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Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 Mpro

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Signal Transduction and Targeted Therapy 2021年第7期6卷 1959-1962页

作者： zhengyuan wang Yao Zhao Qingxing wang Yangfei Xing Lu Feng Juan Kong Chao Peng Leike Zhang Haitao Yang Min Lu Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine(Shanghai)Ruijin Hospital affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghaiChina State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanChina National Facility for Protein Science in Shanghai Zhangjiang LabShanghai Advanced Research InstituteChinese Academy of ScienceShanghaiChina

Dear Editor,Since the beginning of 2020,the Coronavirus(CoV)Disease 2019(COVID-19)pandemic has posed formidable challenges to public health *** main protease(Mpro,3CLpro)of CoVs plays essential roles in viral replicat... 详细信息

关键词： attractive development caspase

Decitabine induces IRF7-mediated immune responses in p53-mutated triple-negative breast cancer:a clinical and translational study

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Frontiers of Medicine 2024年第2期18卷 357-374页

作者： Haoyu wang zhengyuan wang Zheng wang Xiaoyang Li Yuntong Li Ni Yan Lili Wu Ying Liang Jiale Wu Huaxin Song Qing Qu Jiahui Huang Chunkang Chang Kunwei Shen Xiaosong Chen Min Lu Department of General Surgery Comprehensive Breast Health CenterRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine(Shanghai)Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Hematology Shanghai Institute of HematologyRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Hematology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200025China

p53 is mutated in half of cancer ***,no p53-targeting drugs have been ***,we reposition decitabine for triple-negative breast cancer(TNBC),a subtype with frequent p53 mutations and extremely poor *** a retrospective study on tissue microarrays with 132 TNBC cases,DNMT1 overexpression was associated with p53 mutations(P=0.037)and poor overall survival(OS)(P=0.010).In a prospective DEciTabinE and Carboplatin in TNBC(DETECT)trial(NCT03295552),decitabine with carboplatin produced an objective response rate(ORR)of 42%in 12 patients with stage IV *** the 9 trialed patients with available TP53 sequencing results,the 6 patients with p53 mutations had higher ORR(3/6 vs.0/3)and better OS(16.0 vs.4.0 months)than the patients with wild-type *** a mechanistic study,isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type *** the DETECT trial,decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line(upregulation by 16-fold)and the most responsive patient with *** integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

关键词： p53 mutation triple-negative breast cancer decitabine DNMT1 IRF7 innate immune response

Tracking Human Poses with Head Orientation Estimation

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Instrumentation 2017年第3期4卷 40-46页

作者： TIAN Jinglan wang zhengyuan LI Ling LIU Wanquan School of Information Science and Engineering University of Jinan Jinan Tengyue Electronic Co.Ltd. Department of Computing Curtin University

Lots of progress has been made recently on 2 D human pose tracking with tracking-by-detection approaches. However,several challenges still remain in this area which is due to self-occlusions and the confusion between the left and right limbs during tracking. In this work,a head orientation detection step is introduced into the tracking framework to serve as a complementary tool to assist human pose estimation. With the face orientation determined,the system can decide whether the left or right side of the human body is exactly visible and infer the state of the symmetric counterpart. By granting a higher priority for the completely visible side,the system can avoid double counting to a great extent when inferring body poses. The proposed framework is evaluated on the HumanEva dataset. The results show that it largely reduces the occurrence of double counting and distinguishes the left and right sides consistently.

关键词： Human Pose Tracking Head Orientation Tracking by Detection

重返社会的“原始”:张光直三代文明研究中的“社会学年鉴学派”因素

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社会 2021年第6期41卷 109-138页

作者：王正原北京大学考古文博学院

本文回顾了张光直有关"连续性文明"与"破裂性文明"的比较研究,发现他构想"连续性"的方式在于重返社会的"原始"。张光直在"二分制"与萨满教这两项赋予三代文明以"连续性"特征的研究中,借用了"社会学年鉴学派"对于"基本形式"的构想,以赋... 详细信息

本文回顾了张光直有关"连续性文明"与"破裂性文明"的比较研究,发现他构想"连续性"的方式在于重返社会的"原始"。张光直在"二分制"与萨满教这两项赋予三代文明以"连续性"特征的研究中,借用了"社会学年鉴学派"对于"基本形式"的构想,以赋予三代文明以"原始"意象。在对规范性、社会总体性、基本形式、文明多元性的强调上,张光直文明研究的思路与构想与"社会学年鉴学派"相互呼应。该学说体现了张光直作为中国近现代学人的痛苦与思索。

关键词：张光直社会学年鉴学派原始文明

古史重建的社会学路径——读李宗侗《中国古代社会新研》

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南方文物 2022年第5期 65-74页

作者：王正原北京大学考古文博学院

自史语所建立以来,以考古学方法寻找“新材料”,从中梳理出可信历史,是古史重建的通常办法①。不过,“新材料”仅是与“旧材料”相对而言,过去没有见到的史料,本身不等于新的智识。所谓史料,总是人的产物,人必处于特定的集体现象中。观... 详细信息

自史语所建立以来,以考古学方法寻找“新材料”,从中梳理出可信历史,是古史重建的通常办法①。不过,“新材料”仅是与“旧材料”相对而言,过去没有见到的史料,本身不等于新的智识。所谓史料,总是人的产物,人必处于特定的集体现象中。观看史料时,学者必怀有对集体现象的理解,方可使其不失为人产生的东西。在此过程中,学者也可修正自己的理解。故在新材料的喷涌及考古学方法②的发展外,古史重建运动的新意。

关键词：考古学方法史语所史料新意

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话语标记语意义的语用分析

外语学刊 2006年第2期 38-44页

作者：王正元燕山大学秦皇岛066004

语言学家们对话语标记语的意义多有探讨,但认识各有异同。本文在话语标记语的连贯与关联研究的基础上,从语义与语用界面分析话语标记语与语用标记语的区别、话语标记语的语义意义和语用意义、命题意义及其程序意义和概念意义的几个问题。

关键词：话语标记连贯意义语用

Percent body fat,but not body mass index,is associated with cardiometabolic risk factors in children and adolescents

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Chronic Diseases and Translational Medicine 2023年第2期9卷 143-153页

作者： Xin He Zhenni Zhu Jiajie Zang zhengyuan wang Ping Liao Wenjing wang Yan Shi Chen Fu Laboratory of Functional Medicine Division of Chronic Non-communicable Diseases and InjuryShanghai Municipal Center for Disease Control and PreventionShanghaiChina Department of Nutrition Hygiene Division of Health Risk Factor Monitoring and ControlShanghai Municipal Center for Disease Control and PreventionShanghaiChina

Background:The epidemic of overweight and obesity has become a worldwide public health *** diseases may originate in *** investigated the association between percent body fat(PBF)measured by the bioelectrical impedance assay and cardiometabolic risk(CMR)in ***:This cross-sectional study involved 3819 subjects(6-17 years old)in *** assessed the association between PBF and body mass index(BMI)with multiple CMR *** examined the risk for cardiometabolic abnormalities attributable to overweight and obesity based on age-and sexspecific PBF Z-scores and BMI Z-scores,***:PBF,but not BMI,was positively associated with multiple CMR factors in males and females except for total cholesterol in females(all p<0.05).Compared with the non-overweight group based on PBF,overweight and obese subjects had increasingly higher odds ratio of dyslipidemia(2.90(1.99-4.23),4.59(2.88-7.32)for males and 1.82(1.20-2.75),2.46(1.47-4.11)for females)and elevated blood pressure(BP)(3.26(2.35-4.51),4.55(2.92-7.09)for males and 1.59(1.07-2.34),3.98(2.27-6.17)for females).Obesity females showed a higher likelihood for hyperglycemia(2.19(1.24-3.84))than non-overweight *** both sexes,the predictive effect of PBF on dyslipidemia and elevated BP in adolescents was better than that in *** hyperglycemia,the predictive effect of PBF was better in male adolescents and female *** was no risk difference for cardiometabolic abnormalities attributable to BMI-based obesity ***:PBF but not BMI was associated with *** and obesity categories based on PBF had an increased risk for cardiometabolic abnormalities in children and adolescents.

关键词： adolescents cardiometabolic risk factors children obesity percent body fat

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基于导纳测量原理的隐极发电机失磁保护应用

电力自动化设备 2017年第5期37卷 205-210页

作者：兀鹏越徐雷钧王正元王智高西安热工研究院有限公司陕西西安710032 江苏大学电气信息工程学院江苏镇江212013 华能天津煤气化发电有限公司天津300452

介绍了我国传统发电机的失磁保护采用的阻抗判据,指出其存在缺乏直观性、与低励限制整定配合困难的缺点。介绍了基于导纳测量的失磁保护原理,鉴于导纳特性与发电机运行极限特性曲线的相似性,因此其具有物理意义清晰直观、易于整定、易... 详细信息

介绍了我国传统发电机的失磁保护采用的阻抗判据,指出其存在缺乏直观性、与低励限制整定配合困难的缺点。介绍了基于导纳测量的失磁保护原理,鉴于导纳特性与发电机运行极限特性曲线的相似性,因此其具有物理意义清晰直观、易于整定、易于与励磁限制特性配合等优点。分析了基于导纳测量原理的失磁保护的整定原则,指出其与国内保护整定的不同之处,说明了将国内保护整定原则应用于基于导纳测量原理的失磁保护整定的合理性。结合工程实例给出了基于导纳测量原理的失磁保护的整定算例,并通过实际发电机进相试验过程验证了整定计算的正确性。

关键词：发电机继电保护失磁保护静态稳定阻抗测量导纳测量整定计算

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论语言学研究的学术视角

中国外语 2008年第4期5卷 18-22页

作者：王正元燕山大学

语言学研究的不同认识论、方法论及不同的研究维度的存在是必然的,多个语言学理论并存、理论间的平等对话与理论共性的整合是语言学研究和谐发展的基础。本文围绕语言学的跨学科研究倾向、理论并存与兼容、语言本体研究、目标及学术批... 详细信息

语言学研究的不同认识论、方法论及不同的研究维度的存在是必然的,多个语言学理论并存、理论间的平等对话与理论共性的整合是语言学研究和谐发展的基础。本文围绕语言学的跨学科研究倾向、理论并存与兼容、语言本体研究、目标及学术批评与监控问题,对语言学研究的学术视角进行探讨。

关键词：语言学研究共存整合视角