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Acta Metallurgica Sinica(English Letters) 2019年第7期32卷 797-802页

作者： zhi-chao ma Xiao-Xi ma Hong-Wei Zhao Fu Zhang Li-Ming Zhou Lu-Quan Ren School of Mechanical and Aerospace Engineering Jilin University Changchun 130025 China Key Laboratory of Bionic Engineering Ministry of Education Jilin University Changchun 130025. China

Novel crystallization behaviors of Zr55Cu30Al10Ni5 bulk metallic glass are investigated. On the one hand, mixed oxides, including CuO, CuAlO2, CuA12O4 and ZrO2, show sequential oxidation process determined by coupling effects of specific cyclic load and temperature. On the other hand, at a temperature (100℃) by far lower than Tg of 412 ℃, under cyclic loading condition, non-oxidized binary alloy CuZr2 is precipitated;the thermo-mechanical coupled effects of temperature below Tg, and fatigue accumulation on the non-oxidized crystallization behaviors are revealed. Meanwhile, at a constant temperature of 400 ℃, by comparing among the XRD patterns, respectively, obtained from tensile, creep and fatigue fractures, the dominating effect of cyclic load on the generation of non-oxidized CuZr2 is verified. Furthermore, the crystallization behavior of amorphous phases under cyclic loading condition is observed through TEM micrograph and diffraction pattern at 100℃.

关键词： Bulk metallic glass Fatigue Thermo-mechanical coupling Crystallization

A Potential Anti-cancer Compound Separated from the Chloroform Extract of the Chinese Medicine Formula Shenqi San

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Current Medical Science 2020年第1期40卷 138-144页

作者： Lu SHI Yi-jun TU Si-qi YE Yu XIA chao-zhi ma Xiao-zhi PENG Yan-wen LIU Zhong-zhu AI Peng-tao YOU Department of Pharmacy Medical CollegeJianghan UniversityWuhan 430056China Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine Hubei University of Chinese MedicineWuhan 430065China Department of Dermatology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510220China

This study examined anti-cancer compounds present in the chloroform extract of the Chinese medicine formula Shenqi San(CE-SS).Silica gel column chromatography,Sephadex LH-20,octadecylsilyl(ODS)column chromatography,and high performance liquid chromatography(HPLC)were used to separate the compounds from *** structural formulas of the separated compounds were determined using ID1H and 13C experiments as well as high resolution electrospray ionization mass spectroscopy(HRESIMS).The corresponding results were compared with the reported literature data.A total of six compounds were separated and their structures were identified on the basis of corresponding spectroscopic and physico-chemical *** were Saikogenin F(Ⅰ),Prosaikogenin D(Ⅱ),Prosaikogenin F(Ⅲ),p-sitosterol(Ⅳ),3β,16β,23-trihydroxy-13,28-epoxyurs-11-ene-3-O-β-D-glucopyranoside(V),and methyl ursolic acid(VI).The separated compounds were evaluated in vitro for their inhibitory ability against the proliferation of A549 cells via MTT *** was investigated using Annexin V-FITC/propidium iodide(PI)by flow ***-associated proteins were examined by Western *** the compounds were observed to have inhibitory activities against the proliferation of A549 cells to different *** cytometry showed that compound V increased the proportion of apoptotic A549 cells in a dose-dependent *** blotting showed that compound V increased the expression of Bax,cleaved-caspase-3,cleaved-caspase-9 and cleaved-poly ADP-ribose polymerase(PARP),and decreased the expression of *** results indicated that compound V featured a significant inhibitory effect on A549 cells when compared with other compounds,and it may be considered a potential drug against cancers.

关键词： Shenqi San separation identification A549 apoptosis

Adenosine 2A receptor contributes to the facilitation of postinfectious irritable bowel syndrome by γδ T cells via the PKA/CREB/NF-κB signaling pathway

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World Journal of Gastroenterology 2023年第9期29卷 1475-1491页

作者： Li-Wei Dong Yi-Yao Chen chao-chao Chen zhi-chao ma Jiao Fu Bai-Li Huang Fu-Jin Liu Dong-Chun Liang De-Ming Sun Cheng Lan Department of Gastroenterology Hainan General HospitalAffiliated Hainan HospitalHainan Medical UniversityHaikou 570311Hainan ProvinceChina Doheny Eye Institute Department of OphthalmologyDavid Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA 90033United States

BACKGROUND Immunological dysfunction-induced low-grade inflammation is regarded as one of the predominant pathogenetic mechanisms in post-infectious irritable bowel syndrome(PI-IBS).γδT cells play a crucial role in innate and adaptive *** receptors expressed on the surface ofγδT cells participate in intestinal inflammation and immunity *** To investigate the role ofγδT cell regulated by adenosine 2A receptor(A2AR)in *** The PI-IBS mouse model has been established with Trichinella spiralis(***)*** intestinal A2AR and A2AR inγδT cells were detected by immunohistochemistry,and the inflammatory cytokines were measured by western *** role of A2AR on the isolatedγδT cells,including proliferation,apoptosis,and cytokine production,were evaluated in *** A2AR expression was measured by western blot and reverse transcription polymerase chain reaction(RT-PCR).The animals were administered with A2AR agonist,or A2AR ***,γδT cells were also injected back into the animals,and the parameters described above were examined,as well as the clinical ***,the A2AR-associated signaling pathway molecules were assessed by western blot and *** PI-IBS mice exhibited elevated ATP content and A2AR expression(P<0.05),and suppression of A2AR enhanced PI-IBS clinical characteristics,indicated by the abdominal withdrawal reflex and colon transportation ***-IBS was associated with an increase in intestinal T cells,and cytokine levels of interleukin-1(IL-1),IL-6,IL-17A,and interferon-α(IFN-α).Also,γδT cells expressed A2AR in vitro and generated IL-1,IL-6,IL-17A,and IFN-α,which can be controlled by A2AR agonist and *** studies demonstrated that the A2AR antagonist improved the function ofγδT cells through the PKA/CREB/NF-κB signaling *** Our results revealed that A2AR contributes to the facilitation of PI-IBS by regulating the function ofγδT cells via the PK

关键词： Irritable bowel syndrome Adenosine 2A receptor γδT cells Post-infectious irritable bowel syndrome Signaling pathway Regulation

Upregulated adenosine 2A receptor accelerates post-infectious irritable bowel syndrome by promoting CD4+T cells’T helper 17 polarization

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World Journal of Gastroenterology 2022年第25期28卷 2955-2967页

作者： Li-Wei Dong zhi-chao ma Jiao Fu Bai-Li Huang Fu-Jin Liu Deming Sun Cheng Lan Department of Gastroenterology Hainan General HospitalAffiliated Hainan HospitalHainan Medical UniversityHaikou 570311Hainan ProvinceChina Doheny Eye Institute Department of OphthalmologyDavid Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA 90033United States

BACKGROUND Post-infectious irritable bowel syndrome(PI-IBS)is generally regarded as a functional *** recent studies have reported the involvement of lowgrade inflammation and immunological dysfunction in PI-IBS.T helper 17(Th17)polarization occurs in *** and its receptors participate in intestinal inflammation and immune *** To investigate the role of Th17 polarization of CD4+T cells regulated by adenosine 2A receptor(A2AR)in *** A PI-IBS model was established by infecting mice with Trichinella *** intestinal A2AR and CD4+T lymphocytes were detected by immunohistochemistry,and the inflammatory cytokines were detected by enzyme-linked ***4+T lymphocytes present in the animal’s spleen were separated and cultured with or without A2AR agonist and *** blotting and real-time quantitative polymerase chain reaction were performed to determine the effect of A2AR on the cells and intestinal *** production was *** protein and mRNA levels of A2AR associated signaling pathway molecules were also ***,A2AR agonist and antagonist were injected into the mouse model and the clinical features were *** The PI-IBS mouse model showed increased expression of ATP and A2AR(P<0.05),and inhibition of A2AR improved the clinical features in PI-IBS,including the abdominal withdrawal reflex and colon transportation test(P<0.05).The number of intestinal CD4+T cells and interleukin-17(IL-17)protein levels increased during PI-IBS,which was reversed by administration of the A2AR antagonist(P<0.05).CD4+T cells expressed A2AR and produced IL-17 in vitro,which was regulated by the A2AR agonist and *** A2AR antagonist increased the production of IL-17 by CD4+T cells via the Janus kinase-signal transducer and activator of transcriptionreceptor-related orphan receptorγsignaling *** The results of the present study suggested that the upregulation of A

关键词： Adenosine 2A receptor CD4+T cells T helper 17 polarization Post-infectious irritable bowel syndrome Regulation

Diagnosis and treatment experience of atypical hepatic cystic echinococcosis type 1 at a tertiary center in China

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World Journal of Gastroenterology 2024年第5期30卷 462-470页

作者： Yu-Peng Li Jie Zhang zhi-De Li chao ma Guang-Lei Tian Yuan Meng Xiong Chen zhi-Gang ma Department of Hepatobiliary Surgery People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830000Xinjiang Uygur Autonomous RegionChina

BACKGROUND Some hydatid cysts of cystic echinococcosis type 1(CE1)lack well-defined cyst walls or distinctive endocysts,making them difficult to differentiate from simple hepatic *** To investigate the diagnostic methods for atypical hepatic CE1 and the clinical efficacy of laparoscopic *** The clinical data of 93 patients who had a history of visiting endemic areas of CE and were diagnosed with cystic liver lesions for the first time at the People's Hospital of Xinjiang Uygur Autonomous Region(China)from January 2018 to September 2023 were retrospectively *** diagnoses were made based on findings from serum immunoglobulin tests for echinococcosis,routine abdominal ultrasound,high-frequency ultrasound,abdominal computed tomography(CT)scan,and *** to the treatments,these patients underwent reexaminations at the outpatient clinic until October *** evaluations included the diagnostic precision of diverse examinations,the efficacy of surgical approaches,and the incidence of CE *** All 93 patients were diagnosed with simple hepatic cysts by conventional abdominal ultrasound and abdominal CT *** them,16 patients were preoperatively diagnosed with atypical CE1,and 77 were diagnosed with simple hepatic cysts by high-frequency *** the 16 patients preoperatively diagnosed with atypical CE1 underwent laparoscopy,of whom 14 patients were intraoperatively confirmed to have CE1,which was consistent with the postoperative pathological diagnosis,one patient was diagnosed with a mesothelial cyst of the liver,and the other was diagnosed with a hepatic cyst combined with local *** the 77 patients who were preoperatively diagnosed with simple hepatic cysts,4 received aspiration sclerotherapy of hepatic cysts,and 19 received laparoscopic *** patients were intraoperatively diagnosed with simple hepatic *** the followup period,none of the 14 patients with CE1 expe

关键词： Hepatic echinococcosis Hepatic cystic echinococcosis type 1 Hepatic cyst Color Doppler ultrasound Laparoscopy

Nitrogen-doped carbon dots as photocatalysts for organic synthesis:Effect of nitrogen content on catalytic activity

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Nano Research 2024年第6期17卷 4825-4833页

作者： Kai-Kai Niu chao-Qun ma Rui-zhi Dong Hui Liu Sheng-Sheng Yu Ling-Bao Xing School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China

Regulating the doping of carbon dots(CDs)and the generation of reactive oxygen species(ROS)is essential to selectively control their application in photocatalytic organic *** study successfully synthesized five newly developed nitrogen-doped carbon dots(CDs 1-5)with varying nitrogen content,which have the ability to generate ROS when exposed to light radiation,specifically superoxide anion radicals(O_(2)•-)and singlet oxygen(^(1)O_(2)).The utilization of the aforementioned nitrogen-doped CDs as photocatalysts enables the realization of their potential in facilitating efficient photocatalytic organic ***,it was observed that the photocatalytic efficiency exhibited a gradual decrease when the nitrogen content in the CDs *** order to provide more evidence for this claim,we employed a set of five CDs in the context of photocatalytic dehalogenation ofα-bromoacetophenone,photocatalytic oxidative coupling reaction of amines to imines,photooxidation reaction of sulfides to sulfoxides,and cross-dehydrogenation coupling(CDC)reaction,in which it was further observed that there was a steady decrease in the yields of photocatalytic organic reactions as the nitrogen content in CDs ***,CDs 1 exhibited the best photocatalytic efficiency,thereby reinforcing the hypothesis that a higher nitrogen content corresponds to a decreased catalytic *** study not only investigates the impact of the nitrogen content on the catalytic performance of CDs,but also offers valuable insights for the future utilization of CDs for photocatalytic organic reactions in water.

关键词： carbon dots nitrogen-doped reactive oxygen species photocatalysis

Transient Response and Ionic Dynamics in Organic Electrochemical Transistors

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Nano-Micro Letters 2024年第11期16卷 191-223页

作者： chao Zhao Jintao Yang Wei ma State Key Laboratory for Mechanical Behavior of materials Xi’an Jiaotong UniversityXi′an 710049People’s Republic of China

The rapid development of organic electrochemical transistors(OECTs)has ushered in a new era in organic electronics,distinguishing itself through its application in a variety of domains,from high-speed logic circuits to sensitive biosensors,and neuromorphic devices like artificial synapses and organic electrochemical random-access *** recent strides in enhancing OECT performance,driven by the demand for superior transient response capabilities,a comprehensive understanding of the complex interplay between charge and ion transport,alongside electron–ion interactions,as well as the optimization strategies,remains *** review aims to bridge this gap by providing a systematic overview on the fundamental working principles of OECT transient responses,emphasizing advancements in device physics and optimization *** review the critical aspect of transient ion dynamics in both volatile and non-volatile applications,as well as the impact of materials,morphology,device structure strategies on optimizing transient *** paper not only offers a detailed overview of the current state of the art,but also identifies promising avenues for future research,aiming to drive future performance advancements in diversified applications.

关键词： Organic electrochemical transistors Transient response Ion dynamics Electronic dynamics Volatility and non-volatility

Deciphering and integrating invariants for neural operator learning with various physical mechanisms

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National Science Review 2024年第4期11卷 111-122页

作者： Rui Zhang Qi Meng zhi-Ming ma Academy of mathematics and Systems Science Chinese Academy of Sciences(CAS) Microsoft Research

Neural operators have been explored as surrogate models for simulating physical systems to overcome the limitations of traditional partial differential equation(PDE) solvers. However, most existing operator learning methods assume that the data originate from a single physical mechanism, limiting their applicability and performance in more realistic scenarios. To this end, we propose the physical invariant attention neural operator(PIANO) to decipher and integrate the physical invariants for operator learning from the PDE series with various physical mechanisms. PIANO employs self-supervised learning to extract physical knowledge and attention mechanisms to integrate them into dynamic convolutional *** to existing techniques, PIANO can reduce the relative error by 13.6%–82.2% on PDE forecasting tasks across varying coefficients, forces or boundary conditions. Additionally, varied downstream tasks reveal that the PI embeddings deciphered by PIANO align well with the underlying invariants in the PDE systems, verifying the physical significance of PIANO.

关键词： neural operator PDE solver contrastive learning physical invariants

Grain-boundary segregation and grain growth in nanocrystalline substitutional solid solution alloys

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Journal of materials Science & Technology 2024年第1期168卷 239-249页

作者： Fawei Tang chao Hou Hao Lu zhi Zhao Xiaoyan Song Faculty of materials and manufacturing Key Laboratory of Advanced Functional MaterialsMinistry of Education of ChinaBeijing University of TechnologyBeijing 100124China

A model for describing solute segregation at grain boundaries has been developed for substitutional solid solution alloys,which integrates multiple factors from atomic to microstructural scales.A concept of mo-lar Gibbs free energy of segregation was introduced to evaluate the segregating capability of the solute elements in a closed system,through which the influences of grain boundary structure,grain size,ma-terial composition,and external conditions were *** on the evaluation of various energy forms related to solute segregation and grain growth processes,the nature of the thermal stabilization of nanograin structures by solute segregation was disclosed.A criterion for the destabilization of nanostruc-tures,which is determined by the competition of the change rates between the molar Gibbs free energy of segregation and the total energy of grain boundaries with grain size,has been *** study provided guideline to achieve high-temperature stability of nanograin structures of solid solution alloys even for the weakly segregating nanocrystalline systems.

关键词： Substitutional solid solution Grain boundary segregation Thermal stabilization Solute concentration Grain size

High-precision analytical solutions for Earth coverage of constellation equipped with reentry glide vehicles

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Chinese Journal of Aeronautics 2024年第9期37卷 385-398页

作者： Ping ma Weibo SUN Jie GAO Tao chao Control and Simulation Center Harbin Institute of TechnologyHarbin 150001China Beijing Institute of Spacecraft System Engineering Beijing 100094China

To efficiently and accurately design satellite constellations equipped with Reentry Glide Vehicles(RGVs),new analytical solutions are developed for calculating their coverage ***,a new coverage model is established by approximating the Reentry Reachable Domain(RRD).However,the computation of real-time relative distances between satellites and targets,which is essential for coverage analysis based on this model,imposes a significant compu-tational *** address this challenge,a coverage analysis method based on two-dimensional map theory is *** method represents the coverage conditions of a target as a fixed area on a two-dimensional map and transforms the satellite trajectory into a series of parallel *** determining the intersection points between these lines and the area boundaries,the coverage ana-lytical solutions for a target point are *** this basis,coverage theorems are presented for rapid calculation of the constellation coverage performance for an *** results demon-strate the effectiveness and high precision of the proposed analytical solutions.

关键词： Constellation Analytical solutions Reentry glide vehicle Reentry reachable domain Two-dimensional map