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Journal of Iron and Steel Research International 2024年第1期31卷 3-23页

作者： Xue-cheng Peng Han-jie guo Xin-fang Zhang Yi-wa Luo Ye Sun Jing guo Rong-guang Yang Xiao-dan Zheng School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials University of Science and Technology Beijing(USTB)Beijing100083China Beijing Shougang gitane New MATERIALS Co. Ltd.Beijing102206China

Heat-resistant alloys with excellent mechanical properties are widely used in various fields,and further improvement in their properties is essential to meet the requirements in new-generation advanced supercritical boilers,nuclear reactors,superheaters,and other new materials *** effectively enhance the comprehensive performance of heat-resistant alloys,second-phase particle strengthening has been widely studied,and in the face of different service envi-ronments of advanced heat-resistant steels,the selection of suitable second-phase particles is essential to maximize the performance of these *** this end,three major types of reinforcing phases in heat-resistant alloys such as carbides,rare earth oxides,and intermetallic compounds are summarized.A comparative analysis of the precipitation behavior of the reinforcing phases with different types as well as the risks and means of controlling their use in service,is *** parameters for the application of various types of second-phase particles in heat-resistant alloys are provided to support the design and preparation of new ultrahigh-performance heat-resistant alloys.

关键词： Heat-resistant alloy Second-phase particle Carbide Rare earth oxide Intermetallic compound Strengthening

Application and prospects of proteomic technology in inflammation:a review

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Food Science and Human Wellness 2024年第5期13卷 2373-2385页

作者： Senye wang Yanhai Chu Jiajia Yuan Yiqi Li zhenhua Liu Xiaoyu Chen Wenyi Kang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Functional Food Engineering Technology Research Center Kaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China College of Agriculture Henan UniversityKaifeng 475004China

Proteomics is a new technology that has been widely applied in the field of life and health *** effectively addresses issues related to the impact of dietary structure on organs,tissues,and cells,as well as the changes in proteins in various organs,tissues,and cells under disease *** differential proteins identified through proteomics can serve as disease biomarkers and target proteins affecting health and can be used for disease diagnosis and health *** this paper,the application of proteomics in the field of infl ammation in recent years was summarized,especially in the therapeutic target and mechanism of action,which opens up a new way for more effective prevention,diagnosis,and treatment of inflammation,and provides medical protection for human life and health.

关键词： Proteomics technology Inflammation Biomarkers Potential target Signaling pathway

Chemical constituents and anticoagulant activity from Delphinium brunonianum Royle

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未来食品学报(英文) 2024年第3期4卷 241-247页

作者： Changyang Ma Sitan Chen Syed Arif Hussain Rizvi Huihui Zhou Wenyi Kang Xuefeng Xi zhenhua Liu National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Henan ProvinceKaifeng 475004China Pakistan Agricultural Research Council Islamabad 450000Pakistan College of Physical Education Henan UniversityKaifeng 475004China

Delphinium brunonianum Royle belongs to Ranunculaceae family and has the effects of dispelling wind to relieve itching and cooling blood to *** was found that the extracts of *** had good anticoagulant activity which was extracted with 70%ethanol in our previous ***,16 compounds were isolated and identified from the extract of ***,among which compounds 5,7-10,12,14,15-16 were isolated from this genus for the first time,and compounds 2-4 were isolated from this plant for the first *** the coagulation activity assay showed that compounds 10,14 and 15 had good anticoagulant activity by activated partial thromboplastin time(APTT),thrombin time(TT)and prothrombin time(PT)in vitro.

关键词： Delphinium brunonianum Royle 9-Hydroxy-megastigma-4,7-dien-3-one-9-β-Dglucopyranoside 4-O-α-D-glucosyl benzoic acid Isolariciresinol 4-O-β-D-glucopyranoside Anticoagulant activity

Metal vacancy-enriched layered double hydroxide for biomass molecule electrooxidation coupled with hydrogen production

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Fundamental Research 2024年第1期4卷 69-76页

作者： Yingjie Song Shan Jiang Yeheng He Yu Wu Xin wan Wenfu Xie Jingjing wang zhenhua Li Haohong Duan Mingfei Shao State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBeijing 100029China PetroChina Petrochemical Research Institute China National Petroleum CorporationBeijing 100195China Department of Chemistry Tsinghua UniversityBeijing 100084China

The electrochemical oxidation of biomass molecules coupling with hydrogen production is a promising strategy to obtain both green energy and value-added chemicals;however,this strategy is limited by the competing oxygen evolution reactions and high energy ***,we report a hierarchical CoNi layered double hydroxides(LDHs)electrocatalyst with abundant Ni vacancies for the efficient anodic oxidation of 5-hydroxymethylfurfural(HMF)and cathodic hydrogen *** unique hierarchical nanosheet structure and Ni vacancies provide outstanding activity and selectivity toward several biomass molecules because of the finely regulated electronic structure and highly-exposed active *** particular,a high faradaic efficiency(FE)at a high current density(99%at 100 mA cm^(-2))is achieved for HMF oxidation,and a two-electrode electrolyzer is assembled based on the Ni vacancies-enriched LDH,which realized a continuous synthesis of highly-pure 2,5-furandicarboxylic acid products with high yields(95%)and FE(90%).

关键词： Layered double hydroxides Biomass upgrading 5-hydroxymethylfurfural Hydrogen production Coupled oxidation

Systematic analysis of DNA polymerases as therapeutic targets in pan-cancers

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BIOCELL 2024年第1期48卷 123-138页

作者： zhenhua LI HUILAI LV FAN ZHANg ZIMINg ZHU QIANg gUO MINgBO waNg CHAO HUANg LIJUAN CHEN WENPAN ZHANg YUN LI ZIQIANg TIAN Department of Thoracic Surgery Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China Department of Thoracic Surgery The First Hospital of XingtaiXingtai054001China Department of Thoracic Surgery Affiliated Hospital of Hebei UniversityBaoding050017China Shanghai OrigiMed Co. Ltd.Shanghai200000China Department of Thoracic Surgery The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Introduction:DNA polymerases are crucial for maintaining genome stability and influencing ***,the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy targets are not well ***:We conducted a systematic analysis using TCgA Pan-Cancer Atlas data and gene Set Cancer Analysis results to examine the expression profiles of 15 DNA polymerases(POLYs)and their clinical *** also evaluated the prognostic value of POLYs by analyzing their expression levels in relation to overall survival time(OS)using Kaplan-Meier survival ***,we investigated the correlations between POLY expression and immune cells,DNA damage repair(DDR)pathways,and *** sensitivity analysis was performed to assess the relationship between POLY expression and drug ***:Our analysis revealed that 14 out of 15 POLYs exhibited significantly distinct expression patterns between tumor and normal samples across most cancer types,except for DNA nucleotidylexotransferase(DNTT).Specifically,POLD1 and POLE showed elevated expression in almost all cancers,while POLQ exhibited high expression levels in all cancer *** POLYs showed heightened expression in specific cancer subtypes,while others exhibited low ***-Meier survival curves demonstrated significant prognostic value of POLYs in multiple cancers,including PAAD,KIRC,and *** analysis further validated these *** patterns of POLYs varied significantly among different cancer types and were associated with poorer survival *** correlations were observed between the expression of POLY members and immune cells,DDR pathways,and *** sensitivity analysis indicated an inverse relationship between POLY expression and drug ***:Our comprehensive study highlights the significant role of POLYs in cancer development and identifies them as promising prognostic and

关键词： DNA polymerases(POLYs) Prognostic biomarker The Cancer genome Atlas(TCgA) Ubiquitination network

MXene Sediment-Based Poly(vinyl alcohol)/Sodium Alginate Aerogel Evaporator with Vertically Aligned Channels for Highly Efficient Solar Steam generation

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Nano-Micro Letters 2024年第10期16卷 638-654页

作者： Tian wang Meng Li Hongxing Xu Xiao wang Mingshu Jia Xianguang Hou Shuai gao Qingman Liu Qihang Yang Mingwei Tian Lijun Qu zhenhua Song Xiaohu Wu Lili wang Xiansheng Zhang Shandong Key Laboratory of Medical and Health Textile Materials College of Textiles and ClothingState Key Laboratory of Bio-Fibers and Eco-TextilesResearch Center for Intelligent and Wearable TechnologyQingdao UniversityQingdao 266071People's Republic of China Department of Pharmacology Qingdao University School of PharmacyQingdao UniversityQingdao 266071People's Republic of China Shandong Institute of Advanced Technology Jinan 250100People's Republic of China College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061People's Republic of China

Solar-driven interfacial evaporation from seawater is considered an effective way to alleviate the emerging freshwater crisis because of its green and environmentally friendly ***,developing an evaporator with high efficiency,stability,and salt resistance remains a key ***,with an internal photothermal conversion efficiency of 100%,has received tremendous research interest as a photothermal ***,the process to prepare the MXene with monolayer is inefficient and generates a large amount of“waste”MXene sediments(MS).Here,MXene sediments is selected as the photothermal material,and a three-dimensional MXene sediments/poly(vinyl alcohol)/sodium alginate aerogel evaporator with vertically aligned pores by directional freezing method is innovatively *** vertical porous structure enables the evaporator to improve water transport,light capture,and high evaporation *** swabs and polypropylene are used as the water channel and support,respectively,thus fabricating a self-floating *** evaporator exhibits an evaporation rate of 3.6 kg m^(-2)h^(-1)under one-sun illumination,and 18.37 kg m^(-2)of freshwater is collected in the condensation collection device after 7 h of outdoor sun *** evaporator also displays excellent oil and salt *** research fully utilizes“waste”MS,enabling a self-floating evaporation device for freshwater collection.

关键词： MXene sediments Porous structure Desalination Self-floating

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肺疫证治规律探讨与连花清瘟组方新解

中国实验方剂学杂志 2024年第17期30卷 203-210页

作者：贾振华络病理论创新转化全国重点实验室河北省中西医结合医药研究院石家庄050035

病毒类呼吸系统传染病作为严重威胁人类健康的公共卫生事件,属“新病入络”范畴。笔者应用络病理论指导此类疾病防治,提出“肺疫”概念,揭示肺疫“气络-气道-血络”传变规律,提出“卫气同治、表里双解,先证用药、截断病势,整体调节、多... 详细信息

病毒类呼吸系统传染病作为严重威胁人类健康的公共卫生事件,属“新病入络”范畴。笔者应用络病理论指导此类疾病防治,提出“肺疫”概念,揭示肺疫“气络-气道-血络”传变规律,提出“卫气同治、表里双解,先证用药、截断病势,整体调节、多靶治疗”积极干预治疗策略。通过系统梳理历代肺疫治疗用药规律,揭示“存正气”和“避毒气”防控总则,分析解毒、通下、芳化等治法应用规律,基于文献整理、数据挖掘、临床经验荟萃分析,传承创新制订中药连花清瘟组方。全方以银翘散、麻杏石甘汤为基础方加减化裁,汲取明代吴又可治疫病用大黄经验,再结合肺疫病变特点,创新加入红景天、广藿香,具有“清热与辛温兼备、解毒与芳化并用、扶正与通腑同施”组方特色,使清而不过凉,温而不助火,扶正不留邪,祛邪不伤正。同时,系列基础和临床研究证实,连花清瘟组方具有应对呼吸系统传染病的独特优势,揭示了肺络病证治理论指导肺疫防控的科学内涵。

关键词：肺络病证治肺疫传变规律新病入络连花清瘟方剂积极干预治疗策略

CO_(2)地质利用与封存中碳迁移及其相态分布规律

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天然气工业 2024年第4期44卷 56-67页

作者：胡婷芮振华油气资源与工程全国重点实验室·中国石油大学(北京) 中国石油大学(北京)碳中和未来技术学院

CO_(2)地质利用与封存技术是“双碳”战略下重要的碳减排手段,前人的研究多集中于地质利用方面,而对地层的碳封存潜力尤其是CO_(2)矿化潜力的定量评价存在不足。为此,通过程序开发手段,将闪蒸计算加入开源的反应溶质运移模拟软件中,利... 详细信息

CO_(2)地质利用与封存技术是“双碳”战略下重要的碳减排手段,前人的研究多集中于地质利用方面,而对地层的碳封存潜力尤其是CO_(2)矿化潜力的定量评价存在不足。为此,通过程序开发手段,将闪蒸计算加入开源的反应溶质运移模拟软件中,利用改进后的软件建立了松辽盆地大情字井油田H59区块的三维地质模型,通过历史拟合注采过程校正模型地层参数,最后采用校正后模型量化表征了不同注入阶段及注采结束后CO_(2)迁移与相态转化的时空演化过程。研究结果表明:①在油藏CO_(2)混相驱条件下,CO_(2)在注入井端的小范围内呈现气相,在接触到油相前缘后,CO_(2)受浮力影响减弱,在垂向上逐渐趋于均匀分布,并向开采井端均匀推进;②气水同注阶段与注气阶段均有超过70%注入的CO_(2)溶解于油相,但气水同注阶段溶解于水相的CO_(2)含量明显增加;③注采结束后的相态演化特征表现为溶解水相CO_(2)逐渐转变为矿物相,而溶解油相CO_(2)存在转变为游离态气相的趋势;④注采结束后,主要矿化过程为绿泥石及铁白云石溶解产生铁、钙离子,与碳酸根离子结合构成方解石和菱铁矿等沉淀矿物(固碳矿物),而主要溶解矿物有钾长石、钙蒙脱石、铁白云石及绿泥石。结论认为,基于现场实测数据,利用嵌入闪蒸计算的CO_(2)地质利用与封存组分模拟软件,提高了对CO_(2)迁移及分布相态规律的进一步认识,研究结果对实现注CO_(2)高效提高采收率与封存具有重要指导意义。

关键词： CO_(2)地质利用与封存软件开发碳迁移 CO_(2)分布相态矿物固相封存

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genetic analysis of transcription factors in dopaminergic neuronal development in Parkinson’s disease

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Chinese Medical Journal 2024年第4期137卷 450-456页

作者： Yuwen Zhao Lixia Qin Hongxu Pan Tingwei Song Yige wang Xiaoxia Zhou Yaqin Xiang Jinchen Li zhenhua Liu Qiying Sun Jifeng guo Xinxiang Yan Beisha Tang Qian Xu Department of Neurology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Neurology The Second Xiangya HospitalCentral South UniversityChangshaHunan 410011China Bioinformatics Center National Clinical Research Center for geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of geriatrics Xiangya HospitalCentral South UniversityChangshaHunan 410008China Centre for Medical genetics and Hunan Key Laboratory of Medical genetics School of Life SciencesCentral South UniversityChangshaHunan 410008China Key Laboratory of Hunan Province in Neurodegenerative Disorders Central South UniversityChangshaHunan 410008China

Background:genetic variants of dopaminergic transcription factor-encoding genes are suggested to be Parkinson’s disease(PD)risk factors;however,no comprehensive analyses of these genes in patients with PD have been ***,we aimed to genetically analyze 16 dopaminergic transcription factor genes in Chinese patients with ***:Whole-exome sequencing(WES)was performed using a Chinese cohort comprising 1917 unrelated patients with familial or sporadic early-onset PD and 1652 ***,whole-genome sequencing(WgS)was performed using another Chinese cohort comprising 1962 unrelated patients with sporadic late-onset PD and 1279 ***:We detected 308 rare and 208 rare protein-altering variants in the WES and WgS cohorts,***-based association analyses of rare variants suggested that MSX1 is enriched in sporadic late-onset ***,the significance did not pass the Bonferroni ***,72 and 1730 common variants were found in the WES and WgS cohorts,***,single-variant logistic association analyses did not identify significant associations between common variants and ***:Variants of 16 typical dopaminergic transcription factors might not be major genetic risk factors for PD in Chinese ***,we highlight the complexity of PD and the need for extensive research elucidating its etiology.

关键词： Parkinson’s disease Transcription factors Dopaminergic neurons genetic Variants

Conjugated microporous polymers-scaffolded enzyme cascade systems with enhanced catalytic activity

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Chinese Journal of Catalysis 2024年第8期63卷 213-223页

作者： zhenhua Wu Jiafu Shi Boyu Zhang Yushuai Jiao Xiangxuan Meng Ziyi Chu Yu Chen Yiran Cheng Zhongyi Jiang School of Environmental Science and Engineering Tianjin UniversityTianjin 300072China Key Laboratory for green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China College of Chemical Engineering Fuzhou UniversityFuzhou 350108FujianChina Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityFuzhou 350207FujianChina

Enhancing catalytic activity of multi-enzyme in vitro through substrate channeling effect is promis-ing yet ***,conjugated microporous polymers(CMPs)-scaffolded integrated en-zyme cascade systems(I-ECSs)are constructed through co-entrapping glucose oxidase(gOx)and horseradish peroxidase(HRP),in which hydrogen peroxide(H_(2)O_(2))is the intermediate *** interplay of low-resistance mass transfer pathway and appropriate pore wall-H_(2)O_(2)interactions facilitates the directed transfer of H_(2)O_(2),resulting in 2.4-fold and 5.0-fold elevation in catalytic activ-ity compared to free ECSs and separated ECSs,*** substrate channeling effect could be regulated by altering the mass ratio of gOx to ***,I-ECSs demonstrate excellent stabili-ties in harsh environments and multiple recycling.

关键词： Biocatalysis Immobilization Enzyme cascade system Substrate channeling effect Conjugated microporous polymers