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Antiangiogenic therapy for human pancreatic carcinoma xenografts in nude mice

World Journal of Gastroenterology 2005年第3期11卷 447-450页

作者： LinJia Mei-HuaZhang shi-zhenyuan Wen-GeHuang DepartmentofDigestiveDiseases FirstAffiliatedPeople'sHospitalGuangzhouMedicalCollegeGuangzhou510180GuangdongProvinceChina DepartmentofDigestiveDiseases SecondAffiliatedHospitalSunYat-SenUniversityGuangzhou510120GuangdongProvinceChina Animalcenter SunYat-SenUniversityGuangzhou510089GuangdongProvinceChina DepartmentofDigestiveDiseases FirstAffiliatedPeople'sHospitalGuangzhouMedicalCollegeGuangzhou510180GuangdongProvinceChina

AIM: To investigate the anti-tumor effects of antiangiogenic therapy (a combination of TNP-470, an antiangiogenic compound, with gemcitabine, an antimetabolite) on human pancreatic carcinoma xenografts and its mechanism. METHODS: A surgical orthotopic implantation (SOI) model was established by suturing small pieces of SW1990 pancreatic carcinoma into the tail of pancreas in nude male mice. Mice then received either single therapy (n = 24) or combined therapy (n = 32). Mice receiving single therapy were randomly divided into control group, G100 group receiving 100 mg/kg gemcitabine IP on d O, 3, 6 and 9 after transplantation, and T30 group receiving 30 mg/kg TNP-470 s.c on alternate days for 8 wk. Mice receiving combined therapy were randomly divided into control group, T15 group, G50 group and combination group (TNP-470 30 mg/kg and gemcitabine 50 mg/kg). Animals were killed 8 wk after transplantation. Transplanted tumors, liver, lymph node and peritoneum were removed. Weight of transplanted tumors, the T/C rate (the rate of mean treated tumor weight to mean control tumor weight), change of body weight, metastasis rate, and 9-wk survival rate were investigated. Tumor samples were taken from the control group, T30 group, G100 group and combination group. PCNA index (PI) and microvessel density (MVD) were investigated by immunohistochemical staining for PCNA and factor VIII, respectively. RESULTS: There was a significant inhibitory effect on primary tumor growth of pancreatic carcinoma in G100 group, compared to T30 group, whereas tumor metastasis was significantly inhibited in T30 group compared to G100 group. There was no significant improvement in survival rate in these two groups. No significant inhibitory effect on tumor growth and metastasis in T15 group and G50 group. However, significant anti-tumor and anti-metastatic effects were observed in the combination group with a significant improvement in survival rate. The inhibitory effect on tumor growth in combin

关键词： Pancreatic carcinoma TNP-470 Angiogenesis Inhibitors Xenografts

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MULTI-TILLERING DWARF1, a new allele of BRITTLE CULM 12, affects plant height and tiller in rice

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Science Bulletin 2016年第23期61卷 1810-1817页

作者： Haiping Yu Deyong Ren Yangzhou Zhu Jiangmin Xu Yuexing Wang Ruifang Liu Yunxia Fang zhenyuan shi Jiangjie Pan Mei Lu Bojun Ma Jiang Hu Yuchun Rao College of Chemistry and Life Sciences Zhejiang Normal University State Key Laboratory for Rice Biology China National Rice Research Institute Key Laboratory of Northeast Rice Biology and Breeding Ministry of Agriculture and Key Laboratory of Northern Japonica Rice Genetics and Breeding Ministry of EducationRice Research Institute Shenyang Agricultural University

Plant height and tillering are crucial factors determining rice plant architecture and influencing rice grain production. In this study, rnulti-tillering dwarf1 （mtdl）, a stable multi-tiller and dwarf mutant, was screened from the ethylmethane sulfonate-treated japonica rice variety Wuyunging7. Compared with the wild type, mtdl mutant exhibited pleiotropic phenotypes, including dwarf- ism, more tillers, brittle culms and delayed heading date. By employing map-based cloning strategy, the gene MTD1 was finally mapped to an approximately 66-kb region on the short arm of chromosome 9. Sequencing results showed that the gene LOCOsO9g02650 （BC12） in mtdl mutant had a single nucleotide substitution （G to A）, which gen- erated a premature translation stop. Over-expressing MTD1/BC12 coding sequ（nce rescued all the phenotypes of mtdl mutants including plant height and tillers, which confirms that BC12 is the mutated gene in mtdl mutant. Quantitative reverse tran,-eription-PCR analysis showed that MTDI/BCI2 could negatively regulate the expression of MONOCULM 1, IDEAL PLANT ARCHITECTURE1 and Tillering and Dwarf 1, and control rice tillering. Remark- ably, a-amylase activity analysis and gibberellic acid （GA） treatment showed that the dwarf phenotype of mtdl mutant was dependent on GA biosynthesis pathway. These results facilitated to further uncover the molecular mechanism of the growth and development in rice.

关键词： Rice - Dwarf Tillering - mtdl Gene cloning

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Identification and characterization of Mini1, a gene regulating rice shoot development

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Journal of Integrative Plant Biology 2015年第2期57卷 151-161页

作者： Yunxia Fang Jiang Hu Jie Xu Haiping Yu zhenyuan shi Guosheng Xiong Li Zhu Dali Zeng Guangheng Zhang Zhenyu Gao Guojun Dong Meixian Yan Longbiao Guo Yonghong Wang Qian Qian State Key Laboratory of Rice Biology China National Rice Research Institute Chinese Academy of Agricultural Sciences College of Agriculture and Biotechnology Zhejiang University Key Laboratory of Crop Physiology Ecology and Genetic Breeding Ministry of Education Jiangxi Agricultural University State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental Biology The Chinese Academy of Sciences

The aerial parts of higher plants are generated from the shoot apical meristem （SAM）. In this study, we isolated a small rice （Oryza sativa L.） mutant that showed premature termination of shoot development and was named mini rice 1 （mini1）. The mutant was first isolated from a japonica cultivar Zhonghua11 （ZH11） subjected to ethyl methanesulfonate （EMS） treatment. With bulked segregant analysis （BSA） and mapbased cloning method, Mini1 gene was finally fine-mapped to an interval of 48.6 kb on chromosome 9. Sequence analyses revealed a single base substitution from G to A was found in the region, which resulted in an amino acid change from Gly to Asp. The candidate gene Os09go363900 was predicted to encode a putative adhesion of calyx edges protein ACE （putative HOTHEAD precursor） and genetic complementation experiment confirmed the identity of Minil. Os09go36：3900 contains glucose-methanol-choline （GMC） oxidoreductase and NAD（P）-binding Rossmann-like domain, and exhibits high similarity to Arabidopsis HOTHEAD （HTH）. Expression analysis indicated Minil was highly expressed in young shoots but lowly in roots and the expression level of most genes involved in auxin biosynthesis and signal transduction were reduced in mutant. We conclude that Mini1 plays an important role in maintaining SAM activity and promoting shoot development in rice.

关键词： HOTHEAD mini rice shoot development

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A New-Nipponbare Rice Germplasm with High Seed-Setting Rate

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Journal of Genetics and Genomics 2014年第10期41卷 549-552页

作者： Jiang Hu Guojun Dong Yunxia Fang Yuchun Rao Jie Xu Dawei Xue Haiping Yu Changwei Ge zhenyuan shi Jiangjie Pan Li Zhu Dali Zeng Guangheng Zhang Longbiao Guo Qian Qian State Key Laboratory of Rice Biology China National Rice Research Institute College of Chemistry and Life Sciences Zhejiang Normal University College of Life and Environment Sciences Hangzhou Normal University

Rice （Oryza sativa L.） is an important crop providing staple food for more than half the world＇s population and also considered as a model plant for molecular biological study of the cereals. In 1998, the large-scale sequencing of japonica rice cultivar Nipponbare （bred at Aichi Agricultural Center in Japan and released in 1963） was initiated by International Rice Genome Sequencing Project （IRGSP） and the high-quality draft of genome was announced in 2002 （Goff et al,, 2002）. Owing to its easy genetic transformation and released whole genome sequencing data, Nipponbare is widely used in functional genomic research （Piffanelli et al., 2007; Luan et al., 2008; Hu et al., 2010; Thang et al., 2010; Tabuchi et al., 2011; Zhang et al., 2011; Jiang et al., 2012; Lu et al.. 2013）.

关键词： length In more A New-Nipponbare Rice Germplasm with High Seed-Setting Rate than

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抗战胜利后北平邮政经营危机之原因探析

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北京档案 2024年第8期 59-65页

作者：王星晨石镇源内蒙古大学历史与旅游文化学院

抗战胜利后,北平邮政的经营状况持续恶化,收入与支出相差甚远,这一情况的出现是多种因素作用的结果。从收入方面来看,北平邮区战乱不断,网点与邮路变动频繁,邮政业务开展严重受阻。与此同时,国内物价飞涨,邮资长期低于物价运行,邮政收... 详细信息

抗战胜利后,北平邮政的经营状况持续恶化,收入与支出相差甚远,这一情况的出现是多种因素作用的结果。从收入方面来看,北平邮区战乱不断,网点与邮路变动频繁,邮政业务开展严重受阻。与此同时,国内物价飞涨,邮资长期低于物价运行,邮政收入锐减。从支出方面来看,通货膨胀造成邮政支出增加,员工薪水、邮政改良支出也有所增加。此外,还要受到地区经济和全国经济恶化的影响。整体而言,局势动荡造成的经营困难与通货膨胀是造成这一时期邮政经营危机的最为重要的原因。

关键词：北平邮政经营危机通货膨胀

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Characterization and correlation of engineering properties with microstructure in peanuts:A microscopic to macroscopic analysis

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Journal of Integrative Agriculture 2025年第1期24卷 339-352页

作者： Fei Xiang zhenyuan Li Yichen Zheng Caixia Ding Benu Adhikari Xiaojie Ma Xuebing Xu Jinjin Zhu Bello Zaki Abubakar Aimin shi Hui Hu Qiang Wang Institute of Food Science and Technology Chinese Academy of Agricultural Sciences/Comprehensive Utilization Laboratory of Cereal and Oil ProcessingMinistry of Agriculture and Rural AffairsBeijing 100193China Wilmar(Shanghai)Biotechnology Research&Development Center Co. Ltd.Shanghai 200137China School of Science RMIT UniversityMelbourne 3083VICAustralia School of Food Science and Engineering Nanjing University of Finance and Economics/Jiangsu Modern Food Circulation and Safety Collaborative Innovation CenterNanjing 210023China College of Food Science and Pharmacy Xinjiang Agricultural UniversityUrumqi 830052China Department of Agricultural Extension and Rural Development Faculty of AgricultureUsmanu Danfodiyo UniversitySokoto 840101Nigeria

Peanut varieties are diverse globally,with their characters and nutrition determining the product ***,the comparative analysis and statistical analysis of key quality indicators for peanut kernels across the world remains relatively limited,impeding the comprehensive evaluation of peanut quality and hindering the industry development on a global *** study aimed to compare and analyze the apparent morphology,microstructure,single-cell structure,engineering and mechanical properties,as well as major nutrient contents of peanut kernels from 10 different cultivars representing major peanut-producing *** surface and cross-section microstructure of the peanut kernels exhibited a dense“blocky”appearance with a distinct cellular *** lipid droplets were predominantly spherical with a regular distribution within the *** single-cell structure of the kernels from these 10 peanut cultivars demonstrated varying morphologies and dimensions,which exhibited correlations with their mechanical and engineering ***,the mass loss versus temperature profiles of the peanut kernels revealed five distinct stages,corresponding to moisture loss,volatile loss,protein denaturation,and the degradation of various *** were also observed in the lipid,protein,and sucrose contents,texture,bulk density,true density,porosity,geometric mean diameter,and sphericity among the diferent peanut *** study establishes relationships and correlations among microstructure,engineering properties,and nutritional composition of commonly grown peanut varieties in major peanut-processing *** findings provide valuable insights into peanut quality evaluation,empowering the peanut industry to enhance their processing and product development efforts.

关键词： peanut kernels apparent morphology microstructure engineering properties mechanical properties

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UGC对消费者购买意愿的影响

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黑龙江科学 2020年第18期11卷 158-159页

作者：施振远江苏城市职业学院商学院电子商务专业南京210000

针对用户生成内容(UGC)对消费者购买意愿产生的影响进行探究,找出了实际运营过程中出现的问题,并提出了解决方案。对青年人群的社交媒体使用情况及影响青年人群购物的因素进行了分析,发现有超过70%的青年人群会和朋友分享自己所知道的... 详细信息

针对用户生成内容(UGC)对消费者购买意愿产生的影响进行探究,找出了实际运营过程中出现的问题,并提出了解决方案。对青年人群的社交媒体使用情况及影响青年人群购物的因素进行了分析,发现有超过70%的青年人群会和朋友分享自己所知道的产品信息,而且非常重视网上论坛的意见和经验,使得信息传递的速度越来越快。UGC因为其独特的互动性与信息的传播性而对用户产生了深远影响。信息的传播者要积极提高信息的时效性与自身的品牌影响力,使有相同价值观或相同需求的受众能够更好地接受传播的信息,从而更好地刺激用户消费。

关键词： UGC 消费者购买意愿影响

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吐鲁番沙虎对不同食物化合物的反应

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四川动物 2018年第2期37卷 179-184页

作者：何文凤段振渊时磊新疆农业大学动物科学学院乌鲁木齐830052

化学感受在蜥蜴的生态和行为中发挥了重要作用,而中国特有且罕见的食果性壁虎——吐鲁番沙虎Teratoscincus roborowskii是否具有食物的化学识别能力尚不清楚。采用棉签法研究吐鲁番沙虎对不同食物化合物的反应,以饱和蔗糖溶液作为碳水... 详细信息

化学感受在蜥蜴的生态和行为中发挥了重要作用,而中国特有且罕见的食果性壁虎——吐鲁番沙虎Teratoscincus roborowskii是否具有食物的化学识别能力尚不清楚。采用棉签法研究吐鲁番沙虎对不同食物化合物的反应,以饱和蔗糖溶液作为碳水化合物,纯猪肉脂肪作为脂类的复杂混合物,大豆蛋白粉溶液作为蛋白质,蒸馏水作为对照。用棉签分别蘸这些刺激物,进行60 s弹舌试验。用弹舌速率(TFR)和弹舌攻击得分[TFAS(R)]作为响应食物化合物的指标,以探讨吐鲁番沙虎探测不同类型食物的化学识别模式。结果表明,吐鲁番沙虎对不同食物化合物的TFR和TFAS(R)差异有统计学意义;对蒸馏水、饱和蔗糖溶液的TFR极显著或显著大于脂肪;对脂肪的TFAS(R)极显著大于蒸馏水、饱和蔗糖溶液。这些结果也提示,吐鲁番沙虎能使用犁鼻器检测和识别不同食物化合物。

关键词：吐鲁番沙虎行为化学感受器食物化合物弹舌

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A Rare Allele of GS2 Enhances Grain Size anc Grain Yield in Rice

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Molecular Plant 2015年第10期8卷 1455-1465页

作者： Jiang Hu Yuexing Wang Yunxia Fang Longjun Zeng Jie Xu Haiping Yu zhenyuan shi Jiangjie Pan Dong Zhang Shujing Kang Li Zhu Guojun Dong Longbiao Guo Dali Zeng Guangheng Zhang Lihong Xie Guosheng Xiong Jiayang Li Qian Qian The State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen 518120 China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research (Beijing) Institute of Genetics and Developmental BiologyChinese Academy of Sciences Beijing 100101 China These authors contributed equally to this article.

Grain size determines grain weight and affects grain quality. Several major quantitative trait loci （QTLs） regulating grain size have been cloned; however, our understanding of the underlying mechanism that regulates the size of rice grains remains fragmentary. Here, we report the cloning and characterization of a dominant QTL, GRAIN SIZE ON CHROMOSOME 2 （GS2）, which encodes Growth-Regulating Factor 4 （OsGRF4）, a transcriptional regulator. GS2 localizes to the nucleus and may act as a transcription activator. A rare mutation of GS2 affecting the binding site of a microRNA, OsmiR396c, causes elevated expression of GS2/OsGRF4. The increase in GS2 expression leads to larger cells and increased numbers of cells, which thus enhances grain weight and yield. The introduction of this rare allele of GS2/OsGRF4 into rice cultivars could significantly enhance grain weight and increase grain yield, with possible applications in breeding high-yield rice varieties.

关键词： GS2 OsGRF4 QTL grain size miR396c rice

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FY-3G MWRI-RM低频通道亮温观测中的无线电干扰信号及其日变化

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气象科学 2024年第4期44卷 691-706页

作者：史震源邹晓蕾南京信息工程大学资料同化研究和应用联合中心南京210044

由于微波辐射计低频通道的非保护性,亮温观测会受到主动传感器的信号污染,被称为无线电频率干扰(Radio-Frequency Interference,RFI)。RFI信号降低了亮温观测资料及其反演产品的准确度。我国近期发射的风云三号G星(FY-3G)搭载了微波成... 详细信息

由于微波辐射计低频通道的非保护性,亮温观测会受到主动传感器的信号污染,被称为无线电频率干扰(Radio-Frequency Interference,RFI)。RFI信号降低了亮温观测资料及其反演产品的准确度。我国近期发射的风云三号G星(FY-3G)搭载了微波成像仪—降水型(Microwave Radiation Imager-Rainfall Mission,MWRI-RM),在10.65~183.00 GHz的频率范围内设有17个通道,对地球大气进行被动遥感探测。在没有RFI影响情况下,不同通道亮温观测具有高度相关性。利用这一特点,采用标准化主成分分析法,可识别FY-3G MWRI-RM亮温观测资料中RFI的发生位置和强度。与风云三号A/B/C/D/星(FY-3A/B/C/D)不同,FY-3G MWRI-RM可以在不同时间观测到地球同一地点。因此,还可以研究RFI是否有日变化特征。结果表明,RFI信号确实存在于MWRI-RM的低频通道10.65 GHz亮温观测资料中,在中国和欧洲都有集中或零散分布区域,并且呈现日变化特征,RFI强度在白天普遍大于夜间。

关键词： FY-3G微波成像仪—降水型无线电频率干扰信号识别无线电频率干扰信号日变化特征

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