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宝刹飞来蜂台合势:敦煌莫高窟晚唐第14窟建筑意匠探讨

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建筑史学刊 2024年第3期5卷 123-135页

作者：周真如孙毅华清华大学建筑学院敦煌研究院

敦煌晚唐第14窟是一座以塔的意象为核心,集建筑、雕塑、壁画为一体的中心塔柱窟。本文对第14窟西披建筑图像与中心龛柱所组成的宝塔形象进行理论复原,并结合窟内另外四处塔图像、佛教与装饰图像,探讨中心宝塔形象对石窟空间意象的塑造... 详细信息

敦煌晚唐第14窟是一座以塔的意象为核心,集建筑、雕塑、壁画为一体的中心塔柱窟。本文对第14窟西披建筑图像与中心龛柱所组成的宝塔形象进行理论复原,并结合窟内另外四处塔图像、佛教与装饰图像,探讨中心宝塔形象对石窟空间意象的塑造。提出其中心龛柱造型借鉴吐蕃风格弯柱塔图像的可能。剖析晚唐石窟设计如何通过建筑空间的十字对称,建筑与雕塑、图像空间的穿插和装饰渲染等方式,营造了突出主塔的五佛曼陀罗坛场。讨论宋初重修时补绘的法华塔图像和莲花图案与晚唐宝塔形象在视觉与主题上的关联,及由此完成的法华塔与华藏世界之叠映。提出研究敦煌建筑艺术中复合空间的新方法。

关键词：敦煌莫高窟第14窟中心柱窟塔图像五佛曼陀罗法华塔华藏世界重修复合空间

New components of the necroptotic pathway

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Protein & Cell 2012年第11期3卷 811-817页

作者： zhenru zhou Victor Han Jiahuai Han State Key Laboratory of Cellular Stress Biology and School of Life Sciences Xiamen UniversityXiamen 361005China

Programmed necrosis,also known as necroptosis,has recently drawn great *** an important cellular regulation mechanism,knowledge of its signaling components is *** demonstrated to be regulated by the RIP1 and RIP3 kinases,and its pathophysiological importance has been confirmed in a number of disease *** we review the new members of this necroptosis pathway,MLKL,PGAM5,Drp1 and DAI,and discuss some of their possible applications according to recent findings.

关键词： necrosis necroptosis necrosome

Noninvasive Low-Frequency Pulsed Focused Ultrasound Therapy for Rheumatoid Arthritis in Mice

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Research 2023年第3期2022卷 205-219页

作者： Xuqiao Hu Fei Li Jieying Zeng zhenru zhou Zhaoyang Wang Jing Chen Dongyan Cao Yifan Hong Laixin Huang Yongsheng Chen Jinfeng Xu Fajn Dong Rongmin Yu Harong Zhen Department of Ultrasound First Affiliated Hospital of Southern University of Science and TechnologySecond Clinical Medical College of Jinan University(Shenzhen People's Hospital)Shenzhen 518020China integrated Chinese and Western Medicine Postdoctoral Research Station Jinan UniversityGuangzhou 510632China Paul C.Lauterbur Research Center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of Sciences1068 Xueyuan AvenueShenzhen University TownShenzhen 518055China Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200032China institute of Molecular Physiology Institute of Cancer ResearchShenzhen Bay LaboratoryShenzhen 518132P.R.China Department of Pharmacology College of PharmacyJinan University601 Huangpu Avenue WestGuangzhou 510632China Biotechnological Institute of Chinese Materia Medica Jinan University601 Huangpu Avenue WestGuangzhou 510632China

Rheumatoid arthritis(RA)is a common autoimmune disease characterized by chronic and progressive inflammation of the *** ultrasound therapy is an increasingly attractive alternative for treating RA owing to its noninvasiveness;however,it remains unclear which immune subsets respond to ultrasound *** this study,we showed that spleen-targeted low-frequency pulsed focused ultrasound(LFPFU)effectively improved the severity of arthritis in an arthritis mouse model established in DBA/1J ***,we performed in-depth immune profiling of spleen samples from RA mice,RA mice that underwent ultrasound therapy,and healthy controls using mass cytometry along with extensive antibody panels and identified the immune composition of 14 cell populations,including CD4^(+)/CD8^(+)T cells,B cells,natural killer cells,and dendritic ***,multidimensional analysis according to cell-surface markers and phenotypes helped in identifying 4 and 5 cell subpopulations among T and myeloid cells,respectively,with 6 T cell subsets and 3 myeloid cell subsets responsive to ultrasound therapy among the 3 *** these cell subsets,CD8^(+)T cell subsets showed a unique response to ultrasound stimulation in RA ***,CD8^(+)T cells show a noticeable correlation with the degree of arthritis progression and could serve as an indicator for spleen-focused ultrasound-based ***,single-cell RNA sequencing of spleen cells revealed the importance of T,B,and myeloid cell populations in the anti-inflammatory *** results elucidated the unique cell subsets and transcriptome of splenic cells responsive to LFPFU and demonstrated the potential of spleen-focused ultrasound stimulation in the treatment of inflammatory diseases.

关键词： spleen stimulation Focus

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自主性学习在语文基础教学中的应用

科教导刊 2013年第6期 124-125页

作者：周珍如陕西师范大学陕西·西安710062

新的语文课程标准要求：语文课程必须根据学生身心发展水平和语文课程自身的学习特点，爱护学生的好奇心、求知欲，鼓励学生自主阅读，自由表达，充分激发他们的问题意识和进取精神。关注个体差异和不同学生的学习需求，积极倡导自主的... 详细信息

新的语文课程标准要求：语文课程必须根据学生身心发展水平和语文课程自身的学习特点，爱护学生的好奇心、求知欲，鼓励学生自主阅读，自由表达，充分激发他们的问题意识和进取精神。关注个体差异和不同学生的学习需求，积极倡导自主的学习方式。

关键词：自主性学习语文基础教学应用

Mechanism of action of Wuzi Yanzong pill in the treatment of oligoasthenozoospermia in rats determined via serum metabolomics

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Journal of Traditional Chinese Medical Sciences 2024年第2期11卷 180-190页

作者： zhenru Shen Zhaohua Zhang Kejin Tong Chunrui Wang Shuaiqiang Wang Ping Zhao Meng Gu Jingjing Hu Yibo Tang Zhenquan Liu School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China Beijing Tong Ren Tang Company Limited Beijing100062China School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China China Beijing Tong Ren Tang Group Co. Ltd.Beijing100075China Faculty of Chinese Medicine Macao University of Science and TechnologyMacao999078China Department of Pathology University of California San DiegoLa JollaCA92093USA

Objective:To investigate the mechanism of action of Wuzi Yanzong pill(WYP)in rats with oligoasthenozoospermia(OAZ)via metabolomics and to provide a possible basis for improving this WYP-based ***:A rat model of OAZ was established by treating male SpragueeDawley rats with glucosides from Tripterygium wilfordii ***-two rats were randomly divided into six groups:control,L-carnitine(positive control),model,and low-,medium-,and high-dose WYP *** in the experimental groups were treated with WYP for 4 *** the end of the treatment period,sperm cell quality(density,motility,and viability)was assessed using a semen analysis system,mitochondrial membrane potential(MMP)was assessed using flow cytometry,and testicular injury was assessed using hematoxylin and eosin staining to validate the therapeutic effect of WYP in ***,serum metabolomics-based analysis was performed using high-performance liquid chromatography-mass spectrometry to identify differential metabolic pathways and possible mechanisms of action of WYP in OAZ ***:A rat model of OAZ was considered successfully-established after comparing the quality of spermatozoa in the model group to that in the control ***-M and WYP-H treatments significantly improved sperm cell density,motility,and viability compared with those in the model group(all P<.05).Compared with the model group,both WYP-M and WYP-H treatments increased MMP values(P=.006 and P=.021 respectively),while there was no significant difference in the L-carnitine group.L-carnitine and WYP administration reversed damage to the testes to varying degrees compared with that in the model ***,44 differential metabolites and four metabolic pathways,especially autophagy pathway,related to OAZ were identified via ***:WYP improves sperm cell quality and MMP in OAZ primarily via autophagy *** findings can be employed to improve the efficacy of WYP in humans.

关键词： Wuzi Yanzong pill Oligoasthenozoospermia Sperm cell quality Metabolomics Autophagy Male infertility

Parallel Physics-Informed Neural Networks Method with Regularization Strategies for the Forward-Inverse Problems of the Variable Coefficient Modified KdV Equation

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Journal of Systems Science & Complexity 2024年第2期37卷 511-544页

作者： zhou Huijuan School of Science Shanghai Maritime UniversityShanghai 201306China

This paper mainly introduces the parallel physics-informed neural networks(PPINNs)method with regularization strategies to solve the data-driven forward-inverse problems of the variable coefficient modified Korteweg-de Vries(VC-MKdV)*** the forward problem of the VC-MKdV equation,the authors use the traditional PINN method to obtain satisfactory data-driven soliton solutions and provide a detailed analysis of the impact of network width and depth on solving accuracy and ***,the author finds that the traditional PINN method outperforms the one with locally adaptive activation functions in solving the data-driven forward problems of the VC-MKdV *** for the data-driven inverse problem of the VC-MKdV equation,the author introduces a parallel neural networks to separately train the solution function and coefficient function,successfully addressing the function discovery problem of the VC-MKdV *** further enhance the network’s generalization ability and noise robustness,the author incorporates two regularization strategies into the *** amount of numerical experimental data in this paper demonstrates that the PPINNs method can effectively address the function discovery problem of the VC-MKdV equation,and the inclusion of appropriate regularization strategies in the PPINNs can improves its performance.

关键词： Data-driven forward-inverse problems parallel physics-informed neural networks regularization strategies variable coefficient modified KdV equation

文化视野下医药类公共空间特征提炼与转译——以北京中医药大学岐黄殿及组团为例

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住区 2021年第5期 52-61页

作者：周真如张维美国芝加哥大学清华大学建筑设计研究院有限公司

通过建筑语言来保存中国建筑和医药教育的优秀传统是我国现当代医学院建筑的双重文化责任。本文追溯医药学院沿革中人本宗旨的呈现,并以北京中医药大学良乡校区岐黄殿及基础医学院组团设计为例,探讨当代中国的医药类公共空间的设计思想... 详细信息

通过建筑语言来保存中国建筑和医药教育的优秀传统是我国现当代医学院建筑的双重文化责任。本文追溯医药学院沿革中人本宗旨的呈现,并以北京中医药大学良乡校区岐黄殿及基础医学院组团设计为例,探讨当代中国的医药类公共空间的设计思想与场所营造,提出以建筑载道、以环境育人的若干具体措施。该项目以虚化实,以绿十字和院落的空间布局营造人文关怀的公共场所。而岐黄殿的设计提炼“方圆并济”的传统建筑形式语言,并转译“以空纳有”的空间哲学和身体观。建成后,使用者创造性地再诠释,使之成为兼具仪式性、启发性、象征性的复合型空间。

关键词：医学院建筑校园公共空间北京中医药大学岐黄殿设计思想使用后调研

Influence of stearic acid surface modification on flowability and agglomeration of battery grade Li_(2)CO_(3)powder

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Particuology 2024年第9期92卷 263-277页

作者： Ming zhou Lithium Industry Center Zhejiang New Era Zhongneng Technology Co.Ltd.Shaoxing312000China

This work investigates the flow and agglomeration behaviors of battery grade Li_(2)CO_(3)powder and the influence of stearic acid surface *** degree of agglomeration is directly related to the uniformity of Li_(2)CO_(3)and its powder *** to the Chinese National Nonferrous Metal Industry Standard,battery grade Li_(2)CO_(3)powder has D50 equal to 3–8μm which belongs to a micron-sized superfine ***,with the extension of storage time,the serious agglomeration phenomenon occurs due to the large specific surface area and rough and irregular powder *** Hausner ratio(HR)of the unmodified sample increases from 1.14 to 1.41,and the corresponding flowability is classified as good to ***,among samples with doping stearic acid,the optimum amount of it is 0.10 wt%which exhibits an extremely stable HR value from 1.14 to ***,after 156 days,the repose angle(AR)obtained for samples without surface modification and using 0.10 wt%stearic acid are calculated to be 49°and 28°,*** on the values of HR and AR,the flowability of the unmodified sample is poor while the sample modified with 0.10 wt%of stearic acid still maintain excellent powder flow ***,The LiMn_(2)O_(4)cathode material synthesized from modified Li_(2)CO_(3)powder with a stearic acid content of 0.10 wt%exhibits good crystallinity and comparable electrochemical performance to that prepared by commercial Li_(2)CO_(3).These results indicate that stearic acid has the potential to be an ideal modifier for battery grade Li_(2)CO_(3)powder that needs to be kept for a long time.

关键词： Battery grade Li_(2)CO_(3)powder Flowability Surface modification Stearic acid

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成人肠道套细胞淋巴瘤合并回盲型肠套叠一例

中国医学科学院学报 2024年第3期46卷 458-461页

作者：卢振如王婷重庆市第六人民医院放射科重庆400060 中国人民解放军总医院第一医学中心放射诊断科北京100853

肠道套细胞淋巴瘤合并肠套叠在国内外较为罕见,其临床表现缺乏特异性,CT和肠镜检查有助于诊断,需要与结直肠癌、克罗恩病及淋巴瘤的其他病理亚型相鉴别,确诊仍需依靠病理学检查。本文报道1例成人肠道套细胞淋巴瘤合并回盲型肠套叠病例,... 详细信息

肠道套细胞淋巴瘤合并肠套叠在国内外较为罕见,其临床表现缺乏特异性,CT和肠镜检查有助于诊断,需要与结直肠癌、克罗恩病及淋巴瘤的其他病理亚型相鉴别,确诊仍需依靠病理学检查。本文报道1例成人肠道套细胞淋巴瘤合并回盲型肠套叠病例,旨在提高临床及影像科医生对该病的认识。

关键词：套细胞淋巴瘤肠套叠 CT 肠镜