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Cellular & Molecular Immunology 2012年第3期9卷 267-275页

作者： zhenli hu Ruohua Chen Zhijian Cai Lei Yu Yang Fei Lixia Weng Jinghan Wang Xiahui Ge Tianyi Zhu Jianli Wang Chong Bai Department of Respiratory Medicine Changhai Hospitalthe Second Military Medical UniversityShanghai 200433China Department of Vl P Clinical Changhai Hospitalthe Second Military Medical UniversityShanghai 200433China Institute of Immunology Zhejiang University School of MedicineHangzhou 310058China Department of First Biliary Surgery Eastern Hepatobiliary Surgical Hospital&InstituteThe Second Military UniversityShanghai 200438China

Salmeterol is a long-acting β2-agonist that activates adenylate cyclase, causing long-lasting bronchodilation and has been used for many years to control asthma. However, little information is available about the immunoregulatory effects of salmeterol. We found that salmeterol decreases the production of pro-inflammatory cytokines in a model of allergen-challenged mice that expressed tumor-necrosis factor-alpha, interleukin-1 and interleukin-6. Dendritic cells （DCs） are antigen-presenting cells and act as sentinels in the airway. We found that salmeterol （10-s mol/I） reduced the inflammation caused by lipopolysaccharide （0.1 pg/ml） in activated murine bone marrow-derived DCs. Moreover, western blots demonstrated that this protective effect was mediated partially by inhibiting signaling through the nuclear factor-kappa B （NF-κB）, mitogen-activated protein kinase （MAPK） pathways and dramatically decreased levels of p-ERK. We suggest that salmeterol regulates the inflammation of allergen-induced asthma by modulating DCs. In conclusion, we provide evidence that DCs are the target immune cells responsible for the action of salmeterol against asthma.

关键词： asthma dendritic cells pro-inflammatory cytokines salmeterol

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温度梯度相互作用色谱在聚烯烃表征中的应用

石油化工 2024年第6期53卷 816-825页

作者：杜斌秦亚伟胡清张振莉陈商涛李荣波中国石油石油化工研究院北京102206

研究了高温-温度梯度相互作用色谱(HT-TGIC)在聚烯烃表征中的应用,并与结晶分级技术进行了对比,同时分析了实验条件对HT-TGIC曲线的影响。实验结果表明,相比结晶分级技术,HT-TGIC在表征结晶度较低或完全无定形树脂时具有明显优势。HT-T... 详细信息

研究了高温-温度梯度相互作用色谱(HT-TGIC)在聚烯烃表征中的应用,并与结晶分级技术进行了对比,同时分析了实验条件对HT-TGIC曲线的影响。实验结果表明,相比结晶分级技术,HT-TGIC在表征结晶度较低或完全无定形树脂时具有明显优势。HT-TGIC可用于定量表征聚烯烃树脂及其共混物的化学组成分布,并具有良好分辨率。优化的操作条件为:尽可能快的冷却速度、升温速率/淋洗流量的比值在一定范围内、动态降温、较小的动态吸附流量、冷却循环最终温度高于结晶温度。利用辛烯含量差与HT-TGIC淋洗峰偏离值呈线性关系,可快速确定共聚单体含量,包括高共聚单体含量树脂。

关键词：聚烯烃化学组成分布温度梯度相互作用色谱分级吸附

Regulation of function of lipopolysaccharide(LPS)-activated dendritic cells by salmeterol

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Regulation of function of lipopolysaccharide(LPS)-activated ...

四所医院社区获得性肺炎初始治疗阶段经气管镜介入治疗效果及疾病负担比较

中华医学会呼吸病学年会——2011（第十二次全国呼吸病...

作者： zhenli hu 1 Changhai Hospital.the Second Military Medical University 2 Zhejiang University School of Medicine

Salmeterol is a long-acting b,2-agonist that activates adenylate cyclase,causing long-lasting bronchodilation and has been used for many years to control asthma.However,little information is available about the immunoregulatory effects of salmeterol.We found that in vivo,salmeterol decreased the production of pro-inflammatory cytokines in a model of allergen-challenged mice

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中国呼吸与危重监护杂志 2020年第4期19卷 337-341页

作者：王鹏胡珍丽钱叶长张国清李星晶白冲上海交通大学附属上海市第一人民医院宝山分院呼吸内科上海200940 海军军医大学附属第一医院长海医院呼吸与危重症医学科上海200433 上海市宝山区中西医结合医院呼吸内科上海201900 上海交通大学附属上海市第一人民医院呼吸与危重症医学科上海200080 上海复旦大学附属中山医院吴淞医院呼吸内科

目的探讨社区获得性肺炎(CAP)经气管镜介入治疗的疗效,并分析比较其经济负担。方法回顾性分析2017年7月1日至2018年8月31日四所医院(长海医院、上海市第一人民医院、上海市第一人民医院宝山分院、上海市宝山区中西医结合医院)呼吸科住... 详细信息

目的探讨社区获得性肺炎(CAP)经气管镜介入治疗的疗效,并分析比较其经济负担。方法回顾性分析2017年7月1日至2018年8月31日四所医院(长海医院、上海市第一人民医院、上海市第一人民医院宝山分院、上海市宝山区中西医结合医院)呼吸科住院治疗的419例CAP患者临床资料。根据气管镜介入治疗时间段分为3组,在初始治疗期(取得影像学诊断72 h内)进行气管镜干预治疗的127例患者纳入早期干预组;在初始治疗后(取得影像学诊断72 h以后)进行气管镜干预治疗的158例患者纳入中期干预组;134例在治疗中未进行气管镜干预治疗的患者纳入未干预组。比较各组治疗总有效率、临床症状改善情况、影像学吸收情况、血清炎症指标水平、痰培养阳性率、换药率、换药后有效率、住院时间及住院费用。结果早期干预组治疗总有效率高于中期干预组和未干预组,差异有统计学意义(P<0.05);早期干预组体温恢复正常时间、浓痰及咳嗽消失时间、胸部X线片吸收时间均短于中期干预组和未干预组,差异有统计学意义(P<0.05);治疗7 d后,早期干预组外周血白细胞、血清降钙素原和超敏C反应蛋白水平低于中期干预组和未干预组,差异有统计学意义(P<0.05);早期干预组和中期干预组的痰培养阳性率、换药率均高于未干预组,差异有统计学意义(P<0.05);早期干预组住院天数短于中期干预组和未干预组,住院费用少于中期干预组和未干预组,差异有统计学意义(P<0.05)。结论初始治疗期气管镜介入治疗CAP患者不仅疗效显著提高,治疗费用也明显减少、住院时间缩短,值得临床推广。

关键词：社区获得性肺炎初始治疗期气管镜介入疾病负担

Bone Marrow-Derived Mesenchymal Stem Cells Attenuates Lung Inflammation and up-regulate protective cytokine IL-10 and IL-12 in asthmtic Mice model

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Bone Marrow-Derived Mesenchymal Stem Cells Attenuates Lung I...

中华医学会呼吸病学年会——2011（第十二次全国呼吸病...

作者： Xiahui Ge,Ruohua Chen,Jianmin Yang,Chong Bai,Guoliang Lou,zhenli hu,Qiang Li Changhai Hospital,the Second Military Medical University

Recent study prove that Mesenchymal Stem Cells(MSCs)attenuate the severity of lung injury due to its immunomodulatory properties.In this study,we test the immunoregulatory features of administrating BMSCs on ovalbumin-induced asthma mice by intrapulmonary route.Fourty female BALB /c mice were equally randomized into normal control group,BMSCs treatment group,BMSCs

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河南省外来入侵植物新记录种——齿裂大戟

河南林业科技 2024年第1期44卷 4-7页

作者：胡京枝张晓林杨海青樊振利河南省农业科学院农业质量标准与检测技术研究所河南郑州450008 河南省林业技术工作总站河南郑州450008 河南省林业科学研究院河南郑州450008 辉县市赵固镇人民政府河南辉县453633

报道了河南省大戟科大戟属一种外来入侵植物新记录种—齿裂大戟(Euphorbia dentata Michx.)。并结合其生物学、生态学特性及调查结果,对河南省林业、草原、湿地生态系统齿裂大戟入侵风险定量分析,计算出风险值为1.66,属于中风险入侵植物。

关键词：河南省入侵植物新记录齿裂大戟风险评估

Geological significance of nickeliferous minerals in the Fule Pb–Zn deposit, Yunnan Province, China

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Acta Geochimica 2018年第5期37卷 684-690页

作者： zhenli Li Lin Ye Yusi hu Zhilong huang State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of SciencesGuiyang 550002 China University of Chinese Academy of Sciences Beijing 100049China

The Fule Pb–Zn deposit is located in the Sichuan–Yunnan–Guizhou Province, and it is an important and giant low temperature metallogenic domain in China.In our research area, the Pb–Zn deposits are mainly hosted in the Permian Yangxin Formation and are composed of dolostone and limestone. The distance between the ore bodies and the Permian Emeishan basalt ranged from 50 to160 m. In this study, the nickel rich minerals, including vaesite, polydymite and millerite, were reported for the first time in the Fule deposit. These minerals occurred as xenomorphic mineral aggregate and were sporadically distributed in the sphalerite–galena–calcite vein, which is the main ore type in the deposit. Our study indicated that the paragenetic sequence of minerals in the Fule deposit is the following order: polydymite → vaesite→ millerite → sphalerite → galena → tetrahedrite(tennantite).The geological occurrence characteristics of those nickeliferous minerals suggested that the Permian Emeishan basalt is a possible barrier layer of Pb–Zn ore-forming fluid, and it is an important source for the Ni and part of the Cu in the deposit. The Sichuan–Yunnan–Guizhou Pb–Zn mineralization province is a world-class production base of Pb and Zn, in which the Permian Emeishan basalt and Pb–Zn deposits have uniformly spatial distribution, but the relationship of mineralization between them is still under debate. This report provides new evidence forunderstanding the relationship between Pb–Zn mineralization and Permian Emeishan basalt in the Sichuan–Yunnan–Guizhou Pb–Zn mineralization province.

关键词：沉积物矿物质云南省 Zn 地质中国矿石类型矿化作用

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基于附壁生长病理特征的肺腺癌研究进展

国际呼吸杂志 2021年第14期41卷 1047-1053页

作者：周慈航何帆樊剑胡珍丽韩一平海军军医大学附属长海医院全科上海200433 海军军医大学附属长海医院呼吸内科上海200433

肺癌是人类癌症死亡的首要原因,腺癌是主要的组织学类型。其中,原位腺癌、微浸润性腺癌和附壁型腺癌呈附壁生长方式。临床工作中发现这种类型肺腺癌具有独特的临床病理特征,预后也与其他类型的肺腺癌截然不同。本文基于肺腺癌的附壁生... 详细信息

肺癌是人类癌症死亡的首要原因,腺癌是主要的组织学类型。其中,原位腺癌、微浸润性腺癌和附壁型腺癌呈附壁生长方式。临床工作中发现这种类型肺腺癌具有独特的临床病理特征,预后也与其他类型的肺腺癌截然不同。本文基于肺腺癌的附壁生长方式,从肺腺癌独特的影像学表现、病理特点和分子基因表达出发,系统介绍了肺腺癌的临床病理特征及其预后意义,并就目前研究进展和面临的相关挑战作一综述,以期为临床医师的工作提供帮助。

关键词：肺腺癌肿瘤侵润 DNA突变分析附壁生长

Genesis of fahlore in the Tianbaoshan lead–zinc deposit, Sichuan Province, China: a scanning electron microscopy–energy dispersive spectroscopy study

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Acta Geochimica 2018年第6期37卷 842-853页

作者： Yusi hu Lin Ye zhenli Li Zhilong huang Jiawei Zhang State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang550081China University of Chinese Academy of Sciences Beijing100049China Guizhou Geological Survey Bureau of Geology and Mineral Exploration and Development of Guizhou ProvinceGuiyang550081China

The Tianbaoshan deposit, located in the southwestern part of the Yangtze Block, is a representative Pb–Zn deposit in the Sichuan–Yunnan–Guizhou Pb–Zn metallogenic province. The Pb–Zn orebodies are hosted in the upper Sinian Dengying Formation dolostone. The predominant minerals are sphalerite, galena, pyrite, chalcopyrite, quartz, and calcite with minor arsenopyrite,fahlore, and dolomite. The deposit is characterized by relatively strong Cu mineralization. However, the relationship between Pb–Zn and Cu mineralization is unknown. We analyzed the mineralogy and composition of fahlore, chalcopyrite, arsenopyrite, sphalerite, and galena using scanning electron microscopy–energy dispersive spectroscopy, with the aim of providing new evidence for the genesis of the Pb–Zn–(Cu) ore. The results show that the Cu ore in the deposit is dominated by chalcopyrite and fahlore, both of which formed before or during the Pb–Zn ore-forming stage. The fahlore showed dramatic compositional variation and was characterized by negative correlations between Ag and Cu, and between As and Sb,suggesting substitution of Ag for Cu, and that As and Sb substitute in the same site in the fahlore lattice. Based on backscattered electron images and composition, the fahlorewas divided into two types. Type I fahlore crystallized early and is characterized by enrichment of Cu and depletion in Ag and Sb. Type II fahlore formed after Type I, and is rich in Ag and poor in Cu and As. Moreover,galena and fahlore are the host minerals of Ag. The variation of valence state with As host mineral—from fahlore to arsenopyrite—indicates the metallogenic environment changed from relatively oxidizing to reducing with a high p H. In the light of Gibbs energies of reciprocal reactions and isotherms for cation exchange, the composition of the fahlore implies its ore-forming temperature was lower than220 °C, corresponding with typical Mississippi Valley-type(MVT) deposits. Based on the geologic character and geochemical data of this deposit, we suggest that the Tianb

关键词： Fahlore Tianbaoshan Pb-Zn deposit SEM- EDS-MVT deposit

AGREEⅡ系统对现行国内外氧疗指南的评价分析

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国际呼吸杂志 2020年第11期40卷 801-808页

作者：周慈航竺易君柴荣胡珍丽韩一平长海医院全科医学规培基地上海200433 长海医院呼吸与危重症科上海200433

目的采用临床指南研究与评估系统Ⅱ(AGREEⅡ)对目前国内外氧疗指南质量进行评价分析。方法按照纳入和排除标准筛选检索万方、中国知网、维普、PubMed、Cochrane、Elsevier等中英文数据库2003~2019年氧疗指南。统计纳入指南的发布国家、... 详细信息

目的采用临床指南研究与评估系统Ⅱ(AGREEⅡ)对目前国内外氧疗指南质量进行评价分析。方法按照纳入和排除标准筛选检索万方、中国知网、维普、PubMed、Cochrane、Elsevier等中英文数据库2003~2019年氧疗指南。统计纳入指南的发布国家、颁布机构、出版年份和证据评价依据等相关信息。采用AGREEⅡ系统对纳入指南的质量进行评价。各指南评分比较采用多配对样本的非参数Friedman检验。结果共纳入指南8篇,其中国外指南7篇,国内指南1篇。4位评分者对8篇指南的AGREEⅡ评价结果组内相关系数均>0.80(P值均<0.0001),组内一致性良好。评价结果显示,领域1"范围和目的"[(80.38±6.45)%]和领域4"明晰性"[(85.07±8.87)%]得分较高,且8篇指南得分均高于60%;领域2"参与人员"平均得分[(76.91±13.46)%],领域5"实用性"[(69.01±22.29)%];领域3"严谨性"[(57.88±25.40)%]和领域6"独立性"[(60.16±37.62)%]得分较低。结论纳入的国内外氧疗指南总体质量较高,但在"参与人员"、"严谨性"及"独立性"等领域仍存在不足。其推荐级别为A级5篇,B级2篇,C级1篇。我国氧疗指南在诸多方面距离国外高质量指南仍有一定差距。AGREEⅡ工具在国内氧疗指南的开发、制订过程中有相当大的空间,有助于促进我国氧疗的规范应用。

关键词：实践指南评价研究氧疗临床指南研究与评估系统Ⅱ