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Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension

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World Journal of Gastroenterology 2024年第13期30卷 1859-1870页

作者： Rong Chen Ling Luo yun-zhi Zhang Zhen Liu An-Lin Liu Yi-Wen Zhang Department of Infectious Diseases Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Portal hypertension(PHT),primarily induced by cirrhosis,manifests severe symptoms impacting patient *** transjugular intrahepatic portosystemic shunt(TIPS)is a critical intervention for managing PHT,it carries risks like hepatic encephalopathy,thus affecting patient survival *** our knowledge,existing prognostic models for post-TIPS survival in patients with PHT fail to account for the interplay among and collective impact of various prognostic factors on ***,the development of an innovative modeling approach is essential to address this *** To develop and validate a Bayesian network(BN)-based survival prediction model for patients with cirrhosis-induced PHT having undergone *** The clinical data of 393 patients with cirrhosis-induced PHT who underwent TIPS surgery at the Second Affiliated Hospital of Chongqing Medical University between January 2015 and May 2022 were retrospectively *** were selected using Cox and least absolute shrinkage and selection operator regression methods,and a BN-based model was established and evaluated to predict survival in patients having undergone TIPS surgery for *** Variable selection revealed the following as key factors impacting survival:age,ascites,hypertension,indications for TIPS,postoperative portal vein pressure(post-PVP),aspartate aminotransferase,alkaline phosphatase,total bilirubin,prealbumin,the Child-Pugh grade,and the model for end-stage liver disease(MELD)*** on the above-mentioned variables,a BN-based 2-year survival prognostic prediction model was constructed,which identified the following factors to be directly linked to the survival time:age,ascites,indications for TIPS,concurrent hypertension,post-PVP,the Child-Pugh grade,and the MELD *** Bayesian information criterion was 3589.04,and 10-fold cross-validation indicated an average log-likelihood loss of 5.55 with a standard deviation of *** model’s acc

关键词： Bayesian network Cirrhosis Portal hypertension Transjugular intrahepatic portosystemic shunt Survival prediction model

miR-532-3p inhibits the progression of tongue squamous cell carcinoma by targeting podoplanin

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Chinese Medical Journal 2021年第24期134卷 2999-3008页

作者： zhi-yun Liu Chun-Guang Zhao Department of Stomatology The Sixth Hospital of WuhanAffiliated Hospital of Jianghan UniversityWuhanHubei 430015China

Background:The association between miR-532-3p and tongue squamous cell carcinoma(TSCC)has been examined in the literature to improve the survival rate of patients with this ***,further studies are needed to confirm the regulatory roles of this microRNA(miRNA)in *** objective of this study was to investigate the roles played by and the underlying mechanism used by the miR-532-3p/podoplanin(PDPN)axis in TSCC ***:Western blotting and quantitative real-time reverse transcription-polymerase chain reaction(RT-qPCR)were performed to evaluate the PDPN expression level in TSCC tissues and *** proliferative,adhesive,and migratory capabilities of TSCC cells(CAL-27 and CTSC-3)were examined using cell counting kit-8(CCK-8),cell adhesion,and wound-healing assays,*** dual-luciferase reporter(DLR)assay was later conducted to confirm the relationship between miR-532-3p and ***:The results indicated that PDPN expression was enriched in TSCC tissues and cells,and that the expression of PDPN was associated with some clinicopathological parameters of TSCC,including lymph node metastasis(P=0.001),tumor-node-metastasis(TNM)staging(P=0.010),and grading(P=0.010).Further analysis also showed that PDPN knockdown inhibited the viability,adhesive ability,and migratory capacity of CAL-27 and CTSC-3 cells,effects that could be reversed by the application of a miR-532-3p ***,PDPN was found to be a direct target of ***:This research suggested that by targeting PDPN,miR-532-3p could inhibit cell proliferation viability,adhesion,and migration in *** also revealed that the miR-532-3p/PDPN axis might provide more insights into the prognosis and treatment of TSCC.

关键词： Tongue squamous cell carcinoma Podoplanin miR-532-3p

Relationship between resistin level in serum and acute coronary syndrome or stable angina pectoris

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第12期8卷 875-880页

作者： QIAO Xiao-zhi YANG yun-mei XU Zhe-rong YANG Li-ai Department of Very Important Person the First Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310003 China

Objective： To investigate the relationship between serum resistin level and acute coronary syndrome （ACS） or stable angina pectoris （SAP）. Methods： Sixty-five patients, with coronary artery disease, were enrolled and divided into three subgroups： acute myocardial infarction （AMI）, unstable angina pectoris （UAP） and SAP, and 26 healthy people were recruited as controls in the cross-sectional study. Serum resistin levels were determined by ELISA （enzyme-linked immunosorbent assay）, and WBC （white blood cell count）, hsCRP （high sensitive C-reaction protein）, CKmax （maximum of creatinkinase）, CK-MBmax （maximum of isozyme of creatinkinase） and cTnImax （maximum of troponin） were measured by standard laboratory methods. Results： The serum resistin levels were 4 folds higher in AMI patients, 2.43 folds in UAP patients and I. 12 folds in SAP patients than in the healthy controls （P〈0.05）. The resistin levels were also significantly different between AMI [（8.16±0.79） ng/ml], UAP [（5.59±0.75） ng/ml] and SAP [（3.45±0.56） ng/ml] groups （P〈0.01）; WBC, hsCRP, CK CK-MBmax and cTnlmax were significantly increased in AMI patients over UAP and SAP patients. Spearman analysis showed that serum resistin levels were positively correlated with WBC （r=0.412, P=0.046）, hsCRP （r=0.427,p=0.037）, CK CK-MBmax and cTnImax （r=0.731, 0.678, 0.656; P〈0.01）. Conclusion： Serum resistin levels increased with inflammatory factors and myocardial impairment. The results suggest that human resistin might play an important role in the pathogenesis of atherosclerosis and AMI as an inflammatory factor.

关键词： Resistin Acute coronary syndrome (ACS) Stable angina pectoris (SAP)

Role of savolitinib in advanced gastric adenocarcinoma with meningeal carcinomatosis and cerebellar metastasis:A case report

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World Journal of Clinical Cases 2024年第15期12卷 2636-2641页

作者： zhi-yun Weng Wen-Ye Huang Bin-Kan Shi Jian-Jia Pan Department of Hematology The Affiliated Yueqing Hospital of Wenzhou Medical UniversityYueqing 325600Zhejiang ProvinceChina

BACKGROUND Brain metastases(BM)are very rare in gastric adenocarcinoma(GaC),and patients with BMs have a higher mortality rate due to stronger tumor ***,its pathogenesis remains *** testing revealed cellular-mesenchymal epithelial transition factor receptor(MET)***,treatment with savolitinib,a small molecule inhibitor of c-Met,was *** SUMMARY A 66-year-old woman was diagnosed with advanced GaC 6 months prior to presentation due to back *** and meningeal metastases were observed during candonilimab combined with oxaliplatin and capecitabine *** patient experienced frequent generalized seizures and persistent drowsiness in the emergency *** testing of cerebrospinal fluid and peripheral blood revealed increased MET *** discussing treatment options with the patient,savolitinib tablets were *** a month of treatment,the intracranial lesions shrank *** BM is very rare in advanced GaC,especially in meningeal cancer,that is characterized by rapid disease *** are very few effective treatment options available;however,technological breakthroughs in genomics have provided a basis for personalized ***,MET amplification may be a key driver of BM in gastric cancer;however,this conclusion requires further investigation.

关键词： Cellular-mesenchymal epithelial transition factor receptor Savolitinib Meningeal carcinomatosis Gastric adenocarcinoma Case report

Localization of five-dimensional Elko spinors on dS/AdS thick branes

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Chinese Physics C 2022年第2期46卷 1-12页

作者： Xiang-Nan Zhou yun-zhi Du Xin-Yuan Ma Zhen-Hua Zhao College of Physics and Information Engineering.Shanxi Normal University Linfen 04100China Institute of Theoretical Physics Datong UniversityDatong 037009China Department of Applied Physics Shandong University of Science and TechnologyQingdao 266590China

Owing to the special structure of a five-dimensional Elko spinor,its localization on a brane with codimension one becomes completely different from that of a Dirac *** introducing the coupling between the Elko spinor and the scalar field that can generate the brane,we have two types of localization mechanism for the five-dimensional Elko spinor zero mode on a *** is the Yukawa-type coupling,and the other is the non-minimal *** this study,we investigate the localization of the Elko zero mode on de Sitter and Anti-de Sitter thick branes with the two localization mechanisms,*** results show that both the mechanisms can achieve *** forms of the scalar coupling function in both localization mechanisms have similar properties,and they play a similar role in localization.

关键词： localization Elko spinor de Sitter and Anti-de Sitter thick brane Yukawa-type coupling non-minimal coupling

Prediction of suitable water content in granulation of sintering mixture based on Litster's model

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Journal of Iron and Steel Research International 2024年第3期31卷 552-560页

作者： Fang-lei Dai Xiao-hui Fan Xiao-xian Huang Xu-ling Chen Min Gan zhi-yun Ji Zeng-qing Sun School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083HunanChina

Suitable water content plays a decisive role in the granulation of sintering ***,a method was proposed to predict the suitable water content for effective granulation on the basis of Litster's granulation *** granulation effectiveness of a sintering mixture was predicted by the model,with the allowance error of±10%.The effects of the water absorption properties,particle size composition and content of adhesive particles on the suitable water content were *** results showed that the allowable error of prediction was within±0.5%compared to the experimentally determined suitable water *** an increase in adhesive powder content of mixtures with higher water absorption,the suitable water content increased to achieve similar granulation ***,as the amount of concentrates increased,the suitable water content first increased and then remained *** influence of the water absorption characteristics of the adhesive particles on the suitable water content was less than that of their particle size composition in the mixture.

关键词： Adhesive particle Sintering mixture Granulation effectiveness Suitable water content

Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway

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World Journal of Gastroenterology 2019年第12期25卷 1492-1501页

作者： Jie Hu Wei Hong Kan-Nan Yao Xiao-Hong Zhu zhi-yun Chen Lei Ye Department of Infectious Diseases The First Affiliated Hospital of Zhejiang Chinese Medical University the Second Central Laboratory The First Affiliated Hospital of Zhejiang Chinese Medical University

BACKGROUND Nonalcoholic fatty liver disease(NAFLD), the most common chronic liver disease, can progress into nonalcoholic steatohepatitis(NASH), cirrhosis, and even hepatocellular carcinoma. Bile acids such as ursodeoxycholic acid(UDCA)play an essential role in the pathogenesis of NAFLD by regulating the level of sterol regulatory element-binding protein(SREBP) 1 c, but the underlying regulatory mechanism remains elusive. Increased evidence indicates that the AKT/mTOR/SREBP-1 signaling pathway is a key pathway to regulate hepatic cellular lipid metabolism. UDCA may regulate the AKT/mTOR/SREBP-1 signaling pathway to ameliorate hepatic lipid *** To investigate the functional mechanism of UDCA in an oleic acid(OA)-induced cellular model of *** The cellular model of NAFLD was established using OA and treated with ***, the best concentration of UDCA was selected. For the best time-dependent assay, cells were stimulated with OA only or co-treated with OA and 2 mmol/L UDCA for 24 h, 48 h, and 72 h. Oil red O staining was used to observe the accumulation of intracellular lipids, while the intracellular contents of triglyceride, alanine aminotransferase(ALT), gamma-glutamyl transpeptidase(GGT), and aspartate aminotransferase(AST) were detected by enzymatic methods. Meanwhile, the expression levels of AKT/mTOR/SREBP-1 signaling pathway-related proteins were detected by real-time PCR and Western *** In the NAFLD cell model established with LO2 cells induced using OA, lipid accumulation was obvious. UDCA significantly inhibited lipid accumulation at different concentrations(especially 2 mmol/L) and decreased cell growth ability at different time points. The biochemical parameters like ALT, AST, and GGT were significant improved by UDCA. UDCA treatment vividly repressed the activation of AKT, mTOR, and CRTC2 and the expression of nSREBP-1 in LO2 cells induced with *** Our findings demonstrate the effect of UDCA in improving NAFLD. U

关键词： Ursodeoxycholic acid Hepatic lipid metabolism AKT/mTOR/SREBP-1 Hepatic steatosis

Integrating morphological spatial pattern analysis and the minimal cumulative resistance model to optimize urban ecological networks: a case study in Shenzhen City, China

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Ecological Processes 2021年第1期10卷 862-876页

作者： Yang‑Yang Li Yu‑Zhe Zhang zhi‑yun Jiang Cheng‑Xuan Guo Ming‑Yue Zhao zhi‑Guang Yang Ming‑Yan Guo Bing‑Yue Wu Quan‑Ling Chen School of Geography South China Normal UniversityNo.55West of Zhong‑shan AvenueTianhe DistrictGuangzhou 510631China. Institute of Environ‑ment and Sustainable Development in Agriculture Chinese Academy of Agri‑cultural SciencesBeijing 100081China. School of Natural Resources Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China

Background:With the increasing fragmentation of landscape induced by rapid urbanization,the construction of ecological networks is of great signifcance to alleviate the degradation of urban habitats and protect natural envi‑***,there is considerable uncertainty when constructing ecological networks,especially the difer‑ent approaches to selecting ecological *** used the southern Chinese city of Shenzhen as a study area to construct and optimize ecological networks using a coupling *** source areas were extracted using morphological spatial pattern analysis(MSPA)and the landscape index *** networks were con‑structed using the minimal cumulative resistance(MCR)model and the gravity *** stones and ecological fault points were added in corridors to optimize the ecological ***:Ten core areas with maximum importance patch values were extracted by the landscape index method as ecological source areas according to MSPA,after which corridors between ecological sources were constructed based on the MCR *** constructed ecological networks were optimized using 35 stepping stones and 17 ecologi‑cal fault *** optimized ecological networks included 11 important corridors,34 general corridors,and seven potential *** results of corridor landscape-type analysis showed that a suitable ecological corridor is 60 to 200 m ***:Overall,our results imply that ecological source areas can be identifed virtually,and that ecological networks can be signifcantly optimized by combining MSPA and MCR *** results provide a methodologi‑cal reference for constructing ecological networks,and they will be useful for urban planning and biodiversity protec‑tion in Shenzhen and other similar regions around the world.

关键词： MSPA analysis MCR model Ecological corridor Ecological resistance surface Shenzhen City

Construction and validation of a personalized prediction model for postpartum anxiety in pregnant women with preeclampsia

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World Journal of Psychiatry 2023年第10期13卷 763-771页

作者： Le-Jing Lin Hai-Xian Zhou zhi-yun Ye Qi Zhang Shu Chen Department of Obstetrics and Gynecology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou 325000Zhejiang ProvinceChina Department of Gynecology Wenzhou Traditional Chinese Medicine HospitalWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Preeclampsia is a pregnancy-specific multi-system disease with multi-factor and multi-mechanism *** cure for preeclampsia is to terminate the pregnancy and deliver the ***,it will reduce the perinatal survival rate,prolong the pregnancy cycle,and increase the incidence of maternal *** relaxation of the birth policy,the number of elderly pregnant women has increased significantly,and the prevalence rate of preeclampsia has *** treatment can seriously affect the normal postpartum life of pregnant *** have shown that postpartum anxiety in women with preeclampsia can affect physical and mental health,as well as infant growth and *** To analyze the factors influencing preeclampsia in pregnant women complicated with postpartum anxiety,and to construct a personalized predictive *** We retrospectively studied 528 pregnant women with preeclampsia who delivered in Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine between January 2018 and December *** basic data were collected,and various physiological and biochemical indicators were obtained by laboratory *** self-rating anxiety scale was used to determine whether the women had postpartum anxiety 42 d after *** independent factors influ-encing postpartum anxiety in early pregnant women with eclampsia were analyzed with multifactor logistic regression and a predictive model was *** Hosmer-Lemeshow test and receiver operating characteristic(ROC)curve were used to evaluate the calibration and discrimination of the predictive *** pregnant women with preeclampsia admitted to our hospital from January 2022 to May 2022 were retrospectively selected to verify the prediction *** We excluded 46 of the 528 pregnant women with preeclampsia because of loss to follow-up and adverse outcomes.A total of 482 cases completed the assessment of postpartum anxie

关键词： Preeclampsia Postpartum anxiety Risk factors Predictive model