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Correction to:Potentiating CD8^(+)T cell antitumor activity by inhibiting PCSK9 to promote LDLR-mediated TCR recycling and signaling

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Protein & Cell 2022年第9期13卷 694-700页

作者： Juanjuan Yuan Ting Cai Xiaojun Zheng Yangzi Ren Jingwen Qi Xiaofei Lu Huihui Chen Huizhen Lin Zijie Chen Mengnan Liu Shangwen He Qijun Chen Siyang Feng Yingjun wu zhenhai Zhang Yanqing Ding Wei Yang Shunde Hospital Southern Medical University(The First People’s Hospital of Shunde)Foshan 528308China Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Department of PathologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Pathology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Molecular Oncologic Pathology Southern Medical UniversityGuangzhou 510515China Center for Precision Medicine Guangdong Provincial People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhou 510030China

Figure *** deficiency hinders the antitumor activity of CD8^(+)T cells.(A)Transcriptional level of genes involved in cholesterol transport in naïve CD8^(+)T cells,CTLs and CD8^(+)TILs(isolated at Day3 or Day7 post CTLs adoptive transfer),(n=4).(B)LDLR expression level on CTLs and CD8^(+)TILs(isolated at Day3 post CTLs adoptive transfer),(n=4).

关键词： LDLR inhibiting cholesterol

给水式气水混合离子发生装置对颗粒物净化的参数优化研究

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机电工程技术 2024年第2期53卷 89-93页

作者：吴婧怡李春辉李振海同济大学机械与能源工程学院上海200092

铁路隧道内清筛作业中柴油机车排放尾气中含有大量的颗粒物,由于隧道内通风差,颗粒物无法及时有效地排出隧道,严重危害现场作业人员的身体健康。为此,基于气水混合离子技术,利用凝并作用去除颗粒物,设计了一种应用于柴油机车尾气的净化... 详细信息

铁路隧道内清筛作业中柴油机车排放尾气中含有大量的颗粒物,由于隧道内通风差,颗粒物无法及时有效地排出隧道,严重危害现场作业人员的身体健康。为此,基于气水混合离子技术,利用凝并作用去除颗粒物,设计了一种应用于柴油机车尾气的净化装置,探讨不同给水流量、不同放电电压、不同极板间距、不同放置方式和不同针尖个数对装置净化效果的影响。使用气溶胶发生器产生固态颗粒气溶胶作为污染源,在100 L实验舱中对不同影响因素进行了实验研究,结果表明:注射泵水流量为50μL/min、电压为9 200 V、极板间距为55 mm、针头个数为15个是净化装置的最优设计参数,不同放置方式无明显差别。该气水混合离子发生装置可以为净化柴油机尾气颗粒物提供新的方式。

关键词：气水混合离子柴油机车颗粒物净化效果设计参数

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Role of intestinal barrier in pathogenesis of pigment gallstone in a guinea pig model

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Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 443-448页

作者： Yang Su ShuoDong wu JunZhe Jin zhenhai Zhang Ying Fan Department of General Surgery Second Affiliated Hospital China Medical University Shenyang 110004 China.

BACKGROUND: The function of the intestinal barrier has drawn more and more attention from researchers in recent years for its important role in many diseases such as burns, wounds, and pancreatitis. In our experimental studies on pigment gallstone, we found potential relationships between the function of the intestinal barrier and pigment gallstone formation. This study was undertaken to investigate the possible action and mechanism of the function of the intestinal barrier in the pathogenesis of pigment gallstone. METHODS: Eighty guinea pigs were divided into a normal group (CON), a pigment gallstone group (PS) and an intestinal mucosa protection group (GLN). Normal forage, pigment gallstone-forming forage and pigment gallstoneforming forage with supplemental intestinal mucosa protector (glutamine) were given to each group. In the gallstone-forming rate, morphology of intestinal mucosa, intestinal permeability, serum endotoxin and biliaryβ-glucuronidase were assessed after 8 weeks. RESULTS: The rate of gallstone-formation was 73.9% in the PS group. Damage of intestinal mucosa, endotoxemia (from 77±43×106 EU/L to 1367±525×l06 EU/L, P<0.01) and increased activity of biliaryβ-glucuronidase (endogenousβ-glucuromdase from 122.1±39.5 to 209.8±47.5 Fishman Unit, P<0.01, and exogenous p-glucuronidase from 573.5±476.9 to 2206.6±983.9 Fishman Unit, P<0.01) were observed in the PS group compared with the CON group. The rate gallstone-formation decreased significantly to 44.4% and the other indices except P-glucuronidase were lower in the GLN group than in the PS group. CONCLUSIONS: The function of the intestinal barrier is correlated with pigment gallstone formation. Dysfunction of the intestinal barrier function may promote pigment gallstone formation through bacterial translocation, endotoxemia, and biliaryβ-glucuronidase.

关键词： intestinal barrier function pigment gallstone bacterial translocation β-glucuronidase

Progress of Apple Rootstock Breeding and Its Use

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Horticultural Plant Journal 2019年第5期5卷 183-191页

作者： Yi Wang Wei Li Xuefeng Xu Changpeng Qiu Ting wu Qinping Wei Fengwang Ma zhenhai Han College of Horticulture China Agricultural UniversityBeijing100193China Beijing Academy of Forestry and Pomology Sciences Beijing100093China College of Horticulture Northwest A&F UniversityYanglingShaanxi712100China

Apple rootstock breeding has achieved great progress *** this review,we first summarize the rootstock breeding targets and utilization in main apple-producing ***,we discuss the focus and important research areas of apple rootstock breeding through five aspects:parent selection and setting of crosses,target genes and marker-assisted breeding,root configuration-guided breeding,apomictic resource utilization,and the application of genetic ***,we propose an apple rootstock division plan for China,which has a large potential to provide guidance for apple rootstock breeding and utilization in different apple-producing areas of China.

关键词： apple rootstock breeding root configuration apomictic resource utilization rootstock division

Expression of *** sodium channel Nav1.5 in *** colon cancer and its associations with estrogen receptor(ER)-βexpression and clinical outcomes

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Chinese Journal of Cancer 2017年第12期36卷 694-703页

作者： Jianhong Peng Qingjian Ou Xiaojun wu Rongxin Zhang Qian Zhao wu Jiang zhenhai Lu Desen Wan Zhizhong Pan Yujing Fang Department of Colorectal Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yatsen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Experimental Research Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Statistics School of Public HealthGuangzhou Medical UniversityGuangzhou 510182GuangdongP.R.China

Background: Voltage-gated sodium channel 1.5(Nav1.5) potentially promotes the migratory and invasive behaviors of colon cancer cells. Hitherto, the prognostic significance of Nav1.5 expression remains undetermined. The present study aimed to explore the associations of Nav1.5 expression with clinical outcomes and estrogen receptor-β(ER-β)expression in non-metastatic colon cancer patients receiving radical ***: A total of 269 consecutive patients with pathologically confirmed stages Ⅰ-Ⅲ colon cancer who underwent radical resection were selected. Nav1.5 and ER-β expression was detected by using immunohistochemistry(IHC)on tissue microarray constructed from paraffin-embedded specimens. IHC score was determined according to the percentage and intensity of positively stained cells. Statistical analysis was performed with the X-tile method, k coefficient, Chi square test or Fisher's exact test, logistic regression, log-rank test, and Cox proportional hazards ***: We found that Nav1.5 was commonly expressed in tumor tissues with higher mean IHC score as compared with matched tumor-adjacent normal tissues(5.1 ± 3.5 vs. 3.5 ± 2.7, P < 0.001).The high expression of Nav1.5 in colon cancer tissues was associated with high preoperative carcinoembryonic antigen level [odds ratio(OR) = 2.980;95% confidential interval(CI)1.163-7.632; P = 0.023] and high ER-β expression(OR = 2.808; 95% CI 1.243-6.343;p = 0.00 3). Log-rank test results showed that high Nav1.5 expression contributed to a low 5-year disease-free survival(DFS) rate in colon cancer patients(77.2% vs. 92.1%, P = 0.048), especially in patients with high ER-β expression tumor(76.2% vs. 91.3%, P = 0.032). Analysis with Cox proportional hazards model demonstrated that high Nav1.5 expression[hazard ratio(HR) = 2.738; 95% CI 1.100-6.819;P = 0.030] and lymph node metastasis(HR = 2.633; 95% CI 1.632-4.248; P < 0.001) were prognostic factors for unfavorable DFS in colon cancer ***: High ex

关键词： Nav1.5 Estrogen receptor-β Colon cancer Clinical outcome

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葡苷化合物作为植物生长调节剂的探索

武汉大学学报（自然科学版） 1992年第2期38卷 73-77页

作者：刘惠英傅莎莉杨振海吴萍武汉大学化学系

以愈创木酚(邻-甲氧基苯酚)为初始原料,采用相转移催化方法合成了6个葡苷化合物,并作了水稻种子发芽、育苗的初步试验。结果表明,这些葡苷化合物都有一定的生物活性。

关键词：植物生长调节剂葡苷化合物

Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage Ⅲ colon cancer

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Chinese Journal of Cancer 2017年第11期36卷 635-646页

作者： Jianhong Peng Rongxin Zhang Yixin Zhao Xiaojun wu Gong Chen Desen Wan zhenhai Lu Zhizhong Pan Department of Colorectal Surgery State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center 651 Dongfeng Road East GuangzhouGuangdong 510060 P. R. China

Background: The prognostic nutritional index(PNI) has been widely applied for predicting survival outcomes of patients with various malignant tumors. Although a low PNI predicts poor prognosis in patients with colorectal cancer after tumor resection, the prognostic value remains unknown in patients with stage Ⅲ colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy. This study aimed to investigate the prognostic value of PNI in patients with stage III colon ***: Medical records of 274 consecutive patients with stage Ⅲ colon cancer undergoing curative tumor resection followed by adjuvant chemotherapy with oxaliplatin and capecitabine between December 2007 and December2013 were reviewed. The optimal PNI cutoff value was determined using receiver operating characteristic(ROC) curve analysis. The associations of PNI with systemic inflammatory response markers, including lymphocyte-to-monocyte ratio(LMR), neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), and C-reactive protein(CRP)level, and clinicopathologic characteristics were assessed using the Chi square or Fisher's exact test. Correlation analysis was performed using Spearman's correlation coefficient. Disease-free survival(DFS) and overall survival(OS)stratified by PNI were analyzed using Kaplan-Meier method and log-rank test, and prognostic factors were identified by Cox regression ***: The preoperative PNI was positively correlated with LMR(r= 0.483, P < 0.001) and negatively correlated with NLR(r =-0.441, P < 0.001), PLR(r =-0.607, P < 0.001), and CRP level(r =-0.333, P < 0.001). A low PNI(≤49.22)was significantly associated with short OS and DFS in patients with stage ⅢC colon cancer but not in patients with stage ⅢA/ⅢB colon *** addition, patients with a low PNI achieved a longer OS and DFS after being treated with6-8 cycles of adjuvant chemotherapy than did those with < 6 cycles. Multivariate analyses revealed that PNI was indepe

关键词： Prognostic nutritional index Colon cancer Systemic inflammatory response marker Prognosis

基于腧穴敏化理论热敏灸治疗功能性便秘的临床研究

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针灸临床杂志 2024年第3期40卷 46-49页

作者：毛强健迟振海黄国民杨亚男吴德盛周水生李自如李佩玲罗郭峰王玉情陈日新江西中医药大学附属医院江西南昌330006 江西中医药大学江西南昌330004

目的:基于腧穴敏化理论,探查热敏灸治疗功能性便秘的有效性和优效性。方法:将90例患者随机分为3组,分别为热敏灸组、非热敏灸组与西药组,每组30例,疗程结束观察患者中医症状评分、生活质量评分与总疗效,并进行安全性判定。结果:在中医... 详细信息

目的:基于腧穴敏化理论,探查热敏灸治疗功能性便秘的有效性和优效性。方法:将90例患者随机分为3组,分别为热敏灸组、非热敏灸组与西药组,每组30例,疗程结束观察患者中医症状评分、生活质量评分与总疗效,并进行安全性判定。结果:在中医症状评分、生活质量评分方面,3组受试者治疗后分别与治疗前组内比较,差异均有统计学意义(P<0.01),治疗后3组患者两组间比较,差异有统计学意义(P<0.05)。3组受试者疗效比较,热敏灸组总有效率86.67%(26/30),非热敏灸组总有效率80.00%(24/30),西药组总有效率73.33%(22/30),经秩和检验,差异有统计学意义(P<0.05)。结论:在腧穴敏化理论指导下,热敏灸组治疗功能性便秘优于非热敏灸组和西药组,且无任何不良反应。

关键词：腧穴敏化热敏灸功能性便秘

Safety and efficacy of a modified XELOX adjuvant regimen for patients with operated stage III colon cancer:a Chinese single-center experience

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Cancer Communications 2019年第1期39卷 536-547页

作者： Jianhong Peng Weihao Li Rongxin Zhang Junzhong Lin Jinghua Tang Yongshan Wen zhenhai Lu Xiaojun wu Zhizhong Pan Department of Colorectal Surgery State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China

Background:A fixed 8-cycle oxaliplatin and capecitabine(XELOX)regimen has been the standard adjuvant therapy for patients with stage III colon ***,completing the full-cycle of oxaliplatin is often associated with severe *** spare patients from the toxic effects,without comprising the required efficacy,we evaluated the safety and efficacy of a modified XELOX(mXELOX)adjuvant chemotherapy regimen with 6 cycles of oxaliplatin and a full cycle of ***:We retrospectively analyzed 330 eligible patients with stage III colon cancer who underwent cura-tive tumor resection followed by mXELOX,standard XELOX or unfinished XELOX adjuvant chemotherapy between December 2007 and April *** prognostic factors were investigated and their disease-free survival(DFS)and overall survival(OS)rates were also determined and compared among the different regimen ***:Compared with the standard XELOX group,the mXELOX group had lower total incidence rates of neuro-toxicity(39.3%vs.76.2%,P<0.001),leucopenia(53.6%vs.69.8%,P=0.017)and thrombocytopenia(38.1%vs.56.3%,P=0.011).The standard XELOX and mXELOX adjuvant chemotherapy regimens presented with comparable 3-year DFS rates(86.3%vs.89.2%;P=0.838)and 3-year OS rates(92.7%vs.97.6%;P=0.227).Compared to unfinished XELOX chemotherapy,the oncologic benefits of the mXELOX regimen were greater for patients with T4 tumors(3-year DFS:Hazard ratio[HR],2.184;95%confidence interval[CI],1.051-4.540;P=0.036;3-year OS:HR,4.529;95%CI 1.245-16.479;P=0.022)and for high-risk patients(3-year DFS:HR,1.962;95%CI 0.964-3.993;P=0.044;3-year OS:HR,4.193;95%CI 1.182-14.874;P=0.026).Conclusions:The mXELOX adjuvant chemotherapy presented a comparable survival benefit and lower incidence of toxicity than standard XELOX *** could be an alternative treatment for high-risk patients with operated stage III colon cancer.

关键词： Colon cancer Adjuvant chemotherapy Oxaliplatin Capecitabine XELOX Efficacy Safety