C/EBPβ/AEP Signaling Drives Alzheimer's Disease Pathogenesis

作     者：Jing Xiong Zhentao Zhang Keqiang Ye 

作者机构：Department of NeurologyRenmin Hospital of Wuhan UniversityWuhan 430060China Faculty of Life and Health SciencesShenzhen Institute of Advanced Technology(SIAT)Shenzhen 518034China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第7期

页      面：1173-1185页

核心收录：

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

基　　金：supported by start-up funding from Shenzhen Institute of Advanced Technology the National Natural Science Foundation of China(No.82271446) 

主　　题：Alzheimer's disease C/EBPβ Asparagine endopeptidase Pathogenesis Follicle stimulating hormone 

摘      要：Alzheimer’s disease(AD)is the most common type of *** two-thirds of patients with AD are *** reason for the higher susceptibility to AD onset in women is ***,hormone changes during the menopausal transition are known to be associated with *** recently,we reported that follicle-stimulating hormone(FSH)promotes AD pathology and enhances cognitive dysfunctions via activating the CCAAT-enhancer-binding protein(C/EBPβ)/asparagine endopeptidase(AEP)*** review summarizes our current understanding of the crucial role of the C/EBPβ/AEP pathway in driving AD pathogenesis by cleaving multiple critical AD players,including APP and Tau,explaining the roles and the mechanisms of FSH in increasing the susceptibility to AD in postmenopausal *** FSH-C/EBPβ/AEP pathway may serve as a novel therapeutic target for the treatment of AD.