hydrogel electrolyte possesses a high capacity retention ratio of 77%after 10,000 cycles at^(-2)0 ℃.The flexible cell can power light-emitting diode(LED)lamp under bending,warping and cutting without liquid leakage and an electronic watch at the operating temperature of^(-2)0 ℃.

关键词： zinc ion battery hydrogel electrolyte mechanical enhancement freezing resistance

中更新世撞击事件对海洋环境的影响——南海ODP 1144站的高分辨率记录

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微体古生物学报 2004年第2期21卷 130-135页

作者：赵泉鸿翦知湣成鑫荣刘志飞徐建夏佩芬同济大学海洋地质教育部重点实验室上海200092

本文对采自南海北部 ODP114 4站 (2 0°3.18′N,117°2 5 .14′E,水深 2 0 37m) 385 .8— 386 .4 m层段的 2 8个沉积物样品进行了微玻陨石、浮游有孔虫及其同位素分析 ,以评估中更新世撞击事件对环境的影响。微玻陨石见于孔深 386 .12—... 详细信息

本文对采自南海北部 ODP114 4站 (2 0°3.18′N,117°2 5 .14′E,水深 2 0 37m) 385 .8— 386 .4 m层段的 2 8个沉积物样品进行了微玻陨石、浮游有孔虫及其同位素分析 ,以评估中更新世撞击事件对环境的影响。微玻陨石见于孔深 386 .12— 386 .38m,而集中分布在 386 .2 2— 386 .2 5 m厚约 3cm的地层中。研究结果表明 ,中更新世撞击事件对环境的影响很可能只是小幅度和短时间 (百年左右 )的 ,尽管引起了南海表层海水温度约 2°C的下降及其相应的δ1 8O的加重、浮游有孔虫冷水种含量的上升和暖水种含量的减少 ,但没有造成海水稳定同位素重大偏移和全球气候的灾难性影响 ,也没有引起浮游有孔虫在生物演化上的变化。

关键词：撞击事件微玻陨石浮游有孔虫同位素中更新世南海海洋环境