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Real-time tracking of ER turnover during ERLAD by a rhenium complex via lifetime imaging

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National Science Review 2022年第7期9卷 80-87页

作者： Liang Hao Yu-yi Ling zhi-Xin Huang Zheng-yin pan Cai-Ping Tan Zong-Wan Mao MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistryState Key Laboratory of Oncology in South China Sun Yat-Sen University

Endoplasmic reticulum(ER) degradation by autophagy(ER-phagy) is a recently revealed selective autophagy pathway that plays important roles in organelle turnover and protein degradation,but the biological functions of ER-phagy are largely ***,we present an ER-targeting Re(I) tricarbonyl complex(Re-ERLAD) that can accumulate in the ER,induce ER-to-lys osome-associated degradation(ERLAD) upon visible light irradiation,and label ER buds and track their morphological alterations during *** emission of Re-ERLAD is sensitive to viscosity,which is a key parameter reflecting the amount of unfolded protein in the *** detection using two-photon fluorescence lifetime imaging microscopy shows that ER viscosity initially increases and then decreases during ERLAD,which reveals that ERLAD is a pathway for alleviating ER stress caused by unfolded *** conclusion,our work presents the first specific photoinducer and tracker of ERLAD,which can be used in studying the regulatory mechanism and function of this process.

关键词： rhenium ER-phagy viscosity TPFLIM

Bounds on the overall properties of composites with ellipsoidal inclusions

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Acta Mechanica Sinica 2012年第5期28卷 1340-1355页

作者： Lin-zhi Wu Shi-Dong pan Center for Composite Materials Harbin Institute of Technology

A new model is put forward to bound the effective elastic moduli of composites with ellipsoidal inclusions. In the present paper, transition layer for each ellipsoidal inclusion is introduced to make the trial displacement field for the upper bound and the trial stress field for the lower bound satisfy the continuous interface conditions which are absolutely necessary for the application of variational principles. According to the principles of minimum potential energy and minimum complementary energy, the upper and lower bounds on the effective elastic moduli of composites with ellipsoidal inclusions are rigorously derived. The effects of the distribution and geometric parameters of ellipsoidal in- clusions on the bounds of the effective elastic moduli are an- alyzed in details. The present upper and lower bounds are still finite when the bulk and shear moduli of ellipsoidal inclusions tend to infinity and zero, respectively. It should be mentioned that the present method is simple and needs not calculate the complex integrals of multi-point correlation functions. Meanwhile, the present paper provides an entirely different way to bound the effective elastic moduli of composites with ellipsoidal inclusions, which can be developed to obtain a series of bounds by taking different trial displacement and stress fields.

关键词： Composites Ellipsoidal inclusions Effectiveelastic moduli Upper and lower bounds Transition layer

Synthesis,Crystal Structure and Fluorescence Property of [Y(sip)(H_2O)_4]_n with 5-Sulfoisophthalate Ligand

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Chinese Journal of Structural Chemistry 2006年第9期25卷 1057-1062页

作者： WANG Yan pan Zhao-Rui WANG Zuo-Wei HU Zheng LI yi-zhi ZHENG He-Gen Coordination Chemistry Institute State Key Laboratory of Coordination Chemistry Nanjing University Nanjing 210093 China Key Laboratory for Mesoscopic Chemistry. of Ministry of Education College of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 China Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China

The title complex, [Y（sip）（H2O）4], （sip = 5-sulfoisophthalate）, has been synthesized and characterized by elemental analysis, IR spectra and single-crystal X-ray analysis. The crystal belongs to the orthorhombic system, space group Pna21, a = 7.235（4）, b = 16.456（5）, c = 10.316（3） A, V = 1228.2（9） A^3, Z = 4, Mr = 404.14, Dc = 2.186 g/cm63, F（000） = 808,μ= 4.979 mm^-1, the final R = 0.0474 and wR = 0.1125 for 2122 observed reflections with I 〉 2σ（I）. The structural analysis shows that the intermolecular hydrogen bonds and π-π interactions result in a three-dimensional supramolecular structure. The complex shows intense luminescence in solid state at room temperature.

关键词： crystal structure hydrogen bond network structure luminescence

Hybrid bioartificial liver support in cynomolgus monkeys with D-galactosamine-induced acute liver failure

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World Journal of Gastroenterology 2014年第46期20卷 17399-17406页

作者： zhi Zhang yi-Chao Zhao Yuan Cheng Guo-Deng Jian Ming-Xin pan yi Gao Second Department of Hepatobiliary Zhujiang HospitalSouthern Medical University Department of Hepatobiliary Tangshan Gongren Hospital Chancheng District Central Hospital Guangdong Province Institute of Regenerative Medicine Zhujiang HospitalSouthern Medical University

AIM: To evaluate a hybrid bioartificial liver support system (HBALSS) in cynomolgus monkeys with acute liver failure.

关键词： Acute liver failure Chinese human liver cells Cynomolgus monkey Human liver cell Hybrid bioartificial liver

Experimental validation of material discrimination ability of muon scattering tomography at the TUMUTY facility

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Nuclear Science and Techniques 2019年第8期30卷 26-34页

作者： Xing-Yu pan yi-Fan Zheng zhi Zeng Xue-Wu Wang Jian-Ping Cheng Key Laboratory of Particle and Radiation Imaging(Ministry of Education) and Department of Engineering Physics Tsinghua UniversityBeijing 100084China Department of Nuclear Engineering University of CaliforniaBerkeleyCA 94709USA Department of Radiology and Biomedical Imaging University of CaliforniaSan FranciscoCA 94143USA College of Nuclear Science and Technology Beijing Normal UniversityBeijing 100875China

Muon scattering tomography is believed to be a promising technique for cargo container inspection, owing to the ability of natural muons to penetrate into dense materials and the absence of artificial radiation. In this work, the material discrimination ability of muon scattering tomography is evaluated based on experiments at the Tsinghua University cosmic ray muon tomography facility,with four materials: flour(as drugs substitute), aluminum,steel, and lead. The features of the different materials could be discriminated with cluster analysis and classifiers based on support vector machine. The overall discrimination precisions for these four materials could reach 70, 95, and 99% with 1-, 5-, and 10-min-long measurement,respectively.

关键词： Muon tomography Cargo containerinspection Material discrimination SVM classifier

Spontaneous expulsion of a duodenal lipoma after endoscopic biopsy: A case report

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World Journal of Gastroenterology 2022年第34期28卷 5086-5092页

作者： zhi-Hao Chen Li-Hong Lv Wen-Sheng pan yi-Miao Zhu Department of Gastroenterology Zhejiang Provincial People’s HospitalHangzhou 310014Zhejiang ProvinceChina Affiliated Hospital People’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Gastroenterology Xianju County People’s HospitalTaizhou 317300Zhejiang ProvinceChina

BACKGROUND Gastrointestinal(GI)lipomas are benign submucosal tumors of mature adipocytes that arise mainly in the colon and stomach,sometimes in the ileum and jejunum,and rarely in the *** with symptomatic lipomas require endoscopic or surgical *** expulsion of lipomas after biopsy is a rare condition that has limited case *** SUMMARY A 56-year-old man presented to our hospital with intermittent postprandial epigastric ***(EGD)revealed a 10-mm soft yellowish submucosal lesion with the“pillow sign,”located in the second portion of *** ultrasonography(EUS)using a 12-MHz catheter probe showed a hyperechoic,homogenous,and round solid lesion(OLYMPUS EUS EUME2,UM-DP12-25R,12-MHz radial miniprobe,Olympus Corporation,Tokyo,Japan).Deep biopsy was performed using the bite-on-bite technique with *** examination was compatible with submucosal *** lesion spontaneously expelled 12 d after the ***-up EUS performed after 2 mo confirmed this *** Deep biopsy could lead to spontaneous GI lipoma *** might be the first step in lipoma diagnosis and treatment.

关键词： Lipoma Duodenal neoplasms Spontaneous expulsion Endoscopic biopsy Adipose tissue Case report

GSM-MRF based classification approach for real-time moving object detection

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 250-255页

作者： Xiang pan yi-jun WU Institute of Information and Communication Engineering Zhejiang University Hangzhou 310027 China

Statistical and contextual information are typically used to detect moving regions in image sequences for a fixed *** this paper,we propose a fast and stable linear discriminant approach based on Gaussian Single Model(GSM)and Markov Random Field(MRF).The performance of GSM is analyzed first,and then two main improvements corresponding to the drawbacks of GSM are proposed:the latest filtered data based update scheme of the background model and the linear classification judgment rule based on spatial-temporal feature specified by *** results show that the proposed method runs more rapidly and accurately when compared with other methods.

关键词： Moving object detection Markov Random Field (MRF) Gaussian Single Model (GSM) Fisher Linear Discriminant Analysis (FLDA)

Successful treatment of acute carotid artery injuries

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World Journal of Emergency Medicine 2023年第1期14卷 65-68页

作者： yi-feng pan Zhen-jie Liu Li-bin Zhang zhi-wei Gao Bing Chen Department of Vascular Surgery the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China

Vascular injuries can lead to severe consequences, and in particular, carotid artery injury caused by combat, traffic accidents or other external forces is extremely harmful. As the neck has a complex anatomical structure and a relatively small local space, carotid artery injury is usually complicated by neural and spinal injuries.

关键词： injuries carotid artery

Predicting circRNA-Disease Associations by Using Multi-Biomolecular Networks Based on Variational Graph Auto-Encoder with Attention Mechanism

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Chinese Journal of Electronics 2024年第6期33卷 1526-1537页

作者： Jing YANG Xiujuan LEI yi pan School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Shenzhen Key Laboratory of Intelligent Bioinformatics Shenzhen Institute of Advanced Technology

CircRNA-disease association(CDA) can provide a new direction for the treatment of diseases. However,traditional biological experiment is time-consuming and expensive, this urges us to propose the reliable computational model to predict the associations between circRNAs and diseases. And there is existing more and more evidence indicates that the combination of multi-biomolecular information can improve the prediction accuracy. We propose a novel computational model for CDA prediction named MBCDA, we collect the multi-biomolecular information including circRNA, disease, miRNA and lncRNA based on 6 databases, and construct three heterogeneous network among them, then the multi-heads graph attention networks are applied to these three networks to extract the features of circRNAs and diseases from different views, the obtained features are put into variational graph auto-encoder(VGAE) network to learn the latent distributions of the nodes, a fully connected neural network is adopted to further process the output of VGAE and uses sigmoid function to obtain the predicted probabilities of circRNA-disease *** a result, MBCDA achieved the values of AUC and AUPR under 5-fold cross-validation of 0.893 and 0.887. MBCDA was applied to the analysis of the top-25 predicted associations between circRNAs and diseases, these experimental results show that our proposed MBCDA is a powerful computational model for CDA prediction.

关键词： Knowledge engineering Attention mechanisms Computational modeling Biological system modeling Predictive models Feature extraction Heterogeneous networks Topology Data mining Diseases