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基于平均表观传播子磁共振成像鉴别WHO CNS4R较低级别胶质瘤中的CNS5胶质母细胞瘤

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中国医药科学 2024年第7期14卷 139-143页

作者：肖慧楠郑莞怡吴振兴施宇婷徐雪蒋日烽福建医科大学附属协和医院放疗科福建福州350001 福建医科大学附属协和医院放射科福建福州350001

目的探讨平均表观传播子磁共振成像(MAP-MRI)从2016年WHO CNS4R分类下较低级别胶质瘤中鉴别2021年WHO CNS5分类的胶质母细胞瘤(GBM)的价值及意义。方法选取2019年1月至2022年12月于福建医科大学附属协和医院诊疗的28例WHO CNS4R分类为WH... 详细信息

目的探讨平均表观传播子磁共振成像(MAP-MRI)从2016年WHO CNS4R分类下较低级别胶质瘤中鉴别2021年WHO CNS5分类的胶质母细胞瘤(GBM)的价值及意义。方法选取2019年1月至2022年12月于福建医科大学附属协和医院诊疗的28例WHO CNS4R分类为WHOⅡ或Ⅲ级脑弥漫性胶质瘤成人患者为研究对象。所有患者术前均行结构磁共振成像和扩散磁共振成像,其中扩散磁共振成像分别行MAPMRI和扩散张量成像(DTI)分析,并提取肿瘤实体区的均方位移(MSD)、q空间逆方差(QIV)、回归轴概率(RTAP)、回归原点概率(RTOP)、回归平面概率(RTPP)及平均扩散率(MD)均值。术后行病理和基因检测,再根据WHO CNS5分类重新分为GBM组(n=6)和非GBM组(n=22)。使用Mann-Whitney U检验比较两组MSD、QIV、RTAP、RTOP、RTPP及MD值的差异,并进一步绘制受试者工作特征曲线(ROC)评价其对GBM的诊断效能。结果两组肿瘤实体区的QIV、RTAP和MD值比较,差异有统计学意义(P<0.05),其中QIV和RTAP的差异最为显著,受试者工作特征曲线(ROC)的曲线下面积(AUC)均为0.78,特异度均为54.50%,敏感度均为100.00%。结论MAP-MRI在一定程度上具备从WHO CNS4R较低级别胶质瘤中鉴别CNS5胶质母细胞瘤的能力,其中QIV和RTAP的诊断效能最佳。

关键词：磁共振成像平均表观传播子磁共振成像胶质母细胞瘤诊断

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抽油杆检测技术发展浅析

采油工程

采油工程 2024年第2期 1-5,77页

作者：郑贵马千惠王桂全胡振兴舒红宇大庆油田有限责任公司采油工艺研究院黑龙江省油气藏增产增注重点实验室多资源协同陆相页岩油绿色开采全国重点实验室大庆油田有限责任公司第三采油厂

随着我国各大油田非常规油藏的开发,对有杆抽油系统中抽油杆产品的性能提出了更高的要求,导致抽油杆的性能指标也发生了相应的变化。通过研究抽油杆检测标准的发展历程,梳理出抽油杆的性能指标、检测项目及检验方法变化,分析了抽油杆产... 详细信息

随着我国各大油田非常规油藏的开发,对有杆抽油系统中抽油杆产品的性能提出了更高的要求,导致抽油杆的性能指标也发生了相应的变化。通过研究抽油杆检测标准的发展历程,梳理出抽油杆的性能指标、检测项目及检验方法变化,分析了抽油杆产品的发展趋势,并对抽油杆检测技术提出了优化建议,为抽油杆标准的使用、国家标准的制定和检测技术的发展提供了技术参考。

关键词：抽油杆检测项目检验方法性能指标发展趋势

Geochemical characteristics of produced fluids from CBM wells and their indicative significance for gas accumulation in Daning-Jixian block,Ordos Basin

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Frontiers of Earth Science 2023年第3期17卷 661-678页

作者： Taotao YAN Chao YANG Shuai zheng Yadong BAI Wei CHEN Yanfei LIU Wenguang TIAN Shasha SUN Shangwen JIN Jiahang WANG zhenxing LIU Huifang YAO College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China Coal Reservoir Laboratory of National Engineering Research Center of CBM Development&Utilization China University of GeosciencesBeijing 100083China China Coal Geology Group Co. LtdBeijing 100043China Research Institute of Petroleum Exploration and Development(Northwest) PetroChinaLanzhou 730000China Beijing Furuibao Energy Technology Company Beijing 100176China PetroChina Research Institute of Petroleum Exploration and Development Beijing 100083China Engineering Institute of SINOPEC Shanghai Offshore Oil&Gas Company Shanghai 200120China Exploration and Development Research Institute of PetroChina Huabei Oilfield Company PetroChinaRenqiu 062552China

The Daning-Jixian block,the eastern edge of the Ordos Basin,is one of the most potential areas for CO_(2)geological storage,enhanced coalbed methane recovery(ECBM)exploration and production in China in recent *** ionic composition and total dissolved solids(TDS)of the produced water,coal organic matter maturity,molecular composition and carbon isotope characteristics of the produced gas were utilized to analyze the hydrogeological condition,CBM generation and migration characteristics in this *** CBM enrichment patterns and the geological impacts on gas well production characteristics were *** optimal area for CBM development and CO_(2)geological storage in the study area were also *** by the Xueguan reverse fault zone,the hydraulic unit in this area can be divided into two parts(i.e.,the recharge-runoff zone in the east and the weak runoff-stagnation zone in the west).The thermogenic gas is dominating CBM genesis in this *** biogenic gas replenishment is only distributed in the eastern margin area,where theδ13C1 value is less than the thermal simulation results as an influence of hydrodynamic ***,two models of CBM formation and accumulation were proposed,1)thermogenic CBM migrated by hydrodynamic and resorbed for preservation at impermeable fault boundaries;2)thermogenic CBM trapped by fault and accumulated by hydrodynamic in slope *** gas production performance,generally increased from east to west,is mainly dominated by hydrogeological ***,the west side of the fault zone is the enrichment and high-yield area for ECBM development and CO_(2)geological storage in the study area.

关键词： produced water and gas gas accumulation geochemical parameter CBM production CO_(2)geological storage Daning-Jixian block

陕西省榆林市2018年市售食品中化学污染物监测结果分析

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医学动物防制 2020年第6期36卷 564-566,570页

作者：郑振兴王建利田永东李东波延芸李舒王建美师欢焦亚东榆林市疾病预防控制中心陕西719000

目的了解榆林市市售食品中化学污染物现况,发现食品安全监管中的重点食品、重点污染物和重点环节,为监管部门制定科学、可行的监管策略与措施提供依据。方法在榆林市12个县、市、区采集市售食品,定量检测各类化学污染物,分析检测结果。... 详细信息

目的了解榆林市市售食品中化学污染物现况,发现食品安全监管中的重点食品、重点污染物和重点环节,为监管部门制定科学、可行的监管策略与措施提供依据。方法在榆林市12个县、市、区采集市售食品,定量检测各类化学污染物,分析检测结果。结果小型餐饮店、农贸市场、商店、网店共采集15类56种197份样品,检测元素、农药、兽药、食品添加剂共85项化学污染物,检出111份,总检出率为56.35%。农贸市场采集的鸡蛋中强力霉素超标1份、平菇中总汞超标1份,商店采集的鸡蛋中总汞超标1份,其余194份合格,总合格率为98.48%。结论榆林市食品化学污染物的安全风险较高,但处于可控制的水平。需增加市售食品和餐饮店的采样数量,加强食品化学污染物的监测与监管。

关键词：食品化学污染物食品安全风险监测分析

RT-RAA-CRISPR/Cas12a可视化检测番茄褐色皱纹果病毒

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植物检疫 2024年第3期38卷 14-20页

作者：赵振兴范奇璇王思元董铮胡中泽周涛张永江中国检验检疫科学研究院北京100176 中国农业大学植物保护学院江苏省农业科学院泰州农科所

番茄褐色皱纹果病毒(tomato brown rugose fruit virus,ToBRFV)严重威胁番茄等茄科园艺作物的生产安全。本研究根据其外壳蛋白(coat protein,CP)基因及其同属病毒的差异序列,设计了特异性重组酶介导等温核酸扩增技术(recombinase-aided ... 详细信息

番茄褐色皱纹果病毒(tomato brown rugose fruit virus,ToBRFV)严重威胁番茄等茄科园艺作物的生产安全。本研究根据其外壳蛋白(coat protein,CP)基因及其同属病毒的差异序列,设计了特异性重组酶介导等温核酸扩增技术(recombinase-aided amplification,RAA)引物,并基于CRISPR/Cas12a的设计原则,设计了靶向RT-RAA扩增产物的CRISPR RNA(crRNA)。通过优化获得了检测信号最强的反应体系,其中报告基因FQ终浓度为600nmol/L、Cas12a和crRNA终浓度分别为200nmol/L和1000nmol/L,最终总反应时间仅为30 min。该方法可特异性检测ToBRFV,对携带ToBRFV的番茄样品RNA检测灵敏度为RT-PCR和RT-qPCR的10000和100倍,检测限为3.46fg/μL。阳性样品验证结果显示,本研究建立的RT-RAA-CRISPR/Cas12a检测技术可以在不同来源的辣椒、番茄侵染的植物叶片、果实及种子中检测到ToBRFV,表明该技术可用于番茄褐色皱纹果病毒的快速、灵敏的可视化检测。

关键词：番茄褐色皱纹果病毒 RT-RAA CRISPR/Cas12a 可视化检测

Research on effects of hydrostatic pressure on the dielectric property of Pb(Zn_(1/3)Nb_(2/3))O_3-BaTiO_3-PbTiO_3 relaxor ferroelectric ceramics

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Chinese Science Bulletin 2002年第6期47卷 513-518页

作者： XU Zhuo, zheng Shuguang, YUE zhenxing, FENG Yujun, JIN An & YAO XiElectronic Materials Research Laboratory (EMRL), Xi’an Jiaotong University, Xi’an 710049, China Electronic Materials Research Laboratory (EMRL) Xi’an Jiaotong University Xi’an China

The dielectric properties of Pb(Zn1/3Nb2/3)O3-BaTiO3-PbTiO3 relaxor ferroelectric ceramics near the rhombohedral and tetragonal phase boundary were investigated under hydrostatic pressure. It was found that hydrostatic pressure made their phase transition temperature Tc and the peak temperature Tm decreased, and the frequency dispersion and relaxor behavior enhanced. In these disorder systems of composite pervoskite structures, there appeared polar clusters or nanodomains. The unique physical characteristics, which made the relaxor behavior enhanced, is that the correlation length among these nanodo- mains decreases greatly with the pressure increasing.

关键词： hydrostatic pressure relaxor ferroelectric dielectric-temperature spectrum.

Research Progress on a SARS-CoV-2 Vaccine in China

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Journal of Biosciences and Medicines 2021年第11期9卷 76-88页

作者： Jing Zhang Ying Sun zhenxing Zhu Jingtong zheng Department of the Intensive Care Unit First Hospital of Jilin University Changchun China Department of Pathogen Biology College of Basic Medical Sciences Jilin University Changchun China Department of Respiratory and Critical Care Medicine First Hospital of Jilin University Changchun China Department of Hematology and Oncology Third Hospital of Jilin University Changchun China

Although many countries have controlled the pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through strict management, there are still many countries with record-breaking numbers of new cases. Therefore, it is very important to develop a vaccine that can cause wide cross reactivity in clinical trials. At present, more than 90 vaccines are entering clinical trials and progressing smoothly, including inactivated vaccines, adenovirus-vectored vaccines and other types of vaccines. Here, we review and summarize the efficacy and potential threats of a SARS-CoV-2 vaccine. We reviewed whole-virus vaccines, adenovirus-subunit vaccines and recombinant protein vaccines and discussed the positive and negative consequences of a SARS-CoV-2 vaccine. However, there are still heated debates on the mechanism, effectiveness, and breadth of protection. In conclusion, this study can predict the risk of new coronavirus outbreaks in the future by discussing the research and development status of new coronavirus vaccines in China and other countries. Looking to the future, it is important to mine the large amount of data generated in clinical trials of universal new coronavirus vaccines to ensure that these vaccine programs are equally useful in the face of new coronavirus mutations.

关键词： SARS-CoV-2 Whole-Virus Vaccines Adenovirus-Subunit Vaccines Recombinant Protein Vaccines

基于化学计量学与灰色关联度-逼近理想解排序法模型的知母药材质量评价方法

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安徽中医药大学学报 2024年第5期43卷 91-98页

作者：张正王洪东喻璐喆赵梦琦施高程陶振兴胡云飞俞浩安徽中医药大学安徽合肥230012 优效(北京)医学研究有限公司北京100080 山东中医药大学山东济南250000 亳州学院安徽亳州236800

目的采用化学计量学结合灰色关联度—逼近理想解排序(technique for order preference by similarity to an ideal solution,TOPSIS)法模型建立综合评价知母药材质量的方法。方法建立高效液相色谱法(high performance liquid chromatography,HPLC)黄酮特征图谱及水分、总黄酮、总皂苷含量测定方法,采用聚类分析(hierarchical cluster analysis,HCA)、主成分分析(principal component analysis,PCA)和正交偏最小二乘法—判别分析(orthogonal partial least squares-discriminant analysis,OPLS-DA)对不同批次知母样品进行化学计量学分析,利用熵权法结合灰色关联度—TOPSIS构建知母药材质量评价模型。结果建立的知母黄酮特征图谱、含量测定方法稳定、可靠;HCA、PCA和OPLS-DA可将10批知母样品分为2类;灰色关联度—TOPSIS模型综合得分显示,S10号知母样品质量较好,评分靠前。结论所建立的特征图谱结合化学计量学与灰色关联度—TOPSIS分析方法,能客观评价不同批次知母药材质量,为中药质量综合评价与控制的方法学建立提供参考。

关键词：知母特征图谱质量评价化学计量学灰色关联法逼近理想解排序

EFFECTS OF SOURCE PROPERTIES ON CUTOFF FREQUENCY fmax

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中国科学B辑(英文版) 1988年第11期31卷 1387-1397页

作者：郑天愉姚振兴 Institute of Geophysics Academia Sinica Beijing Beijing

The cutoff frequency fmax of radiation from earthquakes is one of the important parameters for studying the source process. By theoretical analysis and numerical experiments on acceleration Fourier spectrum it is suggested that fmax mainly depends on the lower values of slip rise time. This result can be used to explain the observational fact that the greater the earthquake magnitude, the smaller the value of fmax.

关键词： cutoff frequency fmax source process slip rise time near-field acceleration spectra.