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Development of a heart rate variability and complexity model in predicting the need for life-saving interventions amongst trauma patients

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Burns & Trauma 2019年第1期7卷 107-117页

作者： Aravin Kumar Nan Liu zhi xiong koh Jayne Jie Yi Chiang Yuda Soh Ting Hway Wong Andrew Fu Wah Ho Takashi Tagami Stephanie Fook-Chong Marcus Eng Hock Ong Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Health Services Research Centre Singapore Health ServicesAcademia20 College RoadSingapore 169856Singapore Duke-NUS Medical School National University of SingaporeSingaporeSingapore Department of Emergency Medicine Singapore General HospitalSingaporeSingapore Department of General Surgery Singapore General HospitalSingaporeSingapore Department of Emergency and Critical Care Medicine Nippon Medical SchoolTokyoJapan Health Services Research Unit Singapore General HospitalSingaporeSingapore

Background:Triage trauma scores are utilised to determine patient disposition,interventions and prognostication in the care of trauma *** rate variability(HRV)and heart rate complexity(HRC)reflect the autonomic nervous system and are derived from electrocardiogram(ECG)*** this study,we aimed to develop a model incorporating HRV and HRC,to predict the need for life-saving interventions(LSI)in trauma patients,within 24 h of emergency department ***:We included adult trauma patients(≥18 years of age)presenting at the emergency department of Singapore General Hospital between October 2014 and October *** excluded patients who had non-sinus rhythms and larger proportions of artefacts and/or ectopics in ECG *** obtained patient demographics,laboratory results,vital signs and outcomes from electronic health *** conducted univariate and multivariate analyses for predictive model ***:Two hundred and twenty-five patients met inclusion criteria,in which 49 patients required *** LSI group had a higher proportion of deaths(10,20.41%vs 1,0.57%,p<0.001).In the LSI group,the mean of detrended fluctuation analysis(DFA)-α1(1.24 vs 1.12,p=0.045)and the median of DFA-α2(1.09 vs 1.00,p=0.027)were significantly *** stepwise logistic regression analysis determined that a lower Glasgow Coma Scale,a higher DFA-α1 and higher DFA-α2 were independent predictors of requiring *** area under the curve(AUC)for our model(0.75,95%confidence interval,0.66–0.83)was higher than other scoring systems and selected vital ***:An HRV/HRC model outperforms other triage trauma scores and selected vital signs in predicting the need for LSIs but needs to be validated in larger patient populations.

关键词： Triage trauma score Hear trate variability Heart rate complexity Life-saving interventions

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Poor performance of the modified early warning score for predicting mortality in critically ill patients presenting to an emergency department

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World Journal of Emergency Medicine 2013年第4期4卷 273-277页

作者： Le Onn Ho Huihua Li Nur Shahidah zhi xiong koh Papia Sultana Marcus Eng Hock Ong Department of Emergency Medicine Singapore General HospitalSingapore Department of Clinical Research Singapore General HospitalSingapore Office of Clinical Science Duke-NUS Graduate Medical SchoolSingapore

BACKGROUND:This study was undertaken to validate the use of the modified early warning score(MEWS) as a predictor of patient mortality and intensive care unit(ICU)/ high dependency(HD)admission in an Asian ***:The MEWS was applied to a retrospective cohort of 1 024 critically ill patients presenting to a large Asian tertiary emergency department(ED) between November 2006 and *** MEWS was calculated based on vital signs parameters on arrival at *** of mortality and ICU/HD admission were obtained from hospital *** ability of the composite MEWS and its individual components to predict mortality within 30 days from ED visit was ***,specificity,positive and negative predictive values were derived and compared with values from other cohorts.A MEWS of ≥4 was chosen as the cut-off value for poor prognosis based on previous ***:A total of 311(30.4%) critically ill patients were presented with a MEWS ≥*** mean age was 61.4 years(SD 18.1) with a male to female ratio of *** the 311 patients,53(17%)died within 30 days,64(20.6%) were admitted to ICU and 86(27.7%) were admitted to *** area under the receiver operating characteristic curve was 0.71 with a sensitivity of 53.0%and a specificity of 72.1%in addition to a positive predictive value(PPV) of 17.0%and a negative predictive value(NPV)of 93.4%(MEWS cut-off of ≥4) for predicting ***:The composite MEWS did not perform well in predicting poor patient outcomes for critically ill patients presenting to an ED.

关键词： Modified early warning score Emergency department Outcomes Triage

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新质生产力、数字技术创新与产品质量升级

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广西师范大学学报（哲学社会科学版） 2025年第1期61卷 95-114页

作者：施炳展熊治南开大学经济学院天津300071 南开大学经济与社会发展研究院天津300071

数字技术创新是新质生产力的组成部分,出口产品质量升级是高质量开放发展的基本要求。聚焦数字技术创新对出口产品质量的影响,从而探讨新质生产力促进高质量发展的渠道、机制和障碍,理论分析表明:数字技术创新降低资源投入、提升资源效... 详细信息

数字技术创新是新质生产力的组成部分,出口产品质量升级是高质量开放发展的基本要求。聚焦数字技术创新对出口产品质量的影响,从而探讨新质生产力促进高质量发展的渠道、机制和障碍,理论分析表明:数字技术创新降低资源投入、提升资源效率影响在位企业产品质量、临界企业产品质量和整体平均产品质量,对平均产品质量的影响具有不确定性。实证分析发现,数字技术创新自身难以提升平均产品质量,但与传统技术创新交叉项却显著稳健为正,这体现了数实融合、新旧融合的必要性;这一作用对中高技术产品并不显著,意味着中高技术产品质量升级可能更依靠技术创新质量;上述结论在考虑测量误差、样本选择、内生性等因素后依然显著。促进数字技术创新与传统技术创新融合是提升产品质量、促进高质量发展的关键,新质生产力无法孤立于旧生产力而发挥作用。

关键词：新质生产力数字技术创新新旧融合产品质量高质量发展

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腰椎间盘突出症模型大鼠疼痛的针刺干预

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中国组织工程研究 2025年第5期29卷 936-941页

作者：支芳朱满华熊伟林星镇南昌市洪都中医院江西省南昌市330038

背景:针灸是缓解腰椎间盘突出症腰痛的有效方法,但其机制目前尚未明确。JAK2/STAT3信号通路相关因子可调节机体炎症反应,参与神经病理性疼痛的过程。目的:基于JAK2/STAT3信号通路研究针刺对腰椎间盘突出症模型大鼠的作用机制。方法:采... 详细信息

背景:针灸是缓解腰椎间盘突出症腰痛的有效方法,但其机制目前尚未明确。JAK2/STAT3信号通路相关因子可调节机体炎症反应,参与神经病理性疼痛的过程。目的:基于JAK2/STAT3信号通路研究针刺对腰椎间盘突出症模型大鼠的作用机制。方法:采用随机数字表法将40只SD大鼠分为假手术组、模型组、针刺组与针刺+激动剂组,每组10只。模型组、针刺组及针刺+激动剂组采用自体髓核移植法构建L5腰椎间盘突出症模型,造模3 d后,针刺组开始进行针刺治疗(作用于阳陵泉、肾俞、环跳、大肠俞等穴位),针刺+激动剂组造模后第6,12,18天针刺治疗前向L4/L5椎间隙鞘内注射JAK2激动剂香豆霉素A1,针刺治疗1次/d,20 min/次,连续治疗15 d。造模前及造模后3,6,9,12,15,18 d,检测大鼠机械缩足阈值;造模后18 d,检测血清炎症因子水平,苏木精-伊红染色观察L5-L6组织形态,RT-PCR检测L5-L6组织JAK2、STAT3 mRNA表达,Western Blot检测L5-L6组织JAK2、STAT3、p-JAK2及p-STAT3蛋白表达。结果与结论:①模型组大鼠造模后不同时间点的机械缩足阈值均低于假手术组(P<0.05),针刺组大鼠造模后9,12,15,18 d的机械缩足阈值均高于模型组(P<0.05),针刺+激动剂组大鼠造模后9,12,15,18 d的机械缩足阈值均低于针刺组(P<0.05);②与假手术组比较,模型组白细胞介素6、肿瘤坏死因子α、神经递质P物质、脑部神经肽Y水平均升高(P<0.05);与模型组比较,针刺组4种炎症因子水平均降低(P<0.05);与针刺组比较,针刺+激动剂组4种炎症因子水平均升高(P<0.05);③苏木精-伊红染色显示模型组大鼠腰椎退行性变化明显,针刺组与针刺+激动剂组大鼠腰椎退行性变化减轻,针刺组减轻更明显;④与假手术组比较,模型组JAK2与STAT3 mRNA表达、p-JAK2与p-STAT3蛋白表达均升高(P<0.05);与模型组比较,针刺组JAK2与STAT3 mRNA表达、p-JAK2与p-STAT3蛋白表达均降低(P<0.05);与针刺组比较,针刺+激动剂组JAK2与STAT3 mRNA表达、p-JAK2与p-STAT3蛋白表达均升高(P<0.05);⑤结果表明,针刺干预可通过降低腰椎间盘突出症模型大鼠的炎症反应来缓解疼痛,其作用机制可能与抑制JAK2/STAT3信号通路有关。

关键词： JAK2/STAT3信号通路针刺腰椎间盘突出症病理性疼痛机械缩足阈值炎症反应

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Modified constructions of binary sequences using multiplicative inverse

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Applied Mathematics(A Journal of Chinese Universities) 2008年第4期23卷 490-500页

作者： CHEN zhi-xiong LIN zhi-xing Key Laboratory of Applied Mathematics Putian University Putian 351100 China Key Laboratory of Network Security and Cryptology Fujian Normal University Fuzhou 350007China

Two new families of finite binary sequences are constructed using multiplicative inverse. The sequences are shown to have strong pseudorandom properties by using some estimates of certain exponential sums over finite fields. The constructions can be implemented fast since multiplicative inverse over finite fields can be computed in polynomial time.

关键词： stream cipher binary sequence multiplicative inverse pseudorandomness exponential sum

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Effect of stress-relief annealing on thermal fatigue cracks for die-casting die steels

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Journal of Iron and Steel Research International 2024年第5期31卷 1164-1176页

作者： zhi-xiong Bai Xiao-chun Wu School of Materials Science and Engineering Shanghai UniversityShanghai200444China

The effect of stress-relief annealing at different stages of thermal fatigue tests on crack growth was investigated using a self-built thermal cycle *** results showed that annealing could limit crack expansion *** reduced dislocation density and released the accumulation of residual *** addition,the strain accumulation in carbides was reduced by this *** was also found that double annealing was even more effective at inhibiting crack expansion compared to single stress-relief *** 1000 cycles,the maximum crack length was reduced by 31.1%and 45.2%for the samples after using the optimal single and double annealing processes,*** single stress-relief annealing,earlier annealing provides more benefit in delaying crack ***,effective double stress-relief annealing requires a suitable time interval between the annealing ***,after 800 cycles,surface hardness decreased significantly accompanied by an increase in the size and number of carbides,and cracks expanded predominantly along grain boundaries.

关键词： Thermal fatigue Steel Carbide Stress-relief annealing Dislocation Residual stress

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Constructing quasi-random subsets of Z_N by using elliptic curves

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Applied Mathematics(A Journal of Chinese Universities) 2012年第1期27卷 105-113页

作者： LIN zhi-xing CHEN zhi-xiong Department of Mathematics Putian UniversityPutianFujian 351100China State Key Laboratory of Information Security Institute of SoftwareChinese Academy of SciencesBeijing 100049China

Let ε ： y^2 = x3 ＋ Ax ＋ B be an elliptic curve defined over the finite field Zp（p 〉 3） and G be a rational point of prime order N on ε. Define a subset of ZN, the residue class ring modulo N, asS：={n：n∈ZN,n≠0,（X（nG）/p）=1} where X（nG） denotes the x-axis of the rational points nC and （＊/P） is the Legendre symbol. Some explicit results on quasi-randomness of S are investigated. The construction depends on the intrinsic group structures of elliptic curves and character sums along elliptic curves play an important role in the proofs.

关键词： elliptic curve quasi-random subset quasi-randomness character sum Legendre symbol.

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Color gradients of the galaxies at 0.5

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Research in Astronomy and Astrophysics 2018年第11期18卷 145-156页

作者： zhi-xiong Liang Cheng Li Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China University of Chinese Academy of Sciences Beijing 100049China Tsinghua Center for Astrophysics and Physics Department Tsinghua UniversityBeijing 100084China

We investigate the dependence of clustering on luminosity, stellar mass and color gradient for galaxies at 0.5 < z < 1, using a sample of;300 galaxies from the final data release of the VIMOS Public Extragalactic Redshift Survey（VIPERS-PDR2）. We estimate both the auto-correlation function for galaxy samples selected by B-band absolute magnitude and stellar mass, and the cross-correlation function of galaxy samples selected by color gradient with respect to the full galaxy sample. The autocorrelation function amplitudes at fixed scale are found to positively correlate with both galaxy luminosity and stellar mass, and the effect holds for all the scales probed(0.2 h;Mpc < rp< 20 h;Mpc),in good agreement with previous measurements based on an earlier data release of VIPERS. When the stellar mass is limited to a narrow range, we find the clustering power to be essentially independent of galaxy color gradient, and this conclusion is true for all the masses and all the scales considered here. In a parallel paper, we find that the half-light radius is the only galaxy property other than stellar mass that is related to color gradient. Considering the previous finding that clustering depends weakly on galaxy structure at given mass, the non-dependence of clustering on color gradient found here reinforces our conclusion that the color gradient and structural parameters of a galaxy are intrinsically related to each other.

关键词： galaxies: photometry galaxies: statistics galaxies: evolution

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Heparanase and hepatocellular carcinoma:Promoter or inhibitor?

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World Journal of Gastroenterology 2010年第3期16卷 306-311页

作者： Dong, Shuo Wu, xiong-zhi Tianjin Med Univ Canc Inst & Hosp Zhong Shan Men In Patient Dept Tianjin 300171 Peoples R China

Heparan sulphate proteoglycans (HSPGs) consist of a core protein and several heparan sulphate (HS) side chains covalently linked. HS also binds a great deal of growth factors, chemokines, cytokines and enzymes to the extracellular matrix and cell surface. Heparanase can specially cleave HS side chains from HSPGs. There are a lot of conflicting reports about the role of heparanase in hepatocellular carcinoma (HCC). Heparanase is involved in hepatitis B virus infection and hepatitis C virus infection, the activation of signal pathways, metastasis and apoptosis of HCC. Heparanase is synthesized as an inactive precursor within late endosomes and lysosomes. Then heparanase undergoes proteolytic cleavage to form an active enzyme in lysosomes. Active heparanase translocates to the nucleus, cell surface or extracellular matrix. Different locations of heparanase may exert different activities on tumor progression. Furthermore, enzymatic activities and non-enzymatic activities of heparanase may play different roles during HCC development. The expression level of heparanase may also contribute to the discrepant effects of heparanase. Growth promoting as well as growth inhibiting sequences are contained within the tumor cell surface heparan sulfate. Degrading different HSPGs by heparanase may play different roles in HCC. Systemic studies examining the processing, expression, localization and function of heparanase should shed a light on the role of heparanase in HCC.

关键词： Apoptosis Heparanase Heparan sulphate Hepatocellular carcinoma Infection Metastasis

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Color gradients of the galaxies at 0.5

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Research in Astronomy and Astrophysics 2018年第11期18卷 133-144页

We investigate the color gradients of galaxies at 0.5 1010.5M⊙to have larger sizes at given stellar mass(thus lower surface mass densities), and less massive red-cored galaxies with M*< 1010.5M⊙to have lower central galaxy fraction. These findings can be understood if one assumes that the star formation process happens from inside out, in the same way as recently emphasized in studies of low-z galaxies. The similarity between the galaxies at intermediate redshifts and those at low redshifts supports the idea that galaxy evolution since z~1 has been mainly driven by secular processes internal to galaxies rather than galaxy mergers or external environment.

关键词： galaxies: photometry galaxies: statistics galaxies: evolution

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