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No Incidence of Liver Cancer Was Observed in A Retrospective Studyof Patients with Aristolochic Acid Nephropathy

Chinese Journal of Integrative Medicine 2024年第2期30卷 99-106页

作者： SU Tao fang zhi-e GUO Yu-ming WANG Chun-yu WANG Jia-bo JI Dong BAI Zhao-fang YANG Li XiAO Xiao-he Renal Division Department of MedicinePeking University First HospitalBeijing(100034)China Department of Pharmacy Chongqing Hospital of Traditional Chinese MedicineChongqing(400021)China Department of hepatology Fifth Medical Center of Chinese PLA General HospitalBeijing(100039)China China Military Institute of Chinese Materia Fifth Medical Center of Chinese PLA General HospitalBeijing(100039)China Phase I Clinical Trials Unit Department of Medicine for Infectious DiseasesFifth Medical Center of Chinese PLA General HospitalBeijing(100039)China Department of Pharmacy Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan(250000)China National Key Laboratory of Kidney Diseases Beijing(100039)China

Objective:To assess the risk of aristolochic acid(AA)-associated cancer in patients with AA nephropathy(AAN).Methods:A retrospective study was conducted on patients diagnosed with AAN at Peking University First Hospital from January 1997 to December ***-term surveillance and follow-up data were analyzed to investigate the influence of different factors on the prevalence of *** primary endpoint was the incidence of liver cancer,and the secondary endpoint was the incidence of urinary cancer during 1 year after taking AA-containing medication to ***:A total of 337 patients diagnosed with AAN were included in this *** the initiation of taking AA to the termination of follow-up,39 patients were diagnosed with *** cases of liver cancer were observed throughout the entire follow-up period,with urinary cancer being the predominant type(34/39,87.17%).Logistic regression analysis showed that age,follow-up period,and diabetes were potential risk factors,however,the dosage of the drug was not significantly associated with urinary ***:No cases of liver cancer were observed at the end of ***,a high prevalence of urinary cancer was observed in AAN *** a direct causality between AA and HCC is challenging.

关键词： aristolochic acid hepatocellular carcinoma urinary cancer drug safety retrospective study

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On Three-Dimensional Spiral Galaxies

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Chinese Physics Letters 2000年第12期17卷 932-934页

作者： LUO Xin-Lian PENG Qiu-he LONG Min PENG fang ZOU zhi-Gang Department of Astronomy Nanjing UniversityNanjing 210093 Chinese Academy of Sciences-Peking University Joint Beijing Astrophysical Center Beijing UniversityBeijing 100871 Graduate Institute of Astronomy National Central UniversityChung-Li32054TaiwanChina

Density waves in 3D spiral galaxies are *** order to eliminate the forbidden region near the corotation in the grand-design galaxies,we assume that the perturbation satisfies the stable condition Q(r)>1 over all the disk except that at the ***,a new method is put forward here to determine some basic parameters of spiral *** apply it to our Galaxy,and the results are in good agreement with the previous results.

关键词： rotation. galaxies spiral

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Infinitely Many Symmetries of Konopelchenko-Dubrovsky Equation

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Communications in Theoretical Physics 2005年第3X期44卷 385-388页

作者： LI zhi-fang RUAN Hang-Yu Department of Physics Ningbo University Ningbo 315211 China Nonlinear Science Center and Physics Department of Ningbo University Ningbo 315211 China State Key Laboratory of Scientific and Engineering Computing Institute of Computational Mathematics and Scientific Engineering Computing Academy of Mathematics and System Sciences the Chinese Academy of Sciences P.O. Box 2719 Beijing 100080 China

A set of generalized symmetries with arbitrary functions of t for the Konopelchenko-Dubrovsky (KD)equation in 2+1 space dimensions is given by using a direct method called formal function series method presented by Lo... 详细信息

关键词： formal function series method Konopelchenko-Dubrovsky equation infinite dimensional generalized ω∞ algebra

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Maternal sleep deprivation disrupts glutamate metabolism in offspring rats

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Zoological Research 2024年第6期45卷 1221-1231页

作者： Wen-Ting he Dong-Xu Li Jin-Hua Fan Zheng-Yu Yao Yu-Peng Cun zhi-fang Dong Growth Developmentand Mental Health of Children and Adolescence CenterPediatric Research InstituteMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChongqing Key Laboratory of Child Neurodevelopment and Cognitive DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China

Maternal sleep deprivation(MSD)has emerged as a significant public health concern,yet its effects on offspring metabolism remain poorly *** study investigated the metabolomic implications of MSD on offspring cognitive development,with a particular focus on alterations in glutamate *** rats were subjected to sleep deprivation during late *** and brain samples from their offspring were collected at different postnatal days(P1,P7,P14,and P56)and analyzed using untargeted metabolomics with liquid chromatography-mass *** analysis revealed significant differences in various amino acids,including L-glutamate,L-phenylalanine,L-tyrosine,and L-tryptophan,which are crucial for cognitive *** differential analysis and partial least squares discriminant analysis(sPLS-DA)demonstrated a gradual reduction in these metabolic differences in the brain as the offspring underwent growth and *** pathway analysis revealed differential regulation of several pathways,including alanine,aspartate,and glutamate metabolism,glutathione metabolism,arginine biosynthesis,aminoacyl-tRNA biosynthesis,histidine metabolism,and taurine and hypotaurine metabolism,at different developmental *** and Spearman analyses indicated that the observed changes in metabolites in MSD progeny may be related to various gut microbes,Ruminococcus_1,Ruminococcaceae_UCG-005,and Eubacterium_coprostanoligenes_*** assays further demonstrated developmental changes in the L-glutamate metabolic ***,these findings suggest that MSD not only affects maternal wellbeing but also has enduring metabolic consequences for offspring,particularly impacting pathways linked to cognitive *** highlights the importance of addressing maternal sleep health to mitigate potential long-term consequences for offspring.

关键词： Maternal sleep deprivation Glutamate metabolism Metabolomics Cognitive development Offspring

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Non-Darcy flows in layered porous media(LPMs)with contrasting pore space structures

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Petroleum Science 2022年第5期19卷 2004-2013页

作者： Xue-Yi Zhang zhi Dou Jin-Guo Wang zhi-fang Zhou Chao Zhuang School of Earth Sciences and Engineering Hohai UniversityNanjing 210098JiangsuChina

Compared to single layer porous media,fluid flow through layered porous media(LPMs)with contrasting pore space structures is more *** study constructed three-dimensional(3-D)pore-scale LPMs with different grain size ratios of 1.20,1.47,and *** flow behavior in the constructed LPMs and single layer porous media was numerically investigated.A total of 178 numerical experimental data were collected in LPMs and single layer porous *** all cases,two different flow regimes(i.e.,Darcy and Non-Darcy)were *** influence of the interface of layers on Non-Darcy flow behavior in LPMs was analyzed based pore-scale flow *** was found that the available correlations based on single layer porous media fail to predict the flow behavior in LPMs,especially for LPM with large grain size *** effective permeability,which incorporated the influence of the interface is more accurate than the Kozeny-Carman equation for estimating the Darcy permeability of *** inertial pressure loss in LPMs,which determines the onset of the Non-Darcy flow,was underestimated when using a power law expression of mean grain *** constant B,an empirical value in the classical Ergun equation,typically equals *** inertial pressure loss in LPMs can be significantly different from it in single lager porous *** Non-Darcy flow in LPMs,it is necessary to consider a modified larger constant B to improve the accuracy of the Ergun empirical equation.

关键词： Non-Darcy flow Layered porous media heterogeneity Forchheimer equation Simulations

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Maternal sleep deprivation induces gut microbial dysbiosis and neuroinflammation in offspring rats

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Zoological Research 2022年第3期43卷 380-390页

作者： Zheng-Yu Yao Xiao-Huan Li Li Zuo Qian Xiong Wen-Ting he Dong-Xu Li zhi-fang Dong Pediatric Research Institute Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China

Maternal sleep deprivation(MSD)is a global public health problem that affects the physical and mental development of pregnant women and their *** latest research suggests that sleep deprivation(SD)disrupts the gut microbiota,leading to neuroinflammation and psychological ***,it is unclear whether MSD affects the establishment of gut microbiota and neuroinflammation in the *** the present study,MSD was performed on pregnant SpragueDawley rats in the third trimester of pregnancy(gestational days 15-21),after which intestinal contents and brain tissues were collected from offspring at different postnatal days(P1,P7,P14,and P56).Based on microbial profiling,microbial diversity and richness increased in pregnant rats subjected to MSD,as reflected by the significant increase in the phylum *** addition,microbial dysbiosis marked by abundant Firmicutes bacteria was observed in the MSD ***,quantitative real-time polymerase chain reaction(q RT-PCR)and enzyme-linked immunosorbent assay(ELISA)showed that the expression levels of proinflammatory cytokines interleukin 1β(IL-1β)and tumor necrosis factorα(TNF-α)were significantly higher in the MSD offspring at adulthood(P56)than in the control *** Spearman correlation analysis,IL-1βand TNF-αwere also shown to be positively correlated with Ruminococcus_1 and Ruminococcaceae_UCG-005 at P56,which may determine the microbiota-host interactions in MSDrelated ***,these results indicate that MSD changes maternal gut microbiota and affects the establishment of neonatal gut microbiota,leading to neuroinflammation in MSD ***,understanding the role of gut microbiota during physiological development may provide potential interventions for cognitive dysfunction in MSD-impacted offspring.

关键词： Maternal sleep deprivation Gut microbiota Neuroinflammation Gut-brain axis Cognitive function Firmicutes

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Molecular characterization of two novel esterase genes from carmine spider mite, Tetranychus cinnabarinus （Acarina： Tetranychidae）

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Insect Science 2010年第2期17卷 91-100页

作者： Wei Sun Chuan-Hua Xue Lin he Wen-Cai Lu Ming Li Xiao-fang Cao zhi-Mo Zhao Key Laboratory of Entomology and Pest Control Engineering College of Plant Protection Southwest University Chongqing China

Two novel esterase complementary DNAs were identified and cloned from the insecticide-susceptible strain of Tetranychus cinnabarinus （Boisduval）（Acarina： Tetrany- chidae）, which were designated as TCE1 and TCE2, respectively. The cDNA of TCE1 gene contained an open reading frame （ORF） of 1701 bp encoding 567 amino acids, and a predicted molecular weight of 62.75 kDa, the cDNA of TCE2 contained an ORF of 1680 bp encoding 560 amino acids, and a predicted molecular weight of 63.14 kDa. TCE1 and TCE2 were submitted to GenBank, accession number EU 130461 and EU 130462. The well-conserved sequence motif, GXSXG, used as a signature pattern in the esterase fam- ily are present in both TCE1 and TCE2 （GQSAG in TCE1, whereas GESAG in TCE2）, indicating that these two genes are predicted to be esterases. Comparison of the deduced amino acid sequence with the published mite esterase sequence coming from Boophilus microplus showed that TCE1 shares 33.98% identity and TCE2 shares 33.46% identity. TCE1 and TCE2 share 46.4% identity. Quantitative real-time polymerase chain reaction revealed that expression level of the TCE2 gene was relatively higher than that of the TCE1 in all instars examined except the protonymph, and the expression level of these two esterase genes in adults of T. cinnabarinus was significantly higher than that in any other instars, respectively. T. cinnabarinus is an important agricultural mite pest and esterases are important in the metabolisms of insects and mites; the genomic information obtained in this study will contribute to esterase molecular biological study on mite pest species.

关键词： esterase gene molecular cloning quantitative real-time PCR Tetranychus cinnabarinus

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Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease,an Endemic Osteoarthritis,in China

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Biomedical and Environmental Sciences 2017年第2期30卷 150-155页

作者： YU fang fang PING zhi Guang YAO Chong WANG zhi Wen WANG Fu Qi GUO Xiong Institute of Endemic Diseases School of Public Health of Health Science CenterXi'an Jiaotong UniversityKey Laboratory of Trace Elements and Endemic DiseasesNational Health and Family Planning CommissionXi'an 710061ShaanxiChina Department of health Statistics College of Public HealthZhengzhou UniversityZhengzhou 45001HenanChina The Centers for Disease Control of Linyou country Linyou 721500ShaanxiChina

This study aimed to evaluate the sensitivity and specificity of the new clinical diagnostic and classification criteria for Kashin-Beck disease （KBD） using six clinical markers： flexion of the distal part of fingers, deformed fingers, enlarged finger joints, shortened fingers, squat down, and dwarfism. One-third of the total population in Linyou County was sampled by stratified random sampling.

关键词： KBD in China Evaluation of the Sensitivity and Specificity of the New Clinical Diagnostic and Classification Criteria for Kashin-Beck Disease

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Spectral Analysis and Atmospheric Models of Microflares

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Chinese Journal of Astronomy and Astrophysics 2006年第5期6卷 597-607页

作者： Cheng fang Yu-Hua Tang zhi Xu Department of Astronomy Nanjing University Nanjing 210093 National Astronomical Observatories / Yunnan Observatory Chinese Academy of Sciences Kunming650011

By use of the high-resolution spectral data obtained with TheMIS on 2002 September 5, the spectra and characteristics of five well-observed microflares have been analyzed. Our results indicate that some of them are located near the longitudinal magnetic polarity inversion lines. All the microflares are accompanied by mass motions. The most obvious characteristic of the Hα microflare spectra is the emission at the center of both Hα and CaⅡ 8542A lines. For the first time both thermal and non-thermal semi-empirical atmospheric models for the conspicuous and faint microflares are computed. In computing the non-thermal models, we assume that the electron beam resulting from magnetic reconnection is produced in the chromosphere, because it requires lower energies for the injected particles. It is found there is obvious heating in the low chromosphere. The temperature enhancement is about 1000-2200 K in the thermal models. If the non-thermal effects are included, then the required temperature increase can be reduced by 100-150 K. These imply that the Hα microflares can probably be produced by magnetic reconnection in the solar lower atmosphere. The radiative and kinetic energies of the Hα microflares are estimated and the total energy is found to be 10^27 - 4× 10^28 erg.

关键词： Sun Microflares - Sun spectrum - Sun semi-empirical modelling

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Building Ultra-Stable and Low-Polarization Composite Zn Anode Interface via Hydrated Polyzwitterionic Electrolyte Construction

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Nano-Micro Letters 2022年第6期14卷 99-115页

作者： Qiong he Guozhao fang zhi Chang Yifang Zhang Shuang Zhou Miao Zhou Simin Chai Yue Zhong Guozhong Cao Shuquan Liang Anqiang Pan School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan ProvinceCentral South UniversityChangsha 410083People’s Republic of China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Binhai New City Fuzhou 350207People’s Republic of China Department of Materials Science and Engineering University of WashingtonSeattleWA 98195USA

Aqueous zinc metal batteries are noted for their costeffectiveness,safety and environmental ***,the water-induced notorious issues such as continuous electrolyte decomposition and uneven Zn electrochemical deposition remarkably restrict the development of the long-life zinc metal *** this study,zwitterionic sulfobetaine is introduced to copolymerize with acrylamide in zinc perchlorate(Zn(ClO;);)*** designed gel framework with hydrophilic and charged groups can firmly anchor water molecules and construct ion migration channels to accelerate ion *** in situ generated hybrid interface,which is composed of the organic functionalized outer layer and inorganic Clcontaining inner layer,can synergically lower the mass transfer overpotential,reduce water-related side reactions and lead to uniform Zn *** a novel electrolyte configuration enables Zn//Zn cells with an ultra-long cycling life of over 3000 h and a low polarization potential(~0.03 V)and Zn//Cu cells with high Coulombic efficiency of 99.18%for 1000 *** cells matched with MnO;cathodes delivered laudable cycling stability and impressive shelving ***,the flexible quasi-solid-state batteries which are equipped with the anti-vandalism ability(such as cutting,hammering and soaking)can successfully power the LED *** a safe,processable and durable hydrogel promises significant application potential for long-life flexible electronic devices.

关键词： Quasi-solid electrolyte interface Polyzwitterionic hydrogel electrolytes High performance Manganese dioxides Zinc metal anodes

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