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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： zhi-Jian Tang Yuan-ming pan Wei Li Rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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A genetically modified attenuated Listeria vaccine expressing HPV16E7 kill tumor cells in direct and antigen-specific manner

A genetically modified attenuated Listeria vaccine expressin...

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中国畜牧兽医学会动物传染病学分会第九次全国会员代表大会暨第十七次全国学术研讨会

作者：贾艳艳 Wei Jun Tan Fei Fei Duan zhi ming pan Xiang Chen Yue Lan Yin Xin An Jiao Jiangsu Key Laboratory of Zoonosis Joint International Research Laboratory of Agriculture & Agri-Product SafetyJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Disease and ZoonosisYangzhou University

Attenuated Listeria monocytogenes(***,LM)induces specific CD8+and CD4+T cell responses,and has been identified as a promising cancer vaccine *** cancer is the third most common cancer in women worldwide,with human papillomavirus(HPV),particula rly type 16,being the main etiological *** therapeutic HPV vaccines are urgently needed.

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Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

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Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng Li Chunyan Chen Zhenyang Li Peng Yi Haihan Zou Gao Deng ming Fang Junzhe He Xin Sun Ronghai Yu Jianglan Shui Caofeng pan Xiaofang Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第1期68卷 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen ming-ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

关键词： metabolon Diels-Alder reaction semipinacol rearrangement biosynthesis notoamides spiro polycyclic alkaloids

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基于化学动力学理论的中深层地下水资源评价——以四平市区为例

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水土保持研究 2007年第5期14卷 190-191,196页

作者：施枫芝迟宝明潘杰吉林大学环境与资源学院

运用化学动力学和水动力学相结合的理论和方法,提取了反映中深层地下水的赋存环境特征、循环速度、资源量组成、可更新能力等方面的重要信息,并以此为依据进行了四平市区中深层地下水资源评价和补给能力分析。研究结果表明,目前四平市... 详细信息

运用化学动力学和水动力学相结合的理论和方法,提取了反映中深层地下水的赋存环境特征、循环速度、资源量组成、可更新能力等方面的重要信息,并以此为依据进行了四平市区中深层地下水资源评价和补给能力分析。研究结果表明,目前四平市区该层地下水已经处于超采状态,四平市区中深层地下水具有补给能力较弱,补给资源有限,水循环滞缓的特点,作为供水水源缺乏保障性。

关键词：中深层地下水化学动力学评价补给

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Self-assembled carbon monoxide nanoprodrug for chemiexcitationtriggered synergistic chemotherapy against breast cancer

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Science China Chemistry 2025年

作者： Shunfei Cui Yiyao pan Chenzhe Ma Bin Qi Qingqiang Min ming Li Huabing Chen Hengte Ke Xingyue Ji Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development College of Pharmaceutical ScienceSoochow University

Carbon monoxide（CO） has recently been well-established as a promising therapeutic modality against cancer. The development of transition-metal-free and tumor-targeted delivery platforms for CO is highly demanded but remains very sporadic. Herein, we developed a polyprodrug system for the co-delivery of CO and a chemotherapeutic agent combretastin A-4（CA-4） to the tumor site based on a chemiexcitation mechanism. Such a poly-prodrug successfully achieved the co-activation of CO and CA-4 in response to H2O2at the tumor site both in vitro and in vivo. Importantly, a synergist effect between CO and CA-4 was observed in suppressing tumor growth in a mouse tumor model. It is anticipated that such a poly-prodrug system could be potentially adapted for the co-delivery of CO and another drug payload for combinational therapy for other indications.

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Quantitative reconstruction of salinity and precipitation changes in Central Asia over the past 3200 years using diatom and pollen records of lacustrine sediment in Aibi Lake of SW Junggar Basin

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Journal of Earth Science 2025年

作者： Long pan Guoqiang Li Xiaoyan Wang ming Jin Xinrong He Luo Qin Zhong Wang Wenwei Zhao Chunzhu Chen Yuanlu Liu Jin Yang Lele Shu Key Laboratory of Western China's Environmental Systems (Ministry of Education)， College of Earth and Environmental Sciences， Lanzhou University College of Earth Sciences， Chengdu University of Technology School of Geographic Science， Nantong University Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions， Northwest Institute of Eco-Environment and Resources， Chinese Academy of Sciences

The response of lake environments in arid Central Asia to climate change during the Late Holocene over the centennial to millennial timescales remains contentious. The reason that primarily paleoenvironmental proxies interpreting diverse and the scarcity of accurate quantitative reconstruction records. In this study， we employed diatoms and pollen records from lacustrine sediment in the Aibi Lake of SW Junggar Basin to quantitatively reconstruct salinity and watershed precipitation amounts while exploring the associated forcing mechanism. The results indicate that Aibi Lake salinity varied between 2 g/L and 47 g/L during the Late Holocene period， indicating a generally brackish environment， and corresponding to prevailing Tryblionella granulata diatom in the lake basin. Westerly-dominated annual precipitation varied between 250 mm and 320 mm during the Late Holocene period in the basin， exhibiting a generally semi-arid environment and prevailing desert steppe vegetation. The Aibi Lake has a low salinity of average value of ～15 g/L. It exhibits elevated precipitation (average value of ～280 mm) during the periods of the Roman Warm Period (2900-1990 cal yr BP)， Dark Age Cold Period (1570-1140 cal yr BP)， and Little Ice Age (590-120 cal yr BP). The reconstructed precipitation and salinity exhibit a periodicity of ～200 years， which is consistent with the cycle of phase changes of the North Atlantic Oscillation (NAO) and Total Solar Irradiance (TSI). This correlation suggests that variations in NOA and TSI significantly influence the precipitation and salinity changes in Central Asia over centennial to millennial timescales.

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不同避孕措施使用者生殖道人乳头瘤病毒感染检测

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毒理学杂志 2009年第1期23卷 22-24页

作者：吴玉璘姜志欣孙志明潘丽丁菊红李瑛江苏省生殖健康检验中心江苏省计划生育科学技术研究所江苏南京210036

目的了解不同避孕措施长期使用者生殖道人乳头状瘤病毒(HPV)感染的情况。方法采用聚合酶链反应(PCR)检测服用口服避孕药或使用宫内节育器5年以上的妇女226人宫颈分泌物中HPV DNA,研究对象按避孕措施分成1号片组、复方18-甲组和宫内节育... 详细信息

目的了解不同避孕措施长期使用者生殖道人乳头状瘤病毒(HPV)感染的情况。方法采用聚合酶链反应(PCR)检测服用口服避孕药或使用宫内节育器5年以上的妇女226人宫颈分泌物中HPV DNA,研究对象按避孕措施分成1号片组、复方18-甲组和宫内节育器组。结果三组研究对象的HPV总检出率为14.2%,HPV的检出率复方18-甲组最高,宫内节育器组最低,分别为复方18-甲组20.45%、1号片组11.11%、宫内节育器组8.77%,三组间的差异无统计学意义(P>0.05)。三组中HPV感染者的宫颈均有异常表现,但差异无统计学意义(P>0.05)。结论对有性生活,特别是长期使用避孕措施的妇女提供常规的宫颈涂片检查和HPV检测服务,有助于提高避孕措施使用者的身心健康。

关键词：口服避孕药宫内节育器人乳头状瘤病毒聚合酶链反应

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基于功能化COFs材料的样品前处理技术在新兴污染物中的研究进展

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分析测试学报 2025年第1期44卷 12-24页

作者：潘自宇刘智敏许志刚昆明理工大学理学院云南昆明650500

新兴污染物因具有环境持久性、生物累积性、生物毒性以及在环境中痕量存在等特点而备受全球众多国家关注。因此,对环境、食品以及生物样品中的新兴污染物进行高灵敏检测至关重要。传统样品前处理技术存在耗时长、吸附剂用量大,以及对不... 详细信息

新兴污染物因具有环境持久性、生物累积性、生物毒性以及在环境中痕量存在等特点而备受全球众多国家关注。因此,对环境、食品以及生物样品中的新兴污染物进行高灵敏检测至关重要。传统样品前处理技术存在耗时长、吸附剂用量大,以及对不稳定污染物的分析准确性差等缺点,因此,亟需开发设计具有高选择性、高传质效率的新型材料作为前处理技术的吸附剂,以实现新兴污染物的高选择、高灵敏检测。共价有机骨架材料(COFs),特别是功能化的COFs材料,因具有比表面积大、结构可设计、稳定且构筑基元丰富等诸多优点而被广泛用于新兴污染物的富集。该文主要综述了近年来功能化COFs材料的合成策略及其作为样品前处理吸附剂在环境、食品和生物样品中新兴污染物中的分析应用,并对该类材料的未来发展趋势进行了展望。

关键词：新兴污染物功能化COFs材料样品前处理技术

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通过式固相萃取净化/液相色谱-串联质谱法快速检测水产品中11种青霉素残留

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分析测试学报 2017年第3期36卷 337-342页

作者：郭萌萌李兆新王智潘明轩吴海燕邢丽红孙晓杰中国水产科学研究院黄海水产研究所农业部水产品质量安全检测与评价重点实验室山东青岛266071 青岛市产品质量监督检验研究院青岛市产品质量检验技术研究所山东青岛266061 上海海洋大学上海201306

采用通过式固相萃取净化策略去除样品基质中的脂肪和磷脂等杂质干扰,结合液相色谱-串联质谱检测,建立了水产品中11种青霉素残留的同时快速分析方法。样品经80%乙腈水溶液提取,Oasis PRi ME HLB通过式固相萃取柱净化,C_(18)色谱柱分离,0.... 详细信息

采用通过式固相萃取净化策略去除样品基质中的脂肪和磷脂等杂质干扰,结合液相色谱-串联质谱检测,建立了水产品中11种青霉素残留的同时快速分析方法。样品经80%乙腈水溶液提取,Oasis PRi ME HLB通过式固相萃取柱净化,C_(18)色谱柱分离,0.05%甲酸乙腈溶液和0.05%甲酸水溶液梯度洗脱,多反应监测正离子模式扫描,内标法定量。11种目标物在相应浓度范围内线性关系良好,相关系数不低于0.99,检出限为0.30~1.5μg/kg。基质加标回收率为85.5%~110%,相对标准偏差(RSD)为5.9%~14.3%。该方法前处理操作简便,灵敏度和准确度高,可实现水产品中多种青霉素药物残留的同时快速测定。

关键词：青霉素通过式固相萃取液相色谱-串联质谱(LC-MS/MS) 水产品

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