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Chemical Research in Chinese Universities 2015年第2期31卷 192-197页

作者： xia zhenzhen CAI Wensheng SHAO Xueguang Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) State Key Laboratory of Medicinal Chemical Biology Research Center for Analytical Sciences College of Chemistry Nankai University Tianjin 300071 P. R. China

Chlorinated paraffins（CPs） are potential persistent organic pollutants（POPs）, which threat the safety of environment and organisms. However, the analysis of CPs is a difficult task due to their complex composition containing thousands of congeners. In the present work, quantitative structure retention relationship（QSRR） of CPs was studied. A total of 470 molecular descriptors were generated, for describing the structures of 28 CPs and 12 descriptors relevant to retention time of the CPs were selected by stepwise regression. Then, QSRR models between retention time on the one hand and the selected descriptors on the other hand were established by multiple linear regres- sion（MLR）, partial least squares（PLS） and least square support vector regression（LS-SVR）. The result shows that PLS model is better than MLR and LS-SVR, obtaining a squared correlation coefficient（r2） of 0.9996 and a root mean squared error（RMSE） of 0.015. The PLS model was then used to predict the retention time of 49 C10-CPs. Three of them were investigated by gas chromatography coupled with mass spectrometry（GC-MS）. A well-defined correlation was found between the measured retention time and the predicted value.

关键词： Chlorinated paraffin Multivariate calibration Retention time Quantitative structure retention relationship

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枣庄市农业机械化发展薄弱环节探究

中国农机装备 2024年第1期 28-31页

作者：李超孙炜翔倪跃跃夏珍珍邓业芳孙晓筱枣庄市农业农机技术推广中心枣庄277800 枣庄市农业综合执法支队枣庄277800 台儿庄区泥沟镇人民政府枣庄台儿庄277400 枣庄市农业科学研究院枣庄277800

“工欲善其事,必先利其器”。破解今后“谁来种地”“怎么种好地”这一难题,唯有大力发展农业机械化,通过发展现代农业装备,改善农业生产条件,解放农村劳动力,使现代职业农民生活更体面。当前枣庄市农机化发展存在诸多结构性矛盾,在全... 详细信息

“工欲善其事,必先利其器”。破解今后“谁来种地”“怎么种好地”这一难题,唯有大力发展农业机械化,通过发展现代农业装备,改善农业生产条件,解放农村劳动力,使现代职业农民生活更体面。当前枣庄市农机化发展存在诸多结构性矛盾,在全面梳理枣庄农机化发展现状的基础上,通过对枣庄市农业机械化发展薄弱环节进行深层次探究,找出症结、对症施策、助力发展。

关键词：枣庄市农机化薄弱环节分析与探究

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发芽对绿豆皮提取物抗氧化和抗炎活性的影响

农产品加工 2024年第16期 11-15页

作者：张鹏庞晨夏珍珍郑丹张仙华登科廖先清陶明芳长江大学生命科学学院湖北荆州434023 华中农业大学食品科学技术学院湖北武汉430070 农业农村部农产品质量安全风险评估实验室(武汉) 湖北省农业科学院农业质量标准与检测技术研究所湖北武汉430064

为揭示发芽前后绿豆皮提取物(Mung bean coat extract,MBCE)营养物质和体外抗氧化、抗炎活性的变化,以期拓展其应用范围。取未发芽绿豆和发芽4 d绿豆制备MBCE并测定其化学成分含量,通过测定对DPPH自由基、羟基和超氧阴离子自由基的清除... 详细信息

为揭示发芽前后绿豆皮提取物(Mung bean coat extract,MBCE)营养物质和体外抗氧化、抗炎活性的变化,以期拓展其应用范围。取未发芽绿豆和发芽4 d绿豆制备MBCE并测定其化学成分含量,通过测定对DPPH自由基、羟基和超氧阴离子自由基的清除能力评价MBCE抗氧化活性,通过建立体外胰蛋白酶抑制模型评价MBCE的抗炎活性。结果表明,发芽后MBCE总缩合单宁和总糖减少,还原糖、总蛋白质和总黄酮增多,总酚变化不大;发芽前后MBCE均具有抗氧化和胰蛋白酶抑制活性,其活性可能与化学成分密切相关;且发芽前MBCE胰蛋白酶抑制活性优于未发芽MBCE。以上研究表明,发芽前后的绿豆皮均具有丰富的营养成分和良好的活性,极具高值化利用潜能。

关键词：绿豆皮黄酮类化合物胰蛋白酶抗氧化活性抗炎活性

Influence of surface acidity and chemical valence on low temperature activity over Pt-HSiW/CeO2 for catalytic combustion of chlorobenzene

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Journal of Rare Earths 2024年第9期42卷 1693-1703页

作者： Zhongxian Song Zepeng Liu Xuejun Zhang Yanli Mao Wei Liu Chunxiang Gao Haiyang Li xia Zhang Changrui Han zhenzhen Huang Key Laboratory of Carbon Emission Reduction and Combined Air Pollution Control Technology Faculty of Environmental and Municipal EngineeringHenan University of Urban Construction College of Environmental and Safety Engineering Shenyang University of Chemical Technology

Pt-HSiW/CeO2catalysts were prepared for chlorobenzene（CB） catalytic combustion by hydrothermal method at different calcination temperatures,and the effects of the surface acidity and chemical valence on the catalytic activity were *** results show that the catalyst calcined at 450℃（Cat-B）exhibits the outstanding catalytic performance,and the Cat-B catalyst possesses 90% conversion of CB at148℃.The excellent catalytic activity of Cat-B is attributed to more Ce3+/(Ce3++Ce4+),Pt0/(Pt0+Pt2+),Oads/(Olatt+Oads) and Lewis acid *** degradation mechanism is proposed based on the analysis of the intermediates with the following reaction pathway:chlorobenzene→phenates/benzoquinone→acetate→maleate→CO2+H2O.

关键词： Catalytic combustion Chlorobenzene Acid sites Rare earths

Melatonin Alleviates Abscisic Acid Deficiency Inhibition on Photosynthesis and Antioxidant Systems in Rice under Salt Stress

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1421-1440页

作者： Feiyu Yan Xin Chen zhenzhen Wang Yuxuan xia Dehui Zheng Sirui Xue Hongliang Zhao Zhiwei Huang Yuan Niu Guoliang Zhang School of Life Sciences and Food Engineering Huaiyin Institute of TechnologyHuai’an223003China Jianghuai Plain Crop Industry Engineering Research Institute Huaiyin Institute of TechnologyHuai’an223003China

Melatonin and abscisic acid,as major plant hormones,play important roles in the physiological and biochemical activities of crops,but the interaction between the two under salt stress is not yet *** study investigated the endogenous levels of melatonin and abscisic acid in rice by using exogenous melatonin,abscisic acid,and their synthetic inhibitors,and examined their interactions under salt *** research results indicate that melatonin and abscisic acid can improve rice salt *** alleviated the salt sensitivity caused by abscisic acid deﬁciency,increased antioxidant enzyme activity and antioxidant content in rice treated with abscisic acid synth-esis inhibitors,and reduced total reactive oxygen species content and thiobarbituric acid reactive substance *** also increased the activity of key photosynthetic enzymes and the content of photosynthetic pigments,maintaining the parameters of photosynthetic gas exchange and chlorophyllﬂ*** summary,melatonin alleviated the effects of abscisic acid deﬁciency on photosynthesis and antioxidant systems in rice and improved salt *** study is beneﬁcial for expanding the understanding of melatonin regulation of crop salt tolerance.

关键词： Melatonin abscisic acid salt stress rice photosynthesis antioxidant system

Perilipin 5 regulates hepatic stellate cell activation and high-fat diet-induced non-alcoholic fatty liver disease

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Animal Models and Experimental Medicine 2024年第2期7卷 166-178页

作者： Xuecui Yin Lin Dong xiaohan Wang zhenzhen Qin Yuying Ma xiaofei Ke Ya Li Qingde Wang Yang Mi Quanjun Lyu xia Xu Pengyuan Zheng Youcai Tang Department of Internal Medicine the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Pediatrics the Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Clinical Nutrition the First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Key Laboratory of Advanced Drug Preparation Technologies Ministry of Education of ChinaCo-innovation Center of Henan Province for New drug R&D and Preclinical SafetySchool of Pharmaceutical SciencesZhengzhou UniversityZhengzhouChina Department of Pediatrics GastroenterologyHenan Key Laboratory of Rehabilitation MedicineHenan Joint International Research Laboratory of Chronic Liver Injury and Henan Provincial Outstanding Overseas Scientists Chronic Liver Injury Studiothe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Background:Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases *** stellate cells(HSCs)are the major effector cells of liver *** contain abundant lipid droplets(LDs)in their cytoplasm during *** 5(PLIN 5)is a LD surface-associated protein that plays a crucial role in lipid ***,little is known about the role of PLIN 5 in HSC ***:PLIN 5 was overexpressed in HSCs of Sprague–Dawley rats by lentivirus *** the same time,PLIN 5 gene knockout mice were constructed and fed with a high-fat diet(HFD)for 20 weeks to study the role of PLIN 5 in *** corresponding reagent kits were used to measure TG,GSH,Caspase 3 activity,ATP level,and mitochondrial DNA copy *** analysis of mice liver tissue metabolism was performed based on UPLC-MS/***,mitochondrial function,cell proliferation,and apoptosis-related genes and proteins were detected by western blotting and ***:Overexpression of PLIN 5 in activated HSCs led to a decrease in ATP levels in mitochondria,inhibition of cell proliferation,and a significant increase in cell apoptosis through AMPK *** addition,compared with the HFD-fed C57BL/6J mice,PLIN 5 knockout mice fed with HFD showed reduced liver fat deposition,decreased LD abundance and size,and reduced liver ***:These findings highlight the unique regulatory role of PLIN 5 in HSCs and the role of PLIN 5 in the fibrosis process of NAFLD.

关键词： AMPK apoptosis hepatic stellate cell liver fibrosis perilipin 5

Elevated Kallistatin promotes the occurrence and progression of non-alcoholic fatty liver disease

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1730-1744页

作者： zhenzhen Fang Gang Shen Yina Wang Fuyan Hong Xiumei Tang Yongcheng Zeng Ting Zhang Huanyi Liu Yanmei Li Jinhong Wang Jing Zhang Anton Gao Weiwei Qi xia Yang Ti Zhou Guoquan Gao Department of Biochemistry Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China Department of VIP Medical Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Physical Examination Center the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Clinical Laboratory Guangzhou First People's HospitalGuangzhou 510080China Guangdong Key Laboratory of Liver Disease Research the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 51008China Department of Health Sciences College of Health SolutionsArizona State UniversityTempeUSA Guangdong Engineering&Technology Research Center for Gene Manipulation and Biomacromolecular Products Sun Yat-Sen UniversityGuangzhou 510080China Guangdong Province Key Laboratory of Diabetology Guangzhou 510o80China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhou 510080China

Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide,and the development of nonalcoholic steatohepatitis(NASH)might cause irreversible hepatic ***(HLP)is the leading risk factor for *** study aims to illuminate the causative contributor and potential mechanism of Kallistatin(KAL)mediating HLP to NAFLD.221 healthy control and 253 HLP subjects,62 healthy control and 44 NAFLD subjects were *** plasma KAL was significantly elevated in HLP subjects,especially in hypertriglyceridemia(HTG)subjects,and positively correlated with liver ***,KAL levels of NAFLD patients were significantly *** transgenic mice induced hepatic steatosis,inflammation,and fibrosis with time and accelerated inflammation development in high-fat diet(HFD)*** contrast,KAL knockout ameliorated steatosis and inflammation in high-fructose diet(HFruD)and methionine and choline-deficient(MCD)diet-induced NAFLD ***,KAL induced hepatic steatosis and NASH by down-regulating adipose triglyceride lipase(ATGL)and comparative gene identification 58(CGl-58)by LRP6/Gas/PKA/GSK3βpathway through down-regulating peroxisome proliferator-activated receptor(PPARy)and up-regulating kruppel-like factor four(KLF4),***-58 is bound to NF-kB p65 in the cytoplasm,and diminishing CGl-58 facilitated p65 nuclear translocation and TNFa ***,hepatic CGl-58-overexpress reverses NASH in KAL transgenic ***,free fatty acids up-regulated KAL against thyroid hormone in ***,Fenofibrate,one triglyceride-lowering drug,could reverse hepatic steatosis by down-regulating *** results demonstrate that elevated KAL plays a crucial role in the development of HLP to NAFLD and may be served as a potential preventive and therapeutic target.

关键词： GSK3β inflammation elevated

2022年湖北地区市售葡萄中农药残留特征及膳食暴露风险评估

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食品工业科技 2023年第19期44卷 313-319页

作者：张仙胡西洲彭西甜夏珍珍郑丹张隽娴湖北省农业科学院农业质量标准与检测技术研究所湖北武汉430064

为了探讨湖北地区市售葡萄中农药残留特征以及其膳食暴露风险,本研究采用液相色谱串联质谱法和气相色谱串联质谱法对2022年湖北地区大型水果农贸市场和超市的128份葡萄样品中的46种农药残留进行分析,并采用英国兽药残留委员会兽药残留... 详细信息

为了探讨湖北地区市售葡萄中农药残留特征以及其膳食暴露风险,本研究采用液相色谱串联质谱法和气相色谱串联质谱法对2022年湖北地区大型水果农贸市场和超市的128份葡萄样品中的46种农药残留进行分析,并采用英国兽药残留委员会兽药残留风险排序矩阵和食品安全指数法对检出的农药残留进行膳食暴露评估。结果表明,本次抽检的葡萄农药残留检出率为78.1%,有4个样品中的氯氟氰菊酯超标,超标率为3.1%,共检出20种农药,其中有9种未登记农药。根据残留风险得分,检出的农药中有阿维菌素、三唑醇、甲基硫菌灵等7种高风险农药,噻虫嗪、戊唑醇、啶虫脒、氯氰菊酯4种中风险农药,烯酰吗啉、嘧菌酯、抑霉唑等9种低风险农药。按照风险指数排序,中风险样品占3.1%,低风险和极低风险样品占96.9%。根据食品安全指数法的结果,20种检出农药的食品安全指数(IFS)值都低于1,说明膳食暴露风险在可接受的范围内。总体来说,本次监测的湖北葡萄样品质量安全状况良好,农药残留引起的膳食暴露风险较低。

关键词：葡萄农药残留膳食暴露风险评估

Liquid-liquid extraction pretreatment samples method used for pharmacokinetic study of rhubarb in rats after oral administrated

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Journal of Traditional Chinese Medical Sciences 2018年第3期5卷 291-301页

作者： Hongmei Lin Longfei Lin Lingyan Xu Yuanping Xie zhenzhen xia Qing Wu Department of TCM Pharmaceutics School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijingChina

Objective:Pretreatment of biological samples is the most critical step in pharmacokinetic studies,especially pre-treatment of plasma *** pretreatment of biological samples in pharmacokinetic study of Traditional Chinese Medicines (TCM) is difficult due to the complexity of the *** organic solvent system ethyl acetate:acetone (10:1) solution used for liquid-liquid extraction has been developed in this study and compared with the commonly used protein precipitation ***:Rats,Beagle dogs and humans plasma samples were adopted in this study in order to demonstrate the universality of the pretreatment *** of this pretreatment method was also verified through its application to the pharmacokinetics of rhubarb in ***:According to the results of extraction recovery matrix effect,it was indicated that the liquid-liquid extraction methods with new organic solvent might be suitable for variety of structures of compounds and various types of plasma *** pharmacokinetic study result showed that the developed pretreatment method could successfully be used for simultaneous determination of three active compounds modin,emodin-8-O-β-D-glucopyranoside (EDG) and rhein in rat plasma with high sensitivity,accuracy,and recovery by liquid chromatography tandem mass spectrometry (LC-MS/MS).Conclusion:The pretreatment method of liquid-liquid extraction methods with new organic solvent could be successfully applied for multi-component pharmacokinetics of TCM.

关键词： Pretreatment method Liquid-liquid extraction Protein precipitation LC-MS/MS Rhubarb

认知功能训练联合艾地苯醌对血管性痴呆患者血浆神经递质、认知功能的影响

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反射疗法与康复医学 2022年第22期3卷 166-169页

作者：夏珍珍林宏伟烟台市蓬莱人民医院神经内科山东烟台265600

目的探讨认知功能训练联合艾地苯醌对血管性痴呆患者血浆神经递质、认知功能的影响.方法选择2020年5月—2022年3月我院收治的血管性痴呆患者72例,按随机数字表法分为对照组(n=36)和观察组(n=36).对照组采用艾地苯醌治疗,观察组在对照组... 详细信息

目的探讨认知功能训练联合艾地苯醌对血管性痴呆患者血浆神经递质、认知功能的影响.方法选择2020年5月—2022年3月我院收治的血管性痴呆患者72例,按随机数字表法分为对照组(n=36)和观察组(n=36).对照组采用艾地苯醌治疗,观察组在对照组基础上进行认知功能训练,两组均持续干预3个月.对比两组患者的血浆神经递质、认知功能及日常生活活动能力.结果干预后,观察组的5-羟色胺、去甲肾上腺素、多巴胺水平均高于对照组,组间差异有统计学意义(P<0.05).干预后,观察组的简易智力状态量表总分及语言理解、定向时间与地点、即刻记忆、注意力与计算力、延迟记忆、视空间评分均高于对照组,组间差异有统计学意义(P<0.05).干预后,观察组的日常生活活动能力量表评分为(68.94±3.43)分,高于对照组的(55.49±2.64)分,差异有统计学意义(P<0.05).结论认知功能训练联合艾地苯醌能有效提高血管痴呆性患者的血浆神经递质水平,改善其认知功能及日常生活活动能力,值得临床推广使用.

关键词：血管性痴呆认知功能训练艾地苯醌血浆神经递质认知功能