Two-dimensional copper metal-organic frameworks as antibacterial agents for biofilm treatment

作     者：WANG ZhengYuan GUO Wei ZHANG Kai YE YingMin WANG YanMin SUI DanDan ZHAO NaNa XU Fu-Jian WANG ZhengYuan;GUO Wei;ZHANG Kai;YE YingMin;WANG YanMin;SUI DanDan;ZHAO NaNa;XU Fu-Jian

作者机构：Key Laboratory of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical TechnologyMinistry of Education)Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing100029China 

出 版 物：《Science China(Technological Sciences)》 (中国科学（技术科学英文版）)

年 卷 期：2022年第65卷第5期

页      面：1052-1058页

核心收录：

学科分类：08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.52173271,51922022 and 51773013) the Beijing Outstanding Young Scientist Program(Grant No.BJJWZYJH01201910010024) the China Postdoctoral Science Foundation(Grant Nos.2021T140044 and 2020M670110) the Beijing Municipal Natural Science Foundation(Grant No.2214074) the Beijing Municipal Science and Technology Project(Grant No.Z191100006619099) the Fundamental Research Funds for the Central Universities(Grant Nos.BHYC1705A and XK1802-2) 

主　　题：metal-organic frameworks reactive oxygen species antibacterial therapy nanozymes two-dimensional 

摘      要：Metal-organic frameworks(MOFs)composed of functional metal ions/clusters and suitable bridging ligands are highly designable,which have shown excellent catalytic activity as nanozymes and are promising for antibacterial ***,twodimensional(2D)copper MOF nanosheets(Cu-MOF NSs)as effective antibacterial agents were prepared through a simple onestep *** 2D Cu-MOF NSs displayed a peroxidase-like activity toward H_(2)O_(2)decomposition into highly cytotoxic hydroxyl radicals(·OH).Notably,the 2D morphology of Cu-MOF NSs provides a high density of Cu^(2+)/Cu^(+)surface active sites,which could efficiently oxidize the proteins and lipids on the bacterial surface and induce the death of *** is found that the as-prepared 2D Cu-MOF NSs exhibited antibacterial properties against Staphylococcus aureus(***)and could efficiently eradicate the biofilm of *** to 99.9%bacteria were killed at a Cu-MOF concentration of 4μg/m *** study opens a new avenue for the design of MOF-based antibacterial agents to combat pathogenic bacterial infections.