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Compatibility with Fructus Ligustri Lucidi Effectively Mitigates Idiosyncratic Liver Injury of Epimedii Folium by Modulating NOD-like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation

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World Journal of Traditional Chinese Medicine 2024年第2期10卷 159-170页

作者： Xiao-Mei Zhao zhi-Xin Wu Yan Wang ying-Jie Xu Ye Xiu Xu Dong Jun-Jie Li Gui-Ji Lv Si-Hao Wang Yu-Rong Li Zhao-Fang Bai Xiao-He Xiao Department of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu China Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijingChina Department of Military Patient Management The Fifth Medical Center of PLA General HospitalBeijingChina Department of Hepatology China Military Institute of Chinese Materia The Fifth Medical Center of PLA General HospitalBeijingChina Departmentof Hepatology National Key Laboratory of Kidney DiseasesBeijingChina

Background: Idiosyncratic drug-induced liver injury(IDILI) is a serious side effect of drugs, Epimedii Folium(EF) is unequivocally implicated in idiosyncratic liver injury onset, potentially due to its ability to perturb the NOD-like receptor family pyrin domain containing 3(NLRP3) inflammasome. Fructus Ligustri Lucidi(FLL), a frequently used medicinal combination with EF, has not yet been investigated for its ability to ameliorate EF-associated hepatotoxicity. Aims and Objectives: Study on the mechanism of compatibility of FLL to alleviate liver injury caused by EF. Materials and Methods: Western blot was used to determine the expression of related proteins, ELISA was used to detect the secretion of related inflammatory factors IL-1β, IL-18, IL-6 and TNF-α, liver injury indexes were detected and liver pathological tissue staining was used to evaluate the liver injury. Results: Our results demonstrated that EF exerted a particular augmenting effect on the stimulation of the NLRP3 inflammasome mediated by nigericin or ATP, whereas FLL suppressed the NLRP3 inflammasome stimulation. Furthermore, an equal EF to FLL ratio significantly reduced the stimulatory effects of EF. Moreover, EF has the potential to induce hepatic injury and augment pro-inflammatory cytokine synthesis in rats subjected to LPS. However, when combined with FLL, the detrimental effects of EF were mitigated. Conclusions: FLL possesses the capacity to attenuate EF-associated hepatotoxicity by suppressing EF-triggered NLRP3 inflammasome activation. Thus, FLL holds promise for improving the clinical safety profile of EF, shedding light on the potential of compatibility and detoxification theories in traditional Chinese medicine.

关键词： Epimedii Folium Fructus Ligustri Lucidi idiosyncratic drug-induced liver injury NOD-like receptor family pyrin domain containing 3 inflammasome traditional Chinese medicine

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矿渣-白泥固化黄土的力学性能与微观机理

中国公路学报 2024年第6期37卷 181-192页

作者：薛志佳罗江晏长根张营张英立贾小龙长安大学公路学院陕西西安710064 成都市市政工程设计研究院有限公司四川成都610023 宁夏交通建设股份有限公司宁夏银川750002

为探究矿渣与白泥固废材料应用于黄土路基加固的可行性,并解决传统石灰固化黄土强度较低以及生产污染大的问题,制备了矿渣-白泥胶凝材料,随后使用不同掺量(0%、5%、10%、15%)的矿渣-白泥胶凝材料对黄土进行固化,结合基本物理化学性质,... 详细信息

为探究矿渣与白泥固废材料应用于黄土路基加固的可行性,并解决传统石灰固化黄土强度较低以及生产污染大的问题,制备了矿渣-白泥胶凝材料,随后使用不同掺量(0%、5%、10%、15%)的矿渣-白泥胶凝材料对黄土进行固化,结合基本物理化学性质,探究了固化黄土的无侧限抗压强度以及耐久性(干湿和冻融)的变化规律,并通过XRD、TG/DTG和SEM揭示了其微观机理。试验结果表明:矿渣-白泥胶凝材料中矿渣占比越高强度增长潜力越大,但矿渣占比超过70%时,会导致试样无法成型;适当增加其中的白泥占比,可以提高pH值以及早期强度,综合成本来看其最佳配比为60∶40;未浸水条件下,10%掺量时矿渣-白泥固化黄土28 d无侧限抗压强度为4.9 MPa,相比于石灰固化黄土提高2.2倍,水稳定系数提高0.45倍,满足路基填料强度要求;矿渣-白泥胶凝材料可以显著提高黄土的耐久性,10%与15%掺量时固化黄土经14次冻融后强度和质量变化均小于2%,固化黄土的强度随干湿循环次数先增加后降低,并且12次干湿循环后强度均高于28 d强度。微观测试表明:白泥能促进矿渣的水化作用,矿渣-白泥胶凝材料的主要水化产物为CSH等凝胶,CSH凝胶的胶结作用是固化黄土强度和耐久性提升的主要来源,而填充效果起到次要作用。

关键词：路基工程固化黄土力学强度测试矿渣-白泥耐久性

Graphene-loaded nickel−vanadium bimetal oxides as hydrogen pumps to boost solid-state hydrogen storage kinetic performance of magnesium hydride

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Transactions of Nonferrous Metals Society of China 2024年第8期34卷 2645-2657页

作者： Dong-qiang GAO Fu-ying WU zhi ZHANG Zi-chuan LU Ren ZHOU Hu ZHAO Liu-ting ZHANG School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China Instrumental Analysis Center Jiangsu University of Science and TechnologyZhenjiang 212003China School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore 639798Singapore

To modify the thermodynamics and kinetic performance of magnesium hydride(MgH_(2))for solid-state hydrogen storage,Ni_(3)V_(2)O_(8)-rGO(rGO represents reduced graphene oxide)and Ni_(3)V_(2)O_(8)nanocomposites were prepared by hydrothermal and subsequent heat *** beginning hydrogen desorption temperature of 7 wt.%Ni_(3)V_(2)O_(8)-rGO modified MgH_(2)was reduced to 208℃,while the additive-free MgH_(2)and 7 wt.%Ni_(3)V_(2)O_(8)doped MgH_(2)appeared to discharge hydrogen at 340 and 226℃,respectively.A charging capacity of about 4.7 wt.%H_(2)for MgH_(2)+7 wt.%Ni_(3)V_(2)O_(8)-rGO was achieved at 125℃ in 10 min,while the dehydrogenated MgH_(2)took 60 min to absorb only 4.6 wt.%H_(2)at 215℃.The microstructure analysis confirmed that the in-situ generated Mg_(2)Ni/Mg_(2)N_(i)H_(4) and metallic V contributed significantly to the enhanced performance of MgH_(2).In addition,the presence of rGO in the MgH_(2)+7 wt.%Ni_(3)V_(2)O_(8)-rGO composite reduced particle aggregation tendency of Mg/MgH_(2),leading to improving the cyclic stability of MgH_(2)during 20 cycles.

关键词： hydrogen storage properties MgH_(2) graphene-loaded Ni−V bimetal oxides catalytic mechanism

The role of acute normovolemic hemodilution in reducing allogeneic blood transfusion in glioblastoma surgery:a case-control study

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Chinese Neurosurgical Journal 2024年第1期10卷 35-41页

作者： Ping Chen Xin‑Huang Zhang ying Wang Xian‑Zhong Lin De‑zhi Kang Qing‑Song Lin Department of Anesthesiology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityNo.20 Chazhong RdTaijiang DistrictFuzhou 350005FujianChina Department of Neurosurgery Binhai Branch of National Regional Medical CenterThe First Affiliated Hospital of Fujian Medical UniversityFuzhou 350209FujianChina Fujian Provincial Institutes of Brain Disorders and Brain Sciences The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Clinical Research Center for Neurological Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina Fujian Provincial Key Laboratory of Precision Medicine for Cancer The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005FujianChina

Background Acute normovolemic hemodilution(ANH)was first introduced in glioblastoma surgery,and its role in reducing allogeneic blood transfusion was investigated in this *** This study enrolled supratentorial glioblastoma patients who received total *** the ANH group,the patients were required to draw blood before the operation,and the blood will be transfused back to the patient during the *** association between ANH and clinical features was *** Sixty supratentorial glioblastoma patients were enrolled in this study,25 patients were allocated in the ANH group,and another 35 patients were included in the control *** dramatically reduced the need for allogeneic blood transfusion(3[12%]vs 12[34.3%],P=0.049),and the blood transfusion per total of patients was dramatically decreased by the application of ANH(0.40±1.15 units vs 1.06±1.59 units,P=0.069).Furthermore,ANH also markedly reduced the requirement of fresh frozen plasma(FFP)transfusion(2[8%]vs 11[31.4%],P=0.030)and the volume of FFP transfusion per total of patients(32.00±114.46 mL vs 115.71±181.00 mL,P=0.033).The complication rate was similar between the two *** ANH was a safe and effective blood conservation technique in glioblastoma surgery.

关键词： Glioblastoma Acute normovolemic hemodilution Surgery Blood transfusion

A compact multi-pixel superconducting nanowire single-photon detector array supporting gigabit space-to-ground communications

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Light(Science & Applications) 2024年第2期13卷 254-266页

作者： Hao Hao Qing-Yuan Zhao Yang-Hui Huang Jie Deng Fan Yang Sai-ying Ru Zhen Liu Chao Wan Hao Liu zhi-Jian Li Hua-Bing Wang Xue-Cou Tu La-Bao Zhang Xiao-Qing Jia Xing-Long Wu Jian Chen Lin Kang Pei-Heng Wu Research Institute of Superconductor Electronics(RISE) School of Electronic Science and EngineeringNanjing UniversityNanjingJiangsu 210023China Purple Mountain Laboratories NanjingJiangsu 211111China Hefei National Laboratory HefeiAnhui 230088China National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210023China

Classical and quantum space-to-ground communications necessitate highly sensitive receivers capable of extracting information from modulated photons to extend the communication distance from near-earth orbits to deep space *** achieve gigabit data rates while mitigating strong background noise photons and beam drift in a highly attenuated free-space channel,a comprehensive design of a multi-functional detector is *** this study,we present an innovative compact multi-pixel superconducting nanowire single-photon detector array that integrates near-unity detection efficiency(91.6%),high photon counting rate(1.61 Gcps),large dynamic range for resolving different photon numbers(1-24),and four-quadrant position sensing function all within one ***,we have constructed a communication testbed to validate the advantages offered by such an *** 8-PPM(pulse position modulation)format communication experiments,we have achieved an impressive maximum data rate of 1.5 Gbps,demonstrating sensitivities surpassing previous benchmarks at respective *** incorporating photon number information into error correction codes,the receiver can tolerate maximum background noise levels equivalent to 0.8 photons/slot at a data rate of 120 Mbps—showcasing a great potential for daylight operation ***,preliminary beam tracking tests were conducted through open-loop scanning techniques,which revealed clear quantitative dependence indicating sensitivity variations based on beam *** on the device characterizations and communication results,we anticipate that this device architecture,along with its corresponding signal processing and coding techniques,will be applicable in future space-to-ground communication tasks.

关键词： photon supporting correction

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铁路混合梁钢-混结合段受力及理论计算

工程力学 2024年第S1期41卷 282-291页

作者：施洲张莹李英铭何知明时均伟西南交通大学土木工程学院四川成都610031 汉巴南城际铁路有限责任公司四川巴中636099

为研究铁路混合梁钢-混结合段结构的受力及其理论计算公式,在既有公路桥梁钢-混结合段计算公式的基础上,提出铁路混合梁钢-混结合段截面应力、顶底板剪力连接件、承压板传力验算公式;并以主跨335 m汉巴南铁路嘉陵江特大桥为研究背景,采... 详细信息

为研究铁路混合梁钢-混结合段结构的受力及其理论计算公式,在既有公路桥梁钢-混结合段计算公式的基础上,提出铁路混合梁钢-混结合段截面应力、顶底板剪力连接件、承压板传力验算公式;并以主跨335 m汉巴南铁路嘉陵江特大桥为研究背景,采用有限元分析的方法探究结合段受力特性及应力纵、横向分布规律,进而开展结合段受力理论与数值计算对比分析。数值计算结果表明,结合段混凝土均处于受压状态,不同截面位置处结合段钢、混应力横向分布均存在一定的不均匀性。公式验算结果表明:结合段混凝土应力均受压,满足截面应力验算要求;剪力连接件的抗力系数介于1.30~4.49,结合段剪力连接件具有良好的安全储备;承压板抗力系数介于3.18~10.08,表明前后承压板抗力远大于计算传力荷载,并具有优化的空间。理论公式计算的结合段顶底板混凝土应力、剪力钉应力与有限元计算结果总体相近,在修正后可用于钢-混结合段的防开裂/脱离、抗剪受力计算。

关键词：铁路混合梁钢-混结合段受力理论剪力键承压板

生物基δ-己内酯与L-丙交酯顺序开环共聚制备热塑性弹性体及其性质研究

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高分子学报 2024年第5期55卷 582-593页

作者：王丽颖沈勇李志波生态化工国家重点实验室培育基地青岛科技大学化工学院山东省高等学校生物基高分子材料重点实验室青岛科技大学高分子科学与工程学院青岛266042

发展可再生、可降解脂肪族热塑性弹性体有望部分替代目前广泛使用的聚苯乙烯型热塑性弹性体材料,对于解决塑料污染问题具有重要意义.本工作以商品化的生物基单体δ-己内酯和L-丙交酯为原料,利用有机碱(t-BuP_(2))/脲二元催化体系实现其... 详细信息

发展可再生、可降解脂肪族热塑性弹性体有望部分替代目前广泛使用的聚苯乙烯型热塑性弹性体材料,对于解决塑料污染问题具有重要意义.本工作以商品化的生物基单体δ-己内酯和L-丙交酯为原料,利用有机碱(t-BuP_(2))/脲二元催化体系实现其顺序开环聚合,成功制备得到聚乳酸-b-聚(δ-己内酯)-b-聚乳酸三嵌段共聚物.这些三嵌段共聚物随软硬段比例不同表现出不同的力学性质.在硬段体积分数较高时(0.30

关键词：热塑性弹性体压敏胶三嵌段共聚物开环聚合脂肪族聚酯

Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： ying-Shuo Wang Yun-Lian Zhou Guan-Nan Bai Shu-Xian Li Dan Xu Li-Na Chen Xing Chen Xiao-Yan Dong Hong-Min Fu Zhou Fu Chuang-Li Hao Jian-Guo Hong En-Mei Liu Han-Min Liu Xiao-Xia Lu Zheng-Xiu Luo Lan-Fang Tang Man Tian Yong Yin Xiao-Bo Zhang Jian-Hua Zhang Hai-Lin Zhang De-Yu Zhao Shun-ying Zhao Guo-Hong Zhu ying-Xue Zou Quan Lu Yuan-Yuan Zhang zhi-Min Chen Department of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Department of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Department of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Department of Pulmonary and Critical Care Medicine Kunming Children’s HospitalKunming 650034China Department of Respiratory Medicine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Department of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Department of Respiratory Medicine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Medicine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Department of Pediatric Respiratory Medicine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departmen

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been documented in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatment,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatment of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatment of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatment of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,CNKI,Medline,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment

Prognostic role of the stromal cell derived factor-1 in patients with hepatitis B virus-related acute-on-chronic liver failure

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World Journal of Clinical Cases 2024年第19期12卷 3845-3853页

作者： Li Zhang Jian-Yu Wang Cai-Yan Zhao Chuan Shen Mei-Ru Chen zhi-ying Tian Department of Gastroenterology Hengshui People's HospitalHengshui 053000Hebei ProvinceChina Department of Neurology Hengshui People's HospitalHengshui 053000Hebei ProvinceChina Department of Infection The Third Affiliated Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Stromal cell derived factor-1(SDF-1)plays a pivotal role in the recruitment of stem cells to injured ***,the changes of SDF-l in patients with hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF)have yet to be *** To study the SDF-1 changes in patients with HBV-related *** 30 patients with HBV-related ACLF,27 patients with chronic hepatitis B and 20 healthy individuals are involved in our *** SDF-l mRNA expression in liver tissue was detected by quantitative real-time polymerase chain *** staining was performed to illustrate the expression of SDFl,CXC receptor 4(CXCR4)and *** serum SDF-l concentrations were also detected by enzyme-linked immunosorbent *** The expression of SDF-1 mRNA from ACLF patients was remarkably higher than that from other patients(both P<0.05).The expression of SDF-l,CXCR4 and Ki67 from ACLF were the highest among the three groups(all P<0.01).The serum SDF-l levels in ACLF patients were significantly lower than that in other patients(both P<0.01).Moreover,in ACLF patients,the serum SDF-1 Levels were positively correlated with serum total bilirubin and international normalized *** addition,the serum SDF-l levels in survival were significantly lower compared with the non-survivals(P<0.05).The area under the curve for the serum SDF-1 level in predicting 28-d mortality was 0.722(P<0.05).CONCLUSION This study provides the SDF-1 changes in patients with HBV-related *** SDF-1 Level at admission may serve as a promising prognostic marker for predicting short-term prognosis.

关键词： Stromal cell derived factor-1 CXC receptor 4 Acute-on-chronic liver failure Hepatitis B Prognosis