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C/EBPβ/AEP Signaling Drives Alzheimer's Disease Pathogenesis

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Neuroscience Bulletin 2023年第7期39卷 1173-1185页

作者： Jing Xiong zhentao zhang Keqiang Ye Department of Neurology Renmin Hospital of Wuhan UniversityWuhan 430060China Faculty of Life and Health Sciences Shenzhen Institute of Advanced Technology(SIAT)Shenzhen 518034China

Alzheimer’s disease(AD)is the most common type of *** two-thirds of patients with AD are *** reason for the higher susceptibility to AD onset in women is ***,hormone changes during the menopausal transition are known to be associated with *** recently,we reported that follicle-stimulating hormone(FSH)promotes AD pathology and enhances cognitive dysfunctions via activating the CCAAT-enhancer-binding protein(C/EBPβ)/asparagine endopeptidase(AEP)*** review summarizes our current understanding of the crucial role of the C/EBPβ/AEP pathway in driving AD pathogenesis by cleaving multiple critical AD players,including APP and Tau,explaining the roles and the mechanisms of FSH in increasing the susceptibility to AD in postmenopausal *** FSH-C/EBPβ/AEP pathway may serve as a novel therapeutic target for the treatment of AD.

关键词： Alzheimer's disease C/EBPβ Asparagine endopeptidase Pathogenesis Follicle stimulating hormone

Experimental Study on Hydrodynamic Behavior of Falling Film over Vertical Tube

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Journal of Thermal Science 2023年第4期32卷 1512-1522页

作者： YUE Yunkai zhang zhentao zhang Hailun YANG Junling LI Xiaoqiong zhang Yu Key Laboratory of Cryogenics Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of Technology on Space Energy Conversion Technical Institute of Physics and ChemistryChinese Academy of ScienceBeijing100190China

Falling film configurations play an important role in characterizing the heat transfer due to changes in hydrodynamic *** purpose of this study is to establish a novel film distributor to investigate the hydrodynamic behavior of the falling film on the vertical *** falling film thickness and flow patterns on the vertical tube were analyzed at a feed water temperature of 30℃ for film Re ranged from 53 to 4544 and the heat fluxes ranged from 1.33 to 49.45 kW/m^(2).The correlation between the average falling film thickness and the film Re was fitted;the maximum deviation between the experimental data and the predicted values was 7.58%.Additionally,the film thickness changed sharply when the heat flux increased to a certain *** the further increase of the heat flux,dry patches appeared on the surface of the experimental *** was Marangoni effect on vertical tube and the falling film thickness and flow patterns were significantly affected by *** interval value of the critical heat flux with film Re was *** with the porous film distributor reported in the literature,the critical heat flux of the new film distributor increased by 3.72%-56.95%.

关键词： falling film film distributor Marangoni effect film thickness

Spatial Distribution and Temporal Trend Characteristics of Agro-Climatic Resources and Extreme Climate Events during the Soybean Growing Season in Northeast China from 1981 to 2017

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Journal of Meteorological Research 2020年第6期34卷 1309-1323页

作者： Shibo GUO Xiaoguang YANG zhentao zhang Fangliang zhang Tao LIU College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193

Soybean is an important oil ***-climatic resources and extreme climate events during the growing season directly affect the crop growth and grain *** this study,we used historical climate data and phenology observation data to investigate the spatial distributions and temporal trends of agro-climatic resources and extreme climate events during the growing season for soybean in Northeast China(NEC).The results showed that during the soybean growing season,the thermal time increased while both the effective precipitation and photosynthetically active radiation(PAR)*** the growing season,the thermal time increased by 44.0°C day decade–1 during the vegetative stage but decreased by 16.5°C day decade–1 during the reproductive stage;the effective precipitation increased by 1.8 mm decade–1 during the vegetative stage but decreased by 7.3 mm decade–1 during the reproductive stage;PAR decreased by 6.5 and 11.9 MJ m–2 decade–1 during the vegetative and reproductive *** frequency of extreme cold days showed a decreasing trend during the four study phases of sowing to emergence,sowing–flowering,15 days before flowering–flowering,and pod to physiological *** the soybean growing season,the frequency of extreme heat days and the maximum number of consecutive dry days(CDD)increased,and the maximum number of consecutive wet days(CWD)and heavy precipitation days *** results of this study could be used in selecting optimal management in soybean production in order to take advantage of beneficial climatic elements.

关键词： soybean Northeast China(NEC) agro-climatic resources extreme climate events asymmetry

δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities

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Translational Neurodegeneration 2020年第1期9卷 1-9页

作者： zhentao zhang Ye Tian Keqiang Ye Department of Neurology Renmin Hospital of Wuhan UniversityWuhan 430060People’s Republic of China Department of Pathology and Laboratory Medicine Emory University School of MedicineAtlantaGA 30322USA

Mammalian asparagine endopeptidase(AEP)is a cysteine protease that cleaves its protein substrates on the Cterminal side of asparagine *** lines of evidence indicate that AEP may be involved in the pathogenesis of several neurological diseases,including Alzheimer’s disease,Parkinson’s disease,and frontotemporal *** is activated in the aging brain,cleaves amyloid precursor protein(APP)and promotes the production of amyloid-β(Aβ).We renamed AEP to δ-secretase to emphasize its role in APP fragmentation and Aβ *** also cleaves other substrates,such as tau,α-synuclein,SET,and TAR DNA-binding protein 43,generating neurotoxic fragments and disturbing their physiological *** activity of δ-secretase is tightly regulated at both the transcriptional and posttranslational ***,we review the recent advances in the role of δ-secretase in neurodegenerative diseases,with a focus on its biochemical properties and the transcriptional and posttranslational regulation of its activity,and discuss the clinical implications of δ-secretase as a diagnostic biomarker and therapeutic target for neurodegenerative diseases.

关键词： AEP Alzheimer’s disease Parkinson’s disease C/EBPβ TrkB TDP-43

Performance analysis of a single-stage scroll compressor used in a drying heat pump over a wide condensing temperature range(30–80°C)

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Science China(Technological Sciences) 2014年第11期57卷 2131-2137页

作者： WEI Juan YANG LuWei zhang zhentao LIN XueJun zhang Chong LI Bo Technical Institute of Physics and Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences

This study presents the performance of a new single-stage scroll compressor used for the heat pump drying of thermally sensitive materials over a wide temperature range. The performance of the new compressor was predicted by an ARI standard 540 map-based compressor model and verified by a semi-open drying heat pump system constructed for this purpose. A comparison of the experimental data with the predicted data proved that the new scroll compressor used in the drying heat pump works well, can supply a wide range of condensing temperatures （30--80℃）（without auxiliary heating）, and has a minimum coeffi- cient of performance （COP） above 2.0, even in the worst condition.

关键词： drying scroll compressor performance wide temperature range

PRECISE LEVELING OF THE VERY LONG QINLING MOUNTAIN TUNNEL

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Geo-Spatial Information Science 2000年第1期3卷 57-61页

作者： zhang Zhenglu YANG zhentao XU Shaoquan zhang Xiangduo School of Geo-science and Surveying Engineering WTUSM Wuhan China

The Qinling tunnel with length of 18. 488km is located on the railway line from Xi’ an (Shanxi Province) to Ankan (Sichuan Province) in the middle of Qinling moun- tain. It is the longest double track railway tunnel in China and takes the third place in the world. According to the design, the break-through error in vertical direction caused by the al- timetric control surveying is limited to 18mm for the case of one piercing face. Because the leveling route reaches over 120km in length and must go over two mountains in 2 800m height, the first-order precise leveling and precise gravity measurement should be carried out in the construction stage. In this paper the field leveling approach, the application of new technology,some experience as well as the office calculation with final results analysis are in- troduced. By meticulous planning, organization and observation, the final accuracy of vertical difference between two tunnel end points is only 8mm, and it provides reliable surveying guarantee for this great tunnel engineering. Finally it is pointed out that this vertical differ- ence distinguishes obviously from the primary measurement result as high as 114mm. It means that the primary result is not accurate enough.

关键词： tunnel break-through error vertical control surveying gravity measurement

Optimization of environmental maintenance system used in a refuge chamber

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International Journal of Coal Science & Technology 2015年第4期2卷 312-317页

作者： Junling Yang Luwei Yang Chong zhang zhentao zhang Xiaojiang Li Technical Institute of Physics and Chemistry of CAS Beijing 100190 China Changzhou Boruijieneng Energy and EnvironmentCorporation Changzhou 213031 China Xinjiang Coal Scientific Research Institute Urumqi 830091China

Mine refuge chambers are used to shield miners who fail to escape from the mine when incidents occur. Environment maintaining system plays a key role in stabilizing thermal environment of a mine refuge chamber against heat emitted from metabolism and transferred from outside. The safety and comfort of refugees are closely related to the environment maintaining system design. In order to improve the comfort of refugees, optimization on the environment maintaining system has been done based on the previous work. To evaluate the environment of the chamber, eight volunteers were involved into the experiment. Under close observation and safety protection, they lived in a heat-isolated test chamber for 106 hours. The volunteers were asked to maintain low level of activities to simulate refugees＇ situation. It shows that the environment maintaining system worked well and the temperature, relative humidity and emitted harmful air content such as CO2 and CO were all kept in the safety level, and no discomfort was felt by volunteers at all.

关键词： Environment maintaining system Mine refuge chamber Temperature Relative humidity CO2 concentration CO concentration

The fluid biomarkers of Alzheimer's disease

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Brain Science Advances 2021年第1期7卷 1-16页

作者： Qinyu Peng zhentao zhang Department of Neurology Renmin Hospital of Wuhan UniversityWuhan 430060China

Alzheimer’s disease(AD)is the most common neurodegenerative ***,it still has no available disease-modifying *** pathology cascade begins decades before symptomatic *** these reasons,highly sensitive and highly specific fluid biomarkers should be developed for the early diagnosis of *** this study,the well-established and emerging fluid biomarkers of AD are summarized,and recent advances on their role in early diagnosis and progression monitoring as well as their correlations with AD pathology are *** prospects and related research directions are also discussed.

关键词： amyloid-β tau blood cerebrospinal fluid dementia

A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau

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Translational Neurodegeneration 2023年第1期12卷 154-169页

作者： Yang Gao Yuying Wang Huiyang Lei Zhendong Xu Shihong Li Haitao Yu Jiazhao Xie zhentao zhang Gongping Liu Yao zhang Jie Zheng Jian-Zhi Wang Department of Pathophysiology Key Laboratory of Ministry of Education for Neurological DisordersSchool of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurology Renmin Hospital of Wuhan UniversityWuhan 430030China Key Laboratory of Ministry of Education for Neurological Disorders Department of EndocrineLiyuan HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077China Neuroscience Research Institute and Department of Neurobiology School of Basic Medical SciencesPeking UniversityBeijingChina Key Laboratory for Neuroscience Ministry of Education/National Health CommissionPeking UniversityBeijing 100083China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Background Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease(AD).However,mouse models imitating AD-exclusive neuronal tau pathologies are *** We generated a new tet-on transgenic mouse model expressing truncated human tau N1-368(termed hTau368),a tau fragment increased in the brains of AD patients and aged mouse ***(dox)was administered in drinking water to induce hTau368 *** and Western blotting were performed to measure the tau *** sequencing was performed to evaluate gene expression,and several behavioral tests were conducted to evaluate mouse cognitive functions,emotion and *** Dox treatment for 1-2 months at a young age induced overt and reversible human tau accumulation in the brains of hTau368 transgenic mice,predominantly in the ***,the transgenic mice exhibited AD-like high level of tau phosphorylation,glial activation,loss of mature neurons,impaired hippocampal neurogenesis,synaptic degeneration and cognitive *** This study developed a well-characterized and easy-to-use tool for the investigations and drug development for AD and other tauopathies.

关键词： Alzheimer’s disease Animal model Tau hyperphosphorylation Truncated tau Tet-on system