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Carbon dots/Bi_(2)WO_(6) composite with compensatory photo-electronic effect for overall water photo-splitting at normal pressure

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Chinese Chemical Letters 2021年第7期32卷 2283-2286页

作者： Haodong Nie Kaiqiang Wei Yi Li Yan Liu Yajie zhao Hui Huang Mingwang Shao Yang Liu zhenhui Kang Institute of Functional Nano and Soft Materials Laboratory(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyMacao 999078China

Overall water photo-splitting is a prospective ideal pathway to produce ultra-clean H_(2) energy by ***,the band structure of many semiconductors cannot satisfy the requirement of H_(2) and O_(2) production at the same ***,we illustrate that carbon dots(CDs)/Bi_(2)WO_(6) photocatalyst with compensatory photo-electronic effect has enhanced activity for overall water photo-splitting without any sacrificial *** this complex photocatalytic system,the photo-potential provided by CDs makes the CDs/Bi2WO6(C-BWO)composite could satisfy the band structure conditions for overall water *** C-BWO composite(3 wt%CDs content)exhibits optimized hydrogen evolution(oxygen evolution)of 0.28μmol/h(0.12μmol/h)with an approximate 2:1(H_(2):O_(2))stoichiometry at normal *** further employed the in-situ transient photovoltage(TPV)technique to study the photoelectron extraction and the interface charge transfer kinetics of this composite catalyst.

关键词： Carbon dots In-situ transient photovoltage measurement Photoelectron extraction Photocatalytic hydrogen evolution Normal pressure

Two RING-Finger Ubiquitin E3 Ligases Regulate the Degradation of SPX4, An Internal Phosphate Sensor, for Phosphate Homeostasis and Signaling in Rice

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Molecular Plant 2019年第8期12卷 1060-1074页

作者： Wenyuan Ruan Meina Guo Xueqing Wang zhenhui Guo Zhuang Xu Lei Xu Hongyu zhao Haiji Sun Chengqi Yan Keke Yi Key Laboratory of Plant Nutrition and Fertilizer Ministry of AgricultureInstitute of Agricultural Resources and Regional PlanningChinese Academy of Agricultural SciencesBeijing 100081China College of Life Science Shandong Normal UniversityJinan 250014China Ningbo Academy of Agriculture Sciences 19 Dehou StreetNingbo City 315000China

SPX-domain-containing proteins (SPXs) play an important role in inorganic phosphate (Pi) sensing,signaling,and transport in *** plants,SPXs are known to integrate cellular Pi status and negatively regulate the activity of Pi central regulators,the PHOSPATE STARVATION RESPONSE proteins (PHRs).The stability of SPXs,such as SPX4,is reduced under Pi-deficient ***,the mechanisms by which SPXs are degraded remain *** this study,using a yeast-twhybrid screen we *** two RING-finger ubiquitin E3 ligases regulating SPX4 degradation,designated SDEL1 and SDEL2,which were post-transcriptionally induced by Pi *** found that both SDELs were located in the nucleus and cytoplasm,had ubiquitin E3 ligase activity,and directly ubiquitinated the K^213 and K^299 lysine residues in SPX4 to regulate its ***,we found that PHR2,a Pi central regulator in rice,could compete with SDELs by interacting with SPX4 under Pi-sufficient conditions,which protected SPX4 from ubiquitination and *** with the biochemical function of SDEL1 and SDEL2,overexpression of SDEL1 or SDEL2 resulted in Pi overaccumulation and induced Pi-starvation signaling even under Pi-sufficient ***,their loss-of-function mutants displayed decreased Pi accumulation and reduced Pi-starvation ***,our study revealed that SDEL1 and SDEL2 facilitate the degradation of SPX4 to modulate PHR2 activity and regulate Pi homeostasis and Pi signaling in response to external Pi availability in rice.

关键词： rice SPX4 PHR2 ubiquitination Pi signaling Pi homeostasis phosphate regulation network

TiO_(2)和MgO对含钛高炉渣冷却过程中物相析出的影响

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材料研究与应用 2023年第6期17卷 1150-1154页

作者：历有为孙长余杨松陶王硕周媛媛赵振辉司梓均辽宁科技大学材料与冶金学院辽宁鞍山114051

以CaO-SiO_(2)-MgO-Al_(2)O_(3)-TiO_(2)系含钛高炉渣为研究对象,分别研究TiO_(2)和MgO质量分数对含钛高炉渣结晶行为的影响。结果表明:在1500℃时没有晶体析出,渣系主要以玻璃相存在;当温度为1460、1420和1380℃时,析出的晶体主要为镁... 详细信息

以CaO-SiO_(2)-MgO-Al_(2)O_(3)-TiO_(2)系含钛高炉渣为研究对象,分别研究TiO_(2)和MgO质量分数对含钛高炉渣结晶行为的影响。结果表明:在1500℃时没有晶体析出,渣系主要以玻璃相存在;当温度为1460、1420和1380℃时,析出的晶体主要为镁铝尖晶石相和(或)钙钛矿相;当TiO_(2)质量分数由10%增加至25%时,镁铝尖晶石相的析出温度明显降低,钙钛矿相的析出温度升高;当MgO质量分数由10%增加至14%时,镁铝尖晶石相的析出温度明显提高,钙钛矿相的析出温度没有明显改变,但钙钛矿相的析出比例增加。

关键词：含钛高炉渣 TiO_(2) MgO 镁铝尖晶石钙钛矿

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LiF@SiO2 nanocapsules for controlled lithium release and osteoarthritis treatment

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Nano Research 2018年第10期11卷 5751-5760页

作者： Trever Todd zhenhui Lu Jinmin zhao Benjamin Cline Weizhong Zhang Hongmin Chen Anil Kumar Wen Jiang Franklin West Samuel Franklin Li Zheng Jin Xie Department of Chemistry University of Georgia Athens Georgia 30602 USA Guangxi Engineering Center in Biomedical Material for Tissue and Organ Regeneration Guangxi Collaborative Innovation Center for Biomedicine Guangxi Key Laboratory of Regenerative Medicine The First Affiliated Hospital of Guangxi Medical University Nanning 530021 China Center for Molecular Imaging and Translational Medicine State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public Health Xiamen University Xiamen 361102 China Animal Dairy Science University of Georgia Athens Georgia 30602 USA Department of Small Animal Medicine and Surgery College of Veterinary Medicine University of Georgia Athens Georgia 30602 USA

Electrolytes can be taken orally or intravenously as supplements or thera- peutics. However, their therapeutic window may exceed the serum toxicity threshold, making systemic delivery a poor option. Local injection is also not adequate due to rapid diffusion of electrolytes. Here, we solved this issue with a nanocapsule technolog~ comprising an electrolyte nanocrystal as the drug filling and a silica sheath to regulate drug release rates. In particular, we prepared LiF@SiO2 nanocapsules and investigated their potential as a delivery system for lithium, which was shown in recent studies to be an effective therapeutic agent for osteoarthritis （OA）. We demonstrated that LiF@SiO2 can extend lithium release time from minutes to more than 60 h. After intra- articular （i.a.） injection into a rat OA model, the nanocapsules reduced the Osteoarthritis Research Society International （OARSI） score by 71% in 8 weeks while inducing no systemic toxicity. Our study opens new doors for improved delivery of electrolyte therapeutics, which have rarely been studied in the past.

关键词： osteoarthrifis controlled release hyaluronic acid lithium anti-inflammation

Application of a Step-by-Step Fingerprinting Identification Method on a Spilled Oil Accident in the Bohai Sea Area

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Journal of Ocean University of China 2011年第1期10卷 35-41页

作者： SUN Peiyan GAO zhenhui CAO Lixin WANG Xinping ZHOU Qing zhao Yuhui LI Guangmei Key Laboratory of Marine Spill Oil Identification and Damage Assessment Technology SOA Qingdao 266000 P. R. China North China Sea Environmental Monitoring Center of State Oceanic Administration Qingdao 266000 P. R. China

In recent years,oil spill accidents occur frequently in the marine area of *** out the spilled oil source is a key step in the relevant *** this paper,a step-by-step fingerprinting identification method was used in a spilled oil accident in the Bohai Sea in *** chemical fingerprinting and data interpretation techniques were used to characterize the chemical composition and determine the possible sources of two spilled oil *** original gas chromatography -flame ionization detec-tion (GC-FID) chromatogram of saturated hydrocarbons was *** gas chromatography-mass spectrometry (GC/MS) chromatograms of aromatic hydrocarbons terpane and sterane,n-alkane and poly-aromatic hydrocarbons (PAHs) were *** correlation analysis on diagnostic ratios was performed with Student’s *** is found that the oil fingerprinting of the spilled oil (designated as sz1) from the polluted sand beach was identical with the suspected oil (designated as ky1) from a nearby crude oil refinery *** both showed the fingerprinting character of mixed *** oil fingerprinting of the spilled oil (designated as ms1) collected from the port was significantly different from oil ky1 and oil sz1 and was with a lubricating oil fingerprint *** identification result not only gave support for the spilled oil investigation,but also served as an example for studying spilled oil accidents.

关键词： step-by-step fingerprinting identification saturated hydrocarbons poly-aromatic hydrocarbons biomarkers Student'st-test

Prognostic value of a modified Immunoscore in patients with stage Ⅰ-Ⅲ resectable colon cancer

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Chinese Journal of Cancer Research 2021年第3期33卷 379-390页

作者： Ke zhao Xiaomei Wu zhenhui Li Yingyi Wang Zeyan Xu Yajun Li Lin Wu Su Yao Yanqi Huang Changhong Liang Zaiyi Liu Department of Radiology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China School of Medicine South China University of TechnologyGuangzhou 510006China Department of Radiology the Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510655China Department of Radiology the Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunming 650118China Department of Radiology Zhuhai People's HospitalZhuhai Hospital Affiliated with Jinan UniversityZhuhai 519000China Department of Pathology the Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunming 650118China Department of Pathology Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China the Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510080China

Objective: The Immunoscore method has proved fruitful for predicting prognosis in patients with colon ***, there is still room for improvement in this scoring method to achieve further advances in its clinical translation. This study aimed to develop and validate a modified Immunoscore(IS-mod) system for predicting overall survival(OS) in patients with stage Ⅰ-Ⅲ colon ***: The IS-mod was proposed by counting CD3+ and CD8+ immune cells in regions of the tumor core and its invasive margin by drawing two lines of interest. A discovery cohort(N=212) and validation cohort(N=103)from two centers were used to evaluate the prognostic value of the ***: In the discovery cohort, 5-year survival rates were 88.6% in the high IS-mod group and 60.7% in the low IS-mod group. Multivariate analysis confirmed that the IS-mod was an independent prognostic factor for OS[adjusted hazard ratio(HR)=0.36, 95% confidence interval(95% CI): 0.20-0.63]. With less annotation and computation cost, the IS-mod achieved performance comparable to that of the Immunoscore-like(IS-like) system(C-index, 0.676 vs. 0.661, P=0.231). The 2-category IS-mod using 47.5% as the threshold had a better prognostic value than that using a fixed threshold of 25%(C-index, 0.653 vs. 0.573, P=0.004). Similar results were confirmed in the validation ***: Our method simplifies the annotation and accelerates the calculation of Immunoscore method,thus making it easier for clinical implementation. The IS-mod achieved comparable prognostic performance when compared to the IS-like system in both cohorts. Besides, we further found that even with a small reference set(N≥120), the IS-mod still demonstrated a stable prognostic value. This finding may inspire other institutions to develop a local reference set of an IS-mod system for more accurate risk stratification of colon cancer.

关键词： Immunoscore colon cancer whole-slide image overall survival digital pathology

3种饵料对日本囊对虾生长及其呈味氨基酸的影响

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江苏海洋大学学报（自然科学版） 2021年第1期30卷 17-22页

作者：庞智予赵真慧宋厚君牟华赖晓芳王攀攀阎斌伦张庆起高焕江苏海洋大学海洋科学与水产学院江苏连云港222005 江苏海洋大学江苏省海洋生物技术重点实验室江苏连云港222005 江苏省海洋生物产业技术协同创新中心江苏连云港222005 江苏省农业种质资源保护与利用平台江苏南京210014 连云港赣榆佳信水产开发有限公司江苏连云港222100

在水温25~28℃,盐度30~32下,将体质量(22.36±2.48)mg、体长(1.50±0.19)cm的日本囊对虾(Marsupenaeus japonicus)饲养在55 cm×40 cm×30 cm的养殖箱中,分别投喂卤虫无节幼体(A组)、菲律宾蛤仔(B组)、人工配合饲料(C组)。每周测量虾体... 详细信息

在水温25~28℃,盐度30~32下,将体质量(22.36±2.48)mg、体长(1.50±0.19)cm的日本囊对虾(Marsupenaeus japonicus)饲养在55 cm×40 cm×30 cm的养殖箱中,分别投喂卤虫无节幼体(A组)、菲律宾蛤仔(B组)、人工配合饲料(C组)。每周测量虾体长和体质量,实验结束时统计虾的存活率(SR),计算增质量率(WGR)和特定生长率(SGR),测定虾体内呈味氨基酸含量。4周的饲养结果表明,A组日本囊对虾存活率最高,为(85.00±6.03)%,B组的存活率最低,为(60.53±2.54)%,C组的存活率为(78.30±5.00)%;A组和C组的存活率皆显著高于B组(P0.05)。A组(1.28±0.07)%·d-1和C组(1.31±0.08)%·d-1日本囊对虾特定生长率显著高于B组(1.09±0.05)%·d-1(P0.05)。C组日本囊对虾的呈味氨基酸含量最高,为(20.54±0.19)%,B组呈味氨基酸含量最低,为(16.42±0.64)%,A组呈味氨基酸含量为(19.55±0.51)%;A组和C组的呈味氨基酸含量均显著高于B组(P0.05)。该研究可为日本囊对虾人工养殖的饵料选择提供一定依据。

关键词：日本囊对虾呈味氨基酸饵料生长

GP或NX方案在复发转移性三阴性乳腺癌患者中的临床疗效与毒副反应评价

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肿瘤药学 2022年第1期12卷 60-64页

作者：高春燕赵振慧刘炜李妍李红玉马小平李莉刘丹李冰玉李迅新疆医科大学附属肿瘤医院乳腺内科新疆乌鲁木齐830000

目的观察GP方案与NX方案在复发转移性三阴性乳腺癌患者中的临床疗效以及毒副反应。方法选取新疆医科大学附属医院乳腺内科2015年1月1日—2017年12月31日收治的96例既往接受蒽环类或紫杉类药物治疗后复发转移的三阴性乳腺癌患者,按照数... 详细信息

目的观察GP方案与NX方案在复发转移性三阴性乳腺癌患者中的临床疗效以及毒副反应。方法选取新疆医科大学附属医院乳腺内科2015年1月1日—2017年12月31日收治的96例既往接受蒽环类或紫杉类药物治疗后复发转移的三阴性乳腺癌患者,按照数字随机分组法分为GP组(48例)和NX组(48例)。GP组给予GP方案(吉西他滨+顺铂),NX组给予NX方案(长春瑞滨+卡培他滨),共治疗6个周期。主要研究终点为客观缓解率(ORR)和疾病控制率(DCR),次要研究终点为肿瘤进展时间(TTP)和药物毒副反应。结果 NX组ORR、DCR虽高于GP组,但差异无统计学意义(P>0.05);GP组TTP略高于NX组,但差异无统计学意义(P>0.05);GP组患者血小板减少、胃肠道反应、肾功能损害的发生率高于NX组,差异有统计学意义(P<0.05);NX组手足综合征的发生率高于GP组,差异有统计学意义(P<0.05)。结论 GP方案与NX方案对复发转移性三阴性乳腺癌患者的疗效相当,值得肯定,不良反应可耐受,安全性高,可根据患者对不同治疗方案的耐受程度来选择合适的个体化治疗方案。

关键词：三阴性乳腺癌吉西他滨/顺铂长春瑞滨/卡培他滨临床疗效毒副反应

Coupling radiomics analysis of CT image with diversification of tumor ecosystem: A new insight to overall survival in stage Ⅰ-Ⅲ colorectal cancer

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Chinese Journal of Cancer Research 2022年第1期34卷 40-52页

作者： Yanqi Huang Lan He zhenhui Li Xin Chen Chu Han Ke zhao Yuan Zhang Jinrong Qu Yun Mao Changhong Liang Zaiyi Liu The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515China Department of Radiology Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Radiology the Third Affiliated Hospital of Kunming Medical UniversityYunnan Cancer HospitalYunnan Cancer CenterKunming 650118China Department of Radiology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510180China Department of Radiology the Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalZhengzhou 450003China Department of Radiology the First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China

Objective: This study aimed to establish a method to predict the overall survival(OS) of patients with stage Ⅰ-Ⅲ colorectal cancer(CRC) through coupling radiomics analysis of CT images with the measurement of tumor ecosystem ***: We retrospectively identified 161 consecutive patients with stage Ⅰ-Ⅲ CRC who had underwent radical resection as a training cohort. A total of 248 patients were recruited for temporary independent validation as external validation cohort 1, with 103 patients from an external institute as the external validation cohort 2. CT image features to describe tumor spatial heterogeneity leveraging the measurement of diversification of tumor ecosystem, were extracted to build a marker, termed the EcoRad signature. Multivariate Cox regression was used to assess the EcoRad signature, with a prediction model constructed to demonstrate its incremental value to the traditional staging system for OS ***: The EcoRad signature was significantly associated with OS in the training cohort [hazard ratio(HR)=6.670;95% confidence interval(95% CI): 3.433-12.956;P<0.001), external validation cohort 1(HR=2.866;95% CI: 1.646-4.990;P<0.001) and external validation cohort 2(HR=3.342;95% CI: 1.289-8.663;P=0.002).Incorporating the EcoRad signature into the prediction model presented a higher prediction ability(P<0.001) with respect to the C-index(0.813, 95% CI: 0.804-0.822 in the training cohort;0.758, 95% CI: 0.751-0.765 in the external validation cohort 1;and 0.746, 95% CI: 0.722-0.770 in external validation cohort 2), compared with the reference model that only incorporated tumor, node, metastasis(TNM) system, as well as a better calibration,improved reclassification and superior clinical ***: This study establishes a method to measure the spatial heterogeneity of CRC through coupling radiomics analysis with measurement of diversification of the tumor ecosystem, and suggests that this approach could effectively pred

关键词： Radiomics tumor ecosystem spatial heterogeneity survival prediction colorectal cancer