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Four Forbidden Subgraph Pairs for Hamiltonicity of 3-connected Graphs

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Acta Mathematicae Applicatae Sinica 2016年第2期32卷 469-476页

作者： Hou-yuan LIN zhi-quan hu School of Mathematics and Quantitative Economics Shandong University of Finance and Economics Faculty of Mathematics and Statistics Central China Normal University

For non-negative integers i,j and k, we denote the generalized net as Ni,j,k, which is a triangle with disjoint paths of length i, j and k, attached to distinct vertices of the triangle. In this paper, we prove that e... 详细信息

关键词： hamiltonian cycle forbidden subgraphs claw-free graphs closure

Neuroprotective effects of atorvastatin against cerebral ischemia/reperfusion injury through the inhibition of endoplasmic reticulum stress

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Neural Regeneration Research 2015年第8期10卷 1239-1244页

作者： Jian-wen Yang zhi-ping hu Department of Neurology Second Xiangya Hospital Central South University

Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α in the endoplasmic reticulum stress signaling pathway. To verify this hypothesis, we occluded the middle cerebral artery in rats to establish focal cerebral ischemia/reperfusion model. Results showed that the expression levels of protein kinase-like endoplasmic reticulum kinase and caspase-3, as well as the phosphorylation of eukaryotic initiation factor 2α, were increased after ischemia/reperfusion. Administration of atorvastatin decreased the expression of protein kinase-like endoplasmic reticulum kinase, caspase-3 and phosphorylated eukaryotic initiation factor 2α, reduced the infarct volume and improved ultrastructure in the rat brain. After salubrinal, the specific inhibitor of phosphorylated eukaryotic initiation factor 2α was given into the rats intragastrically, the expression levels of caspase-3 and phosphorylated eukaryotic initiation factor 2α in the were decreased, a reduction of the infarct volume and less ultrastructural damage were observed than the untreated, ischemic brain. However, salubrinal had no impact on the expression of protein kinase-like endoplasmic reticulum kinase. Experimental findings indicate that atorvastatin inhibits endoplasmic reticulum stress and exerts neuroprotective effects. The underlying mechanisms of attenuating ischemia/reperfusion injury are associated with the protein kinase-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/caspase-3 pathway.

关键词： nerve regeneration neuroprotection protein kinase-like endoplasmic reticulum kinase eukaryotic initiation factor 2α endoplasmic reticulum stress focal cerebral ischemia/reperfusion atorvastatin apoptosis

Enhancing m^(6)A modification in the motor cortex facilitates corticospinal tract remodeling after spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1749-1763页

作者： Tian Qin Yuxin Jin Yiming Qin Feifei Yuan Hongbin Lu Jianzhong hu Yong Cao Chengjun Li Department of Spine Surgery and Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan ProvinceChangshaHunan ProvinceChina National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Sports Medicine Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Spinal cord injury typically causes corticospinal tract disruption. Although the disrupted corticospinal tract can self-regenerate to a certain degree, the underlying mechanism of this process is still unclear. N6-methyladenosine(m^(6)A) modifications are the most common form of epigenetic regulation at the RNA level and play an essential role in biological processes. However, whether m^(6)A modifications participate in corticospinal tract regeneration after spinal cord injury remains unknown. We found that expression of methyltransferase 14 protein(METTL14) in the locomotor cortex was high after spinal cord injury and accompanied by elevated m^(6)A levels. Knockdown of Mettl14 in the locomotor cortex was not favorable for corticospinal tract regeneration and neurological recovery after spinal cord injury. Through bioinformatics analysis and methylated RNA immunoprecipitation-quantitative polymerase chain reaction, we found that METTL14 regulated Trib2 expression in an m^(6)A-regulated manner, thereby activating the mitogen-activated protein kinase pathway and promoting corticospinal tract regeneration. Finally, we administered syringin, a stabilizer of METTL14, using molecular docking. Results confirmed that syringin can promote corticospinal tract regeneration and facilitate neurological recovery by stabilizing METTL14. Findings from this study reveal that m^(6)A modification is involved in the regulation of corticospinal tract regeneration after spinal cord injury.

关键词： corticospinal tract remodeling epigenetic regulations locomotor cortex m^(6)A modification methyltransferase 14 protein(METTL14) mitogen-activated protein kinase neural regeneration spinal cord injury syringin TRIB2

On a Spanning K-tree Containing Specified Vertices in a Graph

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Acta Mathematicae Applicatae Sinica 2019年第4期35卷 919-923页

作者： Fei-fei SONG zhi-quan hu Department of Information & Computational Science He’nan Agricultural University Zhengzhou 450002 China Faculty ofMath & Statistics Central China Normal UniversityWuhan 430079 China

A k-tree is a tree with maximum degree at most k. In this paper, we give a sharp degree sum condition for a graph to have a spanning k-tree in which specified vertices have degree less than t, where 1≤t≤*** denote by σ_k(G) the minimum value of the degree sum of k independent vertices in a graph G. Let k≥2,s≥0 and 1≤t≤k be integers, and suppose G is an(s + 1)-connected graph with σ_k(G)≥|G|+(k-t)*** for any s specified vertices, G contains a spanning k-tree in which every specified vertex has degree at most t. This improves a result obtained by Matsuda and Matsumura.

关键词： spanning tree k-tree (s + 1)-connected graphs degree sum condition specified vertices

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免费商品对独立产品扩散的影响分析

系统工程理论与实践 2013年第5期33卷 1192-1199页

作者：胡知能李标四川大学不确定决策实验室成都610064

以低值易耗品为研究对象,基于传统的Bass扩散模型,在价格营销策略下建立了多时期免费商品赠送水平的优化模型群,将重复购买、批量购买等众多因素引入模型中,应用灵敏度分析探讨了参数变化时最优解的稳定性,结果表明:免费商品的赠送会加... 详细信息

以低值易耗品为研究对象,基于传统的Bass扩散模型,在价格营销策略下建立了多时期免费商品赠送水平的优化模型群,将重复购买、批量购买等众多因素引入模型中,应用灵敏度分析探讨了参数变化时最优解的稳定性,结果表明:免费商品的赠送会加快独立产品的扩散过程;在价格策略选择时,采用渗透策略的结果最好;免费商品在首期赠送的效果要优于其他时期赠送,形成了"首期赠样效应";当消费者需要批量购买时,就需要更多的免费商品的赠送使得消费者对本商品的了解程度增加,但在批量购买较高时赠送水平会维持在一个稳定水平下.在此基础之上,为企业的实际应用给出了基本操作步骤.

关键词：独立产品免费商品产品扩散价格策略

The Surface Modification of Tourmaline Powder with Triethoxyvinylsilane and Characterization

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武汉理工大学学报 2015年第2期37卷 40-43,49页

作者： hu zhi-ying School of Materials Science and Engineering Wuhan University of Technology

The surface modification of the tourmaline powder with triethoxyvinylsilane was studied to prepare the polymerizable organic *** experimental results showed that the surface of modified tourmaline had the better hydrophobicity compared with unmodified tourmaline,when the mass ratio of triethoxyvinylsilane to tourmaline powder was 1∶5,and reacted at 60 ℃for 1.5hin the mixed-solvent of ethanol and distilled water(1∶5in volume ratio).The structure characterization results indicated that the vinylsiloxane was introduced into the surface of tourmaline powder to generate the polymerizable organic tourmaline,and the crystal structure of tourmaline had no change.

关键词： tourmaline triethoxyvinylsilane surface modification functional polymer

Phase Synchronization in Coupled Oscillators: Dynamical Manifestations

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Chinese Physics Letters 2001年第7期18卷 874-877页

作者： ZHENG zhi-Gang hu Gang Bambi hu Department of Physics Beijing Normal UniversityBeijing 100875 Department of Physics and Center for Nonlinear Studies Hong Kong Baptist UniversityHong Kong Department of Physics University of HoustonHouston TX77204USA

Phase synchronized entrainment of coupled oscillators with distributed natural frequencies is studied by exploring the dynamical *** route from partial to complete phase synchronization is identified as a cascade of transitions from high-to low-dimensional tori(quasiperiodicities)interrupted by intermittent *** ON-OFF intermittency is found at the onset of ***-induced chaos originates from the mixing of intermittent ON-OFF time scales.

关键词： chaos Phase chaos

Effects of annealing temperature on electrochemical performance of SnSx embedded in hierarchical porous carbon with N-carbon coating by in-situ structural phase transformation as anodes for lithium ion batteries

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Journal of Materials Science & Technology 2021年第25期84卷 191-199页

作者： Qianqian hu biao Wang Shiyong Chang Chun Yang Yunjian hu Shubin Cao Jiqun Lu Lingzhi Zhang Ye Hong Guangzhou Institute of Energy Conversion Chinese Academy of SciencesCAS Key Laboratory of Renewable EnergyGuangdong Provincial Key Laboratory of New and Renewable Energy Research and DevelopmentGuangzhouGuangdong 510640China GAC Automotive Research&Development Center Guangzhou 511434China University of Chinese Academy of Sciences Beijing 100049China Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123China Industrial Training Center Guangdong Polytechnic Normal University510665China

Tuned tin chalcogenides rooted in hierarchical porous carbon(HPC)with N-carbon coating layers are prepared by thermal shock under various temperatures(denoted as HPC-SnS_(2)-PAN-Various T).With the increase of annealing temperature,the morphology and phase structure of Sn S_(2),as well as the cyclization degree of polyacrylonitrile(PAN),are significantly changed,which leads to the formation of rod-like Sn S and ordered structure of conductive N-carbon *** combining HPC,N-carbon coating derived from the cyclization of PAN,with 1D Sn S nanorods generated from structural phase transformation of SnS_(2),the optimized composite(HPC-SnS_(2)-PAN-500)as anode for lithium ion batteries(LIBs)provides buffer space for volume changes during alloying/dealloying process,builds a highly conductive network as well as decreases irreversible capacity from solid electrolyte interphase and enhances the ion/electron *** to the above merits from composition regulation and architecture modification by sulfur depletion and PAN cyclization,this target anode exhibits an extraordinary cycling stability with a high specific capacity of 652.5 m A h/g at 0.5 A/g after 900 *** suggests that rod-like Sn S embedded in HPC with cyclized PAN layers by thermal treatment approach renders a potential structural design of anode materials for LIBs.

关键词： Hierarchical porous carbon SnSx Conducting medium Cycling stability Lithium ion batteries

Mediation Effects of Placental Inflammatory Transcriptional Biomarkers on the Sex-Dependent Associations between Maternal Phthalate Exposure and Infant Allergic Rhinitis: A Population-Based Cohort Study

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Biomedical and Environmental Sciences 2022年第8期35卷 711-721页

作者： WANG Jian Qing LI zhi Juan GAO hui SHENG Jie LIANG Chun Mei hu Ya Bin XIA Xun huANG Kun WANG Su Fang Zhu Peng HAO Jia hu TAO Fang biao Department of Maiernal Child and Adolescent HealthSchool of Public HealthAnhui Medical UniversityHefei 230032AnhuiChina MOE Key Laboratory of Popularion Health across Life Cycle Hefei 230032AnhuiChina NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract Hefei 230032AnhuiChina Anhui Provincial Key Laboratory of Population Health and Aristogenics Anhui Medical UniversityHefei 230032AnhuiChina The Fourth Affiliated Hospital Anhui Medical UniversiyHefei 230022AnhuiChina Department of Pediatrics First Afiliated Hospital of Anhui Medical UniversityHefei 230022AnhuiChina

Objective Prenatal phthalate exposure has been associated with placental inflammatory factors and infant allergic rhinitis(AR).However,the results are *** designed a population-based cohort study to examine the effects of placental inflammatory biomarkers on the sex-dependent associations between maternal phthalate exposure and infant *** A total of 2,348 pregnant women from Ma’anshan,Anhui Province,China,who were screened before antenatal visits and met the inclusion criteria,were included in the present *** assessed AR in their offspring aged 36 months with a *** PCR was performed to measure placental inflammatory factor m *** independent samples t-test and multivariable logistic regression were used to determine the associations between infant AR and maternal *** Childhood AR may be related to education and family monthly income(P = 0.01).The phthalate metabolites,mono(2-ethylhexyl) phthalate(MEHP),mono(2-ethyl-5-hydroxyl) phthalate(MEHHP),in pregnant women were associated with a significantly increased risk for infant AR in males[P < 0.05;odds ratio(OR):1.285;95% confidence interval(CI):1.037-1.591,and OR:1.232,95% CI:1.008-1.507,respectively],but not ***,irritably-increased expression levels of HO-1 and IL-4 were associated with AR in male infants(OR:1.175;95% CI:1.038-1.329 and OR:1.181;95% CI:1.056-1.322,respectively).The association between maternal urinary MEHHP and placental HO-1 was marginally significant according to mediation *** The associations of maternal MEHHP and MEOHP levels with fetal AR in males were *** HO-1 was a fractional mediator in the associations between MEHHP and ***,the placenta should be further investigated as a potential mediator of maternal exposure-induced disease risk in children.

关键词： Phthalate Infants Allergic rhinitis Inflammation Sex difference