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Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2024年第3期19卷 671-679页

作者： Chunyun Liu Shangde Guo Rong Liu Minfang Guo Qing Wang zhi Chai Baoguo Xiao Cungen ma Institute of Brain Science Shanxi Datong UniversityDatongShanxi ProvinceChina The Key Research Laboratory of Benefiting Qi for Acting Blood Cireulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine/Research Center of Neurobiology Shanxi University of Chinese MedicineTaiyuanShanxi ProvinceChina Institute of Neurology Huashan HospitalInstitutes of Brain Science and State Key Laboratory of Medical NeurobiologyFudan UniversityShanghaiChina

Multiple sclerosis is characterized by demyelination and neuronal loss caused by inflammatory cell activation and infiltration into the central nervous *** polarization plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis,a traditional experimental model of multiple *** study investigated the effect of Fasudil on macrophages and examined the therapeutic potential of Fasudil-modified macrophages in experimental autoimmune *** found that Fasudil induced the conversion of macrophages from the pro-inflammatory M1 type to the anti-inflammatory M2 type,as shown by reduced expression of inducible nitric oxide synthase/nitric oxide,interleukin-12,and CD16/32 and increased expression of arginase-1,interleukin-10,CD14,and CD206,which was linked to inhibition of Rho kinase activity,decreased expression of toll-like receptors,nuclear factor-κB,and components of the mitogen-activated protein kinase signaling pathway,and generation of the pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,and ***,Fasudil-modified macrophages effectively decreased the impact of experimental autoimmune encephalomyelitis,resulting in later onset of disease,lower symptom scores,less weight loss,and reduced demyelination compared with unmodified *** addition,Fasudil-modified macrophages decreased interleukin-17 expression on CD4^(+)T cells and CD16/32,inducible nitric oxide synthase,and interleukin-12 expression on F4/80^(+)macrophages,as well as increasing interleukin-10 expression on CD4^(+)T cells and arginase-1,CD206,and interleukin-10 expression on F4/80^(+)macrophages,which improved immune regulation and reduced *** findings suggest that Fasudil-modified macrophages may help treat experimental autoimmune encephalomyelitis by inducing M2 macrophage polarization and inhibiting the inflammatory response,thereby providing new insight into cell immunotherapy for m

关键词： anti-inflammatory experimental autoimmune encephalomyelitis Fasudil macrophage multiple sclerosis pro-inflammatory Rho kinase

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Protection of Omicron Sub-Lineage Infection Against Reinfection with Another Omicron Sub-Lineage:Systematic Review,Meta-Analysis,and Meta-Regression-Worldwide,2022-2023

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China CDC weekly 2024年第26期6卷 624-628,I0001-I0009页

作者： Xu Guo Zuyao Cheng Junhong Li Yudan Song Hui Zheng Yamin Wang chao ma Zijian Feng National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease National Immunization ProgramChinese Center for Disease Control and PreventionBeijingChina Chinese Preventive Medicine Association BeijingChina

Summary What is already known about this topic?Both the decline in immunity over time and the evolution of the virus play a role in the level of protection offered by a prior *** is added by this report?Point estimates indicated variations in protection levels based on the initial infecting variant and the reinfecting *** was a consistent correlation between real-world protection,antigenic distance,and humoral immunity ***,shorter antigenic distances and higher humoral immunity levels corresponded to enhanced real-world *** are the implications for public health practice?Our findings suggest that virological and immunological studies could help identify and assess the epidemic risk posed by new variants before they become *** incorporation of the latest variants into the antigen components of the coronavirus disease 2019(COVID-19)vaccines can significantly contribute to effective epidemic prevention and control measures.

关键词： immunity prevention shorter

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Antibacterial properties of cerium oxide nanoparticles:Recent progresses and future challenges

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Particuology 2024年第10期93卷 264-283页

作者： Heishu Zheng Jiajing Tang Yanhua Wei Xi Deng Yingjuan Zhang Xiangyu ma Xudong Jiang zhi Ping Xu Hongbing Liao College&Hospital of Stomatology Guangxi Medical UniversityNanning530021China Guangxi Key Laboratory of Oral and maxillofacial Rehabilitation and Reconstruction Guangxi Medical UniversityNanning530021China The First Affiliated Hospital of Guangxi Medical University Nanning530021China School of Medicine Guangxi University of Science and TechnologyLiuzhou545005China Institute of Biomedical Health Technology and Engineering and Institute of Systems and Physical Biology Shenzhen Bay LaboratoryShenzhen518107China Australian Institute for Bioengineering and Nanotechnology(Bld 75) The University of QueenslandSt LuciaQueensland 4074Australia

Use of cerium oxide nanoparticles(CeO_(2) NPs)to optimize management of resistant microorganisms has received increasing attention due to non-specific activity of inorganic antibacterial *** the mechanism of action is essential to elucidating the antibacterial activity of CeO_(2) NPs against ***,this review aims to summarize the antibacterial mechanisms of CeO_(2) NPs and correlate the structural and physicochemical properties of CeO_(2) NPs to their antibacterial *** further summarize the strategies for the improvement of the antibacterial performance of CeO_(2) NPs and provide our opinions for future challenges as a conclusion.

关键词： Nanoparticles Cerium oxide Antibacterial activity Nanozyme Fenton reaction

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Fast charge transfer kinetics in Sv-ZnIn_(2)S_(4)/Sb_(2)S_(3)S-scheme heterojunction photocatalyst for enhanced photocatalytic hydrogen evolution

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Rare Metals 2024年第2期43卷 533-542页

作者： Wei Li Jia-Jun Li zhi-Fei Liu Hong-Yu ma Peng-Fei Fang Rui Xiong Jian-Hong Wei Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and TechnologyWuhan UniversityWuhan430072China

Constructing a S-scheme heterojunction with tight interface contact and fast charge transfer is beneficial to improving the photocatalytic hydrogen evolution ***,a unique one-dimensional(1D)/two-dimensional(2D)S-scheme heterojunction containing 1D Sb_(2)S_(3) nanorods and 2D ZnIn_(2)S_(4) with affluent sulfur vacancies(denoted as Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3)) was *** introduced sulfur vacancy can promote the effective adsorption of H+for the following interfacial hydrogen-evolution ***,the larger contact area and stronger electron interaction between Sb_(2)S_(3) and ZnIn_(2)S_(4) effectively inhibits the recombination of photo-generated electron–hole pairs and abridges the migration distance of *** a result,the optimal Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3) sample achieves H_(2) evolution activity of 2741.3 mol·h^(−1)·g^(−1),which is 8.6 times that of pristine ZnIn_(2)S_(4) and 3.0 times that of the Sv-ZnIn_(2)S_(4) *** on the experimental result,the photo-reactivity S-scheme mechanism of hydrogen evolution from water splitting with Sv-ZnIn_(2)S_(4)@Sb_(2)S_(3) is *** work provides an effective method for developing S-scheme heterojunction composites of transition metal sulfide with high hydrogen evolution performance.

关键词： ZnIn_(2)S_(4) nanosheets S-scheme heterojunction Sulfur vacancy Charge transfer and separation Photocatalytic H_(2)evolution

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A novel clinical artificial intelligence model for disease detection via retinal imaging

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The Innovation 2024年第2期5卷 11-12页

作者： Yidian Fu Liang ma Sheng Wan Shengfang Ge zhi Yang Department of Ophthalmology Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011China PCA Lab Key Lab of Intelligent Perception and Systems for High-Dimensional Information of Ministry of EducationNanjing 210000China Jiangsu Key Lab of Image and Video Understanding for Social Security School of Computer Science and EngineeringNanjing University of Science and TechnologyNanjing 210000China

Artificial intelligence(AI)is an emerging field in which computerized systems are used to carry out complex tasks in place of *** AI algorithms have been developed for disease diagnosis and prediction and treatment recommendation across various clinical data types,e.g.,chest X-rays,electrocardiograms,and other radiological images.1 In ophthalmology,particularly,great progress has been made in AI systems over the past *** fundus photography(CFP)and optical coherence tomography(OCT),which are readily available in routine clinical practice,are both mainstream and useful retinal imaging modalities in *** September 2023,the 2023 Lasker-Debakey Clinical Medical Research Award was awarded to three scientists for their work on OCT for accurate retinal disease detection.

关键词： clinical routine diagnosis

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Designing ABC-6 family small pore zeolites by epitaxial growth approach

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Chinese Chemical Letters 2024年第3期35卷 508-512页

作者： Xiaohui Cui Jia Lv chao ma Yujiao Wang Zhenghao Jia Daliang Zhang Peng Guo Zhongmin Liu Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450001China National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Multi-scale Porous materials Center Institute of Advanced Interdisciplinary Studies&School of Chemistry EngineeringChongqing UniversityChongqing 400044China University of Chinese Academy of Sciences Beijing 100049China Division of Energy Research Resources Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Aluminosilicate small pore zeolites belonging to ABC-6 family play crucially important roles in the high methanol conversion with the high selectivity of light olefins,gas separation and storage,and selective catalytic reduction of NO_(x).In this work,we report a general method,called the epitaxial growth approach,for designing ABC-6 family small pore *** is mainly realized through the epitaxial growth on the nonporous SOD-type zeolite in the presence of inorganic cations(Na^(+)and K^(+))combined with a variety of organic structure directing agents(OSDAs).In this case,a series of ABC-6 family small pore zeolites such as ERI-,SWY-,LEV-,AFX-,and PTT-type zeolites have been successfully synthesized within a few *** importantly,the advanced focused ion beam(FIB)and the low-dose high-resolution transmission electron microscopy(HRTEM)imaging technique have been utilized for unraveling the zeolite heterojunction at the atomic level during the epitaxial growth *** turns out(222)crystallographic planes of the SOD-type zeolite substrate provide unique pre-building units,which facilitate the growth of targeted ABC-6 family small pore zeolites along its ***,the morphologies of ERI-type zeolite can also be tuned through the epitaxial growth approach,achieving a longer lifetime in the methanol conversion.

关键词： Zeolite structure Zeolite synthesis Structural characterizations Low-dose imaging Focused ion beam

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GNAS mutations suppress cell invasion by activating MEG3 in growth hormone–secreting pituitary adenoma

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Oncology Research 2024年第6期32卷 1079-1091页

作者： chao TANG CHUNYU ZHONG JUNHAO ZHU FENG YUAN JIN YANG YONG XU CHIYUAN ma Department of Neurosurgery Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjing210002China Department of Neurosurgery Children’s Hospital of Nanjing Medical UniversityNanjing210019China Affiliated Eye Hospital Nanjing Medical UniversityNanjing210029China Department of Neurosurgery Jinling HospitalSouthern Medical UniversityNanjing210002China Department of Neurosurgery Jinling HospitalNanjing Medical UniversityNanjing210002China

Approximately 30%–40%of growth hormone–secreting pituitary adenomas(GHPAs)harbor somatic activating mutations in GNAS(αsubunit of stimulatory G protein).Mutations in GNAS are associated with clinical features of smaller and less invasive ***,the role of GNAS mutations in the invasiveness of GHPAs is *** mutations were detected in GHPAs using a standard polymerase chain reaction(PCR)sequencing *** expression of mutation-associated maternally expressed gene 3(MEG3)was evaluated with ***3 was manipulated in GH3 cells using a lentiviral expression *** invasion ability was measured using a Transwell assay,and epithelial–mesenchymal transition(EMT)-associated proteins were quantified by immunofluorescence and western ***,a tumor cell xenograft mouse model was used to verify the effect of MEG3 on tumor growth and *** invasiveness of GHPAs was significantly decreased in mice with mutated GNAS compared with that in mice with wild-type ***,the invasiveness of mutant GNASexpressing GH3 cells ***3 is uniquely expressed at high levels in GHPAs harboring mutated ***,MEG3 upregulation inhibited tumor cell invasion,and conversely,MEG3 downregulation increased tumor cell ***,GNAS mutations inhibit EMT in ***3 in mutated GNAS cells prevented cell invasion through the inactivation of the Wnt/β-catenin signaling pathway,which was further validated in *** data suggest that GNAS mutations may suppress cell invasion in GHPAs by regulating EMT through the activation of the MEG3/Wnt/β-catenin signaling pathway.

关键词： GHPAs GNAS mutation MEG3 β-catenin EMT

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Evolution of chemistry and selection technology for DNA-encoded library

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Acta Pharmaceutica Sinica B 2024年第2期14卷 492-516页

作者： Peixiang ma Shuning Zhang Qianping Huang Yuang Gu zhi Zhou Wei Hou Wei Yi Hongtao Xu Shanghai Key Laboratory of Orthopedic Implants Department of OrthopedicsShanghai Ninth People’s HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech UniversityShanghai 201210China Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology The NMPA and State Key Laboratory of Respiratory DiseaseGuangzhou Medical UniversityGuangzhou 511436China College of Pharmaceutical Science and Institute of Drug Development&Chemical Biology Zhejiang University of TechnologyHangzhou 310014China

DNA-encoded chemical library(DEL)links the power of amplifiable genetics and the nonself-replicating chemical phenotypes,generating a diverse chemical *** analogy with the biological world,the DEL world can evolve by using a chemical central dogma,wherein DNA replicates using the PCR reactions to amplify the genetic codes,DNA sequencing transcripts the genetic information,and DNA-compatible synthesis translates into chemical ***,DNA-compatible synthesis is the key to expanding the DEL chemical ***,the evolution-driven selection system pushes the chemicals to evolve under the selective pressure,i.e.,desired selection *** this perspective,we summarized recent advances in expanding DEL synthetic toolbox and panning strategies,which will shed light on the drug discovery harnessing in vitro evolution of chemicals via DEL.

关键词： DNA-encoded library Drug discovery High-throughput selection DNA-compatible synthesis In vitro evolution Chemical central dogma

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Micelle-directed self-assembly of single-crystal-like mesoporous stoichiometric oxides for high-performance lithium storage

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National Science Review 2024年第4期11卷 195-205页

作者： Yanhua Wan Changyao Wang Xingmiao Zhang Yang Yin Mengmeng Liu Bing ma Linlin Duan Yuzhu ma Wei Zhang Changlin Zheng Dongliang chao Fei Wang Yongyao Xia Wei Li Department of Chemistry Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of Polymers College of Chemistry and Materials ScienceFudan University State Key Laboratory of Surface Physics and Department of Physics Fudan University

Due to their uncontrollable assembly and crystallization process,the synthesis of mesoporous metal oxide single crystals remains a formidable ***,we report the synthesis of single-crystal-like mesoporous Li2TiSiO5by using soft micelles as *** key lies in the atomic-scale self-assembly and step-crystallization processes,which ensure the formation of single-crystal-like mesoporous Li2TiSiO5microparticles via an oriented attachment growth mechanism under the confinement of an in-situ formed carbon *** mesoporous Li2TiSiO5anode achieves a superior rate capability(148 mah g-1at5.0 A g-1) and outstanding long-term cycling stability(138 mah g-1after 3000 cycles at 2.0 A g-1) for lithium storage as a result of the ultrafast Li+diffusion caused by penetrating mesochannels and nanosized crystal frameworks（5-10 nm）.In comparison,bulk Li2TiSiO5exhibits poor rate capability and cycle performance due to micron-scale diffusion *** method is very simple and reproducible,heralding a new way of designing and synthesizing mesoporous single crystals with controllable frameworks and chemical functionalities.

关键词： mesoporous materials micelles single-crystal-like Li2TiSiO5 lithium-ion batteries

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Effect of Room Temperature Ultrasonic Vibration Compression on the Microstructure Evolution and Mechanical Properties of AZ91 Alloy

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1135-1146页

作者： Ziyue Xu Huan Liu Luyao Li chao Sun Xi Tan Baishan Chen Qiangsheng Dong Yuna Wu Jinghua Jiang Jiang ma College of materials Science and Engineering Hohai UniversityNanjing210000China Suzhou Research Institute of Hohai University Suzhou215000China Shenzhen Key Laboratory of High Performance Nontraditional manufacturing College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen518060China Institute of Medical Devices(Suzhou) Southeast UniversitySuzhou215163China Institute for Advanced Study Central South UniversityChangsha410083China Jiangsu Key Laboratory of Advanced Structural materials and Application Technology Nanjing Institute of TechnologyNanjing211167China

To investigate the potential of direct ultrasonic vibration on improving the performance of magnesium alloys,this study first employed the ultrasonic vibration compression(UVC)on the solid solution treated AZ91 alloy,and explored its microstructure evolution and mechanical properties under *** only two seconds,the UVC alloys showed large deformation strains of 34.8–54.4%,and sudden increase of sample temperature to 243℃.Microstructure characterizations proved that UVC promoted the formation of abundant shear bands,fine grains,and the bimodal distribution of Mg17Al12 precipitates consisting of submicron particles located within the shear bands and nano-sized ones within the *** to the unique microstructure,the micro-hardness(and nano-hardness)value of UVC alloy was increased by 37.7%(35%)when compared with the solution-treated ***,the nano-modulus of the developed AZ91 alloy was also significantly increased to 62 GPa by statistical nanoindentation tests,which could be ascribed to increased Mg_(17)Al_(12) precipitates and decreased c/a value to some *** general,this work provides a new insight into the design and preparation of high-performance magnesium alloys by UVC at room temperature.

关键词： AZ91 alloys Ultrasonic vibration compression Precipitation Shear bands Mechanical properties

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